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科研成果融入环境工程专业实验教学的探索——HCO_(3)^(-)活化过一硫酸盐降解Cu^(Ⅱ)-EDTA
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作者 苗洁 周嵬 《广东化工》 CAS 2024年第20期188-190,共3页
将水污染控制领域的前沿成果-过氧碳酸盐活化深度处理重金属络合废水(如Cu^(Ⅱ)-EDTA)的内容引入到环境工程本科专业实验教学中,设计了一个碳酸氢盐活化过一硫酸盐(BAP)的高级氧化反应体系,同步实现水中重金属络合物Cu^(Ⅱ)-EDTA的氧化... 将水污染控制领域的前沿成果-过氧碳酸盐活化深度处理重金属络合废水(如Cu^(Ⅱ)-EDTA)的内容引入到环境工程本科专业实验教学中,设计了一个碳酸氢盐活化过一硫酸盐(BAP)的高级氧化反应体系,同步实现水中重金属络合物Cu^(Ⅱ)-EDTA的氧化破络及游离铜离子的沉淀去除实验。本实验通过BAP氧化体系的建立、药剂投加比例参数的优化、活性反应物种的表征及降解性能测试,不仅可以提升学生的综合实验动手能力,帮助学生熟悉相关实验测试设备的使用,而且能够促进学生全面掌握高级氧化技术的基本反应原理与应用。 展开更多
关键词 碳酸氢盐 过一硫酸盐 cu^()-EDTA 氧化破络 实验教学
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3,5-二氯水杨醛缩-4-氨基安替比林Cu(Ⅱ)和Zn(Ⅱ)配合物的合成、晶体结构及抗肿瘤活性研究
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作者 王佳乐 苏武 +3 位作者 田文豪 张梦瑶 陆飘飘 李文戈 《长春师范大学学报》 2024年第2期186-195,共10页
利用3,5-二氯水杨醛与4-氨基安替比林,通过缩合反应,合成3,5-二氯水杨醛缩-4-氨基安替比林希夫碱配体(HL),配体与CuCl_(2)·2H_(2)O、Zn(Ac)_(2)·2H_(2)O,利用溶剂热反应合成两个新型的希夫碱配合物[CuL_(2)](配合物1)和[ZnL_(... 利用3,5-二氯水杨醛与4-氨基安替比林,通过缩合反应,合成3,5-二氯水杨醛缩-4-氨基安替比林希夫碱配体(HL),配体与CuCl_(2)·2H_(2)O、Zn(Ac)_(2)·2H_(2)O,利用溶剂热反应合成两个新型的希夫碱配合物[CuL_(2)](配合物1)和[ZnL_(2)](配合物2)。对合成的配合物进行了红外光谱、热重分析、PXRD表征,用X射线单晶衍射确定了配体(HL)、配合物1和配合物2的分子结构,单晶衍射分析结果表明,配体(HL)晶体属于单斜晶系,空间群为P2_(1)/n,配合物1晶体属于单斜晶系,空间群为C2/c,配合物2晶体属于单斜晶系,空间群为P2_(1)/c,配合物1是四配位的四方形结构,配合物2是扭曲的六配位的八面体结构。MTT法检测了配体(HL)及配合物对3种人体肿瘤细胞株(MDA-MB-231、CNE-2Z、A-549)体外抗肿瘤活性。检测结果显示,配合物对癌细胞的抑制作用明显比配体好,配合物1对MDA-MB-231细胞和CNE-2Z细胞抗增殖活性最好,其IC_(50)值分别为(1.215±0.07)μmol/L、(4.417±0.28)μmol/L均低于顺铂IC_(50)值,配合物2对A-549细胞和MDA-MB-231细胞也表现出较好的抗增殖活性。 展开更多
关键词 3 5-二氯水杨醛缩-4-氨基安替比林 cu()配合物 Zn()配合物 晶体结构 抗肿瘤活性
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3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物的合成、晶体结构及其与CT-DNA的结合活性
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作者 王洋 李铭 +4 位作者 关金涛 张智勇 闫俊涛 熊兰 毛佳伟 《人工晶体学报》 CAS 北大核心 2023年第10期1858-1866,共9页
本文通过3,3′-((乙基-1,2-二基双((吡啶-2-甲基)杂氮二基))双亚甲基)二(2-羟基-5-甲基苯甲醛)(H2L)和丙二胺在金属离子存在条件下的缩合反应,得到了一个新型3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物,并通过红外光谱、紫外光谱、电喷... 本文通过3,3′-((乙基-1,2-二基双((吡啶-2-甲基)杂氮二基))双亚甲基)二(2-羟基-5-甲基苯甲醛)(H2L)和丙二胺在金属离子存在条件下的缩合反应,得到了一个新型3-甲基吡啶悬臂Cu(Ⅱ)-Zn(Ⅱ)异双核配合物,并通过红外光谱、紫外光谱、电喷雾质谱、X射线单晶衍射等手段对其结构进行了表征。单晶衍射结果表明该配合物属于六方晶系,P63/m空间群,a=1.982 18(17) nm,b=1.982 18(17) nm,c=1.839 4(2) nm,分子式为C37H41CuN6O4Zn。金属中心Cu(Ⅱ)和Zn(Ⅱ)由两个酚氧原子和一个醋酸根桥联,它们的配位环境都可以近似地看作为四方锥结构,Cu(Ⅱ)和Zn(Ⅱ)之间的距离是0.289 7 nm。本文还利用循环伏安实验和黏度实验的方法对该配合物与小牛胸腺DNA(CT-DNA)的相互作用模式进行了研究,结果表明该配合物与CT-DNA的结合方式为弱的插入模式,其相应的结合活性为6.92×103mol/L。 展开更多
关键词 3-甲基吡啶悬臂 cu()-Zn()异双核配合物 单晶衍射 配位环境 CT-DNA结合
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Syntheses and Magnetic Properties of Cu(Ⅱ)-RE(Ⅲ) Heterobinuclear Complexes with N,N′-Bis(3-carboxyisalicylidene)-trimethylenediamine 被引量:4
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作者 TAO Ruo-jie, YU Zliao-wen and ZHOU Xu-ya(Departmeut of Chemistry, Henan University , Kaifeng, 475001 )JIN Dou-man(Hauau Institute of Chemistry . Zhengzhou, 450003 )LIAO Dai-zheng(Department of Chemistry , Nankai University , Tianjin, 300071) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1994年第3期179-184,共6页
