Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds c...Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.展开更多
Recently,deep image-hiding techniques have attracted considerable attention in covert communication and high-capacity information hiding.However,these approaches have some limitations.For example,a cover image lacks s...Recently,deep image-hiding techniques have attracted considerable attention in covert communication and high-capacity information hiding.However,these approaches have some limitations.For example,a cover image lacks self-adaptability,information leakage,or weak concealment.To address these issues,this study proposes a universal and adaptable image-hiding method.First,a domain attention mechanism is designed by combining the Atrous convolution,which makes better use of the relationship between the secret image domain and the cover image domain.Second,to improve perceived human similarity,perceptual loss is incorporated into the training process.The experimental results are promising,with the proposed method achieving an average pixel discrepancy(APD)of 1.83 and a peak signal-to-noise ratio(PSNR)value of 40.72 dB between the cover and stego images,indicative of its high-quality output.Furthermore,the structural similarity index measure(SSIM)reaches 0.985 while the learned perceptual image patch similarity(LPIPS)remarkably registers at 0.0001.Moreover,self-testing and cross-experiments demonstrate the model’s adaptability and generalization in unknown hidden spaces,making it suitable for diverse computer vision tasks.展开更多
Drought tolerance levels and antioxidant protection mechanisms were evaluated for 21 traditional rice varieties of Assam, India, along with Sahbhagi Dhan (drought tolerant) and IR64 (drought sensitive) as controls...Drought tolerance levels and antioxidant protection mechanisms were evaluated for 21 traditional rice varieties of Assam, India, along with Sahbhagi Dhan (drought tolerant) and IR64 (drought sensitive) as controls. Drought was imposed in hydroponic culture with polyethylene glycol 6000 (PEG6000) that was initially standardized with different concentrations. All the rice varieties showed apparent decreases in growth characteristics under drought stress (initially at 15% for 7 d followed by 20% PEG6000 for 7 d in Yoshida medium). On the basis of standard evaluation score (SES), eight rice varieties showed high drought tolerance which were carried forward for further biochemical analyses. Based on different morpho- physiological parameters, SN03 (Bora), SN04 (Prosad Bhog), SN05 (Kola Joha), SN06 (Helash Bora), SN08 (Salihoi Bao), SN12 (Kola Amona), SN20 (Ronga Bora) and SN21 (Sok-Bonglong) were identified as promising drought tolerant varieties. The non-enzymatic antioxidants activities viz., glutathione, ascorbate and enzymatic antioxidant activities such as superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX), glutathione reductase (GR) in shoots and roots of all the selected varieties revealed significant level of protection mechanisms as compared with controls. Enhancement in activities of the overall antioxidant enzymes including SOD, GPX, CAT, GR and APX under drought stress reflects their role in the adaptation process under water stress.展开更多
With the rapid development of the Internet of Things(IoT),Location-Based Services(LBS)are becoming more and more popular.However,for the users being served,how to protect their location privacy has become a growing co...With the rapid development of the Internet of Things(IoT),Location-Based Services(LBS)are becoming more and more popular.However,for the users being served,how to protect their location privacy has become a growing concern.This has led to great difficulty in establishing trust between the users and the service providers,hindering the development of LBS for more comprehensive functions.In this paper,we first establish a strong identity verification mechanism to ensure the authentication security of the system and then design a new location privacy protection mechanism based on the privacy proximity test problem.This mechanism not only guarantees the confidentiality of the user s information during the subsequent information interaction and dynamic data transmission,but also meets the service provider's requirements for related data.展开更多
