Corona virus is an enveloped virus from the category of RNA viruses.The patients are suffering from fever,cough,shortness of breath,and no definitive treatment or vaccine is currently available.The viral disease is gr...Corona virus is an enveloped virus from the category of RNA viruses.The patients are suffering from fever,cough,shortness of breath,and no definitive treatment or vaccine is currently available.The viral disease is gradually self-limiting due to the production of antibodies in the body.CDC has developed a new laboratory test kit for use in testing patient specimens for severe acute respiratory syndrome coronavirus,the virus that causes COVID-19.The test kit is called the Centers for Disease Control and Prevention(CDC)2019-Novel Coronavirus(2019-nCoV)Real-Time Reverse Transcriptase(RT)-PCR Diagnostic Panel.It seems traditional medicine would be usefulness to helping treatment of corona cuvid-19 patients too.It might be other screening distinguishes rapid tests with high detection limit by designing chines scientists are available[1-12].展开更多
Corona Virus Disease 2019 (COVID-19) is a deadly respiratory viral disease that started in China in the year 2019 before spreading to the world. It affects everybody regardless of race, religion, social economic statu...Corona Virus Disease 2019 (COVID-19) is a deadly respiratory viral disease that started in China in the year 2019 before spreading to the world. It affects everybody regardless of race, religion, social economic status or age. However, literature indicates that people with compromised immune status are at a higher risk of contracting viral infections. During pregnancy, the immune status of the woman is suppressed because it acts to protect both the mother and her unborn baby. The purpose of this study was to provide an overview of available evidence on the risk of contracting COVID-19 and COVID-19 infection prevention among pregnant women. Relevant and recent articles were identified from various databases. Article selection was aligned to the study questions. Articles that were related to study objectives were included and those not related to study objectives were excluded. A narrative report was produced and results were described according to study objectives. Approximately 8 data sources were included and most of the reviewed articles indicated that pregnant women are at a higher risk of getting COVID-19. The reviews further indicated that pregnant women can be prevented from this deadly virus by providing community antenatal services instead of visiting the health facilities. If a pregnant woman develops symptoms of respiratory infection, it is advisable to seek immediate diagnosis to rule out COVID-19 and get appropriate management to avoid complications. The selected studies’ quality was appraised through Mixed Methods Appraisal Tool (MMAT) version 2018. Knowledge on the risk of COVID-19 infection among pregnant women will help health workers especially midwives who take care of pregnant women to design confidently and put into action preventive programs to address health needs of pregnant women who are at a higher risk of contracting COVI-19 as compared to other people in the general population. This also will assist health workers to provide appropriate care to pregnant women on the basis of their COVID-19 infection risk status at health facility and community levels. This study review is also creating more awareness on the risk of COVID-19 to pregnant women even in communities. It serves as evidence to guide health policymakers to put emphasis on addressing the preventive measure of this greatly vulnerable group of population. To prevent COVID-19 infection during pregnancy, pregnant women should strictly follow the laid down measures of prevention by World Health Organisation (WHO) and their local health authorities.展开更多
Emerging infectious viral diseases are a major threat to humankind on earth, containing emerging and re-emerging pathogenic physiognomies has raised great public health concern. This study aimed at investigating the g...Emerging infectious viral diseases are a major threat to humankind on earth, containing emerging and re-emerging pathogenic physiognomies has raised great public health concern. This study aimed at investigating the global prevalence, biological and clinical characteristics of novel Corona-virus, Wuhan China (2019-nCoV), Severe Acute Respiratory Syndrome Corona-virus (SARS-CoV), and Middle East Respiratory Syndrome Corona-virus (MERS-CoV) infection outbreaks <a href="#ref1">[1]</a>. Currently, novel Corona-virus disease COVID-2019 is already pandemic and causing havoc throughout the world. Scientific community is still struggling to come out with concrete therapeutic measures against this disease and development of its vaccine is far off from sight in the immediate near future. However, humanity will be put to such pressures very often in the near future and given the present circumstances, what we can expect from the scientific world now? I think QIT (Quantum Information Theory) has an answer to this question. One of the very basic mechanisms that every infectious virus follows to infect is the entry of the virus through cell surface receptors, engulfing, un-coating of viral genome and its transcription to form multiple copies and translation to form viral proteins and coating of viral genome to form multiple copies of the viral particles and then of course the cell bursting to infect other cells. This very basic mechanism does not occur randomly but through a regulated and more dynamic process which we may call coding and decoding of information through reduction in error or noise.展开更多
BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory response.Dexamethasone,a synthetic glucocorticoid,exerts ...BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory response.Dexamethasone,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune cells.This mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 cases.Early on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory support.However,the optimal dosage of corticosteroids remains debatable.Several studies that compare different doses of dexamethasone in COVID-19 exist,but the results are conflicting.AIM To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe COVID-19.METHODS We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March 2024.Our keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their combinations.We employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) tests.RESULTS No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implications on mortality,mean length of hospital stay,and adverse events in COVID-19 patients.Additional research is required in patients requiring invasive or noninvasive ventilation.展开更多
