Baeyer-Villiger oxidation of cyclic ketones utilizing potassium peroxydisulfate(K_2S_2O_8) or sodium perborate(NaBO_3) in acidic media

The efficient, green, facile, mild and straightforward conversion procedure for the oxidation of cyclic ketones to lactones at room temperature utilizing potassium peroxydisulfate （K2S2O8） in acidic media is satisfactory to high yields without using traditional chlorinated solvents is reported. This oxidative reagent is cheap and friendly environmental procedure for industrial purposes than use of organic peracids.

Enantioselective Hydrogenation of α,β-Unsaturated Cyclic Ketones by Double Asymmetric Induction Preparation of (R)-Muscone

By ketal formation with chiral glycols like methyl or ethyl ester of tartaric acid,hydrogenation of ketals from the correspondingα,β-unsaturated 15-membered cyclic ketone produces (R)-muscone in good chemical and optical yield in the presence of chiral catalysts

Efficient Synthesis of Dicycloalkenopyridines:One-pot Multicomponent Condensation of Aldehydes with Cyclic Ketones

Under microwave irradiation, the one-pot multicomponent condensation reaction of three moles of aromatic aldehydes with two moles of cyclic ketones having free a,a＇-methylene positions such as cyclopentanone or cyclohexanone in the presence of ammonium acetate and acetic acid afforded dicycloalkenopyridines with two a-arylidene groups in high yields. Under the similar reaction condition, the reaction of aromatic aldehydes with 1-tetralone having only one a-methylene position alternatively resulted in 10-aryl-2,3：5,6-dibenzoacridines.

Baeyer-Villiger Oxidation of Cyclic Ketones Catalyzed by Amino Acid Ionic Liquids

A series of amino-acid-based ionic liquids was synthesized via one-step protonation of the corresponding L-amiiio acid by utilizing an array of proton sources.The catalytic activity of the amino-acid-based ionic liquids for the Baeyer-Villiger oxidation of cyclic ketones was investigated using cyclopentanone as a model cycloketone.Theproline-based ionic liquid[ProH]CF3SO3 was shown to exliibit thebest catalytic activity.The reaction condition was optimized to give the following reagent ratio of h(cyclopentanone):n(catalyst):w(H2O2)=1:0.06:4,60℃and 6 h.Under the optimum conditions,the conversion of cyclopentanone was 96.57%and the selectivity forδ-valerolactone was 73.01%.The catalytic activity was shown to be constant after 4 cycles.A simple treatment was allowed for the recover and the reuse of[ProH]CF3S03.The successful utilization of[ProH]CF3SO3 to catalyze a host of cyclic ketones via Baeyer-Villiger oxidation clearly demonstrated the capacity of[ProH]CF3S03 to tolerate variation in the substrate.

Synthesis of Novel Cyclic Aryl Ether Thioether Ketone (Sulfone) Oligomers

Two kinds of macrocyclic oligomers containing aromatic sulfide linkages have been synthesized by the solution polycondensation in high yield. The cyclic compounds were characterized by H-1 and C-13 NMR, by and MALDI - TOF MS.

ZrOCl_2·8H_2O catalyzed solvent-free synthesis of isobenzofuran-1(3H)-ones

ZrOCl2·8H2O catalyzed environmentally benign synthesis of isobenzofuran-1（3H）-ones are described.ZrOCl2·8H2O appeared to be an excellent catalyst for the condensation and reactions.Reaction of phthalaldehydic acid（2-carboxybenzaldehyde） with methylaryl and cyclic ketones was initiated by condensation and occurred in one step providing excellent yields（90-98%）.