ine heterobinuclear complexes of Cu (Ⅱ)-RE (Ⅲ) with N, N′-bis-(3-car-boxylsalicylidene ) trimetliylenediamine (TS) were syntliesized and characterized bymeans of elemental analyses, molar conductivity, thermogravim... ine heterobinuclear complexes of Cu (Ⅱ)-RE (Ⅲ) with N, N′-bis-(3-car-boxylsalicylidene ) trimetliylenediamine (TS) were syntliesized and characterized bymeans of elemental analyses, molar conductivity, thermogravimetry,IR and elec-tronic spectra. The measurements of variable-temperature magnetic susceptibilitysliow that there exists only a very weak antiferromagnetic spin exchange interactionbetween the ions of Cut(Ⅱ) and RE(Ⅲ) in CuRETSCI . 3H_2O. 展开更多
关键词 Schiff base cu()-RE(Ⅲ) Heterobinuclear complex Variable-tem-perature magnetic susceptibility
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A Novel Binuclear Cu(Ⅱ) Complex with Nitroxide Radicals Exhibiting Ferromagnetic Interactions 被引量:3
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作者 刘尚远 陈毅雯 高东昭 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第1期39-44,共6页
A new binuclear Cu(Ⅱ) complex with nitronyl nitroxide radicals [Cu(NIT3Py)2Cl2]2(NIT3Py = 2-(3'-pyridinyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) has been synthesized and structurally characterized b... A new binuclear Cu(Ⅱ) complex with nitronyl nitroxide radicals [Cu(NIT3Py)2Cl2]2(NIT3Py = 2-(3'-pyridinyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) has been synthesized and structurally characterized by X-ray diffraction analysis.It crystallizes in monoclinic,space group C2/c with a = 38.483(4),b = 7.2450(8),c = 27.559(3) ,β = 134.0180(10)°,V = 5525.6(10) 3,C48H64Cl4Cu2N12O8,Mr = 1206.00,Z = 4,Dc = 1.450 g/cm3,μ(MoKα) = 1.025 mm-1,F(000) = 2504,S = 1.066,the final R = 0.0471 and wR = 0.1121 for 3286 observed reflections(I 2σ(I)).The title complex consists of centrosymmetric dinuclear units [Cu(NIT3Py)2Cl2]2,in which the copper ions are square-pyramidally coordinated by two pyridyl nitrogen atoms of two radical ligands and three chlorine anions,two of which bridge the copper ions.The magnetic measurements show ferromagnetic interactions between the copper ions and the radical ligands. 展开更多
关键词 cu complex nitroxide radical crystal structure ferromagnetic interaction
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SOD-like Activities of SOD and Cu(Ⅱ)Complexes inLiposomes
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作者 刘艳 李连涛 +1 位作者 孙静 鲁纯素 《Journal of Chinese Pharmaceutical Sciences》 CAS 1995年第4期177-180,共4页
The SOD-like activities of SOD, four Cu(Ⅱ)Complexes, SOD-and Cu(Ⅱ)com-plex-liposomes were determined respectively by using cytochrome C method. The results showed that all of these systems had SOD-like activities to... The SOD-like activities of SOD, four Cu(Ⅱ)Complexes, SOD-and Cu(Ⅱ)com-plex-liposomes were determined respectively by using cytochrome C method. The results showed that all of these systems had SOD-like activities to some extent of which the Cu(His)_2-liposome displayed the highest activity and the Cu(Ⅱ)complexes and liposomes had some positive cooperative action. 展开更多
关键词 Superoxide radical cu()complexes LiposomeIntroductionThis project was supported by National Natural Science Foundation of China
