Correlation Analysis Between Changes of D-Dimer Level and Rheumatoid Arthritis Complicated with Interstitial Lung Disease

Objective:To explore the correlation between the change of D-dimer level and rheumatoid arthritis complicated with interstitial lung disease.Methods:From January 2022 to February 2024,20 rheumatoid arthritis patients complicated with interstitial lung disease(interstitial lung disease group),20 rheumatoid arthritis patients without interstitial lung disease(without interstitial lung disease group),and 20 healthy people(control group)in Xijing Hospital were selected for this study.The fasting venous blood of the three groups of subjects was collected and their D-dimer,C-reactive protein(CRP),rheumatoid factor(RF),and erythrocyte sedimentation rate(ESR)were detected.Subsequently,the correlation between each index and rheumatoid arthritis complicated with interstitial lung disease was analyzed.Results:The D-dimer level of the interstitial lung disease group was significantly higher than the other two groups(P<0.05).The D-dimer level of the group without interstitial lung disease was significantly higher than the control group(P<0.05).CRP levels in the interstitial lung disease group and the group without interstitial lung disease were significantly higher than those of the control group(P<0.05).The ESR and RF levels of the interstitial lung disease group were significantly higher than the other two groups(P<0.05).The levels of ESR and RF levels of the group without interstitial lung disease were significantly higher than the control group(P<0.05).Conclusion:D-dimer levels of rheumatoid arthritis patients are higher than those of healthy individuals,and those complicated with interstitial lung disease present even higher levels.This finding shows that there is a correlation between D-dimer levels and rheumatoid arthritis with interstitial lung disease,which may facilitate the evaluation and diagnosis of this disease.

Volatile profile and multivariant analysis of Sanhuang chicken breast in combination with Chinese 5-spice blend and garam masala

Sanhuang chicken is a popular native breed in China and well-known for delicious flavour.Spices could enhance the chicken meat flavour and work well in preservation.Chinese 5-spice blend(CS)and garam masala(GM)are routinely using spices in China and Pakistan,respectively.The flavour profiles of Sanhuang chicken breast(CB)and its blends with CS and GM were obtained by electronic nose(E-nose),solid-phase microextraction gas chromatography-mass spectrometry(SPME GC-MS)and GC-ion mobility spectrometry(GC-IMS).Principal component analysis(PCA)efficiently discriminated the aroma profiles of three chicken formulations.The GC-chromatographs revealed the significant aroma alterations of chicken breast meat after marination with spices.Aldehydes were the major contributors of chicken aroma,while most of the aromatic hydrocarbons were generated by spices.Almost all chicken key-compounds produced by oxidation reaction were either reduced or eliminated by marination,showing the antioxidation capacity of spices leading to meat preservation.GC-IMS is not only a rapid and comprehensive detection method,but also proved to be more sensitive than GC-MS.The substantial role of both traditional spices in enhancing flavour quality of chicken meat,and their exposure as functional ingredients in Chinese and Pakistan cuisines could lead to the cross-cultural meat trade opportunities.

Multivariate Analysis of Community Structure Variation of Plankton and Zoobenthos in Municipal Polluted River

[Objective] The plankton and macrobenthos samples in municipal polluted river were analyzed by different methods, so as to explore the method suitable for biological data analysis in heavy polluted area. [Method] Shannon-Wiener diversity index, cluster analysis of multivariate statistical analysis and MDS （Non-matric Multi- dimentional Scaling）analysis were used to analyze biological data of phytoplankton, zooplankton and Zoobenthos collected from the representative municipal polluted river in Pearl River Delta. The sediment samples were also collected to determine. Pb, Cd, Hg, Cr, As, Cu, Ni, Zn, as well as CODe, and NH3-N of porewater. Hakanson potential ecological risk index method was used to evaluate the ecological risk. [Re- suit] Shannon-Wiener diversity index analysis results can not effectively reflect the difference of pollution status of various stations in heavy polluted area; despite the presence of some problems, multivariate analysis method is superior to the Shannon-Wiener diversity index method in biological monitoring of heavy polluted river in the city. [Conclusion] The paper provided theoretical basis for biological data analysis in heavy polluted area.

