目的探究胰岛素分泌曲线和血糖谱在2型糖尿病选择胰岛素促泌剂中的价值,为临床胰岛素促泌剂选择提供依据。方法本研究为随机对照试验,选取2015年12月至2020年12月东营市第二人民医院根据降糖治疗需要选用胰岛素促泌剂的2型糖尿病患者12...目的探究胰岛素分泌曲线和血糖谱在2型糖尿病选择胰岛素促泌剂中的价值,为临床胰岛素促泌剂选择提供依据。方法本研究为随机对照试验,选取2015年12月至2020年12月东营市第二人民医院根据降糖治疗需要选用胰岛素促泌剂的2型糖尿病患者120例作为研究对象,采用随机数字表法分为观察组和对照组,各60例。观察组男38例、女22例,年龄(58.27±6.34)岁,病程(3.62±1.28)年;对照组男33例、女27例,年龄(59.04±7.82)岁,病程(3.55±1.17)年。观察组进行馒头餐试验并依据胰岛素分泌曲线选择胰岛素促泌剂;对照组依据血糖谱选择胰岛素促泌剂,两组均治疗24周。对比两组患者血糖控制达标平均天数、血糖达标率、住院天数、低血糖发生率及治疗前后胰岛素β细胞功能[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、C肽(CP)水平]、血糖[空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)]水平、不良反应发生情况。采用t检验、χ^(2)检验。结果观察组血糖控制达标平均天数、住院天数均短于对照组[(7.05±1.42)d比(8.39±1.86)d、(10.29±2.08)d比(11.35±2.17)d],血糖达标率高于对照组[86.67%(52/60)比71.67%(43/60)],差异均有统计学意义(t=4.436、2.732,χ^(2)=4.093;均P<0.05)。治疗后,观察组FINS、CP水平均高于对照组[(9.32±1.55)IU/L比(8.46±1.38)IU/L、(1.49±0.39)μg/L比(1.35±0.32)μg/L],HOMA-IR低于对照组[(1.92±0.43)比(2.37±0.84)],差异均有统计学意义(t=3.210、2.150、3.694,均P<0.05)。治疗后,观察组FPG、2 h PBG、HbA1c水平均低于对照组[(6.47±1.12)mmol/L比(7.35±0.94)mmol/L、(10.52±1.17)mmol/L比(11.83±1.59)mmol/L、(6.12±1.09)%比(6.79±1.35)%],差异均有统计学意义(t=4.662、5.140、2.991,均P<0.05)。观察组不良反应发生率为15.00%(9/60),与对照组[18.33%(11/60)]比较,差异无统计学意义(χ^(2)=0.240,P=0.624)。结论与血糖谱相比,经胰岛素分泌曲线选择胰岛素促泌剂具有较好的促胰岛素分泌效果和降糖效果,有利于缩短血糖控制达标时间和住院时间,提高血糖达标率。展开更多
A new supramolecular compound, { [2-（2-pyridyl）benzimidazoleH2]2＋.[SBC15]2-}2, was synthesized by the hydrothermal reaction of o-diaminobenzene, 2-pyridinecarboxylie acid and SbCl3 in 1：1 HC1 solution, and charact...A new supramolecular compound, { [2-（2-pyridyl）benzimidazoleH2]2＋.[SBC15]2-}2, was synthesized by the hydrothermal reaction of o-diaminobenzene, 2-pyridinecarboxylie acid and SbCl3 in 1：1 HC1 solution, and characterized by chemical analysis, elemental analysis, IR spectra, thermogravimetfic analysis and fluorescence spectra. The crystal structure was deter- mined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P211c, with a = 16.0397（13）, b = 14.3189（12）, c = 15.6370（13） A, β = 105.8980（10）°, V = 3454.0（5） A3, Z = 4, C24H22Cl10N6Sb2, Mr = 992.48, Dc = 1.909 g/cm3,/z = 2.366 mm-1, S = 1.010, F（000） = 1920, R = 0.0254 and wR = 0.0555. The coordination anion, [SbCl5]2- which is a distorted tetragonal pyramid, is composed by coordinating action with Sb3＋ ion and five adjacent chloride ions. Every four coordination anions of [SbCl5]2- form a biquaternion ring structure through the secondary bonding of Sb...Cl. Moreover, the compound adopts a three-dimensional network supramolecular structure because of the hydrogen bonds and π-π stacking between the rings and the 2-（2-pyridyl）benzimidazole divalent cations. The title compound also shows good fluorescent behaviors.展开更多
Borosilicate glass with high rare earth content was fabricated by traditional method. The influence of glass compositions and rare earth content on absorption spectra was examined and discussed. With increasing Sm2O3 ...Borosilicate glass with high rare earth content was fabricated by traditional method. The influence of glass compositions and rare earth content on absorption spectra was examined and discussed. With increasing Sm2O3 content, the intensity of characteristic absorption peak is increased and the absorption peak is broadened. With increasing of the ratios of SiO2/B2O3 and Al2O3/SiO2, the broadening degree of absorption peak is increased. The experimental results provide basis for making special optical glasses which have the characteristics of high absorption for special wavelength laser and high transparence for visible light.展开更多