Depending on various government policies,COVID-19(Corona Virus Disease-19) lockdowns have had diverse impacts on global aerosol concentrations.In 2022,Changchun a provincial capital city in Northeast China,suffered a ...Depending on various government policies,COVID-19(Corona Virus Disease-19) lockdowns have had diverse impacts on global aerosol concentrations.In 2022,Changchun a provincial capital city in Northeast China,suffered a severe COVID-19 outbreak and implemented a very strict lockdown that lasted for nearly two months.Using ground-based polarization Light Detection and Ranging(LiDAR),we detected real-time aerosol profile parameters(EC,extinction coefficient;DR,depolarization ratio;AOD,aerosol optical depth),as well as air-quality and meteorological indexes from 1 March to 30 April in 2021 and 2022 to quantify the effects of lockdown on aerosol concentrations.The period in 2022 was divided into three stages:pre-lockdown(1-10 March),strict lockdown(11 March to 10 April),and partial lockdown(11-30 April).The results showed that,during the strict lockdown period,compared with the pre-lockdown period,there were substantial reductions in aerosol parameters(EC and AOD),and this was consistent with the concentrations of the atmospheric pollutants PM_(2.5)(particulate matter with an aerodynamic diameter ≤2.5 μm) and PM_(2.5)(particulate matter with an aerodynamic diameter ≤10 μm),and the Oconcentration increased by 8.3%.During the strict lockdown,the values of EC within0-1 km and AOD decreased by 16.0% and 11.2%,respectively,as compared to the corresponding period in 2021.Lockdown reduced the conventional and organized emissions of air pollutants,and it clearly delayed the time of seasonal emissions from agricultural burning;however,it did not decrease the number of farmland fire points.Considering meteorological factors and eliminating the influence of wind-blown dust events,the results showed that reductions from conventional organized emission sources during the strict lockdown contributed to a 30% air-quality improvement and a 22% reduction in near-surface extinction(0-2 km).Aerosols produced by urban epidemic prevention and disinfection can also be identified using the EC.Regarding seasonal sources of agricultural straw burning,the concentrated burning induced by the epidemic led to the occurrence of heavy pollution from increased amounts of atmospheric aerosols,with a contribution rate of 62%.These results indicate that there is great potential to further improve air quality in the local area,and suggest that the comprehensive use of straw accompanied by reasonable planned burning is the best way to achieve this.展开更多
文摘Corona virus is an enveloped virus from the category of RNA viruses.The patients are suffering from fever,cough,shortness of breath,and no definitive treatment or vaccine is currently available.The viral disease is gradually self-limiting due to the production of antibodies in the body.CDC has developed a new laboratory test kit for use in testing patient specimens for severe acute respiratory syndrome coronavirus,the virus that causes COVID-19.The test kit is called the Centers for Disease Control and Prevention(CDC)2019-Novel Coronavirus(2019-nCoV)Real-Time Reverse Transcriptase(RT)-PCR Diagnostic Panel.It seems traditional medicine would be usefulness to helping treatment of corona cuvid-19 patients too.It might be other screening distinguishes rapid tests with high detection limit by designing chines scientists are available[1-12].
文摘Corona Virus Disease 2019 (COVID-19) is a deadly respiratory viral disease that started in China in the year 2019 before spreading to the world. It affects everybody regardless of race, religion, social economic status or age. However, literature indicates that people with compromised immune status are at a higher risk of contracting viral infections. During pregnancy, the immune status of the woman is suppressed because it acts to protect both the mother and her unborn baby. The purpose of this study was to provide an overview of available evidence on the risk of contracting COVID-19 and COVID-19 infection prevention among pregnant women. Relevant and recent articles were identified from various databases. Article selection was aligned to the study questions. Articles that were related to study objectives were included and those not related to study objectives were excluded. A narrative report was produced and results were described according to study objectives. Approximately 8 data sources were included and most of the reviewed articles indicated that pregnant women are at a higher risk of getting COVID-19. The reviews further indicated that pregnant women can be prevented from this deadly virus by providing community antenatal services instead of visiting the health facilities. If a pregnant woman develops symptoms of respiratory infection, it is advisable to seek immediate diagnosis to rule out COVID-19 and get appropriate management to avoid complications. The selected studies’ quality was appraised through Mixed Methods Appraisal Tool (MMAT) version 2018. Knowledge on the risk of COVID-19 infection among pregnant women will help health workers especially midwives who take care of pregnant women to design confidently and put into action preventive programs to address health needs of pregnant women who are at a higher risk of contracting COVI-19 as compared to other people in the general population. This also will assist health workers to provide appropriate care to pregnant women on the basis of their COVID-19 infection risk status at health facility and community levels. This study review is also creating more awareness on the risk of COVID-19 to pregnant women even in communities. It serves as evidence to guide health policymakers to put emphasis on addressing the preventive measure of this greatly vulnerable group of population. To prevent COVID-19 infection during pregnancy, pregnant women should strictly follow the laid down measures of prevention by World Health Organisation (WHO) and their local health authorities.
