A novel 1,4,5-trisubstituted 1,2,3-triazole(C18H21N3O3) was synthesized by a one-pot three component reaction of 1-azidocyclohexane, 1-copper(I) phenylethyne and ethoxalyl chloride at room temperature. The molecul...A novel 1,4,5-trisubstituted 1,2,3-triazole(C18H21N3O3) was synthesized by a one-pot three component reaction of 1-azidocyclohexane, 1-copper(I) phenylethyne and ethoxalyl chloride at room temperature. The molecular structure was determined by single-crystal X-ray analysis. The compound crystallizes in the monoclinic system, space group P21/n with a = 12.8167(9), b = 8.0966(6), c = 16.7079(9) A, β = 98.716(2)°, Z = 4 and V = 1713.8(2). In the crystal, the molecules are related by inversion and paired into dimers via C–H…O and C–O…C interactions involving(oxo) acetate groups. Furthermore, X-ray analysis results are compared with the optimized structure computed by using B3 LYP method with 6-311 G basis set. The calculated results showed that optimized geometry can well reproduce the crystal structure parameters. The bioassay results indicate that the compound has good antibacterial and antifungal activities.展开更多
The title compound (-)-N-[(3R)-3-cyclohexyl]-3-phenylpropananoyl]bornane-10,2sultam (C 25 H 35 NO 3 S,M r=429.60),a derivative of camphorsultam,crystallizes in the monoclinic space group P2 1 /c with a=10.3301(...The title compound (-)-N-[(3R)-3-cyclohexyl]-3-phenylpropananoyl]bornane-10,2sultam (C 25 H 35 NO 3 S,M r=429.60),a derivative of camphorsultam,crystallizes in the monoclinic space group P2 1 /c with a=10.3301(7),b=19.4040(13),c=11.8106(8),β=100.5580(10)°,V=2327.3(3) 3,Z=4,D c=1.226 g/cm 3,λ=0.71073,μ(MoKα)=0.165 mm-1 and F(000)=928.X-ray diffraction analysis reveals that the six-membered ring of sultam shows a boat form (Fig.1).The planes constructed by (C(4),C(5),C(6),C(7)) and (C(7),C(8),C(9),C(4)) form a dihedral angle of 69.5°.The C(1)-C(2)-C(3) plane forms dihedral angles to the aforementioned planes of 89.8(1) and 85.9(3)°,respectively.And molecules are linked via hydrogen bonding (C-H···N/O) interactions.展开更多
Seventeen derivatives of mixed trialkyltin carboxylates with the formula (PhMe2SiCH2)Cy2SnO2CR have been synthesised.The results of IR NMR(1H,13C,119Sn) and MS showed that this kind of compounds is four-coordinated an...Seventeen derivatives of mixed trialkyltin carboxylates with the formula (PhMe2SiCH2)Cy2SnO2CR have been synthesised.The results of IR NMR(1H,13C,119Sn) and MS showed that this kind of compounds is four-coordinated and that there are two good linear relationships between the δ 119Sn and Hammett constants of para-substitutent of the corresponding aryloxy-acetates and arylcarboxylates.These compounds have a good acaricidal activity in the preliminary bioassay tests.展开更多
Slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene) (MA-CHVE-DVB) microspheres were prepared via precipitation polymerization while using 2,2- azobisisobutyronitrile as a...Slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene) (MA-CHVE-DVB) microspheres were prepared via precipitation polymerization while using 2,2- azobisisobutyronitrile as an initiator in a mixture of methyl ethyl ketone and n-heptane without any stabilizer. The number-average diameter of the resultant poly(MA-CHVE-DVB) microspheres ranged from 0.478 to 1.386 μm with a polydispersity index of 1.00 to 1.02 that depended on the feed ratios of the MA/CHVE/DVB monomers. The introduction of one electron donor monomer cyclohexyl vinyl ether strongly affected the yield, size, and morphology of these slightly crosslinked microspheres. Quinoline- type chelating resins were obtained after combining the poly(MA-CHVE-DVB) with 8-hydroxyquinoline; the adsorption properties of these materials were measured through their ability to remove Cu^2+ ions from water. The poly(MA-CHVE-DVB) microspheres with low degrees of crosslinking provided more effective functional groups and therefore better ion removal capabilities. These slightly crosslinked microspheres may have applications in water treatment as well as in sensing and drug delivery.展开更多