Advancing Autoencoder Architectures for Enhanced Anomaly Detection in Multivariate Industrial Time Series

In the context of rapid digitization in industrial environments,how effective are advanced unsupervised learning models,particularly hybrid autoencoder models,at detecting anomalies in industrial control system(ICS)datasets?This study is crucial because it addresses the challenge of identifying rare and complex anomalous patterns in the vast amounts of time series data generated by Internet of Things(IoT)devices,which can significantly improve the reliability and safety of these systems.In this paper,we propose a hybrid autoencoder model,called ConvBiLSTMAE,which combines convolutional neural network(CNN)and bidirectional long short-term memory(BiLSTM)to more effectively train complex temporal data patterns in anomaly detection.On the hardware-in-the-loopbased extended industrial control system dataset,the ConvBiLSTM-AE model demonstrated remarkable anomaly detection performance,achieving F1 scores of 0.78 and 0.41 for the first and second datasets,respectively.The results suggest that hybrid autoencoder models are not only viable,but potentially superior alternatives for unsupervised anomaly detection in complex industrial systems,offering a promising approach to improving their reliability and safety.

Analysis of optical axis deviation caused by structural stiffness in equatorial telescopes

The impact of structural stiffness on optical axis deviation poses a significant challenge in the design of equatorial telescope structures.A comprehensive analysis during the design process can reduce the reliance of a telescope on advanced control technologies,thereby improving its economic feasibility.Although full-system finite element analyses are reliable,they are encumbered by significant time requirements and limitations in covering all possible telescope orientations.Therefore,we propose an efficient and comprehensive analytical method to evaluate the optical axis deviation of equatorial telescopes across a full range of angles.To address the challenge of ensuring that the analysis covers all possible positions of an equatorial telescope,based on a model from SiTian project,we analyze the optical axis deviations caused by the fork arm at 25 different angles and then use fitting methods to obtain results for all angles.Based on the analysis results of the optical axis deviation caused by the stiffness of the optical tube in the horizontal position,we derive the results for the tube at any position using geometric relationships.Finally,we calculate the coupling factors and combine these impacts.Furthermore,we identify six discrete feature points to reflect possible telescope orientations and conduct comprehensive finite element analyses.The results are in alignment with those acquired through a comprehensive computational approach.

R-Factor Analysis of Data Based on Population Models Comprising R- and Q-Factors Leads to Biased Loading Estimates

Effects of performing an R-factor analysis of observed variables based on population models comprising R- and Q-factors were investigated. Although R-factor analysis of data based on a population model comprising R- and Q-factors is possible, this may lead to model error. Accordingly, loading estimates resulting from R-factor analysis of sample data drawn from a population based on a combination of R- and Q-factors will be biased. It was shown in a simulation study that a large amount of Q-factor variance induces an increase in the variation of R-factor loading estimates beyond the chance level. Tests of the multivariate kurtosis of observed variables are proposed as an indicator of possible Q-factor variance in observed variables as a prerequisite for R-factor analysis.

Outcomes of treatment of male urethral stricture：a multivariate analysis

目的：分析外伤性和前列腺术后尿道狭窄各种治疗方法的优缺点及影响因素，为临床上合理选择治疗方式、减少狭窄复发提出有益建议。方法：对本科64例外伤性和59例前列腺术后的尿道狭窄初次治疗共123例进行回顾性多因素分析。结果：64例外伤性尿道狭窄患者中，尿扩22例，20例（90．9％）复发；尿道内切开21例，16例（76．2％）复发；尿道端端吻合21例，4例（19％）复发；59例前列腺术后尿道狭窄中，尿扩16例，15例（93．6％）复发；尿道内切开37例，5例（13．5％）复发；6例切开膀胱行膀胱颈疤痕切开切除膀胱颈整形术，3例（50％）复发。结论：①经尿道疤痕切开切除治疗外伤性尿道狭窄，其疗效与狭窄长度有关，狭窄长度〈2cm复发率低，〉2121／1则复发率高。②尿道疤痕切除端端吻合治疗外伤性尿道狭窄，其疗效与狭窄长度、狭窄部位、既往手术史无关，与手术本身有关，即术中如彻底切除狭窄疤痕及坏死组织、吻合无张力则复发率低，反之则高。⑧尿扩适用于尿道黏膜下狭窄，不适用于合并有尿道海绵体纤维化的尿道狭窄。④尿道内切开是治疗前列腺术后尿道狭窄的首选方法且疗效好。

Comprehensive multivariate grey incidence degree based on principal component analysis

