Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine(1).Yunaconitine(1)has similar skeleton to crassicauline A(3);the only difference between them is that 1 contains aα-hydroxyl g...Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine(1).Yunaconitine(1)has similar skeleton to crassicauline A(3);the only difference between them is that 1 contains aα-hydroxyl group at C-3.Our team attempts to convert 1 into 3 because 3 owns pharmacological activity.There are two steps to achieve the transformation above:firstly,use dehydration reaction to transform yunaconitine(1)into dehydroyunaconitine(2);secondly,use hydrogen reduction to acquire crassicauline A(3).Compared with other methods,this one below is more suitable for production application and more concise;moreover,the cost is lower with higher yield.展开更多
文摘Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine(1).Yunaconitine(1)has similar skeleton to crassicauline A(3);the only difference between them is that 1 contains aα-hydroxyl group at C-3.Our team attempts to convert 1 into 3 because 3 owns pharmacological activity.There are two steps to achieve the transformation above:firstly,use dehydration reaction to transform yunaconitine(1)into dehydroyunaconitine(2);secondly,use hydrogen reduction to acquire crassicauline A(3).Compared with other methods,this one below is more suitable for production application and more concise;moreover,the cost is lower with higher yield.
