Mitotic crossover- an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma

Mitotic crossover is a natural mechanism that is a main source of the genetic variability of primitive organisms.In complex organisms such as mammals,it represents an evolutionary rudiment which persisted as one of the numerous DNA repair mechanisms,and results in the production of homozygous allele combinations in all heterozygous genes located on the chromosome arm distal to the crossover.This event is familiar as loss of heterozygosity,which is one of the key mechanisms responsible for the development and progression of almost all cancers.We propose the hypothesis in which mitotic crossover is a principal source of the increased loss of heterozygosity that leads to the initiation and progression of colorectal carcinoma.The hypothesis could be tested by in vitro inhibition of Rad51 protein,orthotopic grafting of human colon cancer tissue into the gut of mice,and treatment with potential inhibitors.After these procedures,the frequency of mitotic crossover would be estimated.The development of selective inhibitors of mitotic crossover could stop further carcinogenesis of colorectal carcinoma,as well as many other neoplastic events.Loss of heterozygosity is an event responsible for carcinogenesis,its reduction by selective inhibitors of mitotic crossover could have a positive effect on cancer chemoprevention,as well as on growth reduction and a cessation in the progression of earlier developed tumors.

Combining ability and heterosis analysis over two environments in a diallel cross of three families of the clam Meretrix meretrix

A 3×3 complete diallel cross comprising three families of the clam Meretrix meretrix（P1, P2 and P3） was used to determine the combining ability of parental families and heterosis of F1 under indoor and openair environments for growth traits. Analysis of variance for shell length and whole body weight indicated highly significant cross effects, environment effects and the interaction of cross by environment. General combining ability（GCA） and specific combing ability exhibited great variation among crosses and between two environments. Pooled over environments, P2 was the top combiner among the three parental families for both traits studied. The cross of P1 and P3 had the highest SCA. Additionally, significant reciprocal effects were observed. For individual environment, about half of the crossbred combinations showed favorable Mid-parent heterosis（MPH）（〉1%） for the shell length and whole body weight. Our data has shown that non-additive genetic and reciprocal effects constituted the major sources of genetic variation for both shell length and whole body weight, which indicates that crossbreeding among selective families could further explore the heterotic effects.

cross,across,through和over的用法区别

(1)cross为动词,表示“穿过、越过、渡过”。主要强调动作。如:The old man is crossing a bridge.那位老人正在过桥。(2)across为介词,表示“横过”强调从物体表面的一边到另一边。

Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual impairment.The therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced stages.In keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe procedure.CXL consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks formation.The aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment protocols.Finally,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

Cross correlation mediated by distant Majorana zero modes with no overlap

Existing studies via shot noise calculation conclude that the cross correlation between the currents in the two leads connected by a pair of Majorana zero modes(MZMs)vanishes when their coupling energy𝜖∈_(M)→0.Motivated by the intrinsic nature of nonlocality of the MZMs,we revisit this important problem and propose an experimental scheme to demonstrate the nonvanishing cross correlation even at the limit𝜖∈_(M)→0.The proposed scheme employs the Andreevprocess-associated branch circuit currents,which are theoretically obtained by applying a decomposition analysis for the total currents while are accessible directly in practical measurement.For different bias voltage setup,we find intriguing results of both negative and positive correlations and carry out simple physical understanding using a quantum jump technique.Importantly,combining together with the evidence of the zero-bias-peak of conductance,the nonlocal cross correlation predicted in this work can help to confirm the existence of the nonlocal MZMs.

A Correlation Potential Method for Electron Scattering Total Cross Section Calculations on Several Diatomic and Polyatomic Molecules over Energy Range 10～5000eV

A complex optical model potential correlated by the concept of bonded atom, which considers the overlapping effect of electron clouds between two atoms in a molecule, is firstly employed to calculate the total cross sections for electron scattering on several molecules (NH3, H2O, CH4, CO, N2, O2, and C2H4) over the energy range 10 ～ 5000 eV using the additivity rule model at Hartree-Fock level. The difference between the bonded atom and the free one in states is that the overlapping effect of electron clouds of bonded atoms in a molecule is considered. The quantitative total cross sections are compared with the experimental data and with the other calculations wherever available and good agreement is obtained over the energy range 10 ～ 5000 eV. It is shown that the correlated calculations are much closer to the available experimental data than the uncorrelated ones at lower energies, especially below 500 eV. Therefore,considering the overlapping effect of electron clouds in the complex optical model potential could be helpful for the better accuracy of the total cross section calculations of electron scattering from molecules.