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Hydrothermal Syntheses, Crystal Structures and Luminescence Properties of Cu(Ⅱ) and Cd(Ⅱ) Complexes Assembled by 6-Hydroxypicolinic Acid and 1,10-Phenanthroline 被引量:1
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作者 YU You-Zhu CHANG Song-Yang +4 位作者 HAN Xi CHEN Guang-Xin XUAN Ya-Wei WU Xian-Li WANG Fang 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第4期651-659,共9页
Two new complexes based on 6-hydroxypicolinic acid(H_2picO) and 1,10-phenanthroline(phen), such as [Cu_4(picO)_4(phen)_4]·12 H_2O(1) and {[Cd_4(picO)_4(phen)_4(H_2O)_2]·5H_2O}_n(2), have been synthesized and... Two new complexes based on 6-hydroxypicolinic acid(H_2picO) and 1,10-phenanthroline(phen), such as [Cu_4(picO)_4(phen)_4]·12 H_2O(1) and {[Cd_4(picO)_4(phen)_4(H_2O)_2]·5H_2O}_n(2), have been synthesized and characterized by IR, elemental analyses, thermogravimetric analyses and X-ray diffraction technique. Single-crystal X-ray diffraction analyses revealed that the two complexes both crystallize in the triclinic system, space group P(16)-. For complex 1, the picO ligands adopt a tridentate coordination mode to link copper(Ⅱ) ions into dimmers. PicO ligands also adopt a tridentate mode in complex 2, which connects the cadmium(Ⅱ) to form a one-dimensional chain. Moreover, luminescent properties of 1 and 2 were also investigated. 展开更多
关键词 cu() and Cd() complexES 6-hydroxypicolinic acid crystal structures luminescent properties
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N,N,N-三齿席夫碱铜(Ⅱ)配合物的合成、晶体结构及儿茶酚酶活性
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作者 白一泽 刘睿端 +1 位作者 鲁秋然 赵海燕 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2024年第7期27-36,共10页
选用N,N,N-三齿席夫碱化合物2-氨基乙基苯并咪唑缩吡啶-2-甲醛(L^(1))和2-氨基丙基苯并咪唑缩吡啶-2-甲醛(L^(2))为配体,与过渡金属Cu(Ⅱ)盐反应合成了4个单核铜配合物:[Cu(L^(1))Cl_(2)](1),[Cu(L^(1))(SCN)_(2)](2),[Cu(L^(1))bpy](Cl... 选用N,N,N-三齿席夫碱化合物2-氨基乙基苯并咪唑缩吡啶-2-甲醛(L^(1))和2-氨基丙基苯并咪唑缩吡啶-2-甲醛(L^(2))为配体,与过渡金属Cu(Ⅱ)盐反应合成了4个单核铜配合物:[Cu(L^(1))Cl_(2)](1),[Cu(L^(1))(SCN)_(2)](2),[Cu(L^(1))bpy](ClO_(4))_(2)·CH_(3)OH(3)和[Cu(L^(2))bpy](ClO_(4))_(2)(4)(bpy=2,2′-联吡啶).通过元素分析、红外光谱、粉末X射线衍射、单晶X射线衍射、热重分析和循环伏安分析等手段对配合物进行了表征.结果表明,在固体状态下,配合物1~4均为单核Cu(Ⅱ)配合物,中心Cu(Ⅱ)均为畸变四方锥构型,结构参数τ=0.088~0.340.以3,5-二叔丁基邻苯二酚为底物,研究了配合物1~4模拟儿茶酚氧化酶的催化活性,采用Michaelis-Menten模型和Lineweaver-Burk图法计算了动力学参数.结果表明,配合物均具有儿茶酚氧化酶活性,催化活性顺序为2>3≈4>1,氧化速率取决于Cu(Ⅱ)配位环境的畸变程度、离去基团与中心Cu(Ⅱ)的键长和配合物的空间位阻. 展开更多
关键词 席夫碱 cu()配合物 晶体结构 儿茶酚氧化酶活性
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3,5-二溴水杨醛缩-4-氨基安替比林席夫碱Cu(Ⅱ)配合物的合成及其抗癌活性评价
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作者 陈司燮阳 李茹 +4 位作者 柴俊 张涤清 殷华军 陈莎莉 胡静 《蚌埠医学院学报》 CAS 2023年第8期1080-1084,1089,共6页
