Objective To discuss the postoperative curative effects of two surgical techniques of minimally invasive total hip arthroplasty (THA) using metal-on-metal largediameter and conventional diameter femoral head for the e...Objective To discuss the postoperative curative effects of two surgical techniques of minimally invasive total hip arthroplasty (THA) using metal-on-metal largediameter and conventional diameter femoral head for the elderly patients展开更多
BACKGROUND: Conventional methods (such as occlusion therapy, fine manipulation, complementary, and alternative medicine) take effects slowly, are time and labor consuming, and have uncertain curative effects in the...BACKGROUND: Conventional methods (such as occlusion therapy, fine manipulation, complementary, and alternative medicine) take effects slowly, are time and labor consuming, and have uncertain curative effects in the treatment of amblyopia. Perceptual learning, a new method for treating amblyopia, improves the ability to process signals from the cerebral optic nerve system by specific visual stimulation and visual learning, as well as activation of the visual signal pathway utilizing brain nervous system plasticity. OBJECTIVE: This study investigated and evaluated the curative effects of perceptual learning, which can directionally increase brain plasticity, on the treatment of amblyopia in children. The relationship between curative effect and time was also analyzed. DESIGN: A self-control experiment. SETTING: Visual Science and Optometry Center, People's Hospital of Guangxi Zhuang Autonomous Region. PARTICIPANTS: A total of 125 amblyopic children (250 amblyopic eyes), 73 males, 52 females, averaging (6±2) years of age, received treatment at the Visual Science and Optometry Center, People's Hospital of Guangxi Zhuang Autonomous Region between September 2006 and February 2007 and were recruited for this study. All children presented with no structural disease of the eyeballs. Written informed consent for therapeutic regiments was obtained from each child's parent. The protocol received approval from the Hospital's Ethics Committee. METHODS: Visual function was tested with a perceptual learning system (Research Center for Human Health and Development of Sun Yat-sen University, National Engineering Technique Research Center for Medical Care Implement) for visual noise, position noise, contour discrimination, contrast sensitivity, grating stereogram, and random-dot fusion. These tests helped to evaluate the efficiency of visual information processing of these children, and to determine the degree of defects of the optic nerve cells and the connections of visual cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures (each training procedure lasted for ten minutes). There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function. MAIN OUTCOME MEASURES: Visual function change; relationship of curative effects and curative time. RESULTS: A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment (P 〈 0.05). Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment (P 〈 0.05). The mean time to reach improved levels with curative effects was (2.82 ± 1.30) months, and to reach a basically cured level was (2.87 ±1.40) months. Percentage of improved visual acuity was the highest [98% (39/40)] in children that received 3 months of treatment and the lowest [55% (31/56)] in children that received 1 month of treatment (P 〈 0.05). The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% (31/46), P 〈 0.05]. CONCLUSION: Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.展开更多
Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ...Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ppm shows a thin coat ot mucus, but the continuous layer of mucus is not retained in 0.3 ppm after 24 h of exposure. Epithelial cells of the gill filament are hyperplastic. Other changcs in the respiratory epithelium are contraction of epithelium, formation of interlamellar bridge and diminishing number of microridges. Massive destruction of the respiratory epithelium by deep lesions and sloughing of epithelial layer in 0.5 and 1.0 ppm solutions after 6-12 h of exposure apparently causes death to the fish. SEM observations are well in conformity with the findings made at light microscopic level展开更多
Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific ...Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.展开更多
Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as ...Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as to seek new drugs for the treatment of community-acquired pneumonia.Methods:120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine,the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group,with 60 patients in each group.The control group was given cefuroxime sodium injection,and the experimental group was given cefuroxime sodium injection+Baimao root decoction.The levels of high-sensitivity C-reactive protein(CRP)and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT),IL-6,IL-8,TNF-αand TLR4/NF-κB mRNA levels,and to observe the effect of Radix Imperata Rubra on community-acquired pneumonia.Results:The fever,cough,expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group,the difference was statistically significant(P<0.05);the total effective rate of the experimental group(96.67%)was higher than that of the control group(85%),the difference was statistically significant(P<0.05);after treatment,the serum CRP,PCT,IL-6,IL-8,TNF-αin the two groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05),There was statistical significance(P<0.05);after treatment,TLR4/NF-κB mRNA of the two groups were decreased,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of cap,Rhizoma Imperata can reduce the levels of CRP,PCT,IL-6,IL-8 and TNF-α.The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.展开更多
Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the in...Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed展开更多
Infrarde thermography is a kind of functional imaging technology to detect the surface temperature of human body.To a certain extent,it provides a scientific basis for the datamation,visualization and objectification ...Infrarde thermography is a kind of functional imaging technology to detect the surface temperature of human body.To a certain extent,it provides a scientific basis for the datamation,visualization and objectification of traditional Chinese medicine(TCM).It has the characteristics of noninvasive,accuracy and predictability.In this paper,infrarde thermography was applied,and summed up its advantages and disadvantages,so as to play a more important role in the field of TCM infrarde thermography.展开更多
Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases i...Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases improved, the cure rate was 85 %; Of the 50 cases in the filiform needle acupuncture group, 25 cases were cured and 23 improved, the cure rate was 50 %. There was a statis-tically significant difference(P<0.01 ) between the two grdrips. It is indicated that the curative effect of beating-acupuncture on cervical spondylopathy is obviously superior to that of fili form-needle acupuncture, which provides a new therapy without traumatic pain for clinical treatment of cervical spondylopathy,展开更多
Objective To explore the treatment effect of human growth factor(NGF)on vascular dementia.Method47cases with vascular dementia were randomly div ided into two groups(study and control).The study group(24cases)were tre...Objective To explore the treatment effect of human growth factor(NGF)on vascular dementia.Method47cases with vascular dementia were randomly div ided into two groups(study and control).The study group(24cases)were treated with NGF,the control group(23cases)were treated with ordinary medicines.Results The intelligence and cognitive abil ity in the study group were obviously higher than those in the control group(P <0.01).Conclusion Compared with other methods,NGF has a significant curative effect.展开更多
Objective: The aim of this retrospective investigation was to explore the influence of femoral osteoporosis on short-term curative effects ofcementless hip arthroplasty and to evaluate the femoral metaphyseal bone mi...Objective: The aim of this retrospective investigation was to explore the influence of femoral osteoporosis on short-term curative effects ofcementless hip arthroplasty and to evaluate the femoral metaphyseal bone mineral density (BMD) for femoral osteoporosis in order to guide prosthesis choice and rehabilitation. Methods: We performed 127 total arthroplasty operations between June 1999 to February 2003 and investigated 49 cementless hip replacements with the Metalcancellous cementless Lubeck Ⅱ system being used in all hips. There were twenty men and twenty-nine women whose mean age at the time of the operation was 60 years (range, 52-81 years). The patients were divided into osteoporosis or normal groups according to the femoral metaphyseal BMD measured preoperatively. The average duration of follow-up was 30 months (range, 8-52 months). We evaluated all of the patients from a clinical standpoint with use of a standard-terminology questionnaire with respect to the short-term curative effects and patients' satisfaction. Hip pain status and functional ability were important indicators of treatment efficacy. Results: Harris hip score and patients' satisfaction in femoral osteoporosis patients who underwent noncemented hip arthroplasty were lower (P=0.004, P=0.03) while the incidence of thigh pain was higher (P=0.03) than the patients with non-osteoporosis. Conclusion: The higher incidence of pain, as well as the decrease in function experienced by the patients in osteoporosis group, supports the case that cementless arthroplasty is not a better choice for those patients and that we had better select prosthesis based on the femoral metaphyseal BMD.展开更多
Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequa...Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequate treatment.The blood supply of vital organs is guaranteed,which helps patients to survive the acute attack and improves the survival rate of FM.Methods In this study,50 clinical data of adult FM patients received in our hospital from July 2018 to July 2023 were collected for retrospective analysis.According to different treatment methods,they were divided into ECMO group(n=25)and non-ECMO group(n=25).After 14 days of treatment,the level of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),creatine kinase isoenzymes(CK-MB),cardiac troponinⅠ(cTnⅠ)and brain natriuretic peptide(BNP),and the incidence of complications were compared between the two groups.Results Before treatment,there was no significant difference in cardiac function between the two groups(P>0.05).After 14 days of treatment,ECMO group showed greater decline than non-ECMO group in LVESD and LVEDD,and LVEF was higher than that in the non-ECMO group(P<0.05).The level of CK-MB,cTnⅠ and BNP in ECMO group were lower than those in non-ECMO(P<0.05).The overall incidence of complications was 8% in the ECMO group,which was lower than 32% in the non-ECMO group(P<0.05).Conclusions The early efficacy of ECMO treatment in adult patients with FM is considerable,which is conducive to improving the cardiac function of patients and preventing complications.展开更多
BACKGROUND Recently,hepatic arterial infusion chemotherapy(HAIC)plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma(uHCC)in China.In the clinic,the hepatic arteries of some patients...BACKGROUND Recently,hepatic arterial infusion chemotherapy(HAIC)plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma(uHCC)in China.In the clinic,the hepatic arteries of some patients shrink significantly during this treatment,leading to improved short-term efficacy.AIM To investigate the relationship between the shrinkage of hepatic arteries and the short-term effect of HAIC plus lenvatinib treatment.METHODS Sixty-seven participants with uHCC were enrolled in this retrospective study.The patients received HAIC every 3 wk,followed by oral lenvatinib after the first HAIC course.Hepatic artery diameters were measured on CT before treatment and after 1 and 2 mo of treatment.Meanwhile,the changes in tumor capillaries were also examined on pathological specimens before and after 1 mo of treatment.The antitumor response after 1,3,and 6 mo of treatment was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST).The relationship between the changes in vessel diameters and the short-term effect of the combination treatment was evaluated by receiver-operating characteristic and logistic regression analyses.RESULTS The hepatic artery diameters were all significantly decreased after 1 and 2 mo of treatment(P<0.001),but there was no difference in the vessel diameters between 1 and 2 mo(P>0.05).The microvessel density in the tumor lesions decreased significantly after 1 mo of combination treatment(P<0.001).According to mRECIST,46,41,and 24 patients had complete or partial responses after 1,3,and 6 mo of treatment,respectively,whereas 21,21,and 32 patients had a stable or progressive disease at these times,respectively.Shrinkage of the tumor-feeding artery was significantly associated with the tumor response after 1,3,and 6 mo of treatment(P<0.001,P=0.004,and P=0.023,respectively);however,changes in other hepatic arteries were not significantly associated with the tumor response.Furthermore,shrinkage of the tumor-feeding artery was an independent factor for treatment efficacy(P=0.001,P=0.001,and P=0.002 and 1,3,and 6 mo,respectively).CONCLUSION The hepatic arteries shrank rapidly after treatment with HAIC plus lenvatinib,and shrinkage of the tumor-feeding artery diameter was closely related to improved short-term efficacy.展开更多
In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration ...In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration in a short time under the condition of breeze,stable weather and constant emission caused by human being's activities. Subsequently,an index of short-term cumulative effect is established with air diffusive equation,and then the macro-scale meteorological situation and micro-scale factors of forming the short-term cumulative effect are discussed with the observation data. The macro-scale meteorological variables contain upper-level weather situations and surface weather situations. The micro-scale factors mainly include the boundary-layer height and boundary-layer stability. The analyses show that boundary-layer factors and weather variables have a significant influence on the short-term cumulative effect. The notion of short-term cumulative effect will play an important role in interpreting the severe pollution weather.展开更多
