AIM To investigate the prognostic value of preoperative fibrinogen concentration(FIB) and D-dimer-fibrinogen ratio(DFR) in gastrointestinal stromal tumors(GISTs).METHODS The purpose of this study was to retrospectivel...AIM To investigate the prognostic value of preoperative fibrinogen concentration(FIB) and D-dimer-fibrinogen ratio(DFR) in gastrointestinal stromal tumors(GISTs).METHODS The purpose of this study was to retrospectively analyze 170 patients with GISTs who were admitted to our hospital from January 2010 to December 2015. The optimal cutoff values of related parameters were estimated by receiver operating characteristic(ROC) curve analysis. The recurrence free survival(RFS) rate was evaluated using Kaplan-Meier curves. Univariate analysis and multivariate Cox regression models were used to analyze the prognostic factors of GISTs. The relationship between the FIB, D-dimer, DFR, platelet count(PLT), and the clinicopathological features of GISTs was described by the chi-square test or nonparametric rank sum test(MannWhitney test).RESULTS In ROC analysis, the optimal cutoff values of FIB, D-dimer, DFR, and PLT were 3.24 g/L, 1.24 mg/L, 0.354, and 197.5(× 109/L), respectively. Univariate analysis and the KaplanMeier survival curve showed that FIB, D-dimer, DFR, PLT,National Institutes of Health(NIH) risk category, tumor size, tumor location, and mitotic index were significantly relevant to the 3-year and 5-year survival rate of patients(P < 0.05). Cox multivariate regression analysis illustrated that FIB(RR : 0.108, 95%CI: 0.031-0.373), DFR(RR : 0.319, 95%CI: 0.131-0.777), and NIH risk category(RR : 0.166, 95%CI: 0.047-0.589) were independent prognostic factors of the RFS rate(P < 0. 05). Moreover, FIB, D-dimer, DFR, and PLT were correlated with the clinical features of GISTs.CONCLUSION FIB, D-dimer, DFR, and PLT are all related to the prognosis of GISTs. Moreover, FIB and DFR may be independent risk factors for predicting the prognosis of resectable GISTs.展开更多
目的分析首次诊断为心力衰竭(heart failure,HF)的窦性心律患者住院期间血浆D-二聚体(D-dimer,D-D)水平、D-D/纤维蛋白原(fibrinogen,FIB)的变化特点,探讨其对血栓形成的预测价值。方法回顾性分析2018-01/2021-11月在作者医院首次诊断...目的分析首次诊断为心力衰竭(heart failure,HF)的窦性心律患者住院期间血浆D-二聚体(D-dimer,D-D)水平、D-D/纤维蛋白原(fibrinogen,FIB)的变化特点,探讨其对血栓形成的预测价值。方法回顾性分析2018-01/2021-11月在作者医院首次诊断为HF窦性心律的165例患者临床资料,根据住院期间是否发生双下肢静脉血栓、左心房血栓、左心室血栓、肺栓塞等血栓事件将患者分为血栓组(n=65)和无血栓组(n=100),比较两组患者基线资料、辅助检查、实验室检查等指标,分析窦性心律HF患者发生血栓的危险因素。结果与无血栓组比较,血栓组患者的年龄大、住院时间长,D-D、FIB、纤维蛋白降解产物(fibrin degradation products,FDP)、Ⅶ因子活性、超敏C反应蛋白(high sensitive c-reactive protein hs-CRP)水平明显升高,D-D/FIB明显降低,组间比较差异具有统计学意义(P均<0.05)。采用受试者工作特征(receiver operating characteristic,ROC)曲线显示,D-D的临界值为455.5μg/L,曲线下面积(area under the curve,AUC)为0.715(95%CI:0.638~0.792);FIB的临界值为3.045,AUC为0.92(95%CI:0.881~0.96)。二元Logistic回归模型分析显示,住院时间(OR=1.907,95%CI:1.324~2.746)、D-D水平(OR=1.024,95%CI:1.002~1.046)、D-D/FIB(OR=0.930,95%CI:0.866~0.998)是首次确诊为HF窦性心律住院患者形成血栓的影响因素。结论住院时间、D-D、D-D/FIB是评估首诊HF窦性心律患者形成血栓的预测因素,对动态观察、指导预防性抗凝治疗有重要临床意义。展开更多