目的:设计并合成新的3,5-二溴水杨醛缩-4-氨基安替比林席夫碱Cu(Ⅱ)配合物([CuL_(2)]),并评价其抗癌活性。方法:利用3,5-二溴水杨醛与4-氨基安替比林发生缩合反应,合成新的3,5-二溴水杨醛缩-4-氨基安替比林席夫碱配体(HL)。将HL与Cu(Ac)... 目的:设计并合成新的3,5-二溴水杨醛缩-4-氨基安替比林席夫碱Cu(Ⅱ)配合物([CuL_(2)]),并评价其抗癌活性。方法:利用3,5-二溴水杨醛与4-氨基安替比林发生缩合反应,合成新的3,5-二溴水杨醛缩-4-氨基安替比林席夫碱配体(HL)。将HL与Cu(Ac)_(2)·H_(2)O通过溶剂热法合成了[CuL_(2)],并利用X射线单晶衍射、多晶粉末衍射(PXRD)、红外光谱(FT-IR)和热重分析(TGA-DSC)等技术对[CuL_(2)]进行表征。MTT法检测HL及[CuL_(2)]对MDA-MB-231细胞、SMMC-7721细胞、CNE-2Z细胞和A-549细胞的体外抗肿瘤活性。流式细胞术(FCM)分析[CuL_(2)]对MDA-MB-231细胞凋亡和周期的影响。结果:X射线单晶衍射分析显示,[CuL_(2)]为单核金属配合物,属单斜晶系,空间群为C 2/c,具有微扭曲的四方形配位结构;PXRD显示,[CuL_(2)]结晶度良好,晶体结构符合单晶测试的分析结果;配体和配合物的FT-IR特征峰与分子结构一致;TGA-DSC显示,[CuL_(2)]在270℃以下具有良好的热稳定性。MTT实验结果显示,当HL与Cu(Ⅱ)形成配合物时,[CuL_(2)]抗癌活性优于HL,其抑制MDA-MB-231细胞和SMMC-7721细胞活性较强,略低于顺铂。FCM分析结果显示,[CuL_(2)]可诱导MDA-MB-231细胞凋亡(P<0.05);[CuL_(2)]诱导MDA-MB-231细胞阻滞在G_(0)/G_(1)期和S期(P<0.05)。结论:合成得到[CuL_(2)],其可抑制MDA-MB-231细胞和SMMC-7721细胞活性,诱导MDA-MB-231细胞凋亡和细胞周期阻滞。 展开更多
关键词 3 5-二溴水杨醛缩-4-氨基安替比林 cu()配合物 晶体结构 抗癌活性
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Two Cu(Ⅱ) Complexes with Hydrolyzed Nicotinamide Ligand: Crystal Structures and Bioactivities
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作者 WANG Ren-Shu FENG Jing +3 位作者 LIAN Ming-Lei KONG De-Shun LEI Yi-Zhu SHI Kai-Yi 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第8期1297-1310,共14页
Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H2O)]·H2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu2(2,4-D)4(Hnta)2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized... Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H2O)]·H2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu2(2,4-D)4(Hnta)2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA(ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA(pBR322-DNA) was determined by gel electrophoresis assay. And at last, the complexes’ cytotoxic activities were reviewed for four kinds of cancer cell lines(HeLa, MCF-7, HepG, SKOV-3), showing that the coordination polymer has anti-tumor activity and cytotoxicity. 展开更多
关键词 cu() complexES Hirshfeld surface analysis crystal structures BIOACTIVITIES
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钙(Ⅱ)和铜(Ⅱ)吡嗪-2-甲酸配合物的合成、结构和性能研究
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作者 陈美娟 郭铭成 +1 位作者 谷长生 郝晓敏 《化学研究与应用》 CAS 北大核心 2024年第8期1851-1860,共10页
配体吡嗪-2-甲酸将其与CaCl_(2)和CuSO_(4)·5H_(2)O在水溶液中反应得到了两个新的单核钙和铜配合物。并通过X-射线单晶衍射、红外和元素分析表征了其晶体结构。配合物1为一个Ca(Ⅱ)离子与二个配体和四个配位水分子形成的单核结构,... 配体吡嗪-2-甲酸将其与CaCl_(2)和CuSO_(4)·5H_(2)O在水溶液中反应得到了两个新的单核钙和铜配合物。并通过X-射线单晶衍射、红外和元素分析表征了其晶体结构。配合物1为一个Ca(Ⅱ)离子与二个配体和四个配位水分子形成的单核结构,配合物2为一个Cu(Ⅱ)离子与一个配体和一个配位水分子形成的单核结构,单核结构之间通过O—H…H、N—H…H氢键作用组装成三维超分子网络结构。测试了配合物的紫外可见光和荧光吸收及配合物2非均相类Fenton试剂的催化性质。测试结果表明,两个配合物在不同溶剂中紫外可见吸收峰均在268 nm,配合物1固态荧光发射峰在414 nm和441 nm及配合物1和2在不同溶剂中荧光发射峰均为364 nm。含Cu(Ⅱ)的配合物2对甲基橙(MO)溶液可以达到81.76%的降解率,显示了良好的类Fenton催化性质,表明其是一种潜在的催化降解有机污染物材料。 展开更多
关键词 Ca()配合物 cu()配合物 吡嗪羧酸 催化降解
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Crystal and Molecular Structure of Copper (Ⅱ) Dimeric Complex of S-Methyl-β-N-(Pyridine N-Oxide-2-ylmethylidene) Dithiocarbazate with Acetonitrile
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作者 Yu Kaibei and Zhou Zhongyuan (Chengdu Center of Analysis and Determination, Academia Sinica, Chengdu)Gou Shaohua, You Xiaozeng and Xu Zheng (Coordination Chemistry Institute, Nanjing University, Nanjing) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1990年第4期262-265,共4页
