Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydroch...Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation.The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent.All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity.Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.展开更多
基金the Madhya Pradesh Council of Science and Technology, Bhopal, India for financial support (No. 4468/CST/R&D/2010)
文摘Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave irradiation.The synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous solvent.All the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory activity.Biological activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.
