Light-Activated Virtual Sensor Array with Machine Learning for Non-Invasive Diagnosis of Coronary Heart Disease

Early non-invasive diagnosis of coronary heart disease(CHD)is critical.However,it is challenging to achieve accurate CHD diagnosis via detecting breath.In this work,heterostructured complexes of black phosphorus(BP)and two-dimensional carbide and nitride(MXene)with high gas sensitivity and photo responsiveness were formulated using a self-assembly strategy.A light-activated virtual sensor array(LAVSA)based on BP/Ti_(3)C_(2)Tx was prepared under photomodulation and further assembled into an instant gas sensing platform(IGSP).In addition,a machine learning(ML)algorithm was introduced to help the IGSP detect and recognize the signals of breath samples to diagnose CHD.Due to the synergistic effect of BP and Ti_(3)C_(2)Tx as well as photo excitation,the synthesized heterostructured complexes exhibited higher performance than pristine Ti_(3)C_(2)Tx,with a response value 26%higher than that of pristine Ti_(3)C_(2)Tx.In addition,with the help of a pattern recognition algorithm,LAVSA successfully detected and identified 15 odor molecules affiliated with alcohols,ketones,aldehydes,esters,and acids.Meanwhile,with the assistance of ML,the IGSP achieved 69.2%accuracy in detecting the breath odor of 45 volunteers from healthy people and CHD patients.In conclusion,an immediate,low-cost,and accurate prototype was designed and fabricated for the noninvasive diagnosis of CHD,which provided a generalized solution for diagnosing other diseases and other more complex application scenarios.

Early diagnostic value of carotid artery ultrasound parameters combined with epicardial adipose layer thickness in coronary heart disease

BACKGROUND Coronary heart disease is associated with coronary atherosclerosis indicated by carotid intima-media thickness(CIMT)thickening and altered vascular elasticity.The epicardial adipose layer can secrete proinflammatory factors that promote the formation of coronary atherosclerosis.Thus,the epicardial fat layer thickness(EAT)may also predict coronary heart disease.AIM To determine the role of common carotid artery ultrasound parameters and EAT in the early diagnosis of coronary artery disease.METHODS Based on coronary angiography,patients with newly suspected coronary heart disease were divided into case(n=107)and control(n=41)groups.The carotid ultrasound parameters,including vascular stiffness(β),elastic coefficient(EP),pulse wave conduction velocity(PWV-β),CIMT,and EAT were compared between the case and control groups and among patients with different lesion numbers in the case group.Pearson correlation was used to evaluate the early diagnostic value of EAT,common carotid artery elasticity,and CIMT for coronary heart disease.RESULTS EP,β,PWV-β,CIMT,and EAT were significantly higher in the case group compared with the levels in the control group(all P<0.001).In the case group,lesions were detected in one vessel in 34 patients,two vessels in 38 patients,and three vessels in 35 patients.Within the case group,β,EP,PWV-β,CIMT,and EAT levels significantly increased with an increased number of lesions(all P<0.001).EAT positively correlated withβ,EP,PWV-β,and CIMT(all P<0.01).The area under the curve for diagnosing coronary heart disease using EAT combined with CIMT and carotid elasticity was 0.893,and the sensitivity and specificity were 0.890 and 0.837.CONCLUSION EAT correlated well with changes in carotid artery elasticity and CIMT in patients with coronary heart disease.The combination of EAT,carotid artery elasticity,and CIMT facilitates the early diagnosis of coronary heart disease.

Multislice computed tomography angiography in the diagnosis of coronary artery disease

Multislice CT angiography represents one of the most exciting technological revolutions in cardiac imaging and it has been increasingly used in the diagnosis of coronary artery disease. Rapid improvements in multislice CT scanners over the last decade have allowed this technique to become a potentially effective alternative to invasive coronary angiography in patients with suspected coronary artery disease. High diagnostic value has been achieved with multislice CT angiography with use of 64- and more slice CT scanners. In addition, multislice CT angiography shows accurate detection and analysis of coronary calcium, characterization of coronary plaques, as well as prediction of the disease progression and major cardiac events. Thus, patients can benefit from multislice CT angiography that provides a rapid and accurate diagnosis while avoiding unnecessary invasive coronary angiography procedures. The aim of this article is present an overview of the clinical applications of multislice CT angiography in coronary artery disease with a focus on the diagnostic accuracy of coronary artery disease; prognostic value of coronary artery disease with regard to the prediction of major cardiac events; detection and quantification of coronary calcium and characterization of coronary plaques. Limitations of multislice CT angiography in coronary artery disease are also briefly discussed, and future directions are highlighted.