This paper presents a new chiral separation technology: two-phase (O/W) recognition chiral extraction. Distribution behavior of α-cyclohexyl-mandelic acid enantiomers was studied in the extraction system with D(L)-is...This paper presents a new chiral separation technology: two-phase (O/W) recognition chiral extraction. Distribution behavior of α-cyclohexyl-mandelic acid enantiomers was studied in the extraction system with D(L)-isobutyl tartrate in 1,2-dichloroethane organic phase and β-CD derivatives in aqueous phase, and the influence of the kind and concentration of extractant and pH on extraction performance was investigated. The experimental results indicate that two-phase (O/W) recognition chiral extraction is of strong chiral separation ability. HP-β-CD, HE-β-CD and Me-β-CD have higher recognition ability for S-CHMA than that for R-CHMA, among which HP-β-CD has the strongest ability; whereas, D-isobutyl tartrate has reversed recognition ability for them. In the extraction system containing HP-β-CD and D-isobutyl tartrate, e.e.% of S-CHMA in aqueous phase reached 27.6% by one stage extraction, and the distribution ratio for R-CHMA(kR) and for S-CHMA(kS) and separation factor (α) are 2.44, 0.89 and 2.49, respectively. Meanwhile, pH and concentration of extractant have great effects on chiral separation ability. Two-phase (O/W) recognition chiral extraction has great significance for preparative separation of racemic compounds.展开更多
The reaction of 2-alkyl-1,3-dimethylbenzimidazolium salts with Grignard reagents gave addition products which were hydrolyzed to give ketones. A new method for the preparation of cyclohexyl ketones and isopropyl keton...The reaction of 2-alkyl-1,3-dimethylbenzimidazolium salts with Grignard reagents gave addition products which were hydrolyzed to give ketones. A new method for the preparation of cyclohexyl ketones and isopropyl ketones is provided.展开更多
Eight novel compounds have been synthesized and they are two series of mixed tri(butyl/ cyclohexyl) tin carboxylates:Bu_nCy_(3-n) SnO_2CR (n=1,2;R=n-C_3H_7,C_6H_5,4-ClC_6H_4,4-NO_2C_6H_4).In addition to the studies of...Eight novel compounds have been synthesized and they are two series of mixed tri(butyl/ cyclohexyl) tin carboxylates:Bu_nCy_(3-n) SnO_2CR (n=1,2;R=n-C_3H_7,C_6H_5,4-ClC_6H_4,4-NO_2C_6H_4).In addition to the studies of their structures with IR,^(119)Sn and ^(13)C NMR,we tested their fungicidal,insec- ticidal and acaricidal activities.The percentage of inhibition to the aforementioned phytopathogen is about 80—100% at 50 ppm in glasshouse and 100% for T.Uriticae at 500 ppm.Those findings indicate that this kindof compounds have both fungicidal and acaricidal activities and mayhave a good prospect for applications.展开更多
基金supported by Higher Education Commission(HEC)Govt.of Pakistan
文摘A novel 1,4,5-trisubstituted 1,2,3-triazole(C18H21N3O3) was synthesized by a one-pot three component reaction of 1-azidocyclohexane, 1-copper(I) phenylethyne and ethoxalyl chloride at room temperature. The molecular structure was determined by single-crystal X-ray analysis. The compound crystallizes in the monoclinic system, space group P21/n with a = 12.8167(9), b = 8.0966(6), c = 16.7079(9) A, β = 98.716(2)°, Z = 4 and V = 1713.8(2). In the crystal, the molecules are related by inversion and paired into dimers via C–H…O and C–O…C interactions involving(oxo) acetate groups. Furthermore, X-ray analysis results are compared with the optimized structure computed by using B3 LYP method with 6-311 G basis set. The calculated results showed that optimized geometry can well reproduce the crystal structure parameters. The bioassay results indicate that the compound has good antibacterial and antifungal activities.
基金sponsored by the Science Foundation of Ministry of Education for the New Teacher at the University of China (No. 20070511006)the Research Initiation Funds of Huazhong Agricultural University (No. 52204-09057)
文摘The title compound (-)-N-[(3R)-3-cyclohexyl]-3-phenylpropananoyl]bornane-10,2sultam (C 25 H 35 NO 3 S,M r=429.60),a derivative of camphorsultam,crystallizes in the monoclinic space group P2 1 /c with a=10.3301(7),b=19.4040(13),c=11.8106(8),β=100.5580(10)°,V=2327.3(3) 3,Z=4,D c=1.226 g/cm 3,λ=0.71073,μ(MoKα)=0.165 mm-1 and F(000)=928.X-ray diffraction analysis reveals that the six-membered ring of sultam shows a boat form (Fig.1).The planes constructed by (C(4),C(5),C(6),C(7)) and (C(7),C(8),C(9),C(4)) form a dihedral angle of 69.5°.The C(1)-C(2)-C(3) plane forms dihedral angles to the aforementioned planes of 89.8(1) and 85.9(3)°,respectively.And molecules are linked via hydrogen bonding (C-H···N/O) interactions.
