A Cul-catalyzed three-component coupling of trifluoromethyl ketone N-tosylhydrazones, alkynes and azides has been developed. The reaction represents a straightforward method to access difluoromethylene substituted 1,2...A Cul-catalyzed three-component coupling of trifluoromethyl ketone N-tosylhydrazones, alkynes and azides has been developed. The reaction represents a straightforward method to access difluoromethylene substituted 1,2,3-triazoles. Mechanistically, it has been proposed that the reaction follows a pathway involving the formation of Cu（1） triazolide intermediate, Cu（I） carbene formation, migratory insertion, and β-fluoride elimination. The trans- formation is featured by mild conditions, wide substrate scope and high efficiency.展开更多
Rh（I）-C.atalyzed synthesis of 1,1-difluoro-2,2-diarylalkenes from trifluoromethylketone N-tosylhydrazones and arylboronates is presented in this communication. This new synthetic method is based on the Rh（l）-carbe...Rh（I）-C.atalyzed synthesis of 1,1-difluoro-2,2-diarylalkenes from trifluoromethylketone N-tosylhydrazones and arylboronates is presented in this communication. This new synthetic method is based on the Rh（l）-carbene migra- tory insertion followed by fl-fluoride elimination. In one particular case the protonation occurs instead offl-fluoride elimination, affording 2,2-diaryl trifluoroethane product.展开更多
文摘A Cul-catalyzed three-component coupling of trifluoromethyl ketone N-tosylhydrazones, alkynes and azides has been developed. The reaction represents a straightforward method to access difluoromethylene substituted 1,2,3-triazoles. Mechanistically, it has been proposed that the reaction follows a pathway involving the formation of Cu（1） triazolide intermediate, Cu（I） carbene formation, migratory insertion, and β-fluoride elimination. The trans- formation is featured by mild conditions, wide substrate scope and high efficiency.
文摘Rh（I）-C.atalyzed synthesis of 1,1-difluoro-2,2-diarylalkenes from trifluoromethylketone N-tosylhydrazones and arylboronates is presented in this communication. This new synthetic method is based on the Rh（l）-carbene migra- tory insertion followed by fl-fluoride elimination. In one particular case the protonation occurs instead offl-fluoride elimination, affording 2,2-diaryl trifluoroethane product.
