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Prognostic value of fibrinogen and D-dimer-fibrinogen ratio in resectable gastrointestinal stromal tumors 被引量:19
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作者 Hua-Xia Cai Xu-Qi Li Shu-Feng Wang 《World Journal of Gastroenterology》 SCIE CAS 2018年第44期5046-5056,共11页
AIM To investigate the prognostic value of preoperative fbri-nogen concentration (FIB) and D-dimer-fibrinogen ratio (DFR) in gastrointestinal stromal tumors (GISTs).METHODS The purpose of this study was to retro... AIM To investigate the prognostic value of preoperative fbri-nogen concentration (FIB) and D-dimer-fibrinogen ratio (DFR) in gastrointestinal stromal tumors (GISTs).METHODS The purpose of this study was to retrospectively ana-lyze 170 patients with GISTs who were admitted to our hospital from January 2010 to December 2015. The op-timal cutoff values of related parameters were estimated by receiver operating characteristic (ROC) curve analysis. The recurrence free survival (RFS) rate was evaluated using Kaplan-Meier curves. Univariate analysis and multivariate Cox regression models were used to analyze the prognostic factors of GISTs. The relationship between the FIB, D-dimer, DFR, platelet count (PLT), and the clinicopathological features of GISTs was described by the chi-square test or nonparametric rank sum test (Mann-Whitney test).RESULTS In ROC analysis, the optimal cutoff values of FIB, D-dimer, DFR, and PLT were 3.24 g/L, 1.24 mg/L, 0.354, and 197.5 (× 109/L), respectively. Univariate analysis and the Kaplan-Meier survival curve showed that FIB, D-dimer, DFR, PLT,National Institutes of Health (NIH) risk category, tumor size, tumor location, and mitotic index were signifcantly relevant to the 3-year and 5-year survival rate of patients ( P 〈 0.05). Cox multivariate regression analysis illustrated that FIB (RR: 0.108, 95%CI: 0.031-0.373), DFR (RR: 0.319, 95%CI: 0.131-0.777), and NIH risk category ( RR: 0.166, 95%CI: 0.047-0.589) were independent prognostic factors of the RFS rate ( P 〈 0. 05). Moreover, FIB, D-dimer, DFR, and PLT were correlated with the clinical features of GISTs.CONCLUSIONFIB, D-dimer, DFR, and PLT are all related to the prognosis of GISTs. Moreover, FIB and DFR may be independent risk factors for predicting the prognosis of resectable GISTs. 展开更多
关键词 d-dimer d-dimer-fbrinogen ratio PROGNOSIS fibrinogen Gastrointestinal stromal tumor
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Combination of preoperative fibrinogen and D-dimer as a prognostic indicator in pancreatic ductal adenocarcinoma patients undergoing R0 resection 被引量:5
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作者 Li-Peng Zhang Hu Ren +3 位作者 Yong-Xing Du Xiao-Hao Zheng Zong-Ming Zhang Cheng-Feng Wang 《World Journal of Gastrointestinal Surgery》 SCIE 2021年第3期279-302,共24页
BACKGROUND Patients with malignant tumors frequently exhibit hyperactivation of the coagulation system and secondary increased fibrinolytic activity.Fibrinogen and D-dimer are common indicators that are crucial in the... BACKGROUND Patients with malignant tumors frequently exhibit hyperactivation of the coagulation system and secondary increased fibrinolytic activity.Fibrinogen and D-dimer are common indicators that are crucial in the coagulation/fibrinolysis system.Both indicators have been verified to have predictive value in the overall survival(OS)of many patients with solid malignancies.AIM To explore the prognostic significance of fibrinogen combined with D-dimer in pancreatic ductal adenocarcinoma(PDAC)patients undergoing radical R0 resection.METHODS We retrospectively analyzed the clinical data of 282 patients with PDAC undergoing radical R0 resection in the Cancer Hospital,Chinese Academy of Medical Sciences,between January 2010 and December 2019.The surv_cutpoint function of R language was used to determine the optimal cutoff values of the preoperative fibrinogen concentration and preoperative D-dimer concentration.Enrolled patients were further divided into the any-high