At present,with the rapid development of social economy,people's awareness of environmental protection continues to increase,and environmental construction and environmental protection work are put on the agenda.H...At present,with the rapid development of social economy,people's awareness of environmental protection continues to increase,and environmental construction and environmental protection work are put on the agenda.Highway slope greening protection is an important means to achieve social sustainable development.Developed countries carried out research earlier in this area,and China's research in this area started later.In engineering construction,ecological protection is to realize slope reinforcement and slope protection depending on the water storage and soil fixation effects of vegetation.Its slope protection can be summarized as the mechanical effect of root system and the hydrological effect of vegetation.As a basic form of slope greening protection,it is necessary for us to understand the mechanism of ecological protection and to enhance the design of ecological protection accordingly.Based on this,the article analyzed the development of slope greening protection technology and ecological protection mechanism from different angles,so as to establish a theoretical framework for future research.展开更多
Drawing the ecological protection red line is to maintain the integrity and benign operation of the ecosystem within the area,and to ensure that the ecological environment is within the boundary of controllable ecolog...Drawing the ecological protection red line is to maintain the integrity and benign operation of the ecosystem within the area,and to ensure that the ecological environment is within the boundary of controllable ecological security.Taking the ecologically vulnerable areas in western China as the research object and using the game theory and literature analysis,this paper studied the game behavior of ecological protection red line in these areas.In addition,this paper also analyzed the stakeholders such as government,enterprises and the masses in the drawing of the ecological protection red line,and comprehensively analyzed the game strategies between the government and the masses,the government and enterprises,and the central and local governments and enterprises.On the basis of the analysis,it came up with a safeguard mechanism for the coordination of the interests of the ecological protection red line.展开更多
This study was conducted to investigate the protective mechanism of V. coloratum fruit polysaccharides( VCFP) on mice with acute alcoholic liver injury. Acute liver injury model was built by one-time alcohol gavage....This study was conducted to investigate the protective mechanism of V. coloratum fruit polysaccharides( VCFP) on mice with acute alcoholic liver injury. Acute liver injury model was built by one-time alcohol gavage. The mice were randomly divided into VCFP-treated groups( low-,medium-,and highdose),alcohol model group and normal control group at the same time. VCFP-treated groups were administrated polysaccharide intragastrically continuously for4 weeks; and the alcohol model group and normal control group were administrated intragastrically the same amount of normal saline. The general situation and liver tissue morphological structure changes were observed. The results showed that the levels of ALT,AST,TC,TG,MDA contents,and CAT and GSH-Px activity of mice in the model group increased significantly( P 〈 0. 01),while the activity of SOD and weight and liver index decreased significantly( P 〈 0. 01) compared with the normal control group. After 4 weeks of gavage,VCFP could significantly improve weight,liver index and SOD activity,and significantly reduce ALT,AST,TC and TG levels,MDA content and CAT and GSH-Px activity. These results suggest that VCFP can improve antioxidant enzyme activity,remove oxygen free radical and reduce membrane lipid peroxidation reaction,thereby protecting liver cells.展开更多
The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable resource.The spent LIBs recycling mainly aimed at the separation of valuable elements.Some is...The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable resource.The spent LIBs recycling mainly aimed at the separation of valuable elements.Some issues still exist in these processes such as high energy consumption and complex separation procedures.This study avoided element separation and proposed a facile approach to transform spent LiCoO_(2) electrode into a lithium(Li)-doped graphitic carbon nitride(g-C_(3)N_(4))/Co_(3)O_(4) composite photocatalyst through one-pot in situ thermal reduction.During the thermal process,melamine served as the reductant for LiCoO_(2) decomposition and the raw material for g-C_(3)N_(4) production.Li was in situ doped in g-C_(3)N_(4) and the generated Co_(3)O_(4) was in situ integrated,forming a Li-doped g-C_(3)N_(4)/Co_(3)O_(4) composite photocatalyst.This special composite exhibited an enhanced photocatalytic performance,and its photocatalytic H2 production and RhB degradation rates were 8.7 and 6.8 times higher than those of g-C_(3)N_(4).The experiments combined with DFT calculation revealed that such enhanced photocatalytic efficiency was ascribed to the synergy effect of Li doping and Co_(3)O_(4) integrating,which extended the visible light absorption(450-900 nm)and facilitated the charge transfer and separation.This study transforms waste into a high-efficient catalyst,realizing high-valued utilization of waste and environmental protection.展开更多