To overcome the too fine-grained granularity problem of multivariate grey incidence analysis and to explore the comprehensive incidence analysis model, three multivariate grey incidences degree models based on principal component analysis （PCA） are proposed. Firstly, the PCA method is introduced to extract the feature sequences of a behavioral matrix. Then, the grey incidence analysis between two behavioral matrices is transformed into the similarity and nearness measure between their feature sequences. Based on the classic grey incidence analysis theory, absolute and relative incidence degree models for feature sequences are constructed, and a comprehensive grey incidence model is proposed. Furthermore, the properties of models are researched. It proves that the proposed models satisfy the properties of translation invariance, multiple transformation invariance, and axioms of the grey incidence analysis, respectively. Finally, a case is studied. The results illustrate that the model is effective than other multivariate grey incidence analysis models.

Groundwater quality assessment using multivariate analysis,geostatistical modeling, and water quality index(WQI): a case of study in the Boumerzoug-El Khroub valley of Northeast Algeria

In this study,the analytical data set of 26 groundwater samples from the alluvial aquifer of Boumerzoug-E1 khroub valley has been processed simultaneously with Multivariate analysis,geostatistical modeling,WQI,and geochemical modeling.Cluster analysis identified three main water types based on the major ion contents,where mineralization increased from group 1 to group 3.These groups were confirmed by FA/PCA,which demonstrated that groundwater quality is influenced by geochemical processes(water-rock interaction)and human practice(irrigation).The exponential semivariogram model WQI.Groundwater chemistry has a strong spatial structure for Mg,Na,Cl,and NO3,and a moderate spatial structure for EC,Ca,K,HCO3,and SO4.Water quality maps generated using ordinary Kriging are consistent with the HCA and PCA results.All water groups are supersaturated with respect to carbonate minerals,and dissolution of kaolinite and Ca-smectite is one of the processes responsible for hydrochemical evolution in the area.

A multivariate partial least squares approach to joint association analysis for multiple correlated traits

Many complex traits are highly correlated rather than independent. By taking the correlation structure of multiple traits into account, joint association analyses can achieve both higher statistical power and more accurate estimation. To develop a statistical approach to joint association analysis that includes allele detection and genetic effect estimation, we combined multivariate partial least squares regression with variable selection strategies and selected the optimal model using the Bayesian Information Criterion(BIC). We then performed extensive simulations under varying heritabilities and sample sizes to compare the performance achieved using our method with those obtained by single-trait multilocus methods. Joint association analysis has measurable advantages over single-trait methods, as it exhibits superior gene detection power, especially for pleiotropic genes. Sample size, heritability,polymorphic information content(PIC), and magnitude of gene effects influence the statistical power, accuracy and precision of effect estimation by the joint association analysis.

Multivariate Statistical Process Monitoring of an Industrial Polypropylene Catalyzer Reactor with Component Analysis and Kernel Density Estimation

Abstract Data-driven tools, such as principal component analysis （PCA） and independent component analysis （ICA） have been applied to different benchmarks as process monitoring methods. The difference between the two methods is that the components of PCA are still dependent while ICA has no orthogonality constraint and its latentvariables are independent. Process monitoring with PCA often supposes that process data or principal components is Gaussian distribution. However, this kind of constraint cannot be satisfied by several practical processes. To ex-tend the use of PCA, a nonparametric method is added to PCA to overcome the difficulty, and kernel density estimation （KDE） is rather a good choice. Though ICA is based on non-Gaussian distribution intormation, .KDE can help in the close monitoring of the data. Methods, such as PCA, ICA, PCA.with .KDE（KPCA）, and ICA with KDE,（KICA）, are demonstrated and. compared by applying them to a practical industnal Spheripol craft polypropylene catalyzer reactor instead of a laboratory emulator.

