Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colit...Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.展开更多
Croton sylvaticus(C. sylvaticus) is widely used as herbal medicine by the indigenous people of tropical Africa. The potential of C. sylvaticus as herbal medicine,the phytochemistry and pharmacological properties of it...Croton sylvaticus(C. sylvaticus) is widely used as herbal medicine by the indigenous people of tropical Africa. The potential of C. sylvaticus as herbal medicine,the phytochemistry and pharmacological properties of its parts used as herbal medicines are reviewed. The extensive literature survey revealed that C. sylvaticus is traditionally used to treat or manage at least 24 human and animal diseases and ailments. The species is used as herbal medicine for diseases and ailments such as abdominal pains,boils,fever,inflammation,malaria,rheumatism,swellings and tuberculosis and as ethnoveterinary medicine. Multiple classes of phytochemicals such as alkaloids,anthraquinones,essential oils,flavonoids,lignan,phenolics,sterols,tannins and terpenoids have been isolated from the species. Scientific studies on C. sylvaticus indicate that it has a wide range of pharmacological activities which include antibacterial,antifungal,anti-inflammatory,antioxidant,larvicidal and effects on the central nervous system. Although studies have confirmed that C. sylvaticus has a wide range of bioactives,further research on the exact bioactive molecules and mechanisms of action are required.展开更多
Two new compounds,badounoids A(1)and B(2),together with 13 known norsesquiterpenes,were isolated from the leaves of Croton tiglium L.The structures of the new compounds were established by means of spectroscopic metho...Two new compounds,badounoids A(1)and B(2),together with 13 known norsesquiterpenes,were isolated from the leaves of Croton tiglium L.The structures of the new compounds were established by means of spectroscopic methods.The absolute configuration of badounoid B was determined by single-crystal X-ray diffraction analysis.All the known compounds were isolated from Croton plants for the first time which added a new chemical facet for this genus.The selected compounds were evaluated for their cytostatic activity against several cancer cell lines.None of them was found to be active.展开更多
From the leaves of a Thai medicinal plant, Croton sublyratus, collected in Thailand, two new cembrane-type diterpenoids, named sublylactones A and B, and a phenolic compound were isolated from the EtOAc-soluble fracti...From the leaves of a Thai medicinal plant, Croton sublyratus, collected in Thailand, two new cembrane-type diterpenoids, named sublylactones A and B, and a phenolic compound were isolated from the EtOAc-soluble fraction of a MeOH extract. Their structures were elucidated on the basis of spectroscopic evidence.展开更多
The antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts of Croton bonplandianum Baill were evaluated in a bid to provide better scientific basis for the isolation of bioactive compounds fro...The antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts of Croton bonplandianum Baill were evaluated in a bid to provide better scientific basis for the isolation of bioactive compounds from the plant. The DPPH and hydroxyl radical scavenging activities of the Methanolic extract were 59.62%, and Dichloromethane extract was not toxic. Gallic acid used as reference compounds showed higher antioxidant activities to the plant extracts. Both methanolic and dichloromethane extracts were evaluated for their brine shrimp lethality. Methanolic extract showed cytotoxic activity in vitro with a LD50 value of 115.76 (0.0048-3.76) μg/ml. Etoposide was used as standard drug. Put together, these results confirm that Croton bonplandianum extracts possess appreciable natural antioxidant and cytotoxic potentials, thereby providing good justification for the isolation of pure bioactive compounds.展开更多
We report the first total synthesis of four possible absolute configurations and four other regional isomers of a naturally occurring alkaloid crotonine,which was isolated from Croton tiglium L.(Euphoriaceae)without e...We report the first total synthesis of four possible absolute configurations and four other regional isomers of a naturally occurring alkaloid crotonine,which was isolated from Croton tiglium L.(Euphoriaceae)without elucidation of its absolute configuration.The concise five-step route with a chirally poor and regioselective strategy starting from monosaccharides was established,and the absolute structure of the natural crotonine was determined by comparison of the NMR spectra and optical rotations of the synthetic products.展开更多
Heavy metal contamination to the environment is a serious problem in the developing countries due to anthropogenic activities, a threat needs to remediate to sustain the life on earth, technology includes use of micro...Heavy metal contamination to the environment is a serious problem in the developing countries due to anthropogenic activities, a threat needs to remediate to sustain the life on earth, technology includes use of microorganisms and different plant species. In consideration of biomass, phytoremediation is a very useful techniques above all, can be exploit by identification of hyperaccumulator, which accumulates the heavy metal under metal stress condition. In view of constraints of efficient plant species in present study thirty seven different plant species were screened for the identification of heavy metal accumulators. Croton bonplandianum, sedges and Balanites aegyptiaca amongst the all exhibit superior potential of heavy metal accumulation. This is the first report to unravel the heavy metal accumulation property of three different plant species which can be exploited for the bioremediation of heavy metals.展开更多
