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D型肝炎病毒的研究现状
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作者 陈可跃 赵连三 《预防医学情报杂志》 CAS 1990年第1期26-29,共4页
近年来国内外学者对D型肝炎病毒(HDV)的研究日益重视。以分子生物学技术等新方法为研究手段,在该病毒的遗传、诊断、流行病学和临床诸领域中取得不少进展。本文就目前的研究现状作一综述。
关键词 d型肝炎病毒 肝炎病毒
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人类HDV由猩猩至土拨鼠感染的实验研究
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作者 施云松 胡绍梯 +2 位作者 张振西 WAWANG APonzetto 《中国人兽共患病杂志》 CSCD 北大核心 1998年第4期40-41,共2页
应用感染D型肝炎病毒(HDV)的猩猩和人血清分别接种上拨鼠(Woodchuck)肝炎病毒(WHV)感染的和未感染的动物。所获结果显示,来自于猩猩和来自人的HDV,均能使携带有WHV的10只上拨鼠全部感染,而非携带有WHV的土拨鼠则不能感染,证... 应用感染D型肝炎病毒(HDV)的猩猩和人血清分别接种上拨鼠(Woodchuck)肝炎病毒(WHV)感染的和未感染的动物。所获结果显示,来自于猩猩和来自人的HDV,均能使携带有WHV的10只上拨鼠全部感染,而非携带有WHV的土拨鼠则不能感染,证明人类的HDV不仅可以由人至猩猩的感染,而且还可以由猩猩至上拨鼠的感染;人至猩猩的感染并未改变HDV从HBsAg为外壳复制,而猩猩至上拨鼠的感染则以WHV的表面抗原(WHAg)为外壳,在动物体内高效复制,由于感染WHV的土拨鼠肝纤维化期短且能在2~3年内形成肝细胞癌。这为研究HBV/HDV感染的慢性化,肝纤维化和肝细胞癌的发生,发展提供了难得的极有价值的材料。 展开更多
关键词 d型肝炎病毒 土拨鼠 猩猩 实验
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Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PⅢNP in hepatitis C virus genotype 4 被引量:12
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作者 Mona F Schaalan Waleed A Mohamed Hesham H Amin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第28期3738-3744,共7页
AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response media... AIM: To assess vitamin D (Vit D) abnormalities in hepatitis C infected patients and their relationship with interleukin (IL)-17, IL-23 and N-terminal propeptide of type Ⅲ pro-collagen (PⅢNP) as immune response mediators. METHODS: The study was conducted on 50 Egyptian patients (36 male, 14 female) with hepatitis C virus (HCV) infection, who visited the Hepatology Outpatient Clinic in the Endemic Disease Hospital at Cairo University. Patients were compared with 25 ageand sexmatched healthy individuals. Inclusion criteria were based on a history of liver disease with HCV genotype 4 (HCV-4) infection (as new patients or under followup). Based on ultrasonography, patients were classified into four subgroups; 14 with bright hepatomegaly; 11 with perihepatic fibrosis; 11 with hepatic cirrhosis; and 14 with cirrhosis and hepatocellular carcinoma (HCC).Total Vit D (i.e., 25-OH-Vit D) and active Vit D [i.e., 1,25-(OH) 2 -Vit D] assays were carried out using commercial kits. IL-17, IL-23 and PⅢNP levels were assayed using enzyme linked immunosorbent assay kits, while HCV virus was measured by quantitative and qualitative polymerase chain reaction. RESULTS: Levels of Vit D and its active form were significantly lower in advanced liver disease (hepatic cirrhosis and/or carcinoma) patients, compared to those with bright hepatomegaly and perihepatic fibrosis. IL-17, IL-23 and PⅢNP levels were markedly increased in HCV patients and correlated with the progression of hepatic damage. The decrease in Vit D and active Vit D was concomitant with an increase in viral load, as well as levels of IL-17, IL-23 and PⅢNP among all subgroups of HCV-infected patients, compared to normal healthy controls. A significant negative correlation was evident between active Vit D and each of IL-17, IL-23 and PⅢNP (r = -0.679, -0.801 and -0.920 at P < 0.001, respectively). HCV-infected men and women showed no differences with respect to Vit D levels. The viral load was negatively correlated with Vit D and active Vit D (r = -0.084 and -0.846 at P < 0.001, respectively), and positively correlated with IL-17, IL-23 and PⅢNP (r = 0.951, 0.922 and 0.94 at P < 0.001, respectively). Whether the deficiency in Vit D was related to HCVinduced chronic liver disease or was a predisposing factor for a higher viral load remains to be elucidated. CONCLUSION: The negative correlations between Vit D and IL-17, IL-23 and PⅢNP highlight their involvement in the immune response in patients with HCV-4related liver diseases in Egypt. 展开更多
关键词 Vitamin d INTERLEUKIN-17 INTERLEUKIN-23 N-terminal propeptide of type pro-collagen Hepatitis genotype 4
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Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis
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作者 Yue-qiu LUO Xiao-xing WU +3 位作者 Zong-xin LING Yi-wen CHENG Li YUAN Charlie XIANG 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2014年第10期900-906,共7页
To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research litera... To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research literatures were identified by searching PubMed and EMBASE databases prior to October 2013 with no restrictions. We included group studies that reported odds ratio(OR) estimates with 95% confidence intervals(CIs) or a mean with standard deviation(SD) for the association between serum vitamin D status and the severity of liver fibrosis in chronic hepatitis C patients. Approximately 8321 participants from several countries were included in this analysis. Six studies on serum vitamin D status and the severity of liver fibrosis were included in this meta-analysis. ORs with 95% CIs were extracted from four studies and the pooled ORs were 0.866(95% CI, 0.649 to 1.157). The means with SDs were extracted from three studies and the pooled means were-0.487(95% CI,-0.659 to-0.315). There was statistically significant heterogeneity among the mean data extracted studies(P=0.029; I^2=71.8%) but not among the OR data extracted studies(P=0.061; I^2=55.6%). Finally, results from the mean data extracted studies suggest that lower serum vitamin D is a risk factor for the severity of liver fibrosis in chronic hepatitis C patients. However, there is no conclusive evidence on this association because of inconsistencies between the OR data extracted studies and the mean data extracted studies. 展开更多
关键词 Vitamin d FIBROSIS Hepatitis C virus META-ANALYSIS
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