文摘Objective To discuss the postoperative curative effects of two surgical techniques of minimally invasive total hip arthroplasty (THA) using metal-on-metal largediameter and conventional diameter femoral head for the elderly patients
基金Grant from Major Scientific Research Program of Medical Treatment and Public Health of Guangxi Zhuang Autonomous Region, No.200730
文摘BACKGROUND: Conventional methods (such as occlusion therapy, fine manipulation, complementary, and alternative medicine) take effects slowly, are time and labor consuming, and have uncertain curative effects in the treatment of amblyopia. Perceptual learning, a new method for treating amblyopia, improves the ability to process signals from the cerebral optic nerve system by specific visual stimulation and visual learning, as well as activation of the visual signal pathway utilizing brain nervous system plasticity. OBJECTIVE: This study investigated and evaluated the curative effects of perceptual learning, which can directionally increase brain plasticity, on the treatment of amblyopia in children. The relationship between curative effect and time was also analyzed. DESIGN: A self-control experiment. SETTING: Visual Science and Optometry Center, People's Hospital of Guangxi Zhuang Autonomous Region. PARTICIPANTS: A total of 125 amblyopic children (250 amblyopic eyes), 73 males, 52 females, averaging (6±2) years of age, received treatment at the Visual Science and Optometry Center, People's Hospital of Guangxi Zhuang Autonomous Region between September 2006 and February 2007 and were recruited for this study. All children presented with no structural disease of the eyeballs. Written informed consent for therapeutic regiments was obtained from each child's parent. The protocol received approval from the Hospital's Ethics Committee. METHODS: Visual function was tested with a perceptual learning system (Research Center for Human Health and Development of Sun Yat-sen University, National Engineering Technique Research Center for Medical Care Implement) for visual noise, position noise, contour discrimination, contrast sensitivity, grating stereogram, and random-dot fusion. These tests helped to evaluate the efficiency of visual information processing of these children, and to determine the degree of defects of the optic nerve cells and the connections of visual cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures (each training procedure lasted for ten minutes). There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function. MAIN OUTCOME MEASURES: Visual function change; relationship of curative effects and curative time. RESULTS: A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment (P 〈 0.05). Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment (P 〈 0.05). The mean time to reach improved levels with curative effects was (2.82 ± 1.30) months, and to reach a basically cured level was (2.87 ±1.40) months. Percentage of improved visual acuity was the highest [98% (39/40)] in children that received 3 months of treatment and the lowest [55% (31/56)] in children that received 1 month of treatment (P 〈 0.05). The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% (31/46), P 〈 0.05]. CONCLUSION: Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.
文摘Alterations in the respiratory epithelium of gills of a catfish, Heteropneustes fossilis by the sublethal and lethal concentrations of HgCl2 have been observcd using scanning electron microscope. Fish exposed to 0.1 ppm shows a thin coat ot mucus, but the continuous layer of mucus is not retained in 0.3 ppm after 24 h of exposure. Epithelial cells of the gill filament are hyperplastic. Other changcs in the respiratory epithelium are contraction of epithelium, formation of interlamellar bridge and diminishing number of microridges. Massive destruction of the respiratory epithelium by deep lesions and sloughing of epithelial layer in 0.5 and 1.0 ppm solutions after 6-12 h of exposure apparently causes death to the fish. SEM observations are well in conformity with the findings made at light microscopic level
基金The National Key Research and Development Plan"Public Safety Risk Prevention and Control and Emergency Technical Equipment"Key Project"Clinical Evaluation Research on Chinese Medicine Intervention in COVID-19 Recovery Period"(2020YFC0845000)。
文摘Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.