The crystal and molecular structure of copper(Ⅱ) dimeric complex of S-methyl-B-N-(pyridine N-oxide-2-ylmethylidene) dithiocarbazate with acetonitrile, [CuL (CH3CN)]2 (ClO4)2, was determined by X-ray diffraction. The ... The crystal and molecular structure of copper(Ⅱ) dimeric complex of S-methyl-B-N-(pyridine N-oxide-2-ylmethylidene) dithiocarbazate with acetonitrile, [CuL (CH3CN)]2 (ClO4)2, was determined by X-ray diffraction. The complex crystalizes in monoclinic system with space group P21/n, a= 7. 685(2), 6=20.160(6), c= 10. 847(5) A ,B = 107.89(3), Z=2,Dc=1.788 g/cm3, F(000) = 835. 8, u= 18. 17 cm-1(Moka,R= 0. 057.Each Cu(Ⅱ) ion in the complex is surrounded by a distorted square pyramidal. The basal plane is comprised of S, N and O atoms of one ligand together with a N atom of the solvent--acetonitrile, while the axial position is occupied by the S atom of the other ligand. The bond length of Cu-S(bridging) is 3. 038A . and Cu-Cu distance is 3. 700A. 展开更多
关键词 complex of cu () Crystal and molecular structure Dimeric complex S-methyl-β-N-(pyridine N-oxide-2-ylmethyndene)dithiocarbazate
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腙基席夫碱配体铜(Ⅱ)配合物的合成、结构表征、生物活性和密度泛函理论计算
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作者 Bhattacharjee Maitri Boruah Smriti Rekha +4 位作者 Dutta Purkayastha R.N. Maniukiewicz Waldemar Chowdhury Shubhamoy Maiti Debasish Akhtar Tamanna 《无机化学学报》 SCIE CAS CSCD 北大核心 2024年第7期1409-1422,共14页
以甲醇为介质,合成了3种新的席夫碱配体HL^(1)(2-hydroxybenzaldehyde2-(2-oxo-1,2-diphenylethylidene)hydrazone)、HL^(2)(4-hydroxybenzaldehyde2-(2-oxo-1,2-diphenylethylidene)hydrazone)和L^(3)(2-methoxybenzaldehyde2-(2-oxo-1... 以甲醇为介质,合成了3种新的席夫碱配体HL^(1)(2-hydroxybenzaldehyde2-(2-oxo-1,2-diphenylethylidene)hydrazone)、HL^(2)(4-hydroxybenzaldehyde2-(2-oxo-1,2-diphenylethylidene)hydrazone)和L^(3)(2-methoxybenzaldehyde2-(2-oxo-1,2-diphenylethylidene)hydrazone)的Cu(Ⅱ)配合物1-3。通过元素分析、光谱方法、磁化率测量和密度泛函理论(DFT)计算对配合物进行了表征。通过单晶X射线衍射研究对合成的配体进行了结构表征。通过DFT计算确定了配合物的优化结构。通过紫外可见吸收光谱和荧光发射光谱研究了配合物与小牛胸腺DNA(CT-DNA)的结合能力。吸收光谱研究揭示了增色效应,并提出了与CT-DNA相互作用的可能模式。溴化乙锭(EB)竞争结合研究表明,配合物可以取代DNA-EB加合物中的DNA,且配合物可能以嵌入模式与CTDNA结合。配合物对革兰氏阴性肺炎克雷伯菌、大肠杆菌、鲍氏志贺菌和革兰氏阳性金黄色葡萄球菌的体外抗菌活性研究表明,配合物2对肺炎克雷伯菌和鲍氏志贺菌具有明显抗菌活性,但配合物1和3没有表现出任何显著的抗菌活性。 展开更多
关键词 cu()配合物 席夫碱 结构 生物活性 密度泛函理论
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Syntheses, Crystal Structures and Magnetic Properties of a New Nitronyl Nitroxide Radical and Its Cu(Ⅱ) Complex
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作者 蒋凯 赵保利 +1 位作者 王利亚 王玉芳 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第7期860-866,共7页
A new compound (NIT-mNO2 = 4,4,5,5-tetramethylimidazoline-2-yl-(2'-chlor-5'- nitrophenyl)-3-oxide-l-oxyl) 1 and its complex (Cu(NIT-mNO2)(hfac)2) 2 have been synthesized and structurally and magnetically c... A new compound (NIT-mNO2 = 4,4,5,5-tetramethylimidazoline-2-yl-(2'-chlor-5'- nitrophenyl)-3-oxide-l-oxyl) 1 and its complex (Cu(NIT-mNO2)(hfac)2) 2 have been synthesized and structurally and magnetically characterized. Complex 1 crystallizes in monoclinic, space group P211n with a = 10.6798(9), b = 11.2705(9), c = 12.9559(10)A, β = 107.3770(10)°, V = 1488.3(2) A^3, C13H15ClN3O4, Mr = 312.73, Z = 4, Dc = 1.396 g/cm^3, g(MoKa) = 0.276 mm^-1, F(000) = 652, the final R = 0.0606 and wR = 0.1773 for 3405 independent reflections with Rint = 