<b>Background:</b><span "=""> The relationship of preoperative D-dimer and Venous thromboembolism (VTE) after total knee arthroplasty (TKA) and total hip arthroplasty (THA) remains con...<b>Background:</b><span "=""> The relationship of preoperative D-dimer and Venous thromboembolism (VTE) after total knee arthroplasty (TKA) and total hip arthroplasty (THA) remains controversial. The purpose of this study was to assess the value of D-dimer in the detection of early VTE after TKA and THA. <b>Materials and Methods:</b> A total of 312 patients were evaluated in this retrospective study from 2016 to 2020 at a tertiary care centre, Mumbai who were operated for THA and TKA. The measurement of plasma D-dimer level was done preoperatively and clinically symptomatic patients were evaluated and confirmed for VTE by Colour Doppler Sonography. The plasma D-dimer levels were correlated statistically with the sonographic VTE. <b>Results:</b> 11 patients developed Deep Vein Thrombosis (DVT) and 1 patient developed Pulmonary embolism (PE). Preoperative plasma D-dimer levels were significantly higher</span><span "=""> </span>(P < 0.01) in patients who developed DVT postoperatively. Colour Doppler Sonography showed that 2 thrombi were seen in proximal veins<span "=""> </span><span "="">(pelvic and femoral veins), and 2 thrombi were seen in distal veins (posterior tibial, peroneal, gastrocnemian veins) of the calf in THA patients, and all 8 thrombi were seen in the distal veins (posterior tibial, peroneal, gastrocnemian veins) of the calf in TKA patients. <b>Conclusion:</b> We infer that if the preoperative D-dimer levels were more than 0.5</span><span "=""> </span>mg/l, the chances of developing VTE postoperatively are more, which can be diagnosed clinically and further by other investigations. In this study, we have shown that doing preoperative D-dimer level can almost PREDICT the development of VTE and thus prevent complications.展开更多
目的研究急性肺栓塞患者血清中Apelin-13、合肽素(Copeptin)与D-二聚体(D-dimer,D-D)表达水平并分析其与疾病严重程度和预后的相关性。方法将2013年9月-2018年9月我院收治的183例急性肺栓塞患者定义为观察组,将同期于我院体检的183例健...目的研究急性肺栓塞患者血清中Apelin-13、合肽素(Copeptin)与D-二聚体(D-dimer,D-D)表达水平并分析其与疾病严重程度和预后的相关性。方法将2013年9月-2018年9月我院收治的183例急性肺栓塞患者定义为观察组,将同期于我院体检的183例健康成年人定为对照组,比较两组患者临床资料、血清Apelin-13、Copeptin与D-D表达水平。将观察组患者按CTPA图像所示阻塞程度进行分级,比较不同分级患者血清Apelin-13、Copeptin与D-D水平,并分析其相关性;统计患者生存及死亡情况,比较不同预后患者血清Apelin-13、Copeptin与D-D水平,并分析其相关性。结果两组性别、年龄、身体质量指数(body mass index,BMI)、胆固醇、甘油三酯、血红蛋白水平无统计学差异(P>0.05);观察组血清Apelin-13、Copeptin与D-D表达水平均高于对照组(P<0.05);观察组中,1、2、3、4级患者例数分别为38、61、54、30例,随着分级的增加,血清Apelin-13、Copeptin与D-D水平也逐渐增加(P<0.05),血清Apelin-13、Copeptin与D-D水平与肺栓塞分级间呈正相关(r=0.349,P=0.021;r=0.422,P=0.036;r=0.534,P=0.009);观察组中21例患者死亡,死亡患者的血清Apelin-13、Copeptin与D-D表达水平高于存活患者(P<0.05),血清Apelin-13、Copeptin与D-D水平与死亡事件的发生呈正相关(r=0.425,P=0.014;r=0.458,P=0.005;r=0.608,P=0.010)。结论患者血清中Apelin-13、Copeptin与D-D水平可作为反映急性肺栓塞患者疾病严重程度和预后的生物学指标,指导临床治疗。展开更多