The basis of the legal protection of resource security is its relative laws, which have four main characteristics, which are foundational, divergent, comprehensive and of long-term social benefits in view. The coordin...The basis of the legal protection of resource security is its relative laws, which have four main characteristics, which are foundational, divergent, comprehensive and of long-term social benefits in view. The coordination mechanism of the legal protection of resource security with its relative laws meets the needs of the sustainable development of the economy, society and environment. It also facilitates and is facilitated by the modern transformation of the legal system in China, and upholds the legal system as a logically self-perfecting entity. Furthermore, this coordination bears scientific feasibility.展开更多
General Secretary Xi Jinping delivered an important speech on China’s Path of Human Rights at a group study session of the Political Bureau of the CPC Central Committee on February 25,2022.Persisting with the law-bas...General Secretary Xi Jinping delivered an important speech on China’s Path of Human Rights at a group study session of the Political Bureau of the CPC Central Committee on February 25,2022.Persisting with the law-based protection of human rights and improving the mechanism for the protection of human rights by the rule of law are essential for unswervingly following the development path of human rights in China.The improvement of the mechanism for the protection of human rights by the rule of law necessitates adhering to the principle of respecting the dominant role of the people and removing the institutional obstacles in rule of law protection of human rights;to comprehensively strengthen the implementation of the Constitution,advance the filing and examination of the Constitution,and safeguard the authority of the Constitution;to accelerate the theoretical innovation of human rights and the construction of the discipline system,the academic system and the discourse system of human rights that meet the needs of the new era in China,and to actively participate in and contribute to the global governance on human rights,etc.Improving the mechanism for the protection of human rights by the rule of law can provide a solid protection for people enjoying a better life.展开更多
When criminal suspects are being investigated for criminal responsibil- ity, they are the most vulnerable to infringement by public power. Thus, they need more special attention and protection. It is the in- evitable ...When criminal suspects are being investigated for criminal responsibil- ity, they are the most vulnerable to infringement by public power. Thus, they need more special attention and protection. It is the in- evitable requirement of the modern democratic rule of law, and also the inevitable historic choice of respecting and protecting human rights.展开更多
基金supported by the National Natural Science Foundation of China(32072142,31972099)Guangxi Science and Technology Base and Talent Special Projects(Guike AD21220004)。
文摘Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.
基金supported by the National Key R&D Program of China(Grant Number 2021YFB2700900)the National Natural Science Foundation of China(Grant Numbers 62172232,62172233)the Jiangsu Basic Research Program Natural Science Foundation(Grant Number BK20200039).
文摘Recently,deep image-hiding techniques have attracted considerable attention in covert communication and high-capacity information hiding.However,these approaches have some limitations.For example,a cover image lacks self-adaptability,information leakage,or weak concealment.To address these issues,this study proposes a universal and adaptable image-hiding method.First,a domain attention mechanism is designed by combining the Atrous convolution,which makes better use of the relationship between the secret image domain and the cover image domain.Second,to improve perceived human similarity,perceptual loss is incorporated into the training process.The experimental results are promising,with the proposed method achieving an average pixel discrepancy(APD)of 1.83 and a peak signal-to-noise ratio(PSNR)value of 40.72 dB between the cover and stego images,indicative of its high-quality output.Furthermore,the structural similarity index measure(SSIM)reaches 0.985 while the learned perceptual image patch similarity(LPIPS)remarkably registers at 0.0001.Moreover,self-testing and cross-experiments demonstrate the model’s adaptability and generalization in unknown hidden spaces,making it suitable for diverse computer vision tasks.