The value of pulse wave velocity in the diagnosis of coronary heart disease

Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P<0. 01; 9. 02±1.71 vs 7. 52±1.50, P<0. 01; 8. 69±1. 37 vs 8. 00±1. 27, P<0. 01; 8.52±1. 03 vs 8. 03±1. 2, P<0. 01 respectively). However, the PWV of both right and left femoral to ankle artery (Rf-a and Lf-a) had no significant differences between the two groups. We then compared the area under curve (AUC) of each ROC(AUCROC) of PWV of Rc-f, Lc-f Rc-r and Lc-r to evaluate their diagnostic efficacy for CHD. We found that AUCROC of Rc-f PWV was the biggest (AUCROC = 0. 818), at the peak point of its ROC curve, the PWV was 8. 32 m/s. PWV>8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.

Echocardiography in Diagnosis and Prevention of the Coronary Artery Lesions in Kawasaki Disease

Kawasaki disease (muco-cutaneous lymph node syndrome, MCLS) was first reported by Kawasaki in 1967. It was characteried by nonvascular polymorphous rash, fever, ulcer in oral mucosa, edema of hands of feet, cervix lymphadenopathy and desquamations in peripheral extremities. Because of unknown pathogens, no lab examination was available as a single easily recognized diagnostic marker; the diagnosis is

Role of ADAMTS-5 Expression in the Prognosis of Patients with Coronary Artery Disease: A Single Retrospective Analysis

This study explores the predictive value of plasma a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) levels for major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD). 595 patients admitted to our hospital were selected. Initially, the serum ADAMTS-5 levels of subjects were analyzed. Subsequently, a receiver operating characteristic (ROC) curve was constructed. Furthermore, the serum levels of ADAMTS-5 were assessed in patients, and based on CAD severity, they were categorized into stable angina pectoris (SAP), unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) groups, with the aim of examining the relationship between ADAMTS-5 levels and CAD severity. Differences in clinical outcomes between patients with high and low levels of ADAMTS-5 were analyzed during the follow-up period. The study found that the serum levels of ADAMTS-5 were significantly higher in the group of patients with coronary artery disease (CAD) compared to the group without CAD, indicating its potential as a diagnostic marker for CAD. The ADAMTS-5 levels in the serum of STEMI patients were higher than those with SAP, while NSTEMI patients showed higher levels of ADAMTS-5 than the UA group. There was a positive correlation between serum ADAMTS-5 levels and the syntax score in CAD patients, suggesting a potential association with adverse clinical outcomes in patients with acute myocardial infarction (AMI). This study indicates that ADAMTS-5 shows promise as a biomarker for CAD and highlights the need for further research and validation.

Diagnostic value of the abnormal systolic blood pressure recovery ratio in patients with coronary artery disease and its mechanism

To evaluate the diagnostic value of the abnormal systolic blood pressure (SBP) re-covery ratio of exercise test and its mechanisms,142 patients with suspectable angina pectorisunderwent coronary angiography and treadmill exercise test.The SBP recovery ratios at the1st,3rd,and 6th min of the recovery period in patients with coronary artery disease (CAD)were significant higher than those in the control subjects.Of the hymodynamic variables,car-diac index (CI),stroke volume index (SI) and ejection fraction (EF) were lower,left ventricu-lar end-diastolic pressure (LVEDP) and systemic vascular resistance (SVR) were higher in pa-tients with abnormal SBP response than in patients with normal SBP response.The sensitivityof abnormal SBP recovery ratio for identifying patients with CAD was 68% and the specificitywas 90%.The false positivity rate of abnormal SBP recovery ratios in 21 patients with hyper-tension without CAD was 38%.These results indicate that an abnormal SBP recovery ratio is auseful index for identifying patients with CAD.When the ST segment response to exercise isnormal or borderline,it can increase the sensitivity and the accuracy of the exercise test.Theabnormal SBP response appears to be due to exercise-induced impairment of left ventricularfunction and increase in systemic vascular resistance.

