A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine p...A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..展开更多
目的:分析外周血核苷酸结合寡聚化结构域样受体蛋白3(nucleotide binding oligomerization domain like receptor protein 3,NLRP3)-半胱氨酸蛋白酶1(cysteine-aspartic acid protease 1,Caspase-1)-白细胞介素(interleukin,IL)-1β信...目的:分析外周血核苷酸结合寡聚化结构域样受体蛋白3(nucleotide binding oligomerization domain like receptor protein 3,NLRP3)-半胱氨酸蛋白酶1(cysteine-aspartic acid protease 1,Caspase-1)-白细胞介素(interleukin,IL)-1β信号轴与肺癌的相关性。方法:选取2021年6月—2023年8月江苏省连云港市赣榆区人民医院收治的肺癌住院患者72例初诊患者(肺癌组)和72例健康体检者(健康对照组)。比较两组外周血单核细胞、NLRP3、Caspase-1、IL-1β水平及肺功能[1秒用力呼气量(forced expiratory volume in one second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、FEV_(1)/FVC],并分析肺癌组外周血中NLRP3、IL-1β水平与FEV_(1)、FVC、FEV_(1)/FVC的相关性。结果:肺癌组患者FEV_(1)、FVC、FEV_(1)/FVC水平均显著低于健康对照组,差异有统计学意义(P均<0.05);外周血中Nlrp3、Caspase-1、Il-1βmRNA相对表达水平和Caspase-1和IL-1β分泌水平均高于健康对照组,差异有统计学意义(P均<0.05);Spearman相关分析显示,肺癌组患者外周血单核细胞Nlrp3基因mRNA相对表达量与FEV_(1)、FEV_(1)/FVC水平呈负相关(P<0.05);而外周血IL-1β分泌水平与FEV_(1)/FVC水平呈正相关(P<0.05)。结论:外周血单核细胞中NLRP3 mRNA相对表达水平及外周血IL-1β分泌水平与肺癌进展呈负相关,可反映肺癌进展程度,对肺癌的筛查和诊断具有潜在的参考价值。展开更多
文摘A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..
文摘目的:分析外周血核苷酸结合寡聚化结构域样受体蛋白3(nucleotide binding oligomerization domain like receptor protein 3,NLRP3)-半胱氨酸蛋白酶1(cysteine-aspartic acid protease 1,Caspase-1)-白细胞介素(interleukin,IL)-1β信号轴与肺癌的相关性。方法:选取2021年6月—2023年8月江苏省连云港市赣榆区人民医院收治的肺癌住院患者72例初诊患者(肺癌组)和72例健康体检者(健康对照组)。比较两组外周血单核细胞、NLRP3、Caspase-1、IL-1β水平及肺功能[1秒用力呼气量(forced expiratory volume in one second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、FEV_(1)/FVC],并分析肺癌组外周血中NLRP3、IL-1β水平与FEV_(1)、FVC、FEV_(1)/FVC的相关性。结果:肺癌组患者FEV_(1)、FVC、FEV_(1)/FVC水平均显著低于健康对照组,差异有统计学意义(P均<0.05);外周血中Nlrp3、Caspase-1、Il-1βmRNA相对表达水平和Caspase-1和IL-1β分泌水平均高于健康对照组,差异有统计学意义(P均<0.05);Spearman相关分析显示,肺癌组患者外周血单核细胞Nlrp3基因mRNA相对表达量与FEV_(1)、FEV_(1)/FVC水平呈负相关(P<0.05);而外周血IL-1β分泌水平与FEV_(1)/FVC水平呈正相关(P<0.05)。结论:外周血单核细胞中NLRP3 mRNA相对表达水平及外周血IL-1β分泌水平与肺癌进展呈负相关,可反映肺癌进展程度,对肺癌的筛查和诊断具有潜在的参考价值。
