To the Editor： A 64-year-old Chinese man had a 12-month history ofnonmetastatic primary scalp angiosarcoma [Figure 1a] that had been confirmed by skin biopsy [Figure I el. Immunohistochemical examination showed CD31-...To the Editor： A 64-year-old Chinese man had a 12-month history ofnonmetastatic primary scalp angiosarcoma [Figure 1a] that had been confirmed by skin biopsy [Figure I el. Immunohistochemical examination showed CD31-, CD34-, and D2-40-positive tumor cells [Figure lf-lh]. Extensive local excision and placement of a free skin graft was performed in December 2016.展开更多
Introduction:Cutaneous radiation-associated(cRAA)angiosarcoma is a rare malignant neoplasm derived from vascular endothelial cells,but a relatively commonly recognized complication of radiation therapy.Here,we present...Introduction:Cutaneous radiation-associated(cRAA)angiosarcoma is a rare malignant neoplasm derived from vascular endothelial cells,but a relatively commonly recognized complication of radiation therapy.Here,we present a patient with cRAA,who undergone radiochemotherapy for cervical cancer 11 years ago.Case presentation:A 48-year-old woman presented with a 6-month history of painless purple skin plaques and nodules on her lower abdomen and right thigh.The patient had undergone radiochemotherapy for cervical cancer 11 years ago.A skin biopsy showed a diffuse proliferation of irregular anastomosing dilated vascular structures with atypical endothelial cells.She was diagnosed as cRAA according to clinical and histological manifestations.Discussion:cRAA is a rare malignant neoplasm but it is a complication of radiation therapy.The incidence of cRAA has increased in recent years.Clinical and pathological manifestations are highly varied.Radical resection is the preferred treatment.Conclusion:Patients with suspicious violaceous lesions should undergo biopsy.Clinical suspicion and pathological examination are of the utmost importance for cRAA.展开更多
文摘To the Editor： A 64-year-old Chinese man had a 12-month history ofnonmetastatic primary scalp angiosarcoma [Figure 1a] that had been confirmed by skin biopsy [Figure I el. Immunohistochemical examination showed CD31-, CD34-, and D2-40-positive tumor cells [Figure lf-lh]. Extensive local excision and placement of a free skin graft was performed in December 2016.
基金This work was supported by the CAMS Innovation Fund for Medical Sciences(No.CIFMS-2017-I2M-1-017)the PUMC Youth Fund(No.3332017168)。
文摘Introduction:Cutaneous radiation-associated(cRAA)angiosarcoma is a rare malignant neoplasm derived from vascular endothelial cells,but a relatively commonly recognized complication of radiation therapy.Here,we present a patient with cRAA,who undergone radiochemotherapy for cervical cancer 11 years ago.Case presentation:A 48-year-old woman presented with a 6-month history of painless purple skin plaques and nodules on her lower abdomen and right thigh.The patient had undergone radiochemotherapy for cervical cancer 11 years ago.A skin biopsy showed a diffuse proliferation of irregular anastomosing dilated vascular structures with atypical endothelial cells.She was diagnosed as cRAA according to clinical and histological manifestations.Discussion:cRAA is a rare malignant neoplasm but it is a complication of radiation therapy.The incidence of cRAA has increased in recent years.Clinical and pathological manifestations are highly varied.Radical resection is the preferred treatment.Conclusion:Patients with suspicious violaceous lesions should undergo biopsy.Clinical suspicion and pathological examination are of the utmost importance for cRAA.