Cross section determination of^(27)Al(n,2n)^(26)Al reaction induced by 14-MeV neutrons uniting with D-T neutron activation and AMS techniques

Aluminum is the primary structural material in nuclear engineering,and its cross section induced by 14-MeV neutrons is of great significance.To address the issue of insufficient accuracy for the^(27)Al(n,2n)^(26)Al reaction cross section,the activation method and accelerator mass spectrometry(AMS)technique were used to determine the^(27)Al(n,2n)^(26)Al cross section,which could be used as a D-T plasma ion temperature monitor in fusion reactors.At the China Academy of Engineering Physics,neutron activation was performed using a K-400 neutron generator produced by the T(d,n)4He reaction.The^(26)Al∕^(27)Al isotope ratios were measured using the newly installed GYIG 1 MV AMS at the Institute of Geochemistry,Chinese Academy of Sciences.The neutron flux was monitored by measuring the activity of 92mNb produced by the 93Nb(n,2n)92mNb reaction.The measured results were compared with available data in the experimental nuclear reaction database,and the measured values showed a reasonable degree of consistency with partially available literature data.The newly acquired cross-sectional data at 12 neutron energy points through systematic measurements clarified the divergence,which has two different growth trends from the existing experimental values.The obtained results are also compared with the corresponding evaluated database,and the newly calculated excitation functions with TALYS−1.95 and EMPIRE−3.2 codes,the agreement with CENDL−3.2,TENDL-2021 and EMPIRE−3.2 results are generally acceptable.A substantial improvement in the knowledge of the^(27)Al(n,2n)^(26)Al reaction excitation function was obtained in the present work,which will lay the foundation for the diagnosis of the fusion ion temperature,testing of the nuclear physics model,evaluation of nuclear data,etc.

Cross - equatorial flow and its effects on the hurricanes occurrence over the Southern Hemisphere

Channels of cross - equatorial flow and their characteristics Winds at every 5 deg. grid point from 30°E to 180° over the equator at 850 hPa and 200hPa from December 1984 to February 1985 have been separated into U(zonal wind) andV(meridional wind).The V component has been used to represent cross- equatorial flow. FromFig. 1 we obtained that as during the Northern summer,there are also severa1 regions in which

Automated Recovery of the 2012 Sumatera Aftershock Sequence Using Waveform Cross Correlation

We assess the performance of waveform cross correlation as applied to automatic and interactive processing of the aftershock sequence of the April 11, 2012 Sumatera Ms（IDC） = 8.2 earthquake. The XSEL （cross correlation standard event list） is compared to the REB （Reviewed Event Bulletin） issued by the IDC （International Data Centre）. The latter includes 1,181 aftershocks between April 11 and May 25. To automatically recover the sequence, sixteen aftershocks were selected from the IDC SEL3 （Standard Event List） available on April 13 and used as master events. Waveform templates from only seven IMS （International Monitoring System） array stations with the largest SNR （signal-to-noise ratio） for the main shock were used to calculate cross correlation coefficients. Approximately 620,000 arrivals were detected and then used to build events according to the IDC definition. After conflict resolution between event hypotheses with similar arrivals found by more than one master, all survived hypotheses populated the XSEL. The total number of distinct hypotheses was 4,924, with 2,763 hypotheses not matched by the REB, i.e. potentially new REB events. To evaluate the quality of the XSEL, we randomly selected a representative portion （-15%） from 2,763 hypotheses and reviewed them interactively according to standard IDC rules and guidelines. There were 119 new REB events built and 145 XSEL hypotheses rejected. Several frequency and probability density distributions have been constructed for all detections, the associated detections, the XSEL detections, the detections in the new REB, and rejected events.