基金Supported by the National Natural Science Foundation of China
文摘Seventeen derivatives of mixed trialkyltin carboxylates with the formula (PhMe2SiCH2)Cy2SnO2CR have been synthesised.The results of IR NMR(1H,13C,119Sn) and MS showed that this kind of compounds is four-coordinated and that there are two good linear relationships between the δ 119Sn and Hammett constants of para-substitutent of the corresponding aryloxy-acetates and arylcarboxylates.These compounds have a good acaricidal activity in the preliminary bioassay tests.
基金The financial supports from the National Science Foundation of China(Grant No.20774037 and 21304037)Shandong Excellent Young Scientist Research Award Fund(No.BS2013CL039)
文摘Slightly crosslinked monodisperse poly(maleic anhydride-cyclohexyl vinyl ether-divinylbenzene) (MA-CHVE-DVB) microspheres were prepared via precipitation polymerization while using 2,2- azobisisobutyronitrile as an initiator in a mixture of methyl ethyl ketone and n-heptane without any stabilizer. The number-average diameter of the resultant poly(MA-CHVE-DVB) microspheres ranged from 0.478 to 1.386 μm with a polydispersity index of 1.00 to 1.02 that depended on the feed ratios of the MA/CHVE/DVB monomers. The introduction of one electron donor monomer cyclohexyl vinyl ether strongly affected the yield, size, and morphology of these slightly crosslinked microspheres. Quinoline- type chelating resins were obtained after combining the poly(MA-CHVE-DVB) with 8-hydroxyquinoline; the adsorption properties of these materials were measured through their ability to remove Cu^2+ ions from water. The poly(MA-CHVE-DVB) microspheres with low degrees of crosslinking provided more effective functional groups and therefore better ion removal capabilities. These slightly crosslinked microspheres may have applications in water treatment as well as in sensing and drug delivery.
基金Supported by the National Natural Science Foundation of China (Grant No. 20776038)
文摘This paper presents a new chiral separation technology: two-phase (O/W) recognition chiral extraction. Distribution behavior of α-cyclohexyl-mandelic acid enantiomers was studied in the extraction system with D(L)-isobutyl tartrate in 1,2-dichloroethane organic phase and β-CD derivatives in aqueous phase, and the influence of the kind and concentration of extractant and pH on extraction performance was investigated. The experimental results indicate that two-phase (O/W) recognition chiral extraction is of strong chiral separation ability. HP-β-CD, HE-β-CD and Me-β-CD have higher recognition ability for S-CHMA than that for R-CHMA, among which HP-β-CD has the strongest ability; whereas, D-isobutyl tartrate has reversed recognition ability for them. In the extraction system containing HP-β-CD and D-isobutyl tartrate, e.e.% of S-CHMA in aqueous phase reached 27.6% by one stage extraction, and the distribution ratio for R-CHMA(kR) and for S-CHMA(kS) and separation factor (α) are 2.44, 0.89 and 2.49, respectively. Meanwhile, pH and concentration of extractant have great effects on chiral separation ability. Two-phase (O/W) recognition chiral extraction has great significance for preparative separation of racemic compounds.
基金theNationalNaturalScienceFoundationofChina (No .2 0 172 0 41)
文摘The reaction of 2-alkyl-1,3-dimethylbenzimidazolium salts with Grignard reagents gave addition products which were hydrolyzed to give ketones. A new method for the preparation of cyclohexyl ketones and isopropyl ketones is provided.
基金the National Natural Science Foundation of China
文摘Eight novel compounds have been synthesized and they are two series of mixed tri(butyl/ cyclohexyl) tin carboxylates:Bu_nCy_(3-n) SnO_2CR (n=1,2;R=n-C_3H_7,C_6H_5,4-ClC_6H_4,4-NO_2C_6H_4).In addition to the studies of their structures with IR,^(119)Sn and ^(13)C NMR,we tested their fungicidal,insec- ticidal and acaricidal activities.The percentage of inhibition to the aforementioned phytopathogen is about 80—100% at 50 ppm in glasshouse and 100% for T.Uriticae at 500 ppm.Those findings indicate that this kindof compounds have both fungicidal and acaricidal activities and mayhave a good prospect for applications.
基金supported by the National Natural Science Foundation of China(2123600121176056)+1 种基金the Programme for 100 Excellent Talents in Universities of Hebei Province(II)(BR2-208)the Natural Science Foundation of Hebei Province(B2015202228)~~