基金National Natural Science Foundation of China(No.81660010,31660329,8191101552)。
文摘Objective:To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway,so as to seek new drugs for the treatment of community-acquired pneumonia.Methods:120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine,the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group,with 60 patients in each group.The control group was given cefuroxime sodium injection,and the experimental group was given cefuroxime sodium injection+Baimao root decoction.The levels of high-sensitivity C-reactive protein(CRP)and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT),IL-6,IL-8,TNF-αand TLR4/NF-κB mRNA levels,and to observe the effect of Radix Imperata Rubra on community-acquired pneumonia.Results:The fever,cough,expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group,the difference was statistically significant(P<0.05);the total effective rate of the experimental group(96.67%)was higher than that of the control group(85%),the difference was statistically significant(P<0.05);after treatment,the serum CRP,PCT,IL-6,IL-8,TNF-αin the two groups were lower than before,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05),There was statistical significance(P<0.05);after treatment,TLR4/NF-κB mRNA of the two groups were decreased,and the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of cap,Rhizoma Imperata can reduce the levels of CRP,PCT,IL-6,IL-8 and TNF-α.The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.
文摘Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed
文摘Infrarde thermography is a kind of functional imaging technology to detect the surface temperature of human body.To a certain extent,it provides a scientific basis for the datamation,visualization and objectification of traditional Chinese medicine(TCM).It has the characteristics of noninvasive,accuracy and predictability.In this paper,infrarde thermography was applied,and summed up its advantages and disadvantages,so as to play a more important role in the field of TCM infrarde thermography.
文摘Beating-acupuncture therapy is developed by Li Xutang, Director of the Section of TCM in the Jingdezhen Municipal First Hospital. Amng the 100 cases in the beating-acupuncture group, 85 cases were cured and 11 cases improved, the cure rate was 85 %; Of the 50 cases in the filiform needle acupuncture group, 25 cases were cured and 23 improved, the cure rate was 50 %. There was a statis-tically significant difference(P<0.01 ) between the two grdrips. It is indicated that the curative effect of beating-acupuncture on cervical spondylopathy is obviously superior to that of fili form-needle acupuncture, which provides a new therapy without traumatic pain for clinical treatment of cervical spondylopathy,
文摘Objective To explore the treatment effect of human growth factor(NGF)on vascular dementia.Method47cases with vascular dementia were randomly div ided into two groups(study and control).The study group(24cases)were treated with NGF,the control group(23cases)were treated with ordinary medicines.Results The intelligence and cognitive abil ity in the study group were obviously higher than those in the control group(P <0.01).Conclusion Compared with other methods,NGF has a significant curative effect.
基金Project (No. 419200-584602) supported by the Start Foundation for Introducing Talent of Zhejiang University, China
文摘Objective: The aim of this retrospective investigation was to explore the influence of femoral osteoporosis on short-term curative effects ofcementless hip arthroplasty and to evaluate the femoral metaphyseal bone mineral density (BMD) for femoral osteoporosis in order to guide prosthesis choice and rehabilitation. Methods: We performed 127 total arthroplasty operations between June 1999 to February 2003 and investigated 49 cementless hip replacements with the Metalcancellous cementless Lubeck Ⅱ system being used in all hips. There were twenty men and twenty-nine women whose mean age at the time of the operation was 60 years (range, 52-81 years). The patients were divided into osteoporosis or normal groups according to the femoral metaphyseal BMD measured preoperatively. The average duration of follow-up was 30 months (range, 8-52 months). We evaluated all of the patients from a clinical standpoint with use of a standard-terminology questionnaire with respect to the short-term curative effects and patients' satisfaction. Hip pain status and functional ability were important indicators of treatment efficacy. Results: Harris hip score and patients' satisfaction in femoral osteoporosis patients who underwent noncemented hip arthroplasty were lower (P=0.004, P=0.03) while the incidence of thigh pain was higher (P=0.03) than the patients with non-osteoporosis. Conclusion: The higher incidence of pain, as well as the decrease in function experienced by the patients in osteoporosis group, supports the case that cementless arthroplasty is not a better choice for those patients and that we had better select prosthesis based on the femoral metaphyseal BMD.