group(high preoperative fibrinogen concentration and/or high preoperative D-dimer concentration)and the low-low group(low preoperative fibrinogen and D-dimer concentrations)according to the optimal cutoff values.RESULTS The optimal cutoff values of the preoperative fibrinogen concentration and preoperative D-dimer concentration were 3.31 g/L and 0.53 mg/L,respectively.Furthermore,multivariate Cox regression analysis showed that the preoperative fibrinogen concentration(HR:1.603,95%CI:1.201-2.140,P=0.001)and preoperative D-dimer concentration(HR:1.355,95%CI:1.019-1.801,P=0.036)exhibited obvious correlations with the OS of PDAC patients undergoing radical R0 resection.A prognostic analysis was further performed based on the subgroup results by using fibrinogen combined with D-dimer.The median OS duration of the low-low group(31.17 mo)was significantly longer than that of the any-high group(15.43 mo).Additionally,multivariate Cox regression analysis revealed that the degree of differentiation(P<0.001),lymph node metastasis(HR:0.663,95%CI:0.497-0.883,P=0.005),preoperative CA19-9 level(HR:1.699,95%CI:1.258-2.293,P=0.001),adjuvant therapy(HR:1.582,95%CI:1.202-2.081,P=0.001)and preoperative combined grouping(HR:2.397,95%CI:1.723-3.335,P<0.001)were independent predictors of OS in PDAC patients undergoing radical R0 resection.CONCLUSION Preoperative fibrinogen combined with D-dimer plays a predictive role in OS,and low preoperative fibrinogen and D-dimer concentrations can indicate prolonged OS in PDAC patients undergoing radical R0 resection. 展开更多
关键词 Pancreatic ductal adenocarcinoma R0 resection fibrinogen d-dimer PROGNOSIS SURVIVAL
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利用凝固曲线分析与手工法检测快速识别1例Fibrinogen Longmont
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作者 徐向东 唐宁 +3 位作者 王雄 廖庆 冯家立 张闽霞 《血栓与止血学》 CAS 2024年第3期131-134,共4页
Fibrinogen Longmont是异常纤维蛋白原血症中比较独特的一种,既往常因光学法异常而磁珠法正常的检测结果被发现。通过一个案例我们观察到Fibrinogen Longmont患者的凝固曲线与典型的低纤维蛋白原血浆凝固曲线存在明显区别:手工法检测可... Fibrinogen Longmont是异常纤维蛋白原血症中比较独特的一种,既往常因光学法异常而磁珠法正常的检测结果被发现。通过一个案例我们观察到Fibrinogen Longmont患者的凝固曲线与典型的低纤维蛋白原血浆凝固曲线存在明显区别:手工法检测可明显观测到凝块的透明特性;样本血浆与正常血浆的混合实验也出现明显的抑制效应。这些实验室表现可能有助于Fibrinogen Longmont的筛查。 展开更多
关键词 fibrinogen Longmont 凝固曲线 手工法
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Combining systemic inflammatory response index and albumin fibrinogen ratio to predict early serious complications and prognosis after resectable gastric cancer
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作者 Jing-Yao Ren Da Wang +3 位作者 Li-Hui Zhu Shuo Liu Miao Yu Hui Cai 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第3期732-749,共18页
BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of treatment.Nonetheless,patient survival rates are still low,and the incidence of major postoperative complications... BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of treatment.Nonetheless,patient survival rates are still low,and the incidence of major postoperative complications cannot be disregarded.The systemic inflammatory response,nutritional level,and coagulation status are key factors affecting the postoperative recovery and prognosis of gastric cancer patients.The systemic inflammatory response index(SIRI)and the albumin fibrinogen ratio(AFR)are two valuable comprehensive indicators of the severity and prognosis of systemic inflammation in various medical conditions.AIM To assess the clinical importance and prognostic significance of the SIRI scores and the AFR on early postoperative outcomes in patients undergoing radical gastric cancer surgery.METHODS We conducted a retrospective analysis of the clinicopathological characteristics and relevant laboratory indices of 568 gastric cancer patients from January 2018 to December 2019.We calculated and compared two indicators of inflammation and then examined the diagnostic ability of combined SIRI and AFR values for serious early postoperative complications.We scored the patients and categorized them into three groups based on their SIRI and AFR levels.COX analysis was