Effect of lipid lowering mixture on blood lipid metabolism, LDL oxidation susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats

Objective:To investigate the effect of lipid lowering mixture on blood lipid metabolism, LDL oxidative susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats.Method: Select 60 male Wistar rats were randomly divided into six groups, ten rats in each group were recorded as low as lipid-lowering mixture, high dose group and simvastatin group, model group and control group. Patients in control group were treated with basic feed for feeding, other groups of rats are used high fat diet were fed to establish hyperlipidemia rat model, in the process of modeling and prophylactically, determination of rats after 10 weeks of lipid metabolism and susceptibility of LDL to oxidation and blood viscosity concentration coagulation state.Result: Antioxidant capacity of the model group rat's serum LDL-C decreased significantly, and simvastatin group and three groups of lipid-lowering mixture group rats serum LDL antioxidant capacity were significantly enhanced;and high lipid mixture, LDL antioxidant ability in middle dose group rats were significantly higher than those of the Jiangzhi Decoction low dose group rats (P<0.05). Lipid mixture of high, middle dose group rats of EET and ETA P, ETA B (high, medium and low shear), IED, HCT, the role of the IEA was significantly higher in Jiangzhi Decoction low dose group rats (P<0.05 or P<0.05).Conclusion:Lipid-lowering mixture on experimental hyperlipidemia rats blood lipid metabolism and blood viscosity concentration coagulation state has a good regulatory role, and lipid-lowering mixture on blood lipid and blood flow abnormalities lipid-lowering mixture can also play a good regulation and therapeutic effect.

降脂合剂对高脂血症大鼠血脂代谢、低密度脂蛋白氧化易感性及血液黏浓聚凝状态的影响

目的:探讨降脂合剂对高脂血症大鼠血脂代谢、低密度脂蛋白(LDL)氧化易感性及血液黏浓聚凝状态的影响。方法:选取雄性Wistar大鼠60只并随机分为6组,每组10只,分别记为降脂合剂低、中、高剂量组和辛伐他汀组、模型组以及对照组。其中对照组采用基础饲料进行喂养,其他各组均采用高脂饲料进行喂养建立高脂血症大鼠模型,同时进行预防给药,测定各组10周后的血脂代谢、LDL氧化易感性及血液黏浓聚凝状态。结果:模型组的血清低密度脂蛋白胆固醇(LDL-C)抗氧化能力明显降低,而辛伐他汀组和3组降脂合剂组的血清LDL抗氧化能力均明显增强;并且降脂合剂高、中剂量组的LDL抗氧化能力均明显高于降脂合剂低剂量组,差异有统计学意义(P <0. 05)。降脂合剂高、中剂量组对红细胞电泳时间(EET)和ηp、ηb(高、中、低切)、红细胞变形指数(IED)、红细胞压积(HCT)、红细胞聚集指数(IEA)、红细胞电泳时间(EET)、红细胞变形指数(IED)的作用均显著强于降脂合剂低剂量组,差异有统计学意义(P <0. 05)。结论:降脂合剂对于实验性高脂血症大鼠的血脂代谢以及血液黏浓聚凝状态具有较好的调节作用,同时降脂合剂在血脂和血流异常方面降脂合剂还能够起到不错的调节和治疗效果。

莼菜多糖蛋白体降低小鼠血脂作用的研究

对模拟成高脂血症的小鼠，以１０ｍｇ／ｋｇ和２０ｍｇ／ｋｇ体重剂量给小鼠莼菜多糖蛋白体，探讨莼菜多糖蛋白体降血脂作用。结果发现它有降低血清胆固醇（ＴＣ）、甘油三脂（ＴＧ）、低密度脂蛋白（ＬＤＬ）、动脉粥样硬化指数（ＡＩ）及升高高密度脂蛋白（ＨＤＬ）的作用。上述指标与对照组比较，差异有高度显著性（Ｐ＜０．０１）。提示莼菜多糖蛋白体能降血脂。

降脂合剂对实验性高脂血症大鼠血脂代谢、LDL氧化易感性及血液黏浓聚凝状态的影响

目的:探讨降脂合剂对实验性高脂血症大鼠血脂代谢、LDL氧化易感性及血液黏浓聚凝状态的影响。方法:选取60只雄性Wistar大鼠并随机分为6组,每组10只,分别记为降脂合剂低、中、高剂量组和辛伐他汀组、模型组以及对照组。其中对照组采用基础饲料进行喂养,其他各组大鼠均采用高脂饲料进行喂养建立高脂血症大鼠模型,在进行的建模的过程中同时进行预防给药,测定各组大鼠10个星期后的血脂代谢、LDL氧化易感性及血液黏浓聚凝状态。结果:模型组大鼠的血清LDL-C抗氧化能力明显降低,而辛伐他汀组和三组降脂合剂组大鼠的血清LDL抗氧化能力均明显增强;并且降脂合剂高、中剂量组大鼠的LDL抗氧化能力均明显高于降脂合剂低剂量组大鼠(均P<0.05)。降脂合剂高、中剂量组大鼠对EET和ηp、ηb(高、中、低切)、IED、HCT、IEA的作用均显著强于降脂合剂低剂量组大鼠(P<0.01或P<0.05)。结论:降脂合剂对于实验性高脂血症大鼠的血脂代谢以及血液黏浓聚凝状态具有较好的调节作用,同时降脂合剂在血脂和血流异常方面降脂合剂还能够起到不错的调节和治疗效果。