The Remote Testing in Abbiategrasso (RTA) Study Protocol: A Counter-Balanced Crossover Trial to Assess the Feasibility of Direct-to-Home-Neuropsychology with Older People

Background: The Sars-Cov-2 pandemic has accelerated the spreading of telemedicine, including TeleNeuroPsychology (TNP). Also in a non-pandemic scenario, TNP gives the advantage of reaching older subjects, which often have mobility or transportation limitations. Previous studies on the feasibility, acceptability and reliability of TNP provide promising indications. However, it remains unclear how elderly populations in Italy welcome this practice, in particular when carried out “direct-to-home” (DTH neuropsychology—DTH-NP), hence without assistance in setting up, i.e., the videoconference, and which tests validated in Italian populations show good comparability between remote (either by voice phone call or videoconference) and face-to-face administration. Aims: Here we present a study protocol aimed at assessing: 1) the recruitment rate in a study on DTH neuropsychological assessment through voice calls or videoconference, 2) the feasibility and acceptability of a DTH neuropsychological assessment, 3) the comparability between DTH and face-to-face neuropsychological assessments. Methods: Fifty-eight older adults (65 - 85 years) were recruited among donors of the Abbiategrasso Brain Bank and will undergo both a face-to-face and a DTH neuropsychological assessment in a counterbalanced cross-over design (Group 1: remote session first;Group 2: face-to-face session first). Recruitment rate will be first evaluated. Then, the responses to an acceptability questionnaire will be compared between the two administration modalities. Finally, the DTH-face-to-face comparability will be evaluated as good reliability of a DTH neuropsychological assessment and agreement between scores obtained in the two modalities. Discussion and Conclusion: This study protocol aims at describing the procedures allowing a more reliable implementation of DTH-NP in the Italian clinical and research contexts. The inclusion of both phone-call and videoconference DTH neuropsychological assessment will give the opportunity to evaluate the feasibility of DTH-NP also in older adults with low digital skills. The results of the comparability analysis will offer the first evidence in the Italian context on which neuropsychological tests can be reliably delivered DTH, by phone call or videoconference.

A Cross-Layer Scheme for Handover in 802.16e Network with F-HMIPv6 Mobility

IEEE802.16e is the major global cellular wireless standard that enables low-cost mobile Internet application. However, existing handover process system still has latency affects time-sensitive applications. In this paper, the handover procedures of 802.16e and Fast Handover for Hierarchical MIPv6 (F-HMIPv6) are reconstructed to achieve a better transmission performance. The concept of cross layer design is adopted to refine the existing handover procedure specified in 802.16e MAC layer and F-HMIPv6. More specifically, layer2 and layer3 signaling messages for handover are analyzed and combined/interleaved to optimize the handover performance. Extensive simulations show that the proposed scheme in this paper is superior to the other scheme proposed by IETF.

Simulation and Design of a Low Crosstalk Hexagonal Photonic Crystal Crossover Waveguide

In this paper, an optical waveguide junction is introduced to reduce crosstalk based on a hexagonal structure of photonic crystals for TE modes. The wavelength is 1330 nm which is an important wavelength for optical fiber data transmission. Simulation results show that the proposed design exhibits a reduction of -50 dB in crosstalk. It translates to a considerable isolation improvement between two crossover waveguides. FDTD method is used to obtain the transmission coefficient.

Three Reverse Adipofascial Cross Finger Flaps Used for Coverage of Raw Areas on Two Fingers of a Patient with Blast Injury of the Hand—Case Report

We report a case of blast injury to the left hand which resulted in fractures of the fingers with exposure of bones and joints of the phalanges. We used three reverse adipofascial cross finger flaps raised at the same time from 2 fingers to reconstruct adjacent fingers of the patient. The patient recovered well postoperatively and had good range of movement of the fingers. This avoided the complications of the use of regional or distal flaps. To our knowledge, this is the first case reported in which three reverse adipofascial cross fingers flaps are raised at the same time, two of them from an injured finger, to cover three raw areas on two fingers of a patient.