Advanced reliability analysis of slopes in spatially variable soils using multivariate adaptive regression splines

This study aims to extend the multivariate adaptive regression splines(MARS)-Monte Carlo simulation(MCS) method for reliability analysis of slopes in spatially variable soils. This approach is used to explore the influences of the multiscale spatial variability of soil properties on the probability of failure(P_f) of the slopes. In the proposed approach, the relationship between the factor of safety and the soil strength parameters characterized with spatial variability is approximated by the MARS, with the aid of Karhunen-Loeve expansion. MCS is subsequently performed on the established MARS model to evaluate Pf.Finally, a nominally homogeneous cohesive-frictional slope and a heterogeneous cohesive slope, which are both characterized with different spatial variabilities, are utilized to illustrate the proposed approach.Results showed that the proposed approach can estimate the P_f of the slopes efficiently in spatially variable soils with sufficient accuracy. Moreover, the approach is relatively robust to the influence of different statistics of soil properties, thereby making it an effective and practical tool for addressing slope reliability problems concerning time-consuming deterministic stability models with low levels of P_f.Furthermore, disregarding the multiscale spatial variability of soil properties can overestimate or underestimate the P_f. Although the difference is small in general, the multiscale spatial variability of the soil properties must still be considered in the reliability analysis of heterogeneous slopes, especially for those highly related to cost effective and accurate designs.

Surgical mortality in patients with malignant obstructive jaundice: a multivariate discriminant analysis

OBJECTIVE: To estimate the operative mortality in patients with malignant obstructive jaundice. METHODS: Twelve risk factors were analyzed using multivariate discriminant analysis in 90 patients who had been operated on. RESULTS: Operative mortality was significantly related to the following factors: age, duration of jaundice, packed RBC volume, white blood cell count and concentration of blood urine nitrogen; it was not significantly related to diseases and types of operation. The following formula was obtained: packed RBC volume×0.09954-age×0. 04018-blood urine nitrogen×0. 23693-duration of jaundice× 2. 07388-WBC count×0. 21118+5. 26593. With this formula, an operative mortality of 77. 8% was predicted. CONCLUSION: With a positive value from the formula, the patient should be operated on; otherwise non-operative treatment is advocated.

Construction of Inorganic Elemental Fingerprint and Multivariate Statistical Analysis of Marine Traditional Chinese Medicine Meretricis concha from Rushan Bay

Meretricis concha is a kind of marine traditional Chinese medicine(TCM), and has been commonly used for the treatment of asthma and scald burns. In order to investigate the relationship between the inorganic elemental fingerprint and the geographical origin identification of Meretricis concha, the elemental contents of M. concha from five sampling points in Rushan Bay have been determined by means of inductively coupled plasma optical emission spectrometry(ICP-OES). Based on the contents of 14 inorganic elements(Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se, and Zn), the inorganic elemental fingerprint which well reflects the elemental characteristics was constructed. All the data from the five sampling points were discriminated with accuracy through hierarchical cluster analysis(HCA) and principle component analysis(PCA), indicating that a four-factor model which could explain approximately 80% of the detection data was established, and the elements Al, As, Cd, Cu, Ni and Pb could be viewed as the characteristic elements. This investigation suggests that the inorganic elemental fingerprint combined with multivariate statistical analysis is a promising method for verifying the geographical origin of M. concha, and this strategy should be valuable for the authenticity discrimination of some marine TCM.

ASSESSMENT OF LOCAL INFLUENCE IN MULTIVARIATE ANALYSIS

A recent method for assessing the local influence is introduced by Cook(1986), in which the normal curvature of the influence graph based on the likelihood displacement is used to monitor the influence of small perturbation. Since then this method has been applied to various kind of models. However, the local influence in multivariate analysis is still an unexplored area because the influence for many statistics in multivariate analysis is not convenient to handle based on the Cook's likelihood displacement. In this paper, we suggest a method with a slight modification in Cook's approach to assess the local influence of small perturbation on a certain statistic. The local influence of the perturbation on eigenvalue and eigenvector of variance-covariance matrix in theoretical and sample version is assessed, some results for the other statistics in multivariate analysis such as generalized variance, canonical correlations are studied. Finally, two examples are analysed for illustration.

ONE-WAY MULTIVARIATE REPEATED MEASUREMENTS ANALYSIS OF VARIANCE MODEL

The one-way multivariate repeated measurements analysis of variance (1-way MRM ANOVA) model for complete data and the sphericity test are studied.