0.0203. The nitronyl nitroxide unit (imidazoline ring) is not coplanar with the phenyl ring with the dihedral angle between them of 55.75°. The compound results in a 1-D zig-zag chain structure by intermolecular H-bond interaction. Compound 2 crystallizes in triclinic, space group Pi with a = 10.3699(10), b = 10.6286(11), c = 15.1683(15)A, a = 77.5330(10), ,β = 773080(10), y = 87.3420(10)*, V = 1592.5(3) A^3, C23HITCIFI2N3O8Cu, Mr = 790.39, Z = 2, Dc = 1.648 g/cm^3, μ(MoKa) = 0.888 mm^-1, F(000) = 788, the final R = 0.0793 and wR = 0.2153 for 5794 independent reflections with Rint = 0.0196. The Cu(Ⅱ) ion is located at a center of symmetry, and each Cu(Ⅱ) is surrounded by six oxygen atoms at the vertices of a distorted tetragonal octahedron. Four of the six oxygen atoms belong to two hfac ligands and occupy the equatorial coordination sites, while the other two of NIT-mNO2 act as μ-1,5 bridge between the Cu(Ⅱ) ion, thus forming a 1-D chain structure. The magnetic susceptibility data indicate intermolecular antiferromagnetic interactions between compound 1 and intrachain ferromagnetic behaviors. 展开更多
关键词 crystal structure magnetic properties nitronyl nitroxide radical cu complex
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Synthesis and Crystal Structure of a New Mononuclear Copper( Ⅱ ) Complex: [Cu(BMI)_4(SO_4)]·DMF·2H_2O
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作者 范承 马成丙 +2 位作者 胡明强 陈昌能 刘秋田 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第3期285-289,共5页
A new copper(Ⅱ) complex, [Cu(BMI)4(SO4)]·DMF·2H2O (BMI = benzimidazole), has been synthesized by the treatment of CuCN with 2-mercaptobenzimidazole in the presence of 1,10-phenanthroline, and charac... A new copper(Ⅱ) complex, [Cu(BMI)4(SO4)]·DMF·2H2O (BMI = benzimidazole), has been synthesized by the treatment of CuCN with 2-mercaptobenzimidazole in the presence of 1,10-phenanthroline, and characterized by single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/n with a = 17.6260(4), b = 11.1252(3), c = 18.6573(4)A°, β= 107.9010(10)°, V = 3481.45(14)A°^3, Z = 4, C31H35CuN9O7S, Mr= 741.28, F(000) = 1540, Dc = 1.414 g/cm^3,μ = 0.746 mm^-1, the final R = 0.0649 and wR = 0.1609 for 4382 observed reflections with I 〉 2σ(I). The Cu(Ⅱ) atom is coordinated by five unidentate ligands (one sulfate and four benzimidazole ligands) generated in situ, displaying a slightly distorted square pyramid geometry. 展开更多
关键词 cu complex synthesis crystal structure
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A New Dinuclear Cu(Ⅱ) Complex of a Ligand with Benzimidazole Group─Synthesis and Crystal Structure
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作者 李庆祥 王修峰 +1 位作者 杨祥良 徐辉碧 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第6期707-710,共4页
