The mobility and connective capabilities of unmanned aerial vehicles(UAVs)are becoming more and more important in defense,commercial,and research domains.However,their open communication makes UAVs susceptible toundes...The mobility and connective capabilities of unmanned aerial vehicles(UAVs)are becoming more and more important in defense,commercial,and research domains.However,their open communication makes UAVs susceptible toundesirablepassive attacks suchas eavesdroppingor jamming.Recently,the inefficiencyof traditional cryptography-based techniques has led to the addition of Physical Layer Security(PLS).This study focuses on the advanced PLS method for passive eavesdropping in UAV-aided vehicular environments,proposing a solution to complement the conventional cryptography approach.Initially,we present a performance analysis of first-order secrecy metrics in 6G-enabled UAV systems,namely hybrid outage probability(HOP)and secrecy outage probability(SOP)over 2×2 Nakagami-m channels.Later,we propose a novel technique for mitigating passive eavesdropping,which considers first-order secrecy metrics as an optimization problem and determines their lower and upper bounds.Finally,we conduct an analysis of bounded HOP and SOP using the interactive Nakagami-m channel,considering the multiple-input-multiple-output configuration of the UAV system.The findings indicate that 2×2 Nakagami-mis a suitable fadingmodel under constant velocity for trustworthy receivers and eavesdroppers.The results indicate that UAV mobility has some influence on an eavesdropper’s intrusion during line-of-sight-enabled communication and can play an important role in improving security against passive eavesdroppers.展开更多
Objectives:The Kirsten rat sarcoma virus(KRAS)G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions.This study aims to explore...Objectives:The Kirsten rat sarcoma virus(KRAS)G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions.This study aims to explore innovative approaches in T cell receptor(TCR)engineering and characterization to target the KRAS G12D7-16 mutation,providing potential strategies for overcoming this therapeutic challenge.Methods:In this innovative study,we engineered and characterized two T cell receptors(TCRs),KDA11-01 and KDA11-02 with high affinity for the KRAS G12D7-16 mutation.These TCRs were isolated from tumor-infiltrating lymphocytes(TILs)derived from tumor tissues of patients with the KRAS G12D mutation.We assessed their specificity and anti-tumor activity in vitro using various cancer cell lines.Results:KDA11-01 and KDA11-02 demonstrated exceptional specificity for the HLA-A*11:01-restricted KRAS G12D7-16 epitope,significantly inducing IFN-γrelease and eliminating tumor cells without cross-reactivity or alloreactivity.Conclusions:The successful development of KDA11-01 and KDA11-02 introduces a novel and precise TCR-based therapeutic strategy against KRAS G12D mutation,showing potential for significant advancements in cancer immunotherapy.展开更多
基金funded by Taif University,Taif,Saudi Arabia,Project No.(TUDSPP-2024-139).
文摘The mobility and connective capabilities of unmanned aerial vehicles(UAVs)are becoming more and more important in defense,commercial,and research domains.However,their open communication makes UAVs susceptible toundesirablepassive attacks suchas eavesdroppingor jamming.Recently,the inefficiencyof traditional cryptography-based techniques has led to the addition of Physical Layer Security(PLS).This study focuses on the advanced PLS method for passive eavesdropping in UAV-aided vehicular environments,proposing a solution to complement the conventional cryptography approach.Initially,we present a performance analysis of first-order secrecy metrics in 6G-enabled UAV systems,namely hybrid outage probability(HOP)and secrecy outage probability(SOP)over 2×2 Nakagami-m channels.Later,we propose a novel technique for mitigating passive eavesdropping,which considers first-order secrecy metrics as an optimization problem and determines their lower and upper bounds.Finally,we conduct an analysis of bounded HOP and SOP using the interactive Nakagami-m channel,considering the multiple-input-multiple-output configuration of the UAV system.The findings indicate that 2×2 Nakagami-mis a suitable fadingmodel under constant velocity for trustworthy receivers and eavesdroppers.The results indicate that UAV mobility has some influence on an eavesdropper’s intrusion during line-of-sight-enabled communication and can play an important role in improving security against passive eavesdroppers.
基金funded by the key R&D Project of Hubei Province(Social Development),China(2022BCA018)the Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province),China(2022KF16)to Kanghong Hu.
文摘Objectives:The Kirsten rat sarcoma virus(KRAS)G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions.This study aims to explore innovative approaches in T cell receptor(TCR)engineering and characterization to target the KRAS G12D7-16 mutation,providing potential strategies for overcoming this therapeutic challenge.Methods:In this innovative study,we engineered and characterized two T cell receptors(TCRs),KDA11-01 and KDA11-02 with high affinity for the KRAS G12D7-16 mutation.These TCRs were isolated from tumor-infiltrating lymphocytes(TILs)derived from tumor tissues of patients with the KRAS G12D mutation.We assessed their specificity and anti-tumor activity in vitro using various cancer cell lines.Results:KDA11-01 and KDA11-02 demonstrated exceptional specificity for the HLA-A*11:01-restricted KRAS G12D7-16 epitope,significantly inducing IFN-γrelease and eliminating tumor cells without cross-reactivity or alloreactivity.Conclusions:The successful development of KDA11-01 and KDA11-02 introduces a novel and precise TCR-based therapeutic strategy against KRAS G12D mutation,showing potential for significant advancements in cancer immunotherapy.
