尽管阿尔金南缘长沙沟-清水泉一带在空间上彼此分隔的4个镁铁-超镁质岩体（或岩体群）在岩石学、岩相学、地球化学上存在着差异,但它们的形成时代均为中奥陶世（465 M a左右）。其中,分布于阿尔金南缘主断裂南侧的清水泉南—长沙沟中段...尽管阿尔金南缘长沙沟-清水泉一带在空间上彼此分隔的4个镁铁-超镁质岩体（或岩体群）在岩石学、岩相学、地球化学上存在着差异,但它们的形成时代均为中奥陶世（465 M a左右）。其中,分布于阿尔金南缘主断裂南侧的清水泉南—长沙沟中段—黄土泉的岩体,超镁铁岩（包括纯橄岩-橄榄岩-辉橄岩-橄辉岩）中的橄榄石Fo值较高（变化于95-85）,且自东向西呈现非常有规律的递减;而北侧的清水泉北岩体辉橄岩中橄榄石的Fo值较低（变化于81~79）。结合各岩体的岩石地球化学特征和岩浆演化过程及橄榄石中N i的含量变化规律,对这些杂岩体形成的地质背景和Cu-N i-PGE含矿可能性作简要讨论。展开更多
The Panxi Rift Zone is a famous metallogenic province in Southwest China. Continental rifting developed in Hercynian period (P 2, 260～250Ma) accompany with a series of basic\|ultrabasic rocks. Various in lithologies,...The Panxi Rift Zone is a famous metallogenic province in Southwest China. Continental rifting developed in Hercynian period (P 2, 260～250Ma) accompany with a series of basic\|ultrabasic rocks. Various in lithologies, such as layered intrusions (V\|Ti\|Fe formation), small\|sized mafic\|ultramafic bodies (stocks) and large\|scale basalt (Emeishan Basalt) are constituted of a complete melanocratic rock system.Most of Cu\|Ni\|PGE sulfide deposits are related to small\|sized ultramafic rock bodies. It is a perfect possibility for them to be an affinity of basic eruptive lava and for the neck facies. But in ① Panzhihua\|Center Yunnan Province, the Gaojiacun, also Jinbaoshan, as large stratiform basic\|ultrabasic complex used to be thought that is older one intruded to basement rocks in Precambrian. However, new evidences suggest it is similar with the small\|sized ultramafic rock bodies containing Cu\|Ni\|PGE, and also the both are affinity of the Emeishan Basalt; ② Miyi district, Cu\|Pt mineralization was discovered in the Xinjie bedded basic complex, and in where ophitic olivine\|pyroxenite\|peridotite facies are exactly Pt\|bearing layers; ③ Longzhoushan district, we have recently researched basic\|ultrabasic clusters which intruded into fracture zones, and Cu\|Ni\|Pt, Pd mineralization developed at the salbands.Generally, the basalt is poor in PGE and rich in Cu. It is suggested as the result of PGE dispersion\|concentration processing in the melanocratic rock system when rifting happened.展开更多
Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment.However,it is unclear whether the signals of bone cells in response to mechanical stress are processed...Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment.However,it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain.In this study,we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2(PGE2)concentration in response to mechanical loading.Bone PGE2 levels are in proportion to their weight bearing.When weight bearing changes in the tail-suspension mice,the PGE2 concentrations in bones change in line with their weight bearing changes.Deletion of cyclooxygenase-2(COX2)in the osteoblast lineage cells or knockout of receptor 4(EP4)in sensory nerve blunts bone formation in response to mechanical loading.Moreover,knockout of TrkA in sensory nerve also significantly reduces mechanical load-induced bone formation.Moreover,mechanical loading induces cAMP-response element binding protein(CREB)phosphorylation in the hypothalamic arcuate nucleus(ARC)to inhibit sympathetic tyrosine hydroxylase(TH)expression in the paraventricular nucleus(PVN)for osteogenesis.Finally,we show that elevated PGE2 is associated with ankle osteoarthritis(AOA)and pain.Together,our data demonstrate that in response to mechanical loading,skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis,while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.展开更多