Significance of Q-Tc,Q-Tr and A Q-Tc during Treadmill Exercise Test in Predicting Coronary Artery Disease

Seventy-eight patients underwent coronary angiography and submaximal tre-admill exercise test to evaluate the Q-Tc,Q-Tr and ΔQ-Tc criteria for predicting co-ronary artery disease(CAD).The sensitivity,specificity,predicting value and correctdiagnostic rate of the Q-Tc and Q-Tr criteria were 84,76,83,81 percent and 69,88,89,77 percent,respectively,which had no significant differences when compared with ST de-pression.The Q-Tc had higher specificity(94%)than that of ST depression but less sen-sitivity(58%).These criteria could reflect the severity of coronary artery disease identi-fied with coronary angiography.Therefore,these criteria are usefel to interpret the resultsof stress test.

Tongue diagnosis based on hue-saturation value color space: controlled study of tongue appearance in patients treated with percutaneous coronary intervention for coronary heart disease

Objective To analyze the characteristics of tongue imaging color parameters in patients treated with percutaneous coronary intervention(PCI)and non-PCI for coronary atherosclerotic heart disease(CHD),and to observethe effects of PCI on the tongue images of patients as a basis for the clinical diagnosis and treatment of patientswith CHD.Methods This study used a retrospective cross-sectional survey to analyze tongue photographs and medicalhistory information from 204 patients with CHD between November 2018 and July 2020.Tongue images ofeach subject were obtained using the Z-BOX Series traditional Chinese medicine(TCM)intelligent diagnosisinstruments,the SMX System 2.0 was used to transform the image data into parameters in the HSV color space,and finally the parameters of the tongue image between patients in the PCI-treated and non-PCI-treated groupsfor CHD were analyzed.Results Among the 204 patients,112 were in the non-PCI treatment group(38 men and 74 women;average age of(68.76±9.49)years),92 were in the PCI treatment group(66 men and 26 women;average age of(66.02±10.22)years).In the PCI treatment group,the H values of the middle and tip of the tongue and the overall coating of thetongue were lower(P<0.05),while the V values of the middle,tip,both sides of the tongue,the whole tongueand the overall coating of the tongue were higher(P<0.05).Conclusion The color parameters of the tongue image could reflect the physical state of patients treated withPCI,which may provide a basis for the clinical diagnosis and treatment of patients with CHD.

LDH、NT-proBNP、ALB水平对不完全性川崎病的早期诊断价值

目的:探讨乳酸脱氢酶(LDH)、N末端脑钠肽前体(NT-proBNP)、白蛋白(ALB)水平对不完全性川崎病(IKD)的早期诊断价值。方法:选取巴彦淖尔市医院2020年1月—2023年1月收治的80例IKD患儿作为IKD组,选取本院同期收治的80例典型川崎病(KD)患儿作为KD组。所有患儿入院后检测LDH、NT-proBNP、ALB水平,对比IKD组与KD组一般情况和LDH、NT-proBNP、ALB水平。通过受试者操作特征(ROC)曲线分析LDH、NT-proBNP、ALB水平对IKD的早期诊断价值。同时将80例IKD患儿依照冠脉损伤情况分为两个亚组,即无损伤组(n=30)和损伤组(n=50),对比两组LDH、NT-proBNP、ALB水平。结果:IKD组和KD组性别、年龄及高热、多形性皮疹、口腔黏膜变化占比对比,差异均无统计学意义(P>0.05);IKD组发热时间长于KD组,指端改变、结膜充血、颈部淋巴结肿大占比低于KD组,差异均有统计学意义(P<0.05);IKD组LDH、NT-proBNP、ALB水平均明显高于KD组,差异均有统计学意义(P<0.05);LDH、NT-proBNP、ALB三者联合对IKD的诊断效能优于单一检测;损伤组LDH、NT-proBNP、ALB水平均明显高于无损伤组,差异均有统计学意义(P<0.05)。结论:LDH、NT-proBNP、ALB水平对IKD的早期诊断价值较高,且临床可考虑通过LDH、NT-proBNP、ALB三者联合来诊断IKD。

Diagnostic Accuracy of Chinese Medicine Diagnosis Scale of Phlegm and Blood Stasis Syndrome in Coronary Heart Disease: A Study Protocol

Background Phlegm and blood stasis syndrome(PBSS) is one of the main syndromes in coronary heart disease(CHD). Syndromes of Chinese medicine(CM) are lack of quantitative and easyimplementation diagnosis standards. To quantify and standardize the diagnosis of PBSS, scales are usually applied. Objective: To evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD. Methods: Six hundred patients with stable angina pectoris of CHD, 300 in case group and 300 in control group, will be recruited from 5 hospitals across China. Diagnosis from 2 experts will be considered as the "gold standard". The study design consists of 2 phases: pilot test is used to evaluate the reliability and validity, and diagnostic test is used to assess the diagnostic accuracy of the scale, including sensitivity, specificity, likelihood ratio and area under the receiver operator characteristic(ROC) curve. Discussion: This study will evaluate the diagnostic accuracy of CM diagnosis scale of PBSS in CHD. The consensus of 2 experts may not be ideal as a "gold standard", and itself still requires further study.(No. ChiCTR-OOC-15006599).