Pathogenetic factors affecting gastroesophageal refluxin patients with esophagitis and concomitant duodenal ulcer:a multivariate analysis

AIM To assess the relationship between gastric acid output (GAO) and both pattern of gastroesophageal reflux (GER) and esophageal lesions, and to evaluate the role of GAO and other potential pathogenetic factors in the development of esophagitis. METHODS Gastric acid secretory testing and 24 h intraesophageal pH monitoring were performed in 31 patients with esophagitis and concomitant duodenal ulcer (E+DU) and compared with those of 72 patients with esophagitis (E) alone. RESULTS The GAO in patients with E+DU was significantly higher than in patients with E ( P <0 05). There was no significant difference between the two groups of patients as to endoscopicl findings and parameters of GER ( P >0 05). A multiple regression analysis with stepwise deletion showed that the pre sence of hiatal hernia (HH), GER in upright position and age appeared to correlate significantly with the presence of esophagitis. CONCLUSIONS No parallel relationship between GAO and severity of GER or esophageal lesions exists in patients with E+DU, and that GAO is not a major pathogenetic factor in GER disease.

Analysis of fatty acid composition of sea cucumber Apostichopus japonicus using multivariate statistics

Fatty acids(FAs) provide energy and also can be used to trace trophic relationships among organisms.Sea cucumber Apostichopus japonicus goes into a state of aestivation during warm summer months.We examined fatty acid profiles in aestivated and non-aestivated A.japonicus using multivariate analyses(PERMANOVA,MDS,ANOSIM,and SIMPER).The results indicate that the fatty acid profiles of aestivated and non-aestivated sea cucumbers differed significantly.The FAs that were produced by bacteria and brown kelp contributed the most to the differences in the fatty acid composition of aestivated and nonaestivated sea cucumbers.Aestivated sea cucumbers may synthesize FAs from heterotrophic bacteria during early aestivation,and long chain FAs such as eicosapentaenoic(EPA) and docosahexaenoic acid(DHA) that produced from intestinal degradation,are digested during deep aestivation.Specific changes in the fatty acid composition of A.japonicus during aestivation needs more detailed study in the future.

Impact of Chronicity on Outcomes Following Post-Hospital Residential Brain Injury Rehabilitation: Application of Multivariate Statistics and Rasch Analysis

This study evaluated the impact of chronicity (onset of injury to admission in-terval) on three domains of functional outcomes for a large group of traumatic brain injured (TBI) survivors. Subjects included 528 TBI adults who were treated in post-hospital residential rehabilitation centers. Subjects were assigned to one of three chronicity groups: 1) Early Interval (EI), 2.00 - 8.00 months n = 245, 2) Mid Interval (MI), 8.01 - 24.00 months n = 129, and (3) Late Interval (LI), 24.01 months and greater n = 154. Functional status was assessed with the MPAI-4. RM MANCOVA was applied to evaluate differences among groups from admission to discharge. Rasch analysis demonstrated satisfactory construct validity and internal consistency (Person reliability = 0.90 - 0.94, Item reliability = 0.99) for the admission and discharge MPAI-4s. Controlling for LOS and age, the RM MANCOVA revealed that each chronicity group showed significant improvement in MPAI-4 abilities, adjustment, and participation indices from admission to discharge (p < 0.001). Improvement observed from admission to discharge was the greatest among the EI group (p < 0.001). This study demonstrated the utility of multivariate statistical approaches for understanding the complexities of TBI treatment outcomes. As measured across three domains of functioning, rehabilitation was effective in reducing disability for participants in each chronicity group. Of the three groups, EI participants presented as the most disabled at admission but also made the greatest gains when assessed at discharge.

Water Quality Analysis of the Songhua River Basin Using Multivariate Techniques

Multivariate statistical techniques, including cluster analysis (CA), principal component analysis (PCA), factor analysis (FA) and discriminant analysis (DA), were used to evaluate temporal and spatial variations and to interpret a large and complex water quality data sets collected from the Songhua River Basin. The data sets, which contained 14 parameters, were generated during the 7-year (1998-2004) monitoring program at 14 different sites along the rivers. Three significant sampling locations (less polluted sites, moderately polluted sites and highly polluted sites) were detected by CA method, and five latent factors (organic, inor-ganic, petrochemical, physiochemical, and heavy metals) were identified by PCA and FA methods. The re-sults of DA showed only five parameters (temperature, pH, dissolved oxygen, ammonia nitrogen, and nitrate nitrogen) and eight parameters (temperature, pH, dissolved oxygen, biochemical oxygen demand, ammonia nitrogen, nitrate nitrogen, volatile phenols and total arsenic) were necessarily in temporal and spatial varia-tions analysis, respectively. Furthermore, this study revealed the major causes of water quality deterioration were related to inflow of effluent from domestic and industrial wastewater disposal.