Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-ba...Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-base group 3. A new chiral stationary phase(BCDS 6) was then prepared by immobilization of β-cyclodextrin derivative with α-Schiff base group onto the surface of sillica gel. A series of compounds with amino groups were readily separated using this CSP. Methanol and acetonitrile were tested as the mobile phase while the influence of temperature and the addition of aqueous triethylammonium acetate buffer to the mobile phase was also innvestigated. Ferrocene ligand with Schiff-based groups have been separated satisfactorilly on BCDS column.展开更多
The Schiff bases bearing ferrocenylphenyl and diferrocenylphenyl groups were synthesized by the reactions of m-ferrocenylaniline with salicylaldehyde or 1, 4-bis (2′-formyl- phenyl)-1, 4-dioxabutane. The title compou...The Schiff bases bearing ferrocenylphenyl and diferrocenylphenyl groups were synthesized by the reactions of m-ferrocenylaniline with salicylaldehyde or 1, 4-bis (2′-formyl- phenyl)-1, 4-dioxabutane. The title compounds were characterized by elemental analysis, IR, 1H NMR and X-ray structural determination.展开更多
Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic a...Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.展开更多
Two Schiff bases(DAMBA-Fc and DAA-Fc)derived from dehydroabietic acid have been successfully synthesized and characterized by means of FT-IR,elemental analysis,HRMS,and NMR spectroscopy.The crystal structure of DAA-Fc...Two Schiff bases(DAMBA-Fc and DAA-Fc)derived from dehydroabietic acid have been successfully synthesized and characterized by means of FT-IR,elemental analysis,HRMS,and NMR spectroscopy.The crystal structure of DAA-Fc can be determined by single-crystal X-ray diffraction.The compound is of monoclinic system,space group P21 with a=10.7379(6),b=7.5004(4),c=33.3294(18)?,β=97.996(3)o,Z=4,V=2658.2(3)?3,Mr=481.48,Dc=1.203 g/cm3,S=1.034,μ=0.585 mm-1,F(000)=1032,the final R=0.0566 and wR=0.0701 for 5645 observed reflections(I>2σ(I)).In addition,cyclic and differential pulse voltammogram techniques have been applied to differentiate the redox properties of the aromatic-and aliphatic-connected Schiff bases DAMBA-Fc and DAA-Fc,respectively.展开更多
Staring from ferrocene,we conveniently synthesized a series of chiral mono,di ferrocenyl schiff bases in ambient condition.The optical yields were good.And their structures were confirmed by IR, 1H NMR,and Elemental a...Staring from ferrocene,we conveniently synthesized a series of chiral mono,di ferrocenyl schiff bases in ambient condition.The optical yields were good.And their structures were confirmed by IR, 1H NMR,and Elemental analysis.In addition.we discussed the effect of the stuctures of bases on the reactions.展开更多
A number of scientists have studied the poly (Schiff-bases) for the past twenty years, but very little about the synthesis of ferrocene-containing poly (Schiff-bases) in their backbones was reported, except that poly ...A number of scientists have studied the poly (Schiff-bases) for the past twenty years, but very little about the synthesis of ferrocene-containing poly (Schiff-bases) in their backbones was reported, except that poly (ferrocenylazomethines) were earlier studied by Neuse. Lenz and the authors studied the cationic polycondensation and copolymeriza-展开更多
文摘Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-base group 3. A new chiral stationary phase(BCDS 6) was then prepared by immobilization of β-cyclodextrin derivative with α-Schiff base group onto the surface of sillica gel. A series of compounds with amino groups were readily separated using this CSP. Methanol and acetonitrile were tested as the mobile phase while the influence of temperature and the addition of aqueous triethylammonium acetate buffer to the mobile phase was also innvestigated. Ferrocene ligand with Schiff-based groups have been separated satisfactorilly on BCDS column.
基金We are grateful to the National Natural Science Foundation of China(project 20072034)the Foundation for Young Teacher in Zhenzhou University for the financial support.
文摘The Schiff bases bearing ferrocenylphenyl and diferrocenylphenyl groups were synthesized by the reactions of m-ferrocenylaniline with salicylaldehyde or 1, 4-bis (2′-formyl- phenyl)-1, 4-dioxabutane. The title compounds were characterized by elemental analysis, IR, 1H NMR and X-ray structural determination.
文摘Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.
基金Supported by the National Natural Science Foundation of China(21601087 and 21401101)the Topnotch Academic Programs Project(TAPP)the Priority Academic Program Development of Jiangsu Higher Education Institution(PAPD)。
文摘Two Schiff bases(DAMBA-Fc and DAA-Fc)derived from dehydroabietic acid have been successfully synthesized and characterized by means of FT-IR,elemental analysis,HRMS,and NMR spectroscopy.The crystal structure of DAA-Fc can be determined by single-crystal X-ray diffraction.The compound is of monoclinic system,space group P21 with a=10.7379(6),b=7.5004(4),c=33.3294(18)?,β=97.996(3)o,Z=4,V=2658.2(3)?3,Mr=481.48,Dc=1.203 g/cm3,S=1.034,μ=0.585 mm-1,F(000)=1032,the final R=0.0566 and wR=0.0701 for 5645 observed reflections(I>2σ(I)).In addition,cyclic and differential pulse voltammogram techniques have been applied to differentiate the redox properties of the aromatic-and aliphatic-connected Schiff bases DAMBA-Fc and DAA-Fc,respectively.
文摘Staring from ferrocene,we conveniently synthesized a series of chiral mono,di ferrocenyl schiff bases in ambient condition.The optical yields were good.And their structures were confirmed by IR, 1H NMR,and Elemental analysis.In addition.we discussed the effect of the stuctures of bases on the reactions.
基金Project supported by the National Natural Science Foundation of China.
文摘A number of scientists have studied the poly (Schiff-bases) for the past twenty years, but very little about the synthesis of ferrocene-containing poly (Schiff-bases) in their backbones was reported, except that poly (ferrocenylazomethines) were earlier studied by Neuse. Lenz and the authors studied the cationic polycondensation and copolymeriza-