动态心电图与常规心电图诊断冠心病伴心律失常的效果比较

目的:比较动态心电图与常规心电图诊断冠心病伴心律失常的效果。方法:选取2018年1月—2022年1月赤峰市医院心内科收治的120例冠心病伴心律失常患者作为研究对象,均进行常规心电图检测与动态心电图检测,比较两种检测方法诊断冠心病伴心律失常的效果。结果:动态心电图对冠心病的检出率高于常规心电图,差异有统计学意义(P<0.001)。冠状动脉造影、动态心电图对单支与多支冠状动脉病变的检出率均高于常规心电图,差异有统计学意义(P<0.05);动态心电图与冠状动脉造影对单支与多支冠状动脉病变的检出率比较,差异无统计学意义(P>0.05)。常规心电图与动态心电图对房性早搏早发、室性早搏早发的检出率比较,差异无统计学意义(P>0.05);动态心电图对室性早搏二三联律、房性早搏二三联律、室性早搏成对、房性早搏成对、短阵室上速的检出率高于常规心电图,差异有统计学意义(P<0.001)。结论:动态心电图诊断冠心病伴心律失常的效果显著,冠心病阳性检出率、冠状动脉病变检出率、心律失常检出率均优于常规心电图。

Clinical feasibility and safety of a novel miniature mobile cardiaccatheterization laboratory in diagnosis and treatment for coronaryheart disease

Background The lack of medical facilities causes delayed diagnosis and treatment of coronary heart disease in remote mountainous area and/or at disaster site. The miniature mobile cardiac catheterization laboratory was developed to be an intervention platform for coronary heart disease diagnosis and treatment by our team. Pre-clinical research indicated that the miniature mobile cardiac catheterization laboratory performed well in the rescue of critical cardiovascular diseases, even ST-segment elevation myocardial infarction. The present study aimed to evaluate the clinical safety and timeliness of the miniature mobile cardiac catheterization laboratory for emergent coronary interventional diagnosis and treatment.Methods X-ray radiation safety and disinfection efficacy in the miniature mobile cardiac catheterization laboratory were tested during working status. Coronary angiography and/or percutaneous coronary intervention were performed in remote mountainous areas on patients who were first diagnosed as having coronary heart disease by senior interventional cardiologists. The percutaneous coronary intervention procedures and results from patients in the miniature mobile cardiac catheterization laboratory were compared with patients who were treated in the hospital catheter lab.Results The X-ray radiation dosages in the miniature mobile cardiac catheterization laboratory were 39.55 μGy/s, 247.4 μGy/h, 90.3 μGy/h and 39.4 μGy/h which were corresponded to 0 m, 1 m, 2 m and 3 m away from the tube central of the medium C-arm. And the radiation dosages used in the miniature mobile cardiac catheterization laboratory were less than the corresponding positions in the hospital catheter lab. The numbers of bacteria colonies in the miniature mobile cardiac catheterization laboratory in different environments range from(60±8) cfu/m3 to(120±10) cfu/m3 and met the demands of percutaneous coronary intervention. A total of 17 patients who received angiography in the miniature mobile cardiac catheterization laboratory, eight received percutaneous coronary intervention. The operations were all successfully accomplished without intraoperative and postoperative complications. The average angiography and percutaneous coronary intervention times were 35±9 minutes and 55±11 minutes, respectively. There was no significant difference in immediate percutaneous coronary intervention results between the miniature mobile cardiac catheterization laboratory and the catheter lab.Conclusions It is safe and feasible to carry out clinical interventional diagnosis and treatment in the miniature mobile cardiac catheterization laboratory as determined by this research. The miniature mobile cardiac catheterization laboratory may be considered a newly developed diagnosis and treatment platform for rescuing coronary heart disease patients in remote mountainous areas and/or at disaster sites.

