AIM： To assess central corneal thickness （CCT） changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS： This was a prospective randomized study of 60 hospita...AIM： To assess central corneal thickness （CCT） changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS： This was a prospective randomized study of 60 hospital volunteers. After baseline CCT measurements of both eyes of 40 subjects were obtained using Scheimpflug system, a drop of preservative-free 2% fluorescein, was instilled in one eye and in other eye, one drop of normal saline （control）. Measurements were repeated after 1, 2, 5, 10, 20, 30, 40, 50 and 60min （continuous assessment group）. Twenty subjects had baseline CCT taken, then fluorescein was instilled in one eye and measurements were taken at lmin. Ten eyes had saline rinse after lmin and 10 other eyes did not, measurements were repeated at 2min （eye rinse group）. RESULTS： The mean baseline CCT for continuous assessment group was 546.2±32.1um （range, 489.0-606.0）, control eyes was 546.6~±30.7 um （range, 489.0-602.0）. At lmin after fluorescein instillation, CCT significantly increased by 37.0±34.0um （P〈0.001）, then decreased gradually, reaching baseline at 60min. CCT variations were not significant in control group （P〉0.05）. For eye rinse group, CCT mean differences between baseline and 2min were 18.2um （95 % Ch -54.7 to 18.3） with rinse and 26.5um （95% CI： -62.9 to 9.9） without rinse; paired sample tests were not significant （P〉0.05）. CONCLUSION： The presence of fluorescein increased CCT value to a clinically relevant level of 6.8%. Eye rinse did not significantly reduce the effect at 2min post fluorescein timepoint.展开更多
AIM： To evaluate the effect of punctal occlusion using thermosensitive（smart plug） versus silicone plug for management of aqueous deficient dry eye on cornea sensitivity, ocular surface health and tear film stabili...AIM： To evaluate the effect of punctal occlusion using thermosensitive（smart plug） versus silicone plug for management of aqueous deficient dry eye on cornea sensitivity, ocular surface health and tear film stability.METHODS： A comparative prospective interventiona case study included 45 patients with bilateral severe form of aqueous deficient dry eye. In each patient, the smar plug was inserted in the lower punctum of the right eye which was considered as study group 1 and silicone plug was inserted in the lower punctum of the left eye o the same patient which was considered as study group2. All patients were subjected to careful history taking and questionnaire for subjective assessment of severity of symptoms. Corneal sensitivity, corneal fluorescein rose bengal staining, Schirmer＇s I test, tear film break up time and conjunctival impression cytology were performed pre and 1, 3 and 6mo post plug insertion.RESULTS： A statistically significant improvement in subjective and objective manifestations occurred following treatment with both types of plugs（P 〈0.01）The thermosensitive plug caused significant overal improvement, decrease in frequency of application o tear substitutes and improvement of conjunctiva impression cytology parameters in the inserted side（P 〈0.01）. Canaliculitis was reported in two eyes（4.4% following punctal occlusion using thermosensitive plug（study group 1）. Spontaneous plug loss occurred in 21eyes（46.6%） in the silicone plug group（study group 2）.CONCLUSION： Improvement of subjective and objective manifestations of aqueous deficient dry eye occurs following punctal plug occlusion. Thermosensitive plug has good patient＇s compliance with fewer complications and lower rates of loss compared to the silicone plug.展开更多
AIM: To evaluate corneal injury during general anesthesia and analyze the protective effect of medical hydro-gel eye patch in clinics.METHODS:Seventy-sixpatientswith152 eyesundergoing general anesthesia were included....AIM: To evaluate corneal injury during general anesthesia and analyze the protective effect of medical hydro-gel eye patch in clinics.METHODS:Seventy-sixpatientswith152 eyesundergoing general anesthesia were included. None had positive corneal fluorescein staining before surgery. Both eyes of each patient were analyzed, with one randomly allocated to receive medical hydro-gel eye patch, and the other to receive common adhesive tape as a control. Corneal injuries were evaluated by scoring fluorescein staining under a hand-held slit lamp immediately after surgery in postanesthesia care unit and 24 h thereafter. Patients’ discomforts were also evaluated.RESULTS: Twelve eyes(15.8%) in the hydro-gel patch group and 30 eyes(39.5%) in the adhesive tape group showed corneal injury immediately after surgery. The eyes protected with hydro-gel patch showed statistically less corneal fluorescein staining than the control group.Four eyes in hydro-gel patch group and 6 eyes in adhesive tape group suffered discomfort immediately after surgery without intergroup difference and all discomforts disappeared after 24h(P =0.257). No side effect was observed in hydro-gel patch group, while 5eyes had brow avulsion and 2 got skin itching in adhesive tape group.CONCLUSION: Corneal injury complication was morefrequent than we thought following general anesthesia.The medical hydro-gel eye patch can protect the occurrence of corneal injury following general anesthesia.展开更多
AIMTo measure central corneal thickness (CCT) and pre-corneal tear film thickness using the Galilei dual-Scheimpflug analyzer (GSA) in New Zealand white rabbits.
