Two series of indomethacin conjugates with D-glucosamine were prepared with theobjectives of reducing ulcerogenic potency, increasing the bioavailability of indomethacin andexerting the coordinative effects on osteoar...Two series of indomethacin conjugates with D-glucosamine were prepared with theobjectives of reducing ulcerogenic potency, increasing the bioavailability of indomethacin andexerting the coordinative effects on osteoarthritis. The structures of the conjugates were identifiedby H NMR and C NMR. The ester conjugates inhibited edema as potent as indomethacin. 1 13展开更多
Ternary deep eutectic solvents(TDESs) comprising choline chloride(Ch Cl), glycerol and L-arginine were synthesized as catalysts and solvents for the conversion of D-glucosamine(GlcNH_(2)) into deoxyfructosazine(DOF). ...Ternary deep eutectic solvents(TDESs) comprising choline chloride(Ch Cl), glycerol and L-arginine were synthesized as catalysts and solvents for the conversion of D-glucosamine(GlcNH_(2)) into deoxyfructosazine(DOF). The interactions between these three components in the prepared TDESs were studied by ^(1)H-,^(35)Cl-NMR spectra and ^(1)H diffusion-ordered spectroscopy(DOSY) measurements. The chemical shift changes of active hydrogen in the ^(1)H-NMR spectra of TDES system and widening of signals in the^(35)Cl-NMR spectra confirmed the hydrogen bonding interaction between the components, which was further supported by the decrease of diffusion coefficients(D) of the TDES components according to ^(1)H DOSY measurements. The influences of reaction temperature and L-arginine content in the TDESs on the yield of DOF were also studied. The experimental results have shown that when the molar ratio of Ch Cl, glycerol, and L-arginine was 1:2:0.1, DOF was the major product with a yield of 22.6% at 90℃ for 120 min. The chemical shift titration indicated that the carboxyl group of L-arginine in the TDES is the catalytical active site, so the mechanism of the catalytic reaction between Glc NH_(2) and the TDES was proposed. Moreover, a reaction intermediate, dihydrofructosazine, was identified in the self-condensation reaction of Glc NH_(2) by an in situ ^(1)H NMR technique.展开更多
通过采用动电位极化曲线法(PDP)和阻抗谱(EIS)等电化学技术研究了多潘立酮作为典型X60管线钢在1 M HCl溶液中的缓蚀剂,同时采用扫描电子显微镜(SEM)对其表面形貌进行表征及对比。结果表明,多潘立酮对X60管线钢在强酸环境下具有良好的缓...通过采用动电位极化曲线法(PDP)和阻抗谱(EIS)等电化学技术研究了多潘立酮作为典型X60管线钢在1 M HCl溶液中的缓蚀剂,同时采用扫描电子显微镜(SEM)对其表面形貌进行表征及对比。结果表明,多潘立酮对X60管线钢在强酸环境下具有良好的缓蚀性能。在25℃、多潘立酮浓度为800 mg/L的条件下,电化学阻抗谱法测得其最佳缓蚀率为90.2%。电位动态极化研究表明,多潘立酮具有混合型抑制剂的功能。展开更多
采用人工模拟熏气办法,研究13种乡土绿化树种对城市中HC l和HF气体的反应。云南红豆杉、长梗润楠、翠柏、麻栗坡含笑、南亚含笑、脉叶虎皮楠对HC l气体的抗性弱。HC l浓度为1.0m g.m-3时,滇润楠、云南拟单性木兰、云南含笑、鸡嗉子树种...采用人工模拟熏气办法,研究13种乡土绿化树种对城市中HC l和HF气体的反应。云南红豆杉、长梗润楠、翠柏、麻栗坡含笑、南亚含笑、脉叶虎皮楠对HC l气体的抗性弱。HC l浓度为1.0m g.m-3时,滇润楠、云南拟单性木兰、云南含笑、鸡嗉子树种具有较强抗性及净化能力,净化量依次为141.8、283.6、354.5、425.4 m g.k-g 1和1 063.5 m g.k-g 1。HF浓度为1.0 m g.m-3时,山玉兰、灯台树、川滇三角枫叶片F净化量依次为0.9、1.9 m g.k-g 1和4.9 m g.kg-1。结果表明,滇润楠、鸡嗉子、山玉兰、云南拟单性木兰、云南含笑、灯台树等树种对HC l气体具有较强的抗性和净化能力,翠柏、云南红豆杉、山玉兰、灯台树、川滇三角枫等树种对HF气体具有一定的抗性和净化能力,试验结果可以为乡土绿化树种的选择和应用提供科学依据。展开更多