A new dinuclear copper complex, [Cu(C9H11N3)Cl2]2(C18H22Cl4Cu2N6), has been synthesized and characterized by X-ray structure determination. It crystallizes in the triclinic P1^- space group with a = 7.526(3), b ... A new dinuclear copper complex, [Cu(C9H11N3)Cl2]2(C18H22Cl4Cu2N6), has been synthesized and characterized by X-ray structure determination. It crystallizes in the triclinic P1^- space group with a = 7.526(3), b = 9.473(4), c = 9.535(3)A, α = 117.214(10), β = 108.251(9), γ = 91.560(6)°, V = 562.3(4)A^3, Z = 1, Mr = 591.30, F(000) = 298, Dc = 1.746 g/cm^3, μ(MoKα) = 2.385 mm^-1, the final R = 0.0577 and wR = 0.1248 for 2188 unique reflections with 1629 observed ones (Ⅰ〉 2σ(Ⅰ)). In the title complex, each copper(Ⅱ) atom is located at the center of a distorted trigonal bipyramid of five coordination atoms (two nitrogen and three chlorine atoms). Two copper(Ⅱ) atoms were bridged by two chlorine anions (Cl(2) and Cl(2a)) to form a Cu(Ⅱ)-Cu(Ⅱ) binuclear entity with the distance between two copper(Ⅱ) atoms of 3.398 (A). 展开更多
关键词 crystal structure BENZIMIDAZOLE dinuclear cu complex
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Synthesis and Crystal Structure of a Dinuclear Cu(Ⅱ) Complex [Cu(C_(13)H_9N_2O)Cl]_2·(CH_3CN)_2 with Ligand 2-Benzimidazol
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作者 LI Qing-Xiang YANG Xiang-Liang XU Hui-Bi 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2007年第2期149-152,共4页
A new dinuclear copper complex, [Cu(C13HgN2O)Cl]2.(CH3CN)2 (C30H24C12Cu2N6O2), has been synthesized and characterized by X-ray structure determination. It crystallizes in the triclirile system, space group P1, w... A new dinuclear copper complex, [Cu(C13HgN2O)Cl]2.(CH3CN)2 (C30H24C12Cu2N6O2), has been synthesized and characterized by X-ray structure determination. It crystallizes in the triclirile system, space group P1, with a = 7.6677(14), b = 9.2375(17), c = 11.227(2) ]A, α = 81.338(3),β = 88.173(4), γ = 66.199(3)°, V = 718.9(2) ]A^3, Z = 1, Mr = 698.53, F(000) = 354, Dc = 1.613 g/cm^3, μ(MoKa) = 1.705 mm^-1, the final R = 0.0645 and wR = 0.1364 for 2474 unique reflections with 1809 observed ones (I 〉 20(I)). In the title complex, each copper(H) atom is located at the center of a distorted tetrahedron consisting of four coordinate atoms (one nitrogen atom, two oxygen anions, and one chlorine atom). Two copper(Ⅱ) atoms are bridged by two oxygen anions (O(1) and O(la)) of two phenolates to form a Cu(Ⅱ)-Cu(Ⅱ) binuclear entity, and the distance between two copper(Ⅱ) atoms is 3.0144(15) A. 展开更多
关键词 2-benzimidazol phenolate cu complex crystal structure
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Four New Cu(Ⅱ) Complexes with Benzotriazole-based Ligands: Syntheses, Crystal Structures and Theoretical Investigations
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作者 李彩云 尚贞峰 +1 位作者 胡同亮 卜显和 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第11期1407-1416,共10页
Four new Cu(Ⅱ) complexes with two benzotriazole-based ligands, [Cu2(L^1)2(NO3)2]· 2H2O (1), [Cu2(L^1)2]·2ClO4·2H2O (2), [Cu2(HL^2)2(NO3)4]·2CH3COCH3 (3) and [Cu(HL^2)2(Cl)]&#... Four new Cu(Ⅱ) complexes with two benzotriazole-based ligands, [Cu2(L^1)2(NO3)2]· 2H2O (1), [Cu2(L^1)2]·2ClO4·2H2O (2), [Cu2(HL^2)2(NO3)4]·2CH3COCH3 (3) and [Cu(HL^2)2(Cl)]·Cl·2CH2Cl2 (4), where HL^1 = 1,3-bis(benzotriazol-2-yl)-2-propanol and HL^2 = 1,3-bis(benzotriazol-1-yl)-2-propanol, were synthesized and structurally characterized by elemental analyses, IR and single-crystal