【目的】观察针刺治疗肝经郁热型干眼症的疗效及其对焦虑情绪的影响。【方法】将78例肝经郁热型干眼症患者随机分为观察组和对照组,每组各39例。对照组给予聚乙烯醇滴眼液滴眼治疗,观察组在对照组的基础上加用针刺治疗,疗程为1个月。观...【目的】观察针刺治疗肝经郁热型干眼症的疗效及其对焦虑情绪的影响。【方法】将78例肝经郁热型干眼症患者随机分为观察组和对照组,每组各39例。对照组给予聚乙烯醇滴眼液滴眼治疗,观察组在对照组的基础上加用针刺治疗,疗程为1个月。观察2组患者治疗前后主观症状评分、泪膜破裂时间(break-up time,BUT)、泪液分泌试验(Schirmer I test,SIT)、角膜荧光染色结果(fluorescein,FL)评分以及焦虑自评量表(SAS)评分的变化情况,并评价2组患者的临床疗效和焦虑改善疗效。【结果】(1)治疗1个月后,观察组的总有效率为89.74%(35/39),对照组为71.79%(28/39),组间比较,观察组的总有效率(χ^(2)检验)和总体疗效(秩和检验)均优于对照组(P<0.05)。(2)治疗后,2组患者的眼睛干燥感、异物感、疲劳感、烧灼感、不适感、视力波动等各项主观症状评分及总积分均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组(P<0.05或P<0.01)。(3)治疗后,2组患者的BUT、SIT、FL评分均较治疗前明显改善(P<0.05),且观察组的改善作用均明显优于对照组(P<0.01)。(4)治疗后,2组患者的SAS评分均较治疗前明显降低(P<0.05),且观察组的降低作用明显优于对照组(P<0.01)。(5)治疗后,观察组的焦虑恢复正常率为89.29%(25/28),对照组为48.15%(13/27),组间比较(χ^(2)检验),观察组的焦虑改善疗效明显优于对照组(P<0.05)。【结论】在人工泪液治疗基础上加用针刺治疗肝经郁热型干眼症患者疗效确切,可有效改善患者临床症状和焦虑情绪,其疗效优于单纯人工泪液治疗。展开更多
目的对比小牛血去蛋白提取物凝胶(兴齐制药)和羟糖苷眼液(爱尔康)在准分子激光原位角膜磨镶术(laser in situkeratomileusis,LASIK)后对角膜上皮损伤修复作用的功能差异,为改善术后干眼的临床用药提供帮助。方法将2010年1月至4月在我院...目的对比小牛血去蛋白提取物凝胶(兴齐制药)和羟糖苷眼液(爱尔康)在准分子激光原位角膜磨镶术(laser in situkeratomileusis,LASIK)后对角膜上皮损伤修复作用的功能差异,为改善术后干眼的临床用药提供帮助。方法将2010年1月至4月在我院实施LASIK手术的76例(152眼)近视患者依据术后用药进行分组,Ⅰ组为小牛血去蛋白提取物凝胶组,Ⅱ组为羟糖苷眼液组,术前和术后1个月分别行角膜荧光素染色检查,记录泪膜破裂时间(break-up time,BUT)和角膜上皮染色评分,对比两种药物对LASIK术后角膜上皮损伤修复作用的差异。结果术前、术后的BUT[术后Ⅰ组:(5.61±2.72)s,Ⅱ组:(5.42±3.17)s]和角膜上皮染色评分,组内比较差异无统计学意义(P值分别为0.877和0.092),组间比较差异亦无统计学意义(P值分别为0.683和0.212)。进一步对术前轻度干眼对象进行比较,手术前后BUT变化量组间差异无统计学意义(P=0.107),角膜上皮染色评分变化量的组间差异亦无统计学意义(P=0.181)。结论对于实施了LASIK的患者,术后为防止干眼,使用两类药物具有等同疗效,在BUT的延长上,小牛去蛋白提取物凝胶具有优势;但对于术前轻度干眼的患者,羟糖苷眼液效果更佳。展开更多
基金Supported by Research Centre, College of Applied Medical Sciencesthe Deanship of Scientific Research at King Saud University
文摘AIM： To assess central corneal thickness （CCT） changes measured with Scheimpflug device following instillation of 2% fluorescein in normal subjects. ~ METHODS： This was a prospective randomized study of 60 hospital volunteers. After baseline CCT measurements of both eyes of 40 subjects were obtained using Scheimpflug system, a drop of preservative-free 2% fluorescein, was instilled in one eye and in other eye, one drop of normal saline （control）. Measurements were repeated after 1, 2, 5, 10, 20, 30, 40, 50 and 60min （continuous assessment group）. Twenty subjects had baseline CCT taken, then fluorescein was instilled in one eye and measurements were taken at lmin. Ten eyes had saline rinse after lmin and 10 other eyes did not, measurements were repeated at 2min （eye rinse group）. RESULTS： The mean