The Croton Watershed (New York State, USA) is a semi-urban region that provides 10% of the drinking water for the City of New York. Nonpoint source contamination in the watershed is a major concern for managers becaus...The Croton Watershed (New York State, USA) is a semi-urban region that provides 10% of the drinking water for the City of New York. Nonpoint source contamination in the watershed is a major concern for managers because the water supply is currently unfiltered water. Results are reported from three synoptic studies of surface water quality from 98 wetland-containing sub-catchments in the Croton Watershed designed to broadly characterize, at a reconnaissance level, the geochemical controls on water quality, in particular as it relates to wetlands. Total dissolved organic carbon concentrations in surface waters draining wetlands correlated well (average R2 of 0.93) with standard Gelbstoff (g440) color measurements, although there is very little correlation between dissolved organic carbon concentrations and wetland areas in the sub-catchments. This may be a potential indication of other sources of colored organic material. Concentrations of dissolved sodium and chloride, while related to road length, stochiometrically had more chloride than expected for pure road-salt dissolution. This offset is likely due to cation exchange and sorbtion of sodium by wetlands in the Croton watershed. The results show contamination in the Croton hydrologic system that should addressed in ongoing management policies and decision-making.展开更多
The reaction of m-dimethoxybenzene with crotonic acid in the presence of PPA affords an unexpected compound,which has been proved to be a dimer by H-NMR and MS.The x-ray struc- tural analysis has the same result.The p...The reaction of m-dimethoxybenzene with crotonic acid in the presence of PPA affords an unexpected compound,which has been proved to be a dimer by H-NMR and MS.The x-ray struc- tural analysis has the same result.The phenomenon has not been reported.展开更多
Lung cancer has been the most common cancer in the world for several decades,and it was also the most common cause of death from cancer.Despite the several advances in the last few years into treatment of lung cancer,...Lung cancer has been the most common cancer in the world for several decades,and it was also the most common cause of death from cancer.Despite the several advances in the last few years into treatment of lung cancer,the survival remains extremely low.There is an urgent need to discover viable leads that can be developed into new clinically therapeutic drugs with good treatment effects.The analysis of current reported literatures suggest that natural products possess strong inhibitory efficacy against lung cancer.The plants of Croton genus belonging to Euphorbiaceae family,are widely used as herbal medicine in the folk.Which are reported to have abilities to treat several cancer cell lines especially lung cancer,a successive study was carried out to identify selective anticancer agents from these plants specie.Herein we employed a network pharmacological approach to understand its multi-therapeutics potentiality in Croton genus against lung cancer.In total,the database of the compound was established based on the methods of network pharmacology prediction and the compound-disease target network was constructed.We believed that our study would provide important clues for finding novel drug inhibitors for lung cancer.展开更多
基金supported by National Nature Science Foundation of China (81973284)Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944).
文摘Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.
基金the National Research Foundation(NRF)Govan Mbeki Research and Development Centre(GMRDC)University of Fort Hare for financial support to conduct this research
文摘Croton sylvaticus(C. sylvaticus) is widely used as herbal medicine by the indigenous people of tropical Africa. The potential of C. sylvaticus as herbal medicine,the phytochemistry and pharmacological properties of its parts used as herbal medicines are reviewed. The extensive literature survey revealed that C. sylvaticus is traditionally used to treat or manage at least 24 human and animal diseases and ailments. The species is used as herbal medicine for diseases and ailments such as abdominal pains,boils,fever,inflammation,malaria,rheumatism,swellings and tuberculosis and as ethnoveterinary medicine. Multiple classes of phytochemicals such as alkaloids,anthraquinones,essential oils,flavonoids,lignan,phenolics,sterols,tannins and terpenoids have been isolated from the species. Scientific studies on C. sylvaticus indicate that it has a wide range of pharmacological activities which include antibacterial,antifungal,anti-inflammatory,antioxidant,larvicidal and effects on the central nervous system. Although studies have confirmed that C. sylvaticus has a wide range of bioactives,further research on the exact bioactive molecules and mechanisms of action are required.
基金This work was financially supported by the Project of Natural Compound Library Construction from Chinese Academy of Sciences(KSCX2-EW-R-15).
文摘Two new compounds,badounoids A(1)and B(2),together with 13 known norsesquiterpenes,were isolated from the leaves of Croton tiglium L.The structures of the new compounds were established by means of spectroscopic methods.The absolute configuration of badounoid B was determined by single-crystal X-ray diffraction analysis.All the known compounds were isolated from Croton plants for the first time which added a new chemical facet for this genus.The selected compounds were evaluated for their cytostatic activity against several cancer cell lines.None of them was found to be active.