hs-CRP、NT-proBNP及NAR对急性冠状动脉综合征患者诊断价值分析

目的 探讨超敏C反应蛋白(hs-CRP)、氨基末端脑钠肽前体(NT-proBNP)及中性粒细胞与白蛋白比值(NAR)对急性冠状动脉综合征(ACS)患者的诊断价值。方法 选取2020年6月—2022年9月收治的ACS 71例作为研究组,同期健康体检者56例作为对照组,并依照不同疾病类型和血管病变支数将研究组分为ST段抬高型心肌梗死(STEMI)组、非ST段抬高型心肌梗死(NSTEMI)组、不稳定型心绞痛(UAP)组及单支、双支、多支病变组各3个亚组。比较研究组与对照组、不同疾病类型和血管病变支数各3个亚组hs-CRP、NT-proBNP及NAR,探讨hs-CRP、NT-proBNP及NAR单独或联合对ACS的诊断价值。结果 研究组hs-CRP、NT-proBNP及NAR均高于对照组;STEMI组、NSTEMI组和UAP组hs-CRP、NT-proBNP及NAR逐渐降低,单支、双支和多支病变组hs-CRP、NT-proBNP及NAR逐渐升高(P<0.05)。受试者工作特征曲线分析显示,hs-CRP、NT-proBNP和NAR单独或联合诊断ACS的曲线下面积分别为0.820、0.815、0.883及0.914,三者联合诊断ACS的曲线下面积高于单独诊断(P<0.05,P<0.01)。结论 hs-CRP、NT-proBNP及NAR三者联合对ACS的诊断价值较高。

冠心病患者血清Lp-PLA2、VEGF、S100-β水平与冠状动脉病变程度的关系研究

目的 探讨冠心病(CHD)患者血清脂蛋白相关磷脂酶(Lp-PLA2)、血管内皮生长因子(VEGF)、中枢神经特异性蛋白(S100-β)水平与冠状动脉病变程度的关系。方法 选取2022年3月至2023年2月该院收治的126例CHD患者作为CHD组,另选取同期该院102例体检健康者作为对照组。比较CHD组和对照组及CHD组冠状动脉病变不同程度患者Lp-PLA2、VEGF、S100-β水平差异。采用受试者工作特征(ROC)曲线分析Lp-PLA2、VEGF、S100-β水平对CHD的诊断效能。结果 CHD组血清Lp-PLA2、VEGF、S100-β水平高于对照组,差异有统计学意义(P<0.05),CHD组冠状动脉病变不同程度患者血清Lp-PLA2、VEGF、S100-β水平随着冠状动脉病变程度增加,水平升高(P<0.05)。ROC曲线分析结果显示,Lp-PLA2单项检测诊断CHD的灵敏度和特异度分别为78.8%、93.3%,曲线下面积(AUC)为0.913(95%CI:0.522~0.974),优于S100-β单项检测(Z=2.289,P<0.05),3项指标联合检测的灵敏度和特异度分别为74.1%、93.5%,AUC为0.921(95%CI:0.812~0.979),优于VEGF、S100-β单项检测,差异有统计学意义(Z=1.936、2.361,P<0.05)。结论 CHD患者血清Lp-pLA2、VEGF、S100-β水平高于健康人群,3项指标单项及联合检测在诊断CHD方面有一定的辅助参考价值。

中医药治疗冠状动脉微血管疾病证治规律及作用机制研究

目的:基于文献探讨中医药治疗冠状动脉微血管疾病(CMVD)的证治特征及用药规律,并借助网络药理学和分子对接技术探讨核心药对治疗CMVD的作用机制。方法:系统检索中国知网、万方、维普、中国生物医学文献数据库、PubMed数据库自建库以来至2022年11月1日收录的有关CMVD中医诊治研究的文献,对中医证治规律进行分类统计,并挖掘中药复方的核心药对,利用TCMSP、GeneCards、DisGeNET、TTD、OMIM、STRING、Metascape数据库和Cytoscape软件分析核心药对与疾病间互作关系及相关通路,最后使用分子对接技术对核心化学成分与关键靶点进行对接验证。结果:获得符合要求的文献160篇,CMVD中医证型主要为气虚血瘀证,中药复方涉及药物89味,支持度最高的药对为黄芪-丹参。黄芪-丹参中槲皮素、木犀草素、山柰酚、异鼠李素等成分可通过作用于白细胞介素6(IL6)、胱天蛋白酶3(CASP3)、缺氧诱导因子1A(HIF1A)、过氧化物酶体增殖物激活受体γ(PPARG)等多个靶点影响糖尿病并发症中的晚期糖基化产物(AGE)-晚期糖基化终末产物受体(RAGE)通路、缺氧诱导因子1(HIF-1)通路、核转录因子κB(NF-κB)通路等来干预CMVD。分子对接结果显示核心活性成分与关键靶点对接良好。结论:中医药治疗CMVD多以益气活血法为主,其核心药对黄芪-丹参治疗CMVD的潜在作用机制可能与抗炎症反应、改善氧化应激、调节细胞凋亡相关。