基金supported by UGC,Maulana Azad National Fellowship for Minority Students,Government of India
文摘Drought tolerance levels and antioxidant protection mechanisms were evaluated for 21 traditional rice varieties of Assam, India, along with Sahbhagi Dhan (drought tolerant) and IR64 (drought sensitive) as controls. Drought was imposed in hydroponic culture with polyethylene glycol 6000 (PEG6000) that was initially standardized with different concentrations. All the rice varieties showed apparent decreases in growth characteristics under drought stress (initially at 15% for 7 d followed by 20% PEG6000 for 7 d in Yoshida medium). On the basis of standard evaluation score (SES), eight rice varieties showed high drought tolerance which were carried forward for further biochemical analyses. Based on different morpho- physiological parameters, SN03 (Bora), SN04 (Prosad Bhog), SN05 (Kola Joha), SN06 (Helash Bora), SN08 (Salihoi Bao), SN12 (Kola Amona), SN20 (Ronga Bora) and SN21 (Sok-Bonglong) were identified as promising drought tolerant varieties. The non-enzymatic antioxidants activities viz., glutathione, ascorbate and enzymatic antioxidant activities such as superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (GPX), ascorbate peroxidase (APX), glutathione reductase (GR) in shoots and roots of all the selected varieties revealed significant level of protection mechanisms as compared with controls. Enhancement in activities of the overall antioxidant enzymes including SOD, GPX, CAT, GR and APX under drought stress reflects their role in the adaptation process under water stress.
基金This work has been partly supported by the National Natural Science Foundation of China under Grant No.61702212the Fundamental Research Funds for the Central Universities under Grand NO.CCNU19TS017.
文摘With the rapid development of the Internet of Things(IoT),Location-Based Services(LBS)are becoming more and more popular.However,for the users being served,how to protect their location privacy has become a growing concern.This has led to great difficulty in establishing trust between the users and the service providers,hindering the development of LBS for more comprehensive functions.In this paper,we first establish a strong identity verification mechanism to ensure the authentication security of the system and then design a new location privacy protection mechanism based on the privacy proximity test problem.This mechanism not only guarantees the confidentiality of the user s information during the subsequent information interaction and dynamic data transmission,but also meets the service provider's requirements for related data.
文摘At present,with the rapid development of social economy,people's awareness of environmental protection continues to increase,and environmental construction and environmental protection work are put on the agenda.Highway slope greening protection is an important means to achieve social sustainable development.Developed countries carried out research earlier in this area,and China's research in this area started later.In engineering construction,ecological protection is to realize slope reinforcement and slope protection depending on the water storage and soil fixation effects of vegetation.Its slope protection can be summarized as the mechanical effect of root system and the hydrological effect of vegetation.As a basic form of slope greening protection,it is necessary for us to understand the mechanism of ecological protection and to enhance the design of ecological protection accordingly.Based on this,the article analyzed the development of slope greening protection technology and ecological protection mechanism from different angles,so as to establish a theoretical framework for future research.
基金Sponsored by Social Science Foundation Project of Hunan Province(16YBX008)Major Program of Hunan Provincial Social Science Evaluation Committee(XSP18YBC143)
文摘Drawing the ecological protection red line is to maintain the integrity and benign operation of the ecosystem within the area,and to ensure that the ecological environment is within the boundary of controllable ecological security.Taking the ecologically vulnerable areas in western China as the research object and using the game theory and literature analysis,this paper studied the game behavior of ecological protection red line in these areas.In addition,this paper also analyzed the stakeholders such as government,enterprises and the masses in the drawing of the ecological protection red line,and comprehensively analyzed the game strategies between the government and the masses,the government and enterprises,and the central and local governments and enterprises.On the basis of the analysis,it came up with a safeguard mechanism for the coordination of the interests of the ecological protection red line.