baseline CCT for continuous assessment group was 546.2±32.1um （range, 489.0-606.0）, control eyes was 546.6~±30.7 um （range, 489.0-602.0）. At lmin after fluorescein instillation, CCT significantly increased by 37.0±34.0um （P〈0.001）, then decreased gradually, reaching baseline at 60min. CCT variations were not significant in control group （P〉0.05）. For eye rinse group, CCT mean differences between baseline and 2min were 18.2um （95 % Ch -54.7 to 18.3） with rinse and 26.5um （95% CI： -62.9 to 9.9） without rinse; paired sample tests were not significant （P〉0.05）. CONCLUSION： The presence of fluorescein increased CCT value to a clinically relevant level of 6.8%. Eye rinse did not significantly reduce the effect at 2min post fluorescein timepoint.
文摘AIM： To evaluate the effect of punctal occlusion using thermosensitive（smart plug） versus silicone plug for management of aqueous deficient dry eye on cornea sensitivity, ocular surface health and tear film stability.METHODS： A comparative prospective interventiona case study included 45 patients with bilateral severe form of aqueous deficient dry eye. In each patient, the smar plug was inserted in the lower punctum of the right eye which was considered as study group 1 and silicone plug was inserted in the lower punctum of the left eye o the same patient which was considered as study group2. All patients were subjected to careful history taking and questionnaire for subjective assessment of severity of symptoms. Corneal sensitivity, corneal fluorescein rose bengal staining, Schirmer＇s I test, tear film break up time and conjunctival impression cytology were performed pre and 1, 3 and 6mo post plug insertion.RESULTS： A statistically significant improvement in subjective and objective manifestations occurred following treatment with both types of plugs（P 〈0.01）The thermosensitive plug caused significant overal improvement, decrease in frequency of application o tear substitutes and improvement of conjunctiva impression cytology parameters in the inserted side（P 〈0.01）. Canaliculitis was reported in two eyes（4.4% following punctal occlusion using thermosensitive plug（study group 1）. Spontaneous plug loss occurred in 21eyes（46.6%） in the silicone plug group（study group 2）.CONCLUSION： Improvement of subjective and objective manifestations of aqueous deficient dry eye occurs following punctal plug occlusion. Thermosensitive plug has good patient＇s compliance with fewer complications and lower rates of loss compared to the silicone plug.