Variants at the GTF2I repeat domain containing 1(GTF2IRD1)–GTF2I locus are associated with primary Sj?gren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that ...Variants at the GTF2I repeat domain containing 1(GTF2IRD1)–GTF2I locus are associated with primary Sj?gren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1–GTF2I polymorphisms and neuromyelitis optica spectrum disorders(NMOSD). This case control study assessed this association by recruiting 305 participants with neuromyelitis optica spectrum disorders and 487 healthy controls at the Department of Neurology, from September 2014 to April 2017. Peripheral blood was collected, DNA extracteds and the genetic association between GTF2IRD1–GTF2I polymorphisms and neuromyelitis optica spectrum disorders in the Chinese Han population was analyzed by genotyping. We found that the T allele of rs117026326 was associated with an increased risk of neuromyelitis optica spectrum disorders(odds ratio(OR) = 1.364, 95% confidence interval(CI) 1.019–1.828; P = 0.037). This association persisted after stratification analysis for aquaporin-4 immunoglobulin G antibodies(AQP4-IgG) positivity(OR = 1.397, 95% CI 1.021–1.912; P = 0.036) and stratification according to coexisting autoimmune diseases(OR = 1.446, 95% CI 1.072–1.952; P = 0.015). Furthermore, the CC genotype of rs73366469 was frequent in AQP4-IgG-seropositive patients(OR = 3.15, 95% CI 1.183–8.393, P = 0.022). In conclusion, the T allele of rs117026326 was associated with susceptibility to neuromyelitis optica spectrum disorders, and the CC genotype of rs73366469 conferred susceptibility to AQP4-IgG-seropositivity in Han Chinese patients. The protocol was approved by the Ethics Committee of West China Hospital of Sichuan University, China(approval number: 2016-31) on March 2, 2016.展开更多
An accurate and efficient Synthetic Aperture Radar(SAR)raw data generator is of considerable value for testing system parameters and verifying imaging algorithms.Nevertheless,the existing simulator cannot exactly hand...An accurate and efficient Synthetic Aperture Radar(SAR)raw data generator is of considerable value for testing system parameters and verifying imaging algorithms.Nevertheless,the existing simulator cannot exactly handle the case of the fast moving targets in high squint geometry.As for the issue,the analytical expression for the two Dimensional(2-D)signal spectrum of moving targets is derived and a fast raw echo simulation method is proposed in this study.The proposed simulator can accommodate the moving targets in the high squint geometry,whose processing steps of the simulation are given in detail and its computational complexity is analyzed.The simulation data for static and moving targets are processed and analyzed,and the results are given to validate the effectiveness of the proposed approach.展开更多
Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In Ch...Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible.展开更多
Based on analysis of NMR T2 spectral characteristics,a new method for identifying fluid properties by decomposing T2 spectrum through signal analysis has been proposed.Because T2 spectrum satisfies lognormal distribut...Based on analysis of NMR T2 spectral characteristics,a new method for identifying fluid properties by decomposing T2 spectrum through signal analysis has been proposed.Because T2 spectrum satisfies lognormal distribution on transverse relaxation time axis,the T2 spectrum can be decomposed into 2 to 5 independent component spectra by fitting the T2 spectrum with Gauss functions.By analyzing the free relaxation response characteristics of crude oil and formation water,the dynamic response characteristics of the core mutual drive between oil and water,the petrophysical significance of each component spectrum is clarified.T2 spectrum can be decomposed into clay bound water component spectrum,capillary bound fluid component spectrum,micropores fluid component spectrum and macropores fluid component spectrum.According to the nature of crude oil in the target area,the distribution range of T2 component spectral peaks of oil-bearing reservoir is 165-500 ms on T2 time axis.This range can be used to accurately identify fluid properties.This method has high adaptability in identifying complex oil and water layers in low porosity and permeability reservoirs.展开更多