文摘Emerging infectious viral diseases are a major threat to humankind on earth, containing emerging and re-emerging pathogenic physiognomies has raised great public health concern. This study aimed at investigating the global prevalence, biological and clinical characteristics of novel Corona-virus, Wuhan China (2019-nCoV), Severe Acute Respiratory Syndrome Corona-virus (SARS-CoV), and Middle East Respiratory Syndrome Corona-virus (MERS-CoV) infection outbreaks <a href="#ref1">[1]</a>. Currently, novel Corona-virus disease COVID-2019 is already pandemic and causing havoc throughout the world. Scientific community is still struggling to come out with concrete therapeutic measures against this disease and development of its vaccine is far off from sight in the immediate near future. However, humanity will be put to such pressures very often in the near future and given the present circumstances, what we can expect from the scientific world now? I think QIT (Quantum Information Theory) has an answer to this question. One of the very basic mechanisms that every infectious virus follows to infect is the entry of the virus through cell surface receptors, engulfing, un-coating of viral genome and its transcription to form multiple copies and translation to form viral proteins and coating of viral genome to form multiple copies of the viral particles and then of course the cell bursting to infect other cells. This very basic mechanism does not occur randomly but through a regulated and more dynamic process which we may call coding and decoding of information through reduction in error or noise.
文摘BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory response.Dexamethasone,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune cells.This mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 cases.Early on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory support.However,the optimal dosage of corticosteroids remains debatable.Several studies that compare different doses of dexamethasone in COVID-19 exist,but the results are conflicting.AIM To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe COVID-19.METHODS We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March 2024.Our keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their combinations.We employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) tests.RESULTS No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implications on mortality,mean length of hospital stay,and adverse events in COVID-19 patients.Additional research is required in patients requiring invasive or noninvasive ventilation.
基金the Key Research Program of Frontier Sciences,Chinese Academy of Sciences (No. QYZDB-SSW-DQC045)the National Natural Science Foundation of China (No. 41775116)。
文摘Depending on various government policies,COVID-19(Corona Virus Disease-19) lockdowns have had diverse impacts on global aerosol concentrations.In 2022,Changchun a provincial capital city in Northeast China,suffered a severe COVID-19 outbreak and implemented a very strict lockdown that lasted for nearly two months.Using ground-based polarization Light Detection and Ranging(LiDAR),we detected real-time aerosol profile parameters(EC,extinction coefficient;DR,depolarization ratio;AOD,aerosol optical depth),as well as air-quality and meteorological indexes from 1 March to 30 April in 2021 and 2022 to quantify the effects of lockdown on aerosol concentrations.The period in 2022 was divided into three stages:pre-lockdown(1-10 March),strict lockdown(11 March to 10 April),and partial lockdown(11-30 April).The results showed that,during the strict lockdown period,compared with the pre-lockdown period,there were substantial reductions in aerosol parameters(EC and AOD),and this was consistent with the concentrations of the atmospheric pollutants PM_(2.5)(particulate matter with an aerodynamic diameter ≤2.5 μm) and PM_(2.5)(particulate matter with an aerodynamic diameter ≤10 μm),and the Oconcentration increased by 8.3%.During the strict lockdown,the values of EC within0-1 km and AOD decreased by 16.0% and 11.2%,respectively,as compared to the corresponding period in 2021.Lockdown reduced the conventional and organized emissions of air pollutants,and it clearly delayed the time of seasonal emissions from agricultural burning;however,it did not decrease the number of farmland fire points.Considering meteorological factors and eliminating the influence of wind-blown dust events,the results showed that reductions from conventional organized emission sources during the strict lockdown contributed to a 30% air-quality improvement and a 22% reduction in near-surface extinction(0-2 km).Aerosols produced by urban epidemic prevention and disinfection can also be identified using the EC.Regarding seasonal sources of agricultural straw burning,the concentrated burning induced by the epidemic led to the occurrence of heavy pollution from increased amounts of atmospheric aerosols,with a contribution rate of 62%.These results indicate that there is great potential to further improve air quality in the local area,and suggest that the comprehensive use of straw accompanied by reasonable planned burning is the best way to achieve this.
