Objective To evaluate the economy of domestic bivalent human papilloma virus(HPV)vaccine,imported 9-valent HPV vaccine and 5 cervical cancer screening programs,and to provide a reference for relevant decision-making.M...Objective To evaluate the economy of domestic bivalent human papilloma virus(HPV)vaccine,imported 9-valent HPV vaccine and 5 cervical cancer screening programs,and to provide a reference for relevant decision-making.Methods A Markov model of the natural disease development of cervical cancer was constructed to simulate the cumulative long-term cost and quality-adjusted life years(QALYs)of one hundred thousand healthy women after they received different interventions for cost-effectiveness analysis.Results and Conclusion Compared with the non-intervention group,the cost of per QALY obtained by two HPV vaccines and 5 screening programs ranged from 1117.56 yuan to 71660.48 yuan.Taking China’s GDP per capita in 2020 as the threshold,two HPV vaccines and 5 screening programs are cost-effective.Domestic bivalent vaccine is cost-effective and it should be introduced to the national immunization program in the future.Different screening programs are all cost-effective,too.Among them,careHPV test once every 5 years has the lowest ICER value and it can be used as the first choice for cervical cancer screening in rural areas or resource-limited areas in China.展开更多
文摘Objective To evaluate the economy of domestic bivalent human papilloma virus(HPV)vaccine,imported 9-valent HPV vaccine and 5 cervical cancer screening programs,and to provide a reference for relevant decision-making.Methods A Markov model of the natural disease development of cervical cancer was constructed to simulate the cumulative long-term cost and quality-adjusted life years(QALYs)of one hundred thousand healthy women after they received different interventions for cost-effectiveness analysis.Results and Conclusion Compared with the non-intervention group,the cost of per QALY obtained by two HPV vaccines and 5 screening programs ranged from 1117.56 yuan to 71660.48 yuan.Taking China’s GDP per capita in 2020 as the threshold,two HPV vaccines and 5 screening programs are cost-effective.Domestic bivalent vaccine is cost-effective and it should be introduced to the national immunization program in the future.Different screening programs are all cost-effective,too.Among them,careHPV test once every 5 years has the lowest ICER value and it can be used as the first choice for cervical cancer screening in rural areas or resource-limited areas in China.
