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A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus 被引量:2
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作者 Qing-Hua Qin Ya-Nan Wang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2012年第6期1678-1692,共15页
A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creat... A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content (BMC) and bone fracture en- ergy (BFE) among different loading schemes (which proves the validity of the model), but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts (OBA), osteoclasts (OCA), nitric oxide (NO) and prostaglandin E2 (PGE2) for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering. 展开更多
关键词 cortical bone remodeling Cell population dy-namics MECHANOTRANSDUCTION MECHANOSENSITIVITY bonefracture energy - bone mineral content
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