文摘AIM To investigate the prognostic value of preoperative fibrinogen concentration(FIB) and D-dimer-fibrinogen ratio(DFR) in gastrointestinal stromal tumors(GISTs).METHODS The purpose of this study was to retrospectively analyze 170 patients with GISTs who were admitted to our hospital from January 2010 to December 2015. The optimal cutoff values of related parameters were estimated by receiver operating characteristic(ROC) curve analysis. The recurrence free survival(RFS) rate was evaluated using Kaplan-Meier curves. Univariate analysis and multivariate Cox regression models were used to analyze the prognostic factors of GISTs. The relationship between the FIB, D-dimer, DFR, platelet count(PLT), and the clinicopathological features of GISTs was described by the chi-square test or nonparametric rank sum test(MannWhitney test).RESULTS In ROC analysis, the optimal cutoff values of FIB, D-dimer, DFR, and PLT were 3.24 g/L, 1.24 mg/L, 0.354, and 197.5(× 109/L), respectively. Univariate analysis and the KaplanMeier survival curve showed that FIB, D-dimer, DFR, PLT,National Institutes of Health(NIH) risk category, tumor size, tumor location, and mitotic index were significantly relevant to the 3-year and 5-year survival rate of patients(P < 0.05). Cox multivariate regression analysis illustrated that FIB(RR : 0.108, 95%CI: 0.031-0.373), DFR(RR : 0.319, 95%CI: 0.131-0.777), and NIH risk category(RR : 0.166, 95%CI: 0.047-0.589) were independent prognostic factors of the RFS rate(P < 0. 05). Moreover, FIB, D-dimer, DFR, and PLT were correlated with the clinical features of GISTs.CONCLUSION FIB, D-dimer, DFR, and PLT are all related to the prognosis of GISTs. Moreover, FIB and DFR may be independent risk factors for predicting the prognosis of resectable GISTs.
文摘目的分析首次诊断为心力衰竭(heart failure,HF)的窦性心律患者住院期间血浆D-二聚体(D-dimer,D-D)水平、D-D/纤维蛋白原(fibrinogen,FIB)的变化特点,探讨其对血栓形成的预测价值。方法回顾性分析2018-01/2021-11月在作者医院首次诊断为HF窦性心律的165例患者临床资料,根据住院期间是否发生双下肢静脉血栓、左心房血栓、左心室血栓、肺栓塞等血栓事件将患者分为血栓组(n=65)和无血栓组(n=100),比较两组患者基线资料、辅助检查、实验室检查等指标,分析窦性心律HF患者发生血栓的危险因素。结果与无血栓组比较,血栓组患者的年龄大、住院时间长,D-D、FIB、纤维蛋白降解产物(fibrin degradation products,FDP)、Ⅶ因子活性、超敏C反应蛋白(high sensitive c-reactive protein hs-CRP)水平明显升高,D-D/FIB明显降低,组间比较差异具有统计学意义(P均<0.05)。采用受试者工作特征(receiver operating characteristic,ROC)曲线显示,D-D的临界值为455.5μg/L,曲线下面积(area under the curve,AUC)为0.715(95%CI:0.638~0.792);FIB的临界值为3.045,AUC为0.92(95%CI:0.881~0.96)。二元Logistic回归模型分析显示,住院时间(OR=1.907,95%CI:1.324~2.746)、D-D水平(OR=1.024,95%CI:1.002~1.046)、D-D/FIB(OR=0.930,95%CI:0.866~0.998)是首次确诊为HF窦性心律住院患者形成血栓的影响因素。结论住院时间、D-D、D-D/FIB是评估首诊HF窦性心律患者形成血栓的预测因素,对动态观察、指导预防性抗凝治疗有重要临床意义。