《2023 AHA/ACC/ACCP/ASPC/NLA/PCNA慢性冠状动脉疾病患者管理指南》要点解读

近期,美国心脏协会(American Heart Association,AHA)、美国心脏病学会(American College of Cardiology,ACC)等六大学会联合发布了《2023 AHA/ACC/ACCP/ASPC/NLA/PCNA慢性冠状动脉疾病患者管理指南》,该指南强调了“以患者为中心,以团队为基础”的总体管理理念和重视生活方式改善对慢性冠状动脉疾病患者预后的影响,并对主要心血管不良事件风险评估及新型药物推荐等作出了新的阐述,指南内容的更新对于指导我国临床医生为慢性冠状动脉疾病患者提供高质量管理具有重要指导意义。

Application value of Qisexingtai hand diagnostic method in diagnosis of coronary artery disease

OBJECTIVE:To evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method in the diagnosis of coronary artery disease(CAD).METHODS:This was an investigator-initiated,prospective,multi-center,cross-sectional study.All the participants from three hospitals in China had been diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.We compared the two diagnostic methods to calculate the sensitivity,the specificity,the omission diagnostic rate,the mistaken diagnostic rate and accuracy in order to evaluate the diagnostic efficacy of Qisexingtai hand diagnostic method for CAD.RESULTS:A total of 326 subjects were enrolled,diagnosed by both Qisexingtai hand diagnostic method and coronary angiography.As a result,there were 166 positive cases according to Qisexingtai hand diagnostic method,and 131 positive cases according to coronary angiography.Compared with the results of coronary angiography,the sensitivity of Qisexingtai hand diagnostic method was 80.2%,the specificity was 68.7%,the omission diagnostic rate was 19.8%,the mistaken diagnostic rate was 31.3%,and the accuracy was 73.3%.Area under the receiver operating characteristic curve was estimated as 0.735 for all,and 0.718,0.735,0.783 for the three sub-centers.CONCLUSION:Qisexingtai hand diagnostic method with high accuracy and sensitivity has certain application value in the diagnosis of CAD.

Apelin-13在冠心病诊治作用中的研究进展

Apelin-13作为Apelin最主要的亚型之一,广泛存在于心血管系统中,其结构稳定且活性较强,通过改善内皮功能、舒张血管调节血压等来保护心肌。冠心病作为心血管疾病谱系中的高发疾病,严重影响人类健康。相关研究表明,Apelin-13在冠心病的发生发展中起重要作用。现对Apelin-13在冠心病中的作用机制、诊断价值及治疗意义进行综述。

腺苷负荷CT心肌灌注扫描、24h动态心电图联合检查在冠心病心肌缺血诊断中的效能

目的:观察腺苷负荷CT心肌灌注扫描、24h动态心电图联合检查在冠心病心肌缺血诊断中的效能。方法:选取2020年12月至2022年12月该院收治的80例疑似冠心病心肌缺血患者进行前瞻性研究,所有患者均接受24h动态心电图和腺苷负荷CT心肌灌注扫描检查,以核素心肌灌注显像检查诊断结果为金标准,比较腺苷负荷CT心肌灌注扫描、24h动态心电图单项及联合检查诊断冠心病心肌缺血的效能。结果:核素心肌灌注显像检查结果显示,阳性52例,阴性28例。24h动态心电图检查结果显示,阳性46例,阴性34例;腺苷负荷CT心肌灌注扫描检查结果显示,阳性46例,阴性34例;联合检查结果显示,阳性51例,阴性29例。腺苷负荷CT心肌灌注扫描、24h动态心电图联合检查诊断冠心病心肌缺血的灵敏度、特异度、准确度、阳性预测值、阴性预测值均高于二者单项检查,差异有统计学意义(P<0.05)。结论:腺苷负荷CT心肌灌注扫描、24h动态心电图联合检查诊断冠心病心肌缺血的效能高于二者单项检查。