The Combination of Moberg Flap with V-Y Advancement and Reverse Adipofascial Cross Finger Flap for Coverage of Degloving Injury of the Thumb-Case Report

We report a case of 22 years old male patient who is a worker in a factory and sustained degloving injury of his left thumb in a machine while working. There was loss of the pulp of the thumb extending circumferentially to the dorsal aspect with loss of the skin of the terminal phalanx and part of the proximal phalanx. The nail and germinal matrix were lost with exposure of the bone and extensor pollicis longus tendon insertion. The thumb was totally covered with a combination of two flaps: Moberg flap with V-Y advancement was used to cover most of the volar surface of the thumb and reverse adipofascial cross finger flap from the adjacent index finger was used to cover the dorsal surface and the tip of the thumb. The reverse adipofascial cross finger flap was covered with split thickness skin graft. Three weeks later this flap was divided and the thumb was mobilized freely. The patient had a full range of movement of the thumb and index finger with few settings of physiotherapy postoperatively. We recommend combining both of these flaps to reconstruct degloving injury of the thumb as they provide near adjacent tissue of similar texture, preserve sensation at the volar aspect of the thumb and also avoid the complications of the distant flaps.

Theoretical study of differential cross sections for the ionization of helium by fast proton impact

We present the angular distribution of the ejected electron for single ionization of He by fast proton impact.A fourbody formalism of the three-Coulomb wave is applied to calculate the triple differential cross sections at several impact energies in the scattering,perpendicular and azimuthal planes.Moreover,the three-body formalism of three-Coulomb,two-Coulomb and first Born approximation models has also been used to study the many-body effect on electron emission and the validity of the models.In the three-Coulomb wave model,the final state wave function incorporates distortion due to the three-body mutual Coulombic interaction.In this formalism,we use an uncorrelated and correlated Born initial state,which consists of a plane wave for the incoming projectile times a two-electron bound state wavefunction of the helium atom representing the 1s2(1S)state.But,in the case of the three-body formalism,the initial state wavefunction consists of a long-range Coulomb distortion for the incoming projectile and one active electron of the He atom described by the Roothaan–Hartree–Fock wavefunction.The structure with a single or two peaks with unequal intensity is observed in the angular distributions of the triple differential cross sections for the different kinematic conditions.In addition,the influence of static electron correlations is investigated using different bound state wavefunctions for the ground state of the He target.In the four-body formalism,the present computations are very fast by reducing a nine-dimensional integral to a two-dimensional real integral.Despite the simplicity and speed of the proposed quadrature,the comparison shows that the obtained results are in reasonable agreement with the experiment and are compatible with those of other theories.

Asymmetric expression of CA2 and CA13 linked to calcification in the bilateral mandibular condyles cause crossed beaks in chickens

Crossed beak is a complex mode of inheritance with prevalence ranging from 0.2 to 7.4% in at least 12 chicken strains worldwide.To reveal the intrinsic factors causing crossed beaks,genes expression patterns in bilateral mandibular condyle between affected and normal birds were characterized by RNA sequencing analysis in the present studies.Crossed beak was induced by short length of unilateral mandibular ramus,and a total of 110differentially expressed genes were up-or down-regulated in the affected(short)mandibular condyle side as compared to the normal side.Carbonic anhydrase 2(CA2)and Carbonic anhydrase 13(CA13)were enriched in the carbonate dehydratase activity,and high-expressed in mandibular condyle and osteoblasts(P<0.05).However,both were low-expressed in short mandibular condyle side of affected birds(P<0.05).The carbonate dehydratase inhibitor experiments confirmed that there is positive association between the calcification and carbonic anhydrase isoenzymes.Quantitative analysis with cetylpyridinium chloride showed a decrease in calcification when the cells were transfected with an anti-CA13 shRNA.Our research suggested that CA2 and CA13 are down-calcified in shortside mandibular condyle,and caused mandibular ramus to grow slowly.CA2 and CA13 have the critical role in crossed beaks by regulating calcification of mandibular condyle.