文摘目的探究胰岛素分泌曲线和血糖谱在2型糖尿病选择胰岛素促泌剂中的价值,为临床胰岛素促泌剂选择提供依据。方法本研究为随机对照试验,选取2015年12月至2020年12月东营市第二人民医院根据降糖治疗需要选用胰岛素促泌剂的2型糖尿病患者120例作为研究对象,采用随机数字表法分为观察组和对照组,各60例。观察组男38例、女22例,年龄(58.27±6.34)岁,病程(3.62±1.28)年;对照组男33例、女27例,年龄(59.04±7.82)岁,病程(3.55±1.17)年。观察组进行馒头餐试验并依据胰岛素分泌曲线选择胰岛素促泌剂;对照组依据血糖谱选择胰岛素促泌剂,两组均治疗24周。对比两组患者血糖控制达标平均天数、血糖达标率、住院天数、低血糖发生率及治疗前后胰岛素β细胞功能[空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、C肽(CP)水平]、血糖[空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)]水平、不良反应发生情况。采用t检验、χ^(2)检验。结果观察组血糖控制达标平均天数、住院天数均短于对照组[(7.05±1.42)d比(8.39±1.86)d、(10.29±2.08)d比(11.35±2.17)d],血糖达标率高于对照组[86.67%(52/60)比71.67%(43/60)],差异均有统计学意义(t=4.436、2.732,χ^(2)=4.093;均P<0.05)。治疗后,观察组FINS、CP水平均高于对照组[(9.32±1.55)IU/L比(8.46±1.38)IU/L、(1.49±0.39)μg/L比(1.35±0.32)μg/L],HOMA-IR低于对照组[(1.92±0.43)比(2.37±0.84)],差异均有统计学意义(t=3.210、2.150、3.694,均P<0.05)。治疗后,观察组FPG、2 h PBG、HbA1c水平均低于对照组[(6.47±1.12)mmol/L比(7.35±0.94)mmol/L、(10.52±1.17)mmol/L比(11.83±1.59)mmol/L、(6.12±1.09)%比(6.79±1.35)%],差异均有统计学意义(t=4.662、5.140、2.991,均P<0.05)。观察组不良反应发生率为15.00%(9/60),与对照组[18.33%(11/60)]比较,差异无统计学意义(χ^(2)=0.240,P=0.624)。结论与血糖谱相比,经胰岛素分泌曲线选择胰岛素促泌剂具有较好的促胰岛素分泌效果和降糖效果,有利于缩短血糖控制达标时间和住院时间,提高血糖达标率。
基金Supported by the Natural Science Foundation of Henan Province (No. 0611023700)Natural Science Foundation of Education Department of Henan Province (No. 2006150019)
文摘A new supramolecular compound, { [2-（2-pyridyl）benzimidazoleH2]2＋.[SBC15]2-}2, was synthesized by the hydrothermal reaction of o-diaminobenzene, 2-pyridinecarboxylie acid and SbCl3 in 1：1 HC1 solution, and characterized by chemical analysis, elemental analysis, IR spectra, thermogravimetfic analysis and fluorescence spectra. The crystal structure was deter- mined by X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P211c, with a = 16.0397（13）, b = 14.3189（12）, c = 15.6370（13） A, β = 105.8980（10）°, V = 3454.0（5） A3, Z = 4, C24H22Cl10N6Sb2, Mr = 992.48, Dc = 1.909 g/cm3,/z = 2.366 mm-1, S = 1.010, F（000） = 1920, R = 0.0254 and wR = 0.0555. The coordination anion, [SbCl5]2- which is a distorted tetragonal pyramid, is composed by coordinating action with Sb3＋ ion and five adjacent chloride ions. Every four coordination anions of [SbCl5]2- form a biquaternion ring structure through the secondary bonding of Sb...Cl. Moreover, the compound adopts a three-dimensional network supramolecular structure because of the hydrogen bonds and π-π stacking between the rings and the 2-（2-pyridyl）benzimidazole divalent cations. The title compound also shows good fluorescent behaviors.
文摘Borosilicate glass with high rare earth content was fabricated by traditional method. The influence of glass compositions and rare earth content on absorption spectra was examined and discussed. With increasing Sm2O3 content, the intensity of characteristic absorption peak is increased and the absorption peak is broadened. With increasing of the ratios of SiO2/B2O3 and Al2O3/SiO2, the broadening degree of absorption peak is increased. The experimental results provide basis for making special optical glasses which have the characteristics of high absorption for special wavelength laser and high transparence for visible light.