文摘From the leaves of a Thai medicinal plant, Croton sublyratus, collected in Thailand, two new cembrane-type diterpenoids, named sublylactones A and B, and a phenolic compound were isolated from the EtOAc-soluble fraction of a MeOH extract. Their structures were elucidated on the basis of spectroscopic evidence.
文摘The antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts of Croton bonplandianum Baill were evaluated in a bid to provide better scientific basis for the isolation of bioactive compounds from the plant. The DPPH and hydroxyl radical scavenging activities of the Methanolic extract were 59.62%, and Dichloromethane extract was not toxic. Gallic acid used as reference compounds showed higher antioxidant activities to the plant extracts. Both methanolic and dichloromethane extracts were evaluated for their brine shrimp lethality. Methanolic extract showed cytotoxic activity in vitro with a LD50 value of 115.76 (0.0048-3.76) μg/ml. Etoposide was used as standard drug. Put together, these results confirm that Croton bonplandianum extracts possess appreciable natural antioxidant and cytotoxic potentials, thereby providing good justification for the isolation of pure bioactive compounds.
基金This work was supported financially and inspired scientifically by Prof.Yongxian Cheng of State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,and Prof.Baomin Fan of Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan University of Nationalities.
文摘We report the first total synthesis of four possible absolute configurations and four other regional isomers of a naturally occurring alkaloid crotonine,which was isolated from Croton tiglium L.(Euphoriaceae)without elucidation of its absolute configuration.The concise five-step route with a chirally poor and regioselective strategy starting from monosaccharides was established,and the absolute structure of the natural crotonine was determined by comparison of the NMR spectra and optical rotations of the synthetic products.
文摘Heavy metal contamination to the environment is a serious problem in the developing countries due to anthropogenic activities, a threat needs to remediate to sustain the life on earth, technology includes use of microorganisms and different plant species. In consideration of biomass, phytoremediation is a very useful techniques above all, can be exploit by identification of hyperaccumulator, which accumulates the heavy metal under metal stress condition. In view of constraints of efficient plant species in present study thirty seven different plant species were screened for the identification of heavy metal accumulators. Croton bonplandianum, sedges and Balanites aegyptiaca amongst the all exhibit superior potential of heavy metal accumulation. This is the first report to unravel the heavy metal accumulation property of three different plant species which can be exploited for the bioremediation of heavy metals.
文摘The Croton Watershed (New York State, USA) is a semi-urban region that provides 10% of the drinking water for the City of New York. Nonpoint source contamination in the watershed is a major concern for managers because the water supply is currently unfiltered water. Results are reported from three synoptic studies of surface water quality from 98 wetland-containing sub-catchments in the Croton Watershed designed to broadly characterize, at a reconnaissance level, the geochemical controls on water quality, in particular as it relates to wetlands. Total dissolved organic carbon concentrations in surface waters draining wetlands correlated well (average R2 of 0.93) with standard Gelbstoff (g440) color measurements, although there is very little correlation between dissolved organic carbon concentrations and wetland areas in the sub-catchments. This may be a potential indication of other sources of colored organic material. Concentrations of dissolved sodium and chloride, while related to road length, stochiometrically had more chloride than expected for pure road-salt dissolution. This offset is likely due to cation exchange and sorbtion of sodium by wetlands in the Croton watershed. The results show contamination in the Croton hydrologic system that should addressed in ongoing management policies and decision-making.
文摘The reaction of m-dimethoxybenzene with crotonic acid in the presence of PPA affords an unexpected compound,which has been proved to be a dimer by H-NMR and MS.The x-ray struc- tural analysis has the same result.The phenomenon has not been reported.
文摘Lung cancer has been the most common cancer in the world for several decades,and it was also the most common cause of death from cancer.Despite the several advances in the last few years into treatment of lung cancer,the survival remains extremely low.There is an urgent need to discover viable leads that can be developed into new clinically therapeutic drugs with good treatment effects.The analysis of current reported literatures suggest that natural products possess strong inhibitory efficacy against lung cancer.The plants of Croton genus belonging to Euphorbiaceae family,are widely used as herbal medicine in the folk.Which are reported to have abilities to treat several cancer cell lines especially lung cancer,a successive study was carried out to identify selective anticancer agents from these plants specie.Herein we employed a network pharmacological approach to understand its multi-therapeutics potentiality in Croton genus against lung cancer.In total,the database of the compound was established based on the methods of network pharmacology prediction and the compound-disease target network was constructed.We believed that our study would provide important clues for finding novel drug inhibitors for lung cancer.