文摘Two series of indomethacin conjugates with D-glucosamine were prepared with theobjectives of reducing ulcerogenic potency, increasing the bioavailability of indomethacin andexerting the coordinative effects on osteoarthritis. The structures of the conjugates were identifiedby H NMR and C NMR. The ester conjugates inhibited edema as potent as indomethacin. 1 13
基金National Natural Science Foundation of China(U1710106,U1810111)the Key Research and Development Program of Shanxi Province(international cooperation)(201703D421041)for financial support。
文摘Ternary deep eutectic solvents(TDESs) comprising choline chloride(Ch Cl), glycerol and L-arginine were synthesized as catalysts and solvents for the conversion of D-glucosamine(GlcNH_(2)) into deoxyfructosazine(DOF). The interactions between these three components in the prepared TDESs were studied by ^(1)H-,^(35)Cl-NMR spectra and ^(1)H diffusion-ordered spectroscopy(DOSY) measurements. The chemical shift changes of active hydrogen in the ^(1)H-NMR spectra of TDES system and widening of signals in the^(35)Cl-NMR spectra confirmed the hydrogen bonding interaction between the components, which was further supported by the decrease of diffusion coefficients(D) of the TDES components according to ^(1)H DOSY measurements. The influences of reaction temperature and L-arginine content in the TDESs on the yield of DOF were also studied. The experimental results have shown that when the molar ratio of Ch Cl, glycerol, and L-arginine was 1:2:0.1, DOF was the major product with a yield of 22.6% at 90℃ for 120 min. The chemical shift titration indicated that the carboxyl group of L-arginine in the TDES is the catalytical active site, so the mechanism of the catalytic reaction between Glc NH_(2) and the TDES was proposed. Moreover, a reaction intermediate, dihydrofructosazine, was identified in the self-condensation reaction of Glc NH_(2) by an in situ ^(1)H NMR technique.
文摘通过采用动电位极化曲线法(PDP)和阻抗谱(EIS)等电化学技术研究了多潘立酮作为典型X60管线钢在1 M HCl溶液中的缓蚀剂,同时采用扫描电子显微镜(SEM)对其表面形貌进行表征及对比。结果表明,多潘立酮对X60管线钢在强酸环境下具有良好的缓蚀性能。在25℃、多潘立酮浓度为800 mg/L的条件下,电化学阻抗谱法测得其最佳缓蚀率为90.2%。电位动态极化研究表明,多潘立酮具有混合型抑制剂的功能。
文摘采用人工模拟熏气办法,研究13种乡土绿化树种对城市中HC l和HF气体的反应。云南红豆杉、长梗润楠、翠柏、麻栗坡含笑、南亚含笑、脉叶虎皮楠对HC l气体的抗性弱。HC l浓度为1.0m g.m-3时,滇润楠、云南拟单性木兰、云南含笑、鸡嗉子树种具有较强抗性及净化能力,净化量依次为141.8、283.6、354.5、425.4 m g.k-g 1和1 063.5 m g.k-g 1。HF浓度为1.0 m g.m-3时,山玉兰、灯台树、川滇三角枫叶片F净化量依次为0.9、1.9 m g.k-g 1和4.9 m g.kg-1。结果表明,滇润楠、鸡嗉子、山玉兰、云南拟单性木兰、云南含笑、灯台树等树种对HC l气体具有较强的抗性和净化能力,翠柏、云南红豆杉、山玉兰、灯台树、川滇三角枫等树种对HF气体具有一定的抗性和净化能力,试验结果可以为乡土绿化树种的选择和应用提供科学依据。