文摘尽管阿尔金南缘长沙沟-清水泉一带在空间上彼此分隔的4个镁铁-超镁质岩体（或岩体群）在岩石学、岩相学、地球化学上存在着差异,但它们的形成时代均为中奥陶世（465 M a左右）。其中,分布于阿尔金南缘主断裂南侧的清水泉南—长沙沟中段—黄土泉的岩体,超镁铁岩（包括纯橄岩-橄榄岩-辉橄岩-橄辉岩）中的橄榄石Fo值较高（变化于95-85）,且自东向西呈现非常有规律的递减;而北侧的清水泉北岩体辉橄岩中橄榄石的Fo值较低（变化于81~79）。结合各岩体的岩石地球化学特征和岩浆演化过程及橄榄石中N i的含量变化规律,对这些杂岩体形成的地质背景和Cu-N i-PGE含矿可能性作简要讨论。
文摘The Panxi Rift Zone is a famous metallogenic province in Southwest China. Continental rifting developed in Hercynian period (P 2, 260～250Ma) accompany with a series of basic\|ultrabasic rocks. Various in lithologies, such as layered intrusions (V\|Ti\|Fe formation), small\|sized mafic\|ultramafic bodies (stocks) and large\|scale basalt (Emeishan Basalt) are constituted of a complete melanocratic rock system.Most of Cu\|Ni\|PGE sulfide deposits are related to small\|sized ultramafic rock bodies. It is a perfect possibility for them to be an affinity of basic eruptive lava and for the neck facies. But in ① Panzhihua\|Center Yunnan Province, the Gaojiacun, also Jinbaoshan, as large stratiform basic\|ultrabasic complex used to be thought that is older one intruded to basement rocks in Precambrian. However, new evidences suggest it is similar with the small\|sized ultramafic rock bodies containing Cu\|Ni\|PGE, and also the both are affinity of the Emeishan Basalt; ② Miyi district, Cu\|Pt mineralization was discovered in the Xinjie bedded basic complex, and in where ophitic olivine\|pyroxenite\|peridotite facies are exactly Pt\|bearing layers; ③ Longzhoushan district, we have recently researched basic\|ultrabasic clusters which intruded into fracture zones, and Cu\|Ni\|Pt, Pd mineralization developed at the salbands.Generally, the basalt is poor in PGE and rich in Cu. It is suggested as the result of PGE dispersion\|concentration processing in the melanocratic rock system when rifting happened.
基金This research was supported by NIH National Institute on Aging under Award Number R01 AG076783,R01 AG068997 and P01 AG066603(to X.C.).
文摘Bone is a mechanosensitive tissue and undergoes constant remodeling to adapt to the mechanical loading environment.However,it is unclear whether the signals of bone cells in response to mechanical stress are processed and interpreted in the brain.In this study,we found that the hypothalamus of the brain regulates bone remodeling and structure by perceiving bone prostaglandin E2(PGE2)concentration in response to mechanical loading.Bone PGE2 levels are in proportion to their weight bearing.When weight bearing changes in the tail-suspension mice,the PGE2 concentrations in bones change in line with their weight bearing changes.Deletion of cyclooxygenase-2(COX2)in the osteoblast lineage cells or knockout of receptor 4(EP4)in sensory nerve blunts bone formation in response to mechanical loading.Moreover,knockout of TrkA in sensory nerve also significantly reduces mechanical load-induced bone formation.Moreover,mechanical loading induces cAMP-response element binding protein(CREB)phosphorylation in the hypothalamic arcuate nucleus(ARC)to inhibit sympathetic tyrosine hydroxylase(TH)expression in the paraventricular nucleus(PVN)for osteogenesis.Finally,we show that elevated PGE2 is associated with ankle osteoarthritis(AOA)and pain.Together,our data demonstrate that in response to mechanical loading,skeletal interoception occurs in the form of hypothalamic processing of PGE2-driven peripheral signaling to maintain physiologic bone homeostasis,while chronically elevated PGE2 can be sensed as pain during AOA and implication of potential treatment.
