Objective:To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative colitis.Methods:Rats were randomly divided into six groups:n...Objective:To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative colitis.Methods:Rats were randomly divided into six groups:normal control,negative control,positive control(dexamethasone or sulfasalazine)as well as Persicaria lanigera(100-600 mg/kg)-treated groups.The effects of the extracts on body weight,antioxidant,and hematological parameters,as well as mast cell proliferation,were assessed.In addition,a histological evaluation was conducted.Results:Persicaria lanigera extract significantly decreased the mean exudate amount and suppressed granuloma tissue formation in a concentration-dependent manner in rats(P<0.05).Additionally,the extract significantly increased body weight,improved hematological profile,reduced the disease activity index score and malondialdehyde level,as well as enhanced catalase and superoxide dismutase activities(P<0.05).Histological evaluation showed Persicaria lanigera extract alleviated acetic acid-induced colonic damages,as evidenced by decreased cell necrosis,edema,and inflammatory cell infiltration.Conclusions:Persicaria lanigera extract possesses antiproliferative,antioxidative,and anti-colitis activities.However,its underlying mechanisms of action need further investigation.展开更多
Background:BioCen-128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature.Positive results of similar thymus extracts have been shown to be effective in dela...Background:BioCen-128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature.Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging,immunosenescence and Alzheimer’s disease(AD),where the inflammation plays an important role.Because of the anti-i nflammatory potential of BioCen-128,the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular(ICV)administration of streptozotocin(STZ).Method:The experiment was carried out using male OF-1mice weighing 20±2 g.Results:Mice administered BioCen-128 in via the IP route at 5,10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma,providing evidence of a systemic anti-i nflammatory effect.In the ICV model of STZ,the administration of BioCen-128 improved cognitive function.Conclusion:These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosinβ4 and thymosin alfa proteins.The results suggested that BioCen-128 could be used in the prevention and treatment of some diseases,for example AD,where neuroinflammation is one of the biological events that take place.展开更多
Objective:To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract(PCEE) at doses of 200 and 400 mg /kg body weight in acute and chronic models of inflammation in experimental...Objective:To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract(PCEE) at doses of 200 and 400 mg /kg body weight in acute and chronic models of inflammation in experimental animals.Methods:In the acute toxicity study,a single dose of PCEE of 2 000 mg/kg body weight,p.o.was administered and observed for 48 h.In acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed. Results:In acute models,egg albumin induced paw edema PCEE significantly(P【0.01) inhibited the edema formation.In chronic model,cotton pellet induced granuloma formation in rats PCEE significantly(P【0.01) reduced the granuloma formation with percentage inhibition of 35.17%and 50.38%respectively.Conclusions:The present study establishes the antiinflammatory activity of Premna corymbosa leaves.展开更多
Objective:To evaluate the anti-inflammatory effect of Nardostachys jatamansi(N.jatamansi)rhizome against acute,subacute and chronic models of inflammation in experimental animals.Methods:N.jatamansi rhizome extract(15...Objective:To evaluate the anti-inflammatory effect of Nardostachys jatamansi(N.jatamansi)rhizome against acute,subacute and chronic models of inflammation in experimental animals.Methods:N.jatamansi rhizome extract(150 and 300 mg/kg,p.o.)and the reference drugs phenylbutazone(100 mg/kg,p.o.)and acetylsalicylic acid(300 mg/kg,p.o.)were evaluated using models for inflammation(autacoids induced hind paw oedema,formaldehyde induced hind paw oedema,carrageenin-induced paw oedema,cotton pellet granuloma and subcutaneous air pouch model).Results:In acute inflammation as produced by carrageenin 29.06%and 55.81%,by histamine 25.0%and 39.28%,by 5-hydroxytryptamine 21.37%and 36.95%and by prostaglandin E2-induced hind paw oedema 31.03%and 44.82%protection was observed.While in subacute anti-inflammatory models using formaldehyde-induced hind paw oedema(after 1.5 h)13.88%and 33.33%and in chronic anti-inflammatory model using cotton pellet granuloma 7.4%and 17.58%protection from inflammation was observed.N.jatamansi rhizome extract also inhibited the inflammatory mediators(nitric oxide by 12.81%and 38.41%,by prostaglandin E212.58%and 47.82%while by TNF-α13.51%and 41.89%)produced in the pouch.Conclusions:The results of this study strongly indicate the protective effect of N.jatamansi rhizome extract against acute,subacute and chronic models of inflammation,which may be attributed to its anti-inflammatory potential.展开更多
文摘Objective:To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative colitis.Methods:Rats were randomly divided into six groups:normal control,negative control,positive control(dexamethasone or sulfasalazine)as well as Persicaria lanigera(100-600 mg/kg)-treated groups.The effects of the extracts on body weight,antioxidant,and hematological parameters,as well as mast cell proliferation,were assessed.In addition,a histological evaluation was conducted.Results:Persicaria lanigera extract significantly decreased the mean exudate amount and suppressed granuloma tissue formation in a concentration-dependent manner in rats(P<0.05).Additionally,the extract significantly increased body weight,improved hematological profile,reduced the disease activity index score and malondialdehyde level,as well as enhanced catalase and superoxide dismutase activities(P<0.05).Histological evaluation showed Persicaria lanigera extract alleviated acetic acid-induced colonic damages,as evidenced by decreased cell necrosis,edema,and inflammatory cell infiltration.Conclusions:Persicaria lanigera extract possesses antiproliferative,antioxidative,and anti-colitis activities.However,its underlying mechanisms of action need further investigation.