Correction to:Feasibility study of the photonuclear reaction cross section of medical radioisotopes using a laser Compton scattering gamma source

Correction to:Nuclear Science and Techniques(2024)35:155 https://doi.org/10.1007/s41365-024-01481-7 In Eq.(2)of this article,the term'i'should be denoted as a subscript,the corrected equation should read N_(0)=σ(E)N_(t)QC_(kbeam)^(e^(-λt_(i)))∫_(0)^(t_(i))e^(λt)dt,(2)The original article has been corrected.

Tailoring the texture and mechanical properties of 3%Y_(2)O_(3)p/ZGK200 composites fabricated by unidirectional and cross rolling followed by annealing

3%Y_(2)O_(3)p/ZGK200 composites were subjected to unidirectional rolling(UR)and cross rolling(CR)at 400℃and 350℃followed by annealing at 300℃for 1 h.The microstructure,texture and mechanical properties of rolled and annealed composites were systematically studied.The rolled composites exhibited a heterogeneous microstructure,consisting of deformed grains elongated along rolling direction(RD)and Y_(2)O_(3)particles bands distributed along RD.After annealing,static recrystallization(SRX)occurred and most deformed grains transformed into equiaxed grains.A non-basal texture with two strong T-texture components was obtained after UR while a non-basal elliptical/circle texture with circle multi-peaks was obtained after CR,indicating that rolling path had great influences on texture of the composites.After annealing process,R-texture component disappeared or weakened,as results,a non-basal texture with double peaks tilting from normal direction(ND)to transverse direction(TD)and a more random non-basal texture with circle multi-peaks were obtained for UR and CR composites,respectively.The yield strength of rolled composites after UR showed obvious anisotropy along RD and TD while a low anisotropic yield strength was obtained after CR.Some Y_(2)O_(3)particles broke during rolling.The fracture of the composites was attributed to the existence of Y_(2)O_(3)clusters and interfacial debonding between particles and matrix during tension,as a result,the ductility was not as superior as matrix alloy.

Three‑dimensional numerical simulation of dynamic strength and failure mode of a rock mass with cross joints

To study the dynamic mechanical properties and failure characteristics of intersecting jointed rock masses with different joint distributions under confining pressure,considering the cross angleαand joint persistence ratioη,a numerical model of the biaxial Hopkinson bar test system was established using the finite element method–discrete-element model coupling method.The validity of the model was verified by comparing and analyzing it in conjunction with laboratory test results.Dynamics-static combined impact tests were conducted on specimens under various conditions to investigate the strength characteristics and patterns of crack initiation and expansion.The study revealed the predominant factors influencing intersecting joints with different angles and penetrations under impact loading.The results show that the peak stress of the specimens decreases first and then increases with the increase of the cross angle.Whenα<60°,regardless of the value ofη,the dynamic stress of the specimens is controlled by the main joint.Whenα≥60°,the peak stress borne by the specimens decreases with increasingη.Whenα<60°,the initiation and propagation of cracks in the cross-jointed specimens are mainly controlled by the main joint,and the final failure surface of the specimens is composed of the main joint and wing cracks.Whenα≥60°orη≥0.67,the secondary joint guides the expansion of the wing cracks,and multiple failure surfaces composed of main and secondary joints,wing cracks,and co-planar cracks are formed.Increasing lateral confinement significantly increases the dynamic peak stress able to be borne by the specimens.Under triaxial conditions,the degree of failure of the intersecting jointed specimens is much lower than that under uniaxial and biaxial conditions.

State-selective charge exchange cross sections in collisions of highly-charged sulfur ions with helium and molecular hydrogen

The state-selective cross section data are useful for understanding and modeling the x-ray emission in celestial observations.In the present work,using the cold target recoil ion momentum spectroscopy,for the first time we investigated the state-selective single electron capture processes for S^(q+)–He and H_(2)(q=11–15)collision systems at an impact energy of q×20 keV and obtained the relative state-selective cross sections.The results indicate that only a few principal quantum states of the projectile energy level are populated in a single electron capture process.In particular,the increase of the projectile charge state leads to the population of the states with higher principal quantum numbers.It is also shown that the experimental averaged n-shell populations are reproduced well by the over-barrier model.The database is openly available in Science Data Bank at 10.57760/sciencedb.j00113.00091.