A phosphine-promoted [3 ＋ 2] cycloaddition from readily accessible MBH （Morita-Baylis-Hillman） carbonate and aryl trifluoromethyl ketone is described. The use of methyl vinyl ketone-derived allylic carbonate rather...A phosphine-promoted [3 ＋ 2] cycloaddition from readily accessible MBH （Morita-Baylis-Hillman） carbonate and aryl trifluoromethyl ketone is described. The use of methyl vinyl ketone-derived allylic carbonate rather than common acrylate-derived counterpart renders the reaction pathway exclusive for 5-endo process, which enables the expeditious preparation of a range of trifluoromethylated 2, 3-dihydrofuran in a chemospecific manner.展开更多
基金supported by the National Natural Science Foundation of China (No.21302034)the Fundamental Research Funds for the Central Universities (No.2013HGQC0028)
文摘A phosphine-promoted [3 ＋ 2] cycloaddition from readily accessible MBH （Morita-Baylis-Hillman） carbonate and aryl trifluoromethyl ketone is described. The use of methyl vinyl ketone-derived allylic carbonate rather than common acrylate-derived counterpart renders the reaction pathway exclusive for 5-endo process, which enables the expeditious preparation of a range of trifluoromethylated 2, 3-dihydrofuran in a chemospecific manner.