文摘Background:BioCen-128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature.Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging,immunosenescence and Alzheimer’s disease(AD),where the inflammation plays an important role.Because of the anti-i nflammatory potential of BioCen-128,the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular(ICV)administration of streptozotocin(STZ).Method:The experiment was carried out using male OF-1mice weighing 20±2 g.Results:Mice administered BioCen-128 in via the IP route at 5,10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma,providing evidence of a systemic anti-i nflammatory effect.In the ICV model of STZ,the administration of BioCen-128 improved cognitive function.Conclusion:These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosinβ4 and thymosin alfa proteins.The results suggested that BioCen-128 could be used in the prevention and treatment of some diseases,for example AD,where neuroinflammation is one of the biological events that take place.
文摘Objective:To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract(PCEE) at doses of 200 and 400 mg /kg body weight in acute and chronic models of inflammation in experimental animals.Methods:In the acute toxicity study,a single dose of PCEE of 2 000 mg/kg body weight,p.o.was administered and observed for 48 h.In acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed. Results:In acute models,egg albumin induced paw edema PCEE significantly(P【0.01) inhibited the edema formation.In chronic model,cotton pellet induced granuloma formation in rats PCEE significantly(P【0.01) reduced the granuloma formation with percentage inhibition of 35.17%and 50.38%respectively.Conclusions:The present study establishes the antiinflammatory activity of Premna corymbosa leaves.
基金Supported by Royal College of Pharmacy and Health Sciences Berhampur(Grant No-RCPHS/PH-09).
文摘Objective:To evaluate the anti-inflammatory effect of Nardostachys jatamansi(N.jatamansi)rhizome against acute,subacute and chronic models of inflammation in experimental animals.Methods:N.jatamansi rhizome extract(150 and 300 mg/kg,p.o.)and the reference drugs phenylbutazone(100 mg/kg,p.o.)and acetylsalicylic acid(300 mg/kg,p.o.)were evaluated using models for inflammation(autacoids induced hind paw oedema,formaldehyde induced hind paw oedema,carrageenin-induced paw oedema,cotton pellet granuloma and subcutaneous air pouch model).Results:In acute inflammation as produced by carrageenin 29.06%and 55.81%,by histamine 25.0%and 39.28%,by 5-hydroxytryptamine 21.37%and 36.95%and by prostaglandin E2-induced hind paw oedema 31.03%and 44.82%protection was observed.While in subacute anti-inflammatory models using formaldehyde-induced hind paw oedema(after 1.5 h)13.88%and 33.33%and in chronic anti-inflammatory model using cotton pellet granuloma 7.4%and 17.58%protection from inflammation was observed.N.jatamansi rhizome extract also inhibited the inflammatory mediators(nitric oxide by 12.81%and 38.41%,by prostaglandin E212.58%and 47.82%while by TNF-α13.51%and 41.89%)produced in the pouch.Conclusions:The results of this study strongly indicate the protective effect of N.jatamansi rhizome extract against acute,subacute and chronic models of inflammation,which may be attributed to its anti-inflammatory potential.