基金supported by the Natural Science Foundation of Hunan Province,China(No.2021JJ40505/No.2021JJ30619/No.2020JJ8002)the Scientific Research Project of Hunan Provincial Health Commission(No.202210004450)。
文摘Background Adult Fulminant myocarditis(FM)is the more serious form of acute myocarditis,and extracorporeal membrane oxygenation(ECMO)is an effective adjunction that helps to maintain circulation while providing adequate treatment.The blood supply of vital organs is guaranteed,which helps patients to survive the acute attack and improves the survival rate of FM.Methods In this study,50 clinical data of adult FM patients received in our hospital from July 2018 to July 2023 were collected for retrospective analysis.According to different treatment methods,they were divided into ECMO group(n=25)and non-ECMO group(n=25).After 14 days of treatment,the level of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),creatine kinase isoenzymes(CK-MB),cardiac troponinⅠ(cTnⅠ)and brain natriuretic peptide(BNP),and the incidence of complications were compared between the two groups.Results Before treatment,there was no significant difference in cardiac function between the two groups(P>0.05).After 14 days of treatment,ECMO group showed greater decline than non-ECMO group in LVESD and LVEDD,and LVEF was higher than that in the non-ECMO group(P<0.05).The level of CK-MB,cTnⅠ and BNP in ECMO group were lower than those in non-ECMO(P<0.05).The overall incidence of complications was 8% in the ECMO group,which was lower than 32% in the non-ECMO group(P<0.05).Conclusions The early efficacy of ECMO treatment in adult patients with FM is considerable,which is conducive to improving the cardiac function of patients and preventing complications.
文摘BACKGROUND Recently,hepatic arterial infusion chemotherapy(HAIC)plus lenvatinib has been frequently used to treat unresectable hepatocellular carcinoma(uHCC)in China.In the clinic,the hepatic arteries of some patients shrink significantly during this treatment,leading to improved short-term efficacy.AIM To investigate the relationship between the shrinkage of hepatic arteries and the short-term effect of HAIC plus lenvatinib treatment.METHODS Sixty-seven participants with uHCC were enrolled in this retrospective study.The patients received HAIC every 3 wk,followed by oral lenvatinib after the first HAIC course.Hepatic artery diameters were measured on CT before treatment and after 1 and 2 mo of treatment.Meanwhile,the changes in tumor capillaries were also examined on pathological specimens before and after 1 mo of treatment.The antitumor response after 1,3,and 6 mo of treatment was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST).The relationship between the changes in vessel diameters and the short-term effect of the combination treatment was evaluated by receiver-operating characteristic and logistic regression analyses.RESULTS The hepatic artery diameters were all significantly decreased after 1 and 2 mo of treatment(P<0.001),but there was no difference in the vessel diameters between 1 and 2 mo(P>0.05).The microvessel density in the tumor lesions decreased significantly after 1 mo of combination treatment(P<0.001).According to mRECIST,46,41,and 24 patients had complete or partial responses after 1,3,and 6 mo of treatment,respectively,whereas 21,21,and 32 patients had a stable or progressive disease at these times,respectively.Shrinkage of the tumor-feeding artery was significantly associated with the tumor response after 1,3,and 6 mo of treatment(P<0.001,P=0.004,and P=0.023,respectively);however,changes in other hepatic arteries were not significantly associated with the tumor response.Furthermore,shrinkage of the tumor-feeding artery was an independent factor for treatment efficacy(P=0.001,P=0.001,and P=0.002 and 1,3,and 6 mo,respectively).CONCLUSION The hepatic arteries shrank rapidly after treatment with HAIC plus lenvatinib,and shrinkage of the tumor-feeding artery diameter was closely related to improved short-term efficacy.
基金Supported by the National Science Foundation of China(41675046)
文摘In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration in a short time under the condition of breeze,stable weather and constant emission caused by human being's activities. Subsequently,an index of short-term cumulative effect is established with air diffusive equation,and then the macro-scale meteorological situation and micro-scale factors of forming the short-term cumulative effect are discussed with the observation data. The macro-scale meteorological variables contain upper-level weather situations and surface weather situations. The micro-scale factors mainly include the boundary-layer height and boundary-layer stability. The analyses show that boundary-layer factors and weather variables have a significant influence on the short-term cumulative effect. The notion of short-term cumulative effect will play an important role in interpreting the severe pollution weather.