EFFICIENT STRIP-MODE SAR RAW SIGNAL SIMULATION OF MIXED TARGETS BASED ON ACCURATE 2-D SPECTRUM

An accurate and efficient Synthetic Aperture Radar(SAR)raw data generator is of considerable value for testing system parameters and verifying imaging algorithms.Nevertheless,the existing simulator cannot exactly handle the case of the fast moving targets in high squint geometry.As for the issue,the analytical expression for the two Dimensional(2-D)signal spectrum of moving targets is derived and a fast raw echo simulation method is proposed in this study.The proposed simulator can accommodate the moving targets in the high squint geometry,whose processing steps of the simulation are given in detail and its computational complexity is analyzed.The simulation data for static and moving targets are processed and analyzed,and the results are given to validate the effectiveness of the proposed approach.

LCM纯化的鼻咽癌间质和正常鼻咽间质的定量蛋白质组学研究

间质在肿瘤发生发展中的作用越来越受到重视.为寻找与鼻咽癌(nasopharyngeal carcinoma,NPC)发生发展相关的特异性间质蛋白,采用激光捕获显微切割技术(laser capture microdissection,LCM)纯化鼻咽癌间质和正常鼻咽黏膜间质,荧光差异双向凝胶电泳(fluorescent two-dimensional difference gel electrophoresis 2-D,DIGE)结合质谱技术分离鉴定间质相关蛋白.Westernblot及免疫组织化学技术验证了其中3个差异蛋白(CapG、L-plastin和S100A9),证实了2D-DIGE结果的可靠性.建立了LCM纯化的鼻咽癌间质和正常鼻咽间质的荧光差异蛋白表达图谱,高通量筛选与肿瘤发生相关的间质蛋白,共得到34个有统计学意义的蛋白质点,质谱鉴定得到20个差异蛋白.研究结果提示:这些差异表达的蛋白质将有助于阐明鼻咽癌细胞和周围间质的关系.对间质蛋白功能的进一步研究,将有助于解析间质在肿瘤发生中的作用机制,并为从间质途径寻找肿瘤治疗靶标提供新思路.

基于区域分解的二维海面生成及多普勒分析

提出一种基于区域分解的二维海面生成方法,将海谱划分为若干个子区域,分区域生成同完整海谱相对应的海面。将加权曲率近似方法与区域分解相结合,计算整幅海面的电磁散射,仿真并分析了L和X波段下海面多普勒谱特性。结果表明,所提出的方法解决了具有庞大采样网格的海面生成和电磁散射计算问题,使得在微波高频段下的粗糙海面多普勒谱仿真仍可在普通微机上实现,且更适应于多线程并行运算。