A human being is a complex type of creature whose existence depends on three components;the spirit, the soul and the body which interact in a reversible manner. I do believe that there comes a time when there is lack ...A human being is a complex type of creature whose existence depends on three components;the spirit, the soul and the body which interact in a reversible manner. I do believe that there comes a time when there is lack of a reversible interaction between the soul and the spirit in certain individuals which leads to a state of mental offset. For humans to live in sociality the world is governed by humans’ laws but the mentally offset human do not live according to these laws. Due to this, they are considered as being useless in the society but I do believe that they have complete natural human rights and are not useless for they are aware of each act they perform. It is observed that the mentally offset human hardly acquire a disease from natural origin, I do believe that due to this lack of a reversible interaction between the soul and the spirit, the immune system is reprogrammed such that there is a lack of recognition of exogenous and endogenous pathological substances and there is no means of interaction between these substances and the body cells.展开更多
Objective To observe the seasonal changes in serum levels of interleukin-1 beta(IL-1β), interleukin-6(IL-6) and melatonin(MT) in Bizheng rat model, and explore the relationship between MT and the pathogenesis of rheu...Objective To observe the seasonal changes in serum levels of interleukin-1 beta(IL-1β), interleukin-6(IL-6) and melatonin(MT) in Bizheng rat model, and explore the relationship between MT and the pathogenesis of rheumatoid arthritis. Methods One hundred and sixty Sprague-Dawley rats were randomly divided into four groups in summer(n=80) and winter(n=80) respectively: normal group, collagen-induced arthritis(CIA) model group, operation group, and sham-operation group(n=20 in each group). The CIA model group was injected with collagen emulsion at the base of the tail to induce arthritis. The rats in the operation group received pineal gland resection, and 7 days after the first operation, underwent testectomy or oophorectomy. The rats in the sham-operation group were operated to ligature the sagittal sinus, without extracting the pineal gland. After the operations, the operation group and the sham-operation group both were immunized as the CIA group was. The serum levels of IL-1β, IL-6 and MT in different groups were measured by radioimmunoassay. Results Compared with the normal group, the serum levels of IL-1β and IL-6 increased in the CIA model, operation, and sham-operation groups both in summer and in winter(IL-1β in summer, P=0.008, P<0.01, P=0.012; IL-1β in winter, P=0.019, P<0.01, P=0.027; IL-6 in summer, P=0.028, P<0.01, P=0.024; IL-6 in winter, P=0.006, P<0.01, P=0.008). In the operation group, the serum levels of IL-1β and IL-6 in winter were higher than in summer, but with no statistically significant differences(P=0.844, 0.679). Compared with the normal group, the serum level of MT significantly increased in summer and winter in both the CIA model group(P=0.002, 0.008) and the sham-operation group(P=0.003, 0.007), while significantly decreased in the operation group(P=0.023, 0.003). There was no significant difference in MT level in the operation group between summer and winter(P=0.947). Conclusions The increase of serum levels of IL-1β and IL-6 may exacerbate the inflammatoryreaction and cause a more severe condition in the rheumatoid arthritis. The concentrations of IL-1β, IL-6, and MT correspond with the change of seasons, confirming that there are connections between nature and human body.展开更多
In his book of 1672,De Legibus Naturae,Richard Cumberland tries to refute Hobbes’s theory of human nature,demonstrating that man is not a homo insociabilis but a homo benevolens.Using Thomas Willis’s Cerebri Anatome...In his book of 1672,De Legibus Naturae,Richard Cumberland tries to refute Hobbes’s theory of human nature,demonstrating that man is not a homo insociabilis but a homo benevolens.Using Thomas Willis’s Cerebri Anatome.Cui Accessit Nervorum Descriptio et Usus(1665)as well as the works of other physicians and anatomists,Cumberland tries to show that human body(especially thanks to its peculiar brain,blood,and plexus nervous)predisposes men to a sociable life and to the building of a peaceful and civil society.展开更多
文摘A human being is a complex type of creature whose existence depends on three components;the spirit, the soul and the body which interact in a reversible manner. I do believe that there comes a time when there is lack of a reversible interaction between the soul and the spirit in certain individuals which leads to a state of mental offset. For humans to live in sociality the world is governed by humans’ laws but the mentally offset human do not live according to these laws. Due to this, they are considered as being useless in the society but I do believe that they have complete natural human rights and are not useless for they are aware of each act they perform. It is observed that the mentally offset human hardly acquire a disease from natural origin, I do believe that due to this lack of a reversible interaction between the soul and the spirit, the immune system is reprogrammed such that there is a lack of recognition of exogenous and endogenous pathological substances and there is no means of interaction between these substances and the body cells.
基金Supported by the Autonomous Subject of Beijing University of Chinese Medicine(JYB22)the Gasification Theory Innovation Team Funding of Beijing University of Chinese Medicine(JS011)
文摘Objective To observe the seasonal changes in serum levels of interleukin-1 beta(IL-1β), interleukin-6(IL-6) and melatonin(MT) in Bizheng rat model, and explore the relationship between MT and the pathogenesis of rheumatoid arthritis. Methods One hundred and sixty Sprague-Dawley rats were randomly divided into four groups in summer(n=80) and winter(n=80) respectively: normal group, collagen-induced arthritis(CIA) model group, operation group, and sham-operation group(n=20 in each group). The CIA model group was injected with collagen emulsion at the base of the tail to induce arthritis. The rats in the operation group received pineal gland resection, and 7 days after the first operation, underwent testectomy or oophorectomy. The rats in the sham-operation group were operated to ligature the sagittal sinus, without extracting the pineal gland. After the operations, the operation group and the sham-operation group both were immunized as the CIA group was. The serum levels of IL-1β, IL-6 and MT in different groups were measured by radioimmunoassay. Results Compared with the normal group, the serum levels of IL-1β and IL-6 increased in the CIA model, operation, and sham-operation groups both in summer and in winter(IL-1β in summer, P=0.008, P<0.01, P=0.012; IL-1β in winter, P=0.019, P<0.01, P=0.027; IL-6 in summer, P=0.028, P<0.01, P=0.024; IL-6 in winter, P=0.006, P<0.01, P=0.008). In the operation group, the serum levels of IL-1β and IL-6 in winter were higher than in summer, but with no statistically significant differences(P=0.844, 0.679). Compared with the normal group, the serum level of MT significantly increased in summer and winter in both the CIA model group(P=0.002, 0.008) and the sham-operation group(P=0.003, 0.007), while significantly decreased in the operation group(P=0.023, 0.003). There was no significant difference in MT level in the operation group between summer and winter(P=0.947). Conclusions The increase of serum levels of IL-1β and IL-6 may exacerbate the inflammatoryreaction and cause a more severe condition in the rheumatoid arthritis. The concentrations of IL-1β, IL-6, and MT correspond with the change of seasons, confirming that there are connections between nature and human body.
文摘In his book of 1672,De Legibus Naturae,Richard Cumberland tries to refute Hobbes’s theory of human nature,demonstrating that man is not a homo insociabilis but a homo benevolens.Using Thomas Willis’s Cerebri Anatome.Cui Accessit Nervorum Descriptio et Usus(1665)as well as the works of other physicians and anatomists,Cumberland tries to show that human body(especially thanks to its peculiar brain,blood,and plexus nervous)predisposes men to a sociable life and to the building of a peaceful and civil society.