基金Supported by Project of Education Department of Gansu Province(2015B-148)Science and technology project of Longnan City 2016(2016-9)
文摘This study was conducted to investigate the protective mechanism of V. coloratum fruit polysaccharides( VCFP) on mice with acute alcoholic liver injury. Acute liver injury model was built by one-time alcohol gavage. The mice were randomly divided into VCFP-treated groups( low-,medium-,and highdose),alcohol model group and normal control group at the same time. VCFP-treated groups were administrated polysaccharide intragastrically continuously for4 weeks; and the alcohol model group and normal control group were administrated intragastrically the same amount of normal saline. The general situation and liver tissue morphological structure changes were observed. The results showed that the levels of ALT,AST,TC,TG,MDA contents,and CAT and GSH-Px activity of mice in the model group increased significantly( P 〈 0. 01),while the activity of SOD and weight and liver index decreased significantly( P 〈 0. 01) compared with the normal control group. After 4 weeks of gavage,VCFP could significantly improve weight,liver index and SOD activity,and significantly reduce ALT,AST,TC and TG levels,MDA content and CAT and GSH-Px activity. These results suggest that VCFP can improve antioxidant enzyme activity,remove oxygen free radical and reduce membrane lipid peroxidation reaction,thereby protecting liver cells.
基金supported by the National Natural Science Foundation of China(51534005)Postdoctoral Innovative Talent Support Program(BX20190200)China Postdoctoral Science Foundation(2020M671129)。
文摘The ever-increasing quantity of spent lithium-ion batteries(LIBs)is both a potential environmental pollutant and a valuable resource.The spent LIBs recycling mainly aimed at the separation of valuable elements.Some issues still exist in these processes such as high energy consumption and complex separation procedures.This study avoided element separation and proposed a facile approach to transform spent LiCoO_(2) electrode into a lithium(Li)-doped graphitic carbon nitride(g-C_(3)N_(4))/Co_(3)O_(4) composite photocatalyst through one-pot in situ thermal reduction.During the thermal process,melamine served as the reductant for LiCoO_(2) decomposition and the raw material for g-C_(3)N_(4) production.Li was in situ doped in g-C_(3)N_(4) and the generated Co_(3)O_(4) was in situ integrated,forming a Li-doped g-C_(3)N_(4)/Co_(3)O_(4) composite photocatalyst.This special composite exhibited an enhanced photocatalytic performance,and its photocatalytic H2 production and RhB degradation rates were 8.7 and 6.8 times higher than those of g-C_(3)N_(4).The experiments combined with DFT calculation revealed that such enhanced photocatalytic efficiency was ascribed to the synergy effect of Li doping and Co_(3)O_(4) integrating,which extended the visible light absorption(450-900 nm)and facilitated the charge transfer and separation.This study transforms waste into a high-efficient catalyst,realizing high-valued utilization of waste and environmental protection.
文摘The basis of the legal protection of resource security is its relative laws, which have four main characteristics, which are foundational, divergent, comprehensive and of long-term social benefits in view. The coordination mechanism of the legal protection of resource security with its relative laws meets the needs of the sustainable development of the economy, society and environment. It also facilitates and is facilitated by the modern transformation of the legal system in China, and upholds the legal system as a logically self-perfecting entity. Furthermore, this coordination bears scientific feasibility.
文摘General Secretary Xi Jinping delivered an important speech on China’s Path of Human Rights at a group study session of the Political Bureau of the CPC Central Committee on February 25,2022.Persisting with the law-based protection of human rights and improving the mechanism for the protection of human rights by the rule of law are essential for unswervingly following the development path of human rights in China.The improvement of the mechanism for the protection of human rights by the rule of law necessitates adhering to the principle of respecting the dominant role of the people and removing the institutional obstacles in rule of law protection of human rights;to comprehensively strengthen the implementation of the Constitution,advance the filing and examination of the Constitution,and safeguard the authority of the Constitution;to accelerate the theoretical innovation of human rights and the construction of the discipline system,the academic system and the discourse system of human rights that meet the needs of the new era in China,and to actively participate in and contribute to the global governance on human rights,etc.Improving the mechanism for the protection of human rights by the rule of law can provide a solid protection for people enjoying a better life.
文摘When criminal suspects are being investigated for criminal responsibil- ity, they are the most vulnerable to infringement by public power. Thus, they need more special attention and protection. It is the in- evitable requirement of the modern democratic rule of law, and also the inevitable historic choice of respecting and protecting human rights.