A new C21 steroidal glycoside, neocynapanogenin F 3-O-β-D-thevetoside 1, as well as its known aglycone neocynapanogenin F 2, which have an aberrant 13, 14：14, 15-disecopregnane-type skeleton were isolated from the r...A new C21 steroidal glycoside, neocynapanogenin F 3-O-β-D-thevetoside 1, as well as its known aglycone neocynapanogenin F 2, which have an aberrant 13, 14：14, 15-disecopregnane-type skeleton were isolated from the root of Cynanchum paniculatum. Their structures were elucidated on the basis of spectroscopic data analysis. These compounds showed certain cytotoxic activities in vitro.展开更多
Two new C21 steroidal glycosides,paniculatumosides H and I,together with four known ones were isolated from the roots of Cynanchum paniculatum(Bge.)Kitag.Their structures were identifed by spectroscopic methods includ...Two new C21 steroidal glycosides,paniculatumosides H and I,together with four known ones were isolated from the roots of Cynanchum paniculatum(Bge.)Kitag.Their structures were identifed by spectroscopic methods including extensive 1D and 2D NMR techniques.All compounds were subjected to detect the anti-tobacco mosaic virus(TMV)activities and their cytotoxities against three human tumor cell lines(SMMC-7721,MDA-MB-231 and A549).The results showed that compounds 1 and 5 exhibited potent protective activities against TMV,while 2,4 and 6 had moderate efects on the SMMC7721 cancer cells viability.展开更多
基金This project was supported by Fund for Distinguished Chinese Young Scholars of the National Natural Science Foundation of China(No.30325046).
文摘A new C21 steroidal glycoside, neocynapanogenin F 3-O-β-D-thevetoside 1, as well as its known aglycone neocynapanogenin F 2, which have an aberrant 13, 14：14, 15-disecopregnane-type skeleton were isolated from the root of Cynanchum paniculatum. Their structures were elucidated on the basis of spectroscopic data analysis. These compounds showed certain cytotoxic activities in vitro.
基金supported financially by grants from the National Natural Science Foundation of China(Nos.31770389,81703393).
文摘Two new C21 steroidal glycosides,paniculatumosides H and I,together with four known ones were isolated from the roots of Cynanchum paniculatum(Bge.)Kitag.Their structures were identifed by spectroscopic methods including extensive 1D and 2D NMR techniques.All compounds were subjected to detect the anti-tobacco mosaic virus(TMV)activities and their cytotoxities against three human tumor cell lines(SMMC-7721,MDA-MB-231 and A549).The results showed that compounds 1 and 5 exhibited potent protective activities against TMV,while 2,4 and 6 had moderate efects on the SMMC7721 cancer cells viability.
文摘目的:研究徐长卿(Cynanchum paniculatumBge.)中C21甾体化学成分。方法:应用多种色谱柱层析法对徐长卿的乙酸乙酯部位进行化学成分的分离,并通过波谱技术鉴定化合物的结构。结果:分离鉴定了7个C21甾体化合物,分别为3β,14-dihydroxy-14-βpregn-5-en-20-one(Ⅰ),glaucogenin C(Ⅱ),glaucogenin A(Ⅲ),glauco-genin D(Ⅳ),neocynapanogenin F(Ⅴ),glaucogenin C 3-O-β-D-thevetoside(Ⅵ),neocynapanogenin F 3-O-β-D-oleandropy-ranoside(Ⅶ)。结论:化合物Ⅲ、Ⅳ、Ⅵ为首次从该植物中分离得到。