X-ray diffraction analyses. It is revealed that complexes 1~3 have dinuclear structures, while 4 possesses a one-dimensional (1-D) chain structure, which extends in two orthogonal orientations. In 1~4, the coordination numbers of Cu(Ⅱ) centers range from four to six, which may be attributed to the different geometries and coordination abilities of the ligands and anions. The L^1 ligand in complexes 1 and 2 adopts a tridentate di-chelating coordination mode, whereas ligand HL^2 in complexes 3 and 4 has a bidentate bridging coordination mode. The different coordination modes of these two ligands may be explained by the different charges of nitrogen donor atoms in the benzotriazole ring, which has been investigated by density functional theory (DFT) calculations. 展开更多
关键词 benzotriazole-based ligands cu complexes crystal structures DFT calculations
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Catalytic Asymmetric Cyclopropanation using a New Chiral β-Diketone Cu (Ⅱ) Complex as a Catalyst
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作者 Yu XU Zhong Yi WANG and Tian Pa YOU(Department of Chemistry, University of Science and Technology of China, Hefei 230026) 《Chinese Chemical Letters》 SCIE CAS CSCD 1998年第7期607-608,共2页
A new chiral β-diketone Cu (Ⅱ) catalyst was synthesized and used for the asymmetric cyclopropanation of styrene with diazoester. A high optical yield (~90%) was achieved. The effect of the structure of substrate on ... A new chiral β-diketone Cu (Ⅱ) catalyst was synthesized and used for the asymmetric cyclopropanation of styrene with diazoester. A high optical yield (~90%) was achieved. The effect of the structure of substrate on the enantioselectivity was studied. Both chendcal yield and optical yield being reduced when the steric bulky substrate was employed. The reaction mechanism and the chiral model of the transition state are under fufther investigation. 展开更多
关键词 Asymmetric cyclopropanation β-Diketone cu () complex
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SOD-like Activity of Some Cu(Ⅱ)Complexes in Micelles
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作者 Master’s Degree Yu-Hui Ying Supervisor Prof.Chun-Su Lu Department of Physical Chemistry School of Pharmaceutical Sciences,Beijing Medical University,Beijing 100083 《Journal of Chinese Pharmaceutical Sciences》 CAS 1993年第2期173-173,共1页
The SOD-like activity of five Cu(Ⅱ)complexes[Cu(HSal)_2·EtOH,Cu(Gly)_2,Cu(Lys)_2,Cu(His)_2,Cu(Try)_2]have been studied by using cytochrome C method,as well as chemilumine-scence and ESR technique.The four surfac... The SOD-like activity of five Cu(Ⅱ)complexes[Cu(HSal)_2·EtOH,Cu(Gly)_2,Cu(Lys)_2,Cu(His)_2,Cu(Try)_2]have been studied by using cytochrome C method,as well as chemilumine-scence and ESR technique.The four surfactants(CTAB,SDS,Triton X-100 and Tween 20)werepurified and their critical miceile concentration(CMC)in phosphate buffer(pH=7.4)was mea-sured.The effects of four surfactants on O_2^- have been investigated.The co-operative effects 展开更多
关键词 cu()complexes MICELLE Superoxide radical
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