基金supported by the National Natural Science Foundation of China,No.81271321(to HYZ)a grant from the Department of Science and Technology Research Projects in Sichuan Province of China,No.2013FZ0015(to HYZ)the Fundamental Research Funds for the Central Universities,China,No.2017SCU11049(to QZ)
文摘Variants at the GTF2I repeat domain containing 1(GTF2IRD1)–GTF2I locus are associated with primary Sj?gren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1–GTF2I polymorphisms and neuromyelitis optica spectrum disorders(NMOSD). This case control study assessed this association by recruiting 305 participants with neuromyelitis optica spectrum disorders and 487 healthy controls at the Department of Neurology, from September 2014 to April 2017. Peripheral blood was collected, DNA extracteds and the genetic association between GTF2IRD1–GTF2I polymorphisms and neuromyelitis optica spectrum disorders in the Chinese Han population was analyzed by genotyping. We found that the T allele of rs117026326 was associated with an increased risk of neuromyelitis optica spectrum disorders(odds ratio(OR) = 1.364, 95% confidence interval(CI) 1.019–1.828; P = 0.037). This association persisted after stratification analysis for aquaporin-4 immunoglobulin G antibodies(AQP4-IgG) positivity(OR = 1.397, 95% CI 1.021–1.912; P = 0.036) and stratification according to coexisting autoimmune diseases(OR = 1.446, 95% CI 1.072–1.952; P = 0.015). Furthermore, the CC genotype of rs73366469 was frequent in AQP4-IgG-seropositive patients(OR = 3.15, 95% CI 1.183–8.393, P = 0.022). In conclusion, the T allele of rs117026326 was associated with susceptibility to neuromyelitis optica spectrum disorders, and the CC genotype of rs73366469 conferred susceptibility to AQP4-IgG-seropositivity in Han Chinese patients. The protocol was approved by the Ethics Committee of West China Hospital of Sichuan University, China(approval number: 2016-31) on March 2, 2016.
文摘An accurate and efficient Synthetic Aperture Radar(SAR)raw data generator is of considerable value for testing system parameters and verifying imaging algorithms.Nevertheless,the existing simulator cannot exactly handle the case of the fast moving targets in high squint geometry.As for the issue,the analytical expression for the two Dimensional(2-D)signal spectrum of moving targets is derived and a fast raw echo simulation method is proposed in this study.The proposed simulator can accommodate the moving targets in the high squint geometry,whose processing steps of the simulation are given in detail and its computational complexity is analyzed.The simulation data for static and moving targets are processed and analyzed,and the results are given to validate the effectiveness of the proposed approach.
基金This work was supported by the Chinese National Nature Science Foundation research Grant 30572015Beijing Nature Science Foundation research Grant 7062062.
文摘Mutations in GJB2 gene are the most frequently found mutations in patients with nonsyndromic hearing impairment. However, the spectrum and prevalence of mutations in this gene vary among different ethnic groups. In China, 30,000 infants are born with congenital hearing impairment annually. In order to provide appropriate genetic testing and counseling to the families, we investigated the molecular etiology of nonsyndromic deafness in 103 unrelated school children attending Nantong School for the Deaf and Mute in Jiangsu Province, China. The coding exon of the GJB2 gene was PCR amplified and sequenced. Sixty two GJB2 mutant alleles were identified in 35.9% (37/103) of the patients. Twenty five patients carried two pathogenic mutations and 12 patients carried one mutant allele. The 235delC was the most common mutation accounting for 69.4% (43/62) of GJB2 mutant alleles. The GJB2 mutant alleles accounted for 30.1% (62/206) of all chromosomes responsible for nonsyndromic hearing impairment. Testing of the 3 most prevalent deleterious frame shift mutations in this cohort detected 100% of all GJB2 mutant alleles. These results demonstrate that an effective genetic testing of GJB2 gene for patients and families with nonsyndromic hearing impairment is possible.
基金Supported by the China National Science and Technology Major Project(2016ZX05050)
文摘Based on analysis of NMR T2 spectral characteristics,a new method for identifying fluid properties by decomposing T2 spectrum through signal analysis has been proposed.Because T2 spectrum satisfies lognormal distribution on transverse relaxation time axis,the T2 spectrum can be decomposed into 2 to 5 independent component spectra by fitting the T2 spectrum with Gauss functions.By analyzing the free relaxation response characteristics of crude oil and formation water,the dynamic response characteristics of the core mutual drive between oil and water,the petrophysical significance of each component spectrum is clarified.T2 spectrum can be decomposed into clay bound water component spectrum,capillary bound fluid component spectrum,micropores fluid component spectrum and macropores fluid component spectrum.According to the nature of crude oil in the target area,the distribution range of T2 component spectral peaks of oil-bearing reservoir is 165-500 ms on T2 time axis.This range can be used to accurately identify fluid properties.This method has high adaptability in identifying complex oil and water layers in low porosity and permeability reservoirs.