基金Supported by National Natural Science Foundation of China (No.81070705 81270974)+1 种基金Zhejiang Provincial Natural Science Foundation of China (LQ13H120003)Zhejiang Key Laboratory Fund of China (No.2011233)
文摘AIM: To evaluate corneal injury during general anesthesia and analyze the protective effect of medical hydro-gel eye patch in clinics.METHODS:Seventy-sixpatientswith152 eyesundergoing general anesthesia were included. None had positive corneal fluorescein staining before surgery. Both eyes of each patient were analyzed, with one randomly allocated to receive medical hydro-gel eye patch, and the other to receive common adhesive tape as a control. Corneal injuries were evaluated by scoring fluorescein staining under a hand-held slit lamp immediately after surgery in postanesthesia care unit and 24 h thereafter. Patients’ discomforts were also evaluated.RESULTS: Twelve eyes(15.8%) in the hydro-gel patch group and 30 eyes(39.5%) in the adhesive tape group showed corneal injury immediately after surgery. The eyes protected with hydro-gel patch showed statistically less corneal fluorescein staining than the control group.Four eyes in hydro-gel patch group and 6 eyes in adhesive tape group suffered discomfort immediately after surgery without intergroup difference and all discomforts disappeared after 24h(P =0.257). No side effect was observed in hydro-gel patch group, while 5eyes had brow avulsion and 2 got skin itching in adhesive tape group.CONCLUSION: Corneal injury complication was morefrequent than we thought following general anesthesia.The medical hydro-gel eye patch can protect the occurrence of corneal injury following general anesthesia.
文摘AIMTo measure central corneal thickness (CCT) and pre-corneal tear film thickness using the Galilei dual-Scheimpflug analyzer (GSA) in New Zealand white rabbits.
文摘【目的】观察针刺治疗肝经郁热型干眼症的疗效及其对焦虑情绪的影响。【方法】将78例肝经郁热型干眼症患者随机分为观察组和对照组,每组各39例。对照组给予聚乙烯醇滴眼液滴眼治疗,观察组在对照组的基础上加用针刺治疗,疗程为1个月。观察2组患者治疗前后主观症状评分、泪膜破裂时间(break-up time,BUT)、泪液分泌试验(Schirmer I test,SIT)、角膜荧光染色结果(fluorescein,FL)评分以及焦虑自评量表(SAS)评分的变化情况,并评价2组患者的临床疗效和焦虑改善疗效。【结果】(1)治疗1个月后,观察组的总有效率为89.74%(35/39),对照组为71.79%(28/39),组间比较,观察组的总有效率(χ^(2)检验)和总体疗效(秩和检验)均优于对照组(P<0.05)。(2)治疗后,2组患者的眼睛干燥感、异物感、疲劳感、烧灼感、不适感、视力波动等各项主观症状评分及总积分均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组(P<0.05或P<0.01)。(3)治疗后,2组患者的BUT、SIT、FL评分均较治疗前明显改善(P<0.05),且观察组的改善作用均明显优于对照组(P<0.01)。(4)治疗后,2组患者的SAS评分均较治疗前明显降低(P<0.05),且观察组的降低作用明显优于对照组(P<0.01)。(5)治疗后,观察组的焦虑恢复正常率为89.29%(25/28),对照组为48.15%(13/27),组间比较(χ^(2)检验),观察组的焦虑改善疗效明显优于对照组(P<0.05)。【结论】在人工泪液治疗基础上加用针刺治疗肝经郁热型干眼症患者疗效确切,可有效改善患者临床症状和焦虑情绪,其疗效优于单纯人工泪液治疗。
文摘目的对比小牛血去蛋白提取物凝胶(兴齐制药)和羟糖苷眼液(爱尔康)在准分子激光原位角膜磨镶术(laser in situkeratomileusis,LASIK)后对角膜上皮损伤修复作用的功能差异,为改善术后干眼的临床用药提供帮助。方法将2010年1月至4月在我院实施LASIK手术的76例(152眼)近视患者依据术后用药进行分组,Ⅰ组为小牛血去蛋白提取物凝胶组,Ⅱ组为羟糖苷眼液组,术前和术后1个月分别行角膜荧光素染色检查,记录泪膜破裂时间(break-up time,BUT)和角膜上皮染色评分,对比两种药物对LASIK术后角膜上皮损伤修复作用的差异。结果术前、术后的BUT[术后Ⅰ组:(5.61±2.72)s,Ⅱ组:(5.42±3.17)s]和角膜上皮染色评分,组内比较差异无统计学意义(P值分别为0.877和0.092),组间比较差异亦无统计学意义(P值分别为0.683和0.212)。进一步对术前轻度干眼对象进行比较,手术前后BUT变化量组间差异无统计学意义(P=0.107),角膜上皮染色评分变化量的组间差异亦无统计学意义(P=0.181)。结论对于实施了LASIK的患者,术后为防止干眼,使用两类药物具有等同疗效,在BUT的延长上,小牛去蛋白提取物凝胶具有优势;但对于术前轻度干眼的患者,羟糖苷眼液效果更佳。
