Living systems,including human beings,animals,and plants,display the power to self-heal spontaneously after being damaged.The self-healing is usually selective,which means that the healing efficiency is related to the...Living systems,including human beings,animals,and plants,display the power to self-heal spontaneously after being damaged.The self-healing is usually selective,which means that the healing efficiency is related to the spatial distribution of dynamic interfacial interactions of the two rupturing surfaces.Current artificial systems use noncovalent interactions or dynamic covalent bonds to prepare self-healing materials.However,they can only show nonselective self-healing due to their homogeneous internal structures.Herein,we report the construction of a composite hydrogel Gel-C consisting of three different self-healing hydrogels(Gel-Y,Gel-G,and Gel-O)through the use of classic bilayer hydrogel technology.When the composite hydrogel was cut into two pieces,the relative orientation of the parts was rotated through different angles to study the differences in self-healing.Owing to the heterogeneous internal structure of the composite hydrogel and the recognition specificity of each included hydrogel,the interfacial dynamic interactions distribution of the two rupturing surfaces is diverse.The results of tensile tests demonstrated that these rotated samples exhibited different self-healing efficiencies.This system realized the transformation of artificial materials from nonselective self-healing to selective selfhealing,providing inspiration for the development of novel biological materials and engineering materials.展开更多
Hydrogels are three-dimensional(3D)crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields,including water treatment,energy storage,and regenerative medicine.However,conventiona...Hydrogels are three-dimensional(3D)crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields,including water treatment,energy storage,and regenerative medicine.However,conventional synthetic polymer hydrogels have poor biocompatibility.In this context,polysaccharides,a class of renewable natural materials with biocompatible and biodegradable properties,have been utilized as building blocks to yield polysaccharide-based hydrogels through physical and/or chemical crosslinking of polysaccharides via a variety of monomers or ions.These polysaccharide-derived hydrogels exhibit peculiar physicochemical properties and excellent mechanical properties due to their unique structures and abundant functional groups.This review focuses on recent advances in synthesis and applications of polysaccharide-based hydrogels by capitalizing on a set of biocompatible and biodegradable polysaccharides(i.e.,cellulose,alginate,chitosan,and cyclodextrins[CDs]).First,we introduce the design and synthesis principles for crafting polysaccharide-based hydrogels.Second,polysaccharidebased hydrogels that are interconnected via various crosslinking strategies(e.g.,physical crosslinking,chemical crosslinking,and double networking)are summarized.In particular,the introduction of noncovalent and/or dynamic covalent interactions imparts polysaccharide-based hydrogels with a myriad of intriguing performances(e.g.,stimuli–response and self-recovery).Third,the diverse applications of polysaccharide-based hydrogels in self-healing,sensory,supercapacitor,battery,drug delivery,wound healing,tissues engineering,and bioimaging fields are discussed.Finally,the perspectives of polysaccharide-based hydrogels that promote their future design to enable new functions and applications are outlined.展开更多
1 Results Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers.The epidermal growth factor receptor (EGFR) prot...1 Results Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers.The epidermal growth factor receptor (EGFR) protein tyrosine kinase is one of the important kinases that play a fundamental role in cell growth signal pathways.We focused on the 4-anilinoquinazoline framework,which is observed in both compounds as a common structure.A boron atom has a vacant orbital and interconverts with ease between th...展开更多
基金B.Z.T.acknowledges the financial support from the National Science Foundation of China(nos.21788102,21490570,and 21490574)the Research Grant Council of Hong Kong(nos.16305518,N-HKUST609/19,and C6009-17G)+3 种基金the Science and Technology Plan of Shenzhen(no.JCYJ20170818113602462)the Innovation and Technology Commission(no.ITC-CNERC149C01)X.J.acknowledges initial funding from Huazhong University of Science and Technology,where he is being supported by Fundamental Research Funds for the Central Universities(grant no.2020kfyXJJS013)Z.L.acknowledges the financial support from Beijing Institute of Technology Research Fund Program for Young Scholars。
文摘Living systems,including human beings,animals,and plants,display the power to self-heal spontaneously after being damaged.The self-healing is usually selective,which means that the healing efficiency is related to the spatial distribution of dynamic interfacial interactions of the two rupturing surfaces.Current artificial systems use noncovalent interactions or dynamic covalent bonds to prepare self-healing materials.However,they can only show nonselective self-healing due to their homogeneous internal structures.Herein,we report the construction of a composite hydrogel Gel-C consisting of three different self-healing hydrogels(Gel-Y,Gel-G,and Gel-O)through the use of classic bilayer hydrogel technology.When the composite hydrogel was cut into two pieces,the relative orientation of the parts was rotated through different angles to study the differences in self-healing.Owing to the heterogeneous internal structure of the composite hydrogel and the recognition specificity of each included hydrogel,the interfacial dynamic interactions distribution of the two rupturing surfaces is diverse.The results of tensile tests demonstrated that these rotated samples exhibited different self-healing efficiencies.This system realized the transformation of artificial materials from nonselective self-healing to selective selfhealing,providing inspiration for the development of novel biological materials and engineering materials.
基金supported by the Air Force Office of Scientific Research(FA9550-19-1-0317)the NSF(DMR 1903990,and Chemistry 1903957).
文摘Hydrogels are three-dimensional(3D)crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields,including water treatment,energy storage,and regenerative medicine.However,conventional synthetic polymer hydrogels have poor biocompatibility.In this context,polysaccharides,a class of renewable natural materials with biocompatible and biodegradable properties,have been utilized as building blocks to yield polysaccharide-based hydrogels through physical and/or chemical crosslinking of polysaccharides via a variety of monomers or ions.These polysaccharide-derived hydrogels exhibit peculiar physicochemical properties and excellent mechanical properties due to their unique structures and abundant functional groups.This review focuses on recent advances in synthesis and applications of polysaccharide-based hydrogels by capitalizing on a set of biocompatible and biodegradable polysaccharides(i.e.,cellulose,alginate,chitosan,and cyclodextrins[CDs]).First,we introduce the design and synthesis principles for crafting polysaccharide-based hydrogels.Second,polysaccharidebased hydrogels that are interconnected via various crosslinking strategies(e.g.,physical crosslinking,chemical crosslinking,and double networking)are summarized.In particular,the introduction of noncovalent and/or dynamic covalent interactions imparts polysaccharide-based hydrogels with a myriad of intriguing performances(e.g.,stimuli–response and self-recovery).Third,the diverse applications of polysaccharide-based hydrogels in self-healing,sensory,supercapacitor,battery,drug delivery,wound healing,tissues engineering,and bioimaging fields are discussed.Finally,the perspectives of polysaccharide-based hydrogels that promote their future design to enable new functions and applications are outlined.
基金supported by the National Key Projects for Fundamental Research and Development of China(2016YFA0202801)the National Natural Science Foundation of China(21673226+3 种基金91645203 and 21590792)the “Transformational Technologies for Clean Energy and Demonstration”the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA21040200 and XDB17000000)supported by the Tsinghua Xuetang Talents Program
文摘1 Results Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers.The epidermal growth factor receptor (EGFR) protein tyrosine kinase is one of the important kinases that play a fundamental role in cell growth signal pathways.We focused on the 4-anilinoquinazoline framework,which is observed in both compounds as a common structure.A boron atom has a vacant orbital and interconverts with ease between th...
