Background Many postmenopausal women with low-density lipoprotein-cholesterol(LDL-C)<130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions.However,few studies...Background Many postmenopausal women with low-density lipoprotein-cholesterol(LDL-C)<130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions.However,few studies specifically focused on the cardiovascular risks of this subgroup of postmenopausal women.Methods A total of 270 postmenopausal women with LDL-C<130 mg/dL from Chaoshan region were enrolled in this cohort study.Patients with angiographically proven coronary artery diseases(CAD)served as CAD group(n=174),while the ones with angiographically proven normal coronary arteries served as Control group(n=96).Results The age of CAD group(68.5±8.4 years)was older than that of Control group(60.0±6.9 years)(P<0.001).The prevalence rates of hypertension,diabetes mellitus(DM)and hyperuricemia in CAD group were significantly higher than those of Control group(P<0.05 for both comparisons).The serum level of uric acid(UA)in CAD group was significantly higher than that in Control group(P<0.001).Age,DM and UA were independent cardiovascular predictors of postmenopausal women with LDL-C<130 mg/dL from Chaoshan Region[ORAGE:1.140(95%CI:1.095-1.188),ORDM:2.740(95%CI:1.368-5.486),ORUA:1.003(95%CI:1.001-1.006),PAGE<00.001,PDM=0.004,PUA=0.019].Conclusions Postmenopausal women with LDL-C<130 mg/dL complicating CAD are elder with higher prevalence rates of hyperuricemia and DM.Age,DM and UA are considered as independent cardiovascular risk factors in the postmenopausal women with LDL-C<130 mg/dL from Chaoshan Region of China.展开更多
Sickle cell disease(SCD) is the first molecular disease in the literature. Although the structural alteration and dysfunction of the sickle hemoglobin(HbS) are well understood, the many factors modifying the clinical ...Sickle cell disease(SCD) is the first molecular disease in the literature. Although the structural alteration and dysfunction of the sickle hemoglobin(HbS) are well understood, the many factors modifying the clinical signs and symptoms of the disease are under investigation. Besides having an abnormal electrophoretic mobility and solubility, HbS is unstable. The autooxidation rate of the abnormal HbS has been reported to be almost two times of the normal. There are two more components of the oxidative damage in SCD: Free radical induced oxidative damage during vaso-occlusion induced ischemia-reperfusion injury and decreased antioxidant capacity in the erythrocyte and in the circulation. We will discuss the effects of oxidative alterations in the erythrocyte and in the plasma of SCD patients in this review.展开更多
文摘Background Many postmenopausal women with low-density lipoprotein-cholesterol(LDL-C)<130 mg/dL from Chaoshan region suffer from coronary artery diseases,especially severe coronary artery lesions.However,few studies specifically focused on the cardiovascular risks of this subgroup of postmenopausal women.Methods A total of 270 postmenopausal women with LDL-C<130 mg/dL from Chaoshan region were enrolled in this cohort study.Patients with angiographically proven coronary artery diseases(CAD)served as CAD group(n=174),while the ones with angiographically proven normal coronary arteries served as Control group(n=96).Results The age of CAD group(68.5±8.4 years)was older than that of Control group(60.0±6.9 years)(P<0.001).The prevalence rates of hypertension,diabetes mellitus(DM)and hyperuricemia in CAD group were significantly higher than those of Control group(P<0.05 for both comparisons).The serum level of uric acid(UA)in CAD group was significantly higher than that in Control group(P<0.001).Age,DM and UA were independent cardiovascular predictors of postmenopausal women with LDL-C<130 mg/dL from Chaoshan Region[ORAGE:1.140(95%CI:1.095-1.188),ORDM:2.740(95%CI:1.368-5.486),ORUA:1.003(95%CI:1.001-1.006),PAGE<00.001,PDM=0.004,PUA=0.019].Conclusions Postmenopausal women with LDL-C<130 mg/dL complicating CAD are elder with higher prevalence rates of hyperuricemia and DM.Age,DM and UA are considered as independent cardiovascular risk factors in the postmenopausal women with LDL-C<130 mg/dL from Chaoshan Region of China.
文摘Sickle cell disease(SCD) is the first molecular disease in the literature. Although the structural alteration and dysfunction of the sickle hemoglobin(HbS) are well understood, the many factors modifying the clinical signs and symptoms of the disease are under investigation. Besides having an abnormal electrophoretic mobility and solubility, HbS is unstable. The autooxidation rate of the abnormal HbS has been reported to be almost two times of the normal. There are two more components of the oxidative damage in SCD: Free radical induced oxidative damage during vaso-occlusion induced ischemia-reperfusion injury and decreased antioxidant capacity in the erythrocyte and in the circulation. We will discuss the effects of oxidative alterations in the erythrocyte and in the plasma of SCD patients in this review.
