Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional...Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the right oculomotor nerves of adult dogs. Stimulating electrodes were positioned in both proximal and distal locations of the lesion, and non-continuous rectangular, biphasic current pulses （0.7 V, 5 Hz） were administered 1 hour daily for 2 consecutive weeks. Analysis of the results showed that electrophysiological and morphological recovery of the injured oc- ulomotor nerve was enhanced, indicating that electrical stimulation improved neural regeneration. Thus, this therapy has the potential to promote the recovery of oculomotor nerve dysfunction.展开更多
目的:探讨较大电流强度的经颅微电流刺激(cranial electrical stimulation,CES)的疗效。方法:随机给予15名健康男性受试相隔一周的CES真刺激(0.3 m A、20 min)和假刺激(0.3 m A、30 s),测量作用前后的血压、心率,并且让受试者填写口头...目的:探讨较大电流强度的经颅微电流刺激(cranial electrical stimulation,CES)的疗效。方法:随机给予15名健康男性受试相隔一周的CES真刺激(0.3 m A、20 min)和假刺激(0.3 m A、30 s),测量作用前后的血压、心率,并且让受试者填写口头评分量表、状态焦虑量表、特质焦虑量表、恐惧调查量表-Ⅱ。结果:CES真刺激后受试者的心率减慢(P<0.05),收缩压升高(P<0.05),状态焦虑(P<0.05)、恐惧和疼痛程度均降低(P<0.05)。然而CES假刺激后被试者的恐惧程度也降低了(P<0.05)。结论:CES对改善精神状况和疼痛水平有一定的疗效,它可以作为一种辅助技术应用于临床病人,以减小药物的副作用和依赖性。展开更多
目的:探究经颅电刺激(Transcranial direct current stimulation,tDCS)联合口肌生物反馈训练在中风后吞咽障碍患者治疗中的应用价值。方法:选取2019年5月~2021年2月我院神经科收治的86例中风后吞咽障碍患者作为研究对象,根据就诊序号采...目的:探究经颅电刺激(Transcranial direct current stimulation,tDCS)联合口肌生物反馈训练在中风后吞咽障碍患者治疗中的应用价值。方法:选取2019年5月~2021年2月我院神经科收治的86例中风后吞咽障碍患者作为研究对象,根据就诊序号采用随机数字表法分为对照组和观察组,各43例。对照组采用基础西药治疗联合口肌生物反馈训练,观察组于此基础上采用tDCS治疗。两组均治疗3 m后评估临床效果、对比治疗前及治疗3 m后神经营养指标水平、吞咽功能、吞咽障碍严重程度、神经损伤程度及生活质量。结果:治疗3 m后,观察组总有效率高于对照组,神经营养指标水平、改良曼恩吞咽功能量表(Modified Mann Assessment of Swallowing Ability,MMASA)评分、吞咽障碍的结局与严重度量表(Dysphagia outcome and severity scale,DOSS)评分、吞咽功能生活质量量表(Swallowing quality of life questionnaire,SWAL-QOL)评分均高于对照组,美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)评分低于对照组(P<0.05)。结论:对中风后吞咽障碍患者实施tDCS联合口肌生物反馈训练治疗效果确切,能调节神经营养因子水平,减轻神经功能损伤程度,有助于改善吞咽功能,且能提高患者生活质量。展开更多
基金supported by a grant from the National Natural Science Foundation of China,No.30571907the International Science and Technology Cooperation Foundation of the Shanghai Committee of Science and Technology,China,No.10410711400
文摘Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the right oculomotor nerves of adult dogs. Stimulating electrodes were positioned in both proximal and distal locations of the lesion, and non-continuous rectangular, biphasic current pulses （0.7 V, 5 Hz） were administered 1 hour daily for 2 consecutive weeks. Analysis of the results showed that electrophysiological and morphological recovery of the injured oc- ulomotor nerve was enhanced, indicating that electrical stimulation improved neural regeneration. Thus, this therapy has the potential to promote the recovery of oculomotor nerve dysfunction.
文摘目的:探讨较大电流强度的经颅微电流刺激(cranial electrical stimulation,CES)的疗效。方法:随机给予15名健康男性受试相隔一周的CES真刺激(0.3 m A、20 min)和假刺激(0.3 m A、30 s),测量作用前后的血压、心率,并且让受试者填写口头评分量表、状态焦虑量表、特质焦虑量表、恐惧调查量表-Ⅱ。结果:CES真刺激后受试者的心率减慢(P<0.05),收缩压升高(P<0.05),状态焦虑(P<0.05)、恐惧和疼痛程度均降低(P<0.05)。然而CES假刺激后被试者的恐惧程度也降低了(P<0.05)。结论:CES对改善精神状况和疼痛水平有一定的疗效,它可以作为一种辅助技术应用于临床病人,以减小药物的副作用和依赖性。
文摘目的:探究经颅电刺激(Transcranial direct current stimulation,tDCS)联合口肌生物反馈训练在中风后吞咽障碍患者治疗中的应用价值。方法:选取2019年5月~2021年2月我院神经科收治的86例中风后吞咽障碍患者作为研究对象,根据就诊序号采用随机数字表法分为对照组和观察组,各43例。对照组采用基础西药治疗联合口肌生物反馈训练,观察组于此基础上采用tDCS治疗。两组均治疗3 m后评估临床效果、对比治疗前及治疗3 m后神经营养指标水平、吞咽功能、吞咽障碍严重程度、神经损伤程度及生活质量。结果:治疗3 m后,观察组总有效率高于对照组,神经营养指标水平、改良曼恩吞咽功能量表(Modified Mann Assessment of Swallowing Ability,MMASA)评分、吞咽障碍的结局与严重度量表(Dysphagia outcome and severity scale,DOSS)评分、吞咽功能生活质量量表(Swallowing quality of life questionnaire,SWAL-QOL)评分均高于对照组,美国国立卫生研究院卒中量表(National institute of health stroke scale,NIHSS)评分低于对照组(P<0.05)。结论:对中风后吞咽障碍患者实施tDCS联合口肌生物反馈训练治疗效果确切,能调节神经营养因子水平,减轻神经功能损伤程度,有助于改善吞咽功能,且能提高患者生活质量。