文摘<b>Background:</b><span "=""> The relationship of preoperative D-dimer and Venous thromboembolism (VTE) after total knee arthroplasty (TKA) and total hip arthroplasty (THA) remains controversial. The purpose of this study was to assess the value of D-dimer in the detection of early VTE after TKA and THA. <b>Materials and Methods:</b> A total of 312 patients were evaluated in this retrospective study from 2016 to 2020 at a tertiary care centre, Mumbai who were operated for THA and TKA. The measurement of plasma D-dimer level was done preoperatively and clinically symptomatic patients were evaluated and confirmed for VTE by Colour Doppler Sonography. The plasma D-dimer levels were correlated statistically with the sonographic VTE. <b>Results:</b> 11 patients developed Deep Vein Thrombosis (DVT) and 1 patient developed Pulmonary embolism (PE). Preoperative plasma D-dimer levels were significantly higher</span><span "=""> </span>(P < 0.01) in patients who developed DVT postoperatively. Colour Doppler Sonography showed that 2 thrombi were seen in proximal veins<span "=""> </span><span "="">(pelvic and femoral veins), and 2 thrombi were seen in distal veins (posterior tibial, peroneal, gastrocnemian veins) of the calf in THA patients, and all 8 thrombi were seen in the distal veins (posterior tibial, peroneal, gastrocnemian veins) of the calf in TKA patients. <b>Conclusion:</b> We infer that if the preoperative D-dimer levels were more than 0.5</span><span "=""> </span>mg/l, the chances of developing VTE postoperatively are more, which can be diagnosed clinically and further by other investigations. In this study, we have shown that doing preoperative D-dimer level can almost PREDICT the development of VTE and thus prevent complications.
文摘目的研究急性肺栓塞患者血清中Apelin-13、合肽素(Copeptin)与D-二聚体(D-dimer,D-D)表达水平并分析其与疾病严重程度和预后的相关性。方法将2013年9月-2018年9月我院收治的183例急性肺栓塞患者定义为观察组,将同期于我院体检的183例健康成年人定为对照组,比较两组患者临床资料、血清Apelin-13、Copeptin与D-D表达水平。将观察组患者按CTPA图像所示阻塞程度进行分级,比较不同分级患者血清Apelin-13、Copeptin与D-D水平,并分析其相关性;统计患者生存及死亡情况,比较不同预后患者血清Apelin-13、Copeptin与D-D水平,并分析其相关性。结果两组性别、年龄、身体质量指数(body mass index,BMI)、胆固醇、甘油三酯、血红蛋白水平无统计学差异(P>0.05);观察组血清Apelin-13、Copeptin与D-D表达水平均高于对照组(P<0.05);观察组中,1、2、3、4级患者例数分别为38、61、54、30例,随着分级的增加,血清Apelin-13、Copeptin与D-D水平也逐渐增加(P<0.05),血清Apelin-13、Copeptin与D-D水平与肺栓塞分级间呈正相关(r=0.349,P=0.021;r=0.422,P=0.036;r=0.534,P=0.009);观察组中21例患者死亡,死亡患者的血清Apelin-13、Copeptin与D-D表达水平高于存活患者(P<0.05),血清Apelin-13、Copeptin与D-D水平与死亡事件的发生呈正相关(r=0.425,P=0.014;r=0.458,P=0.005;r=0.608,P=0.010)。结论患者血清中Apelin-13、Copeptin与D-D水平可作为反映急性肺栓塞患者疾病严重程度和预后的生物学指标,指导临床治疗。