used to compare the three groups of patients the prognostic value of various preoperative SIRI-AFR scores for 5-year overall survival(OS)and disease-free survival(DFS).RESULTS SIRI-AFR scores were an independent risk factor for prognosis[OS:P=0.004;hazards ratio(HR)=3.134;DFS:P<0.001;HR=3.543]and had the highest diagnostic power(area under the curve:0.779;95%confidence interval:0.737-0.820)for early serious complications in patients with gastric cancer.The tumor-node-metastasis stage(P=0.001),perioperative transfusion(P=0.044),positive carcinoembryonic antigen(P=0.014)findings,and major postoperative complications(P=0.011)were factors associated with prognosis.CONCLUSION Preoperative SIRI and AFR values were significantly associated with early postoperative survival and the occurrence of severe complications in gastric cancer patients. 展开更多
关键词 Inflammation Albumin fibrinogen ratio Gastric cancer COMPLICATIONS PROGNOSIS
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Impact of D-dimer on in-hospital mortality following aortic dissection:A systematic review and meta-analysis
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作者 Sashwath Srikanth Shabnam Abrishami +6 位作者 Lakshmi Subramanian Ashwini Mahadevaiah Ankit Vyas Akhil Jain Sangeetha Nathaniel Subramanian Gnanaguruparan Rupak Desai 《World Journal of Cardiology》 2024年第6期355-362,共8页
BACKGROUND The utility of D-dimer(DD)as a biomarker for acute aortic dissection(AD)is recognized.Yet,its predictive value for in-hospital mortality remains uncertain and subject to conflicting evidence.AIM To conduct ... BACKGROUND The utility of D-dimer(DD)as a biomarker for acute aortic dissection(AD)is recognized.Yet,its predictive value for in-hospital mortality remains uncertain and subject to conflicting evidence.AIM To conduct a meta-analysis of AD-related in-hospital mortality(ADIM)with elevated DD levels.METHODS We searched PubMed,Scopus,Embase,and Google Scholar for AD and ADIM literature through May 2022.Heterogeneity was assessed using I2 statistics and effect size(hazard or odds ratio)analysis with random-effects models.Sample size,study type,and patients’mean age were used for subgroup analysis.The significance threshold was P<0.05.RESULTS Thirteen studies(3628 patients)were included in our study.The pooled prevalence of ADIM was 20%(95%CI:15%-25%).Despite comparable demographic characteristics and comorbidities,elevated DD values were associated with higher ADIM risk(unadjusted effect size:1.94,95%CI:1.34-2.8;adjusted effect size:1.12,95%CI:1.05-1.19,P<0.01).Studies involving patients with a mean age of<60 years exhibited an increased mortality risk(effect size:1.43,95%CI:1.23-1.67,P<0.01),whereas no significant difference was observed in studies with a mean age>60 years.Prospective and larger sample size studies(n>250)demonstrated a heightened likelihood of ADIM associated with elevated DD levels(effect size:2.57,95%CI:1.30-5.08,P<0.01 vs effect size:1.05,95%CI:1.00-1.11,P=0.05,respectively).CONCLUSION Our meta-analysis shows elevated DD increases in-hospital mortality risk in AD patients,highlighting the need for larger,prospective studies to improve risk prediction models. 展开更多
关键词 d-dimer Aortic dissection MORTALITY BIOMARKER Systematic review META-ANALYSIS
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Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy
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作者 Taiichiro Miyake Hiroaki Yanagimoto +16 位作者 Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto 《World Journal of Clinical Cases》 SCIE 2024年第2期276-284,共9页
BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of hepatectomy.The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the... BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of hepatectomy.The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative bleeding.Therefore,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy.AIM To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after hepatectomy.METHODS The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively analyzed.Patients were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower extremities.Clinicopathological factors,including demographic data and perioperative D-dimer values,were compared between the two groups.Receiver operating characteristic curve analysis was performed to determine the D-dimer cutoff value.Univariate and multivariate analyses were performed using logistic regression analysis to identify significant predictors.RESULTS In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE group.In the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after hepatectomy.CONCLUSION Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the postoperative period. 展开更多
关键词 HEPATECTOMY Malignant tumor Postoperative complication d-dimer Early diagnosis Venous thromboembolism
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Associations of serum D-dimer and glycosylated hemoglobin levels with third-trimester fetal growth restriction in gestational diabetes mellitus
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作者 Ying Zhang Teng Li +1 位作者 Chao-Yan Yue Yun Liu 《World Journal of Diabetes》 SCIE 2024年第5期914-922,共9页
BACKGROUND Gestational diabetes mellitus(GDM)is a special type of diabetes that commonly occurs in women during pregnancy and involves impaired glucose tolerance and abnormal glucose metabolism;GDM is diagnosed for th... BACKGROUND Gestational diabetes mellitus(GDM)is a special type of diabetes that commonly occurs in women during pregnancy and involves impaired glucose tolerance and abnormal glucose metabolism;GDM is diagnosed for the first time during pregnancy and can affect fetal growth and development.AIM To investigate the associations of serum D-dimer(D-D)and glycosylated hemoglobin(HbA1c)levels with third-trimester fetal growth restriction(FGR)in GDM patients.METHODS The clinical data of 164 pregnant women who were diagnosed with GDM and delivered at the Obstetrics and Gynecology Hospital of Fudan University from January 2021 to January 2023 were analyzed retrospectively.Among these women,63 whose fetuses had FGR were included in the FGR group,and 101 women whose fetuses had normal body weights were included in the normal body weight group(normal group).Fasting venous blood samples were collected from the elbow at 28-30 wk gestation and 1-3 d before delivery to measure serum D-D and HbA1c levels for comparative analysis.The diagnostic value of serum D-D and HbA1c levels for FGR was evaluated by receiver operating characteristic analysis,and the influencing factors of third-trimester FGR in GDM patients were analyzed by logistic regression.RESULTS Serum fasting blood glucose,fasting insulin,D-D and HbA1c levels were significantly greater in the FGR group than in the normal group,while the homeostasis model assessment of insulin resistance values were lower(P<0.05).Regarding the diagnosis of FGR based on serum D-D and HbA1c levels,the areas under the curves(AUCs)were 0.826 and 0.848,the cutoff values were 3.04 mg/L and 5.80%,the sensitivities were 81.0%and 79.4%,and the specificities were 88.1%and 87.1%,respectively.The AUC of serum D-D plus HbA1c levels for diagnosing FGR was 0.928,and the sensitivity and specificity were 84.1%and 91.1%,respectively.High D-D and HbA1c levels were risk factors for third-trimester FGR in GDM patients(P<0.05).CONCLUSION D-D and HbA1c levels can indicate the occurrence of FGR in GDM patients in the third trimester of pregnancy to some extent,and their combination can be used as an important index for the early prediction of FGR. 展开更多
关键词 Gestational diabetes mellitus d-dimer HEMOGLOBIN Fetal growth restriction Fasting blood glucose
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D-Dimer: Predictor of Postpartum Hemorrhage among Pre-Eclampsia at Kilimanjaro Christian Medical Centre
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作者 Husna Silim Ally Nyasatu G. Chamba +12 位作者 Raziya Gaffur Nasra Batchu Glory Mangi Pendo S. Mlay Bariki Mchome Mtoro J. Mtoro Thomas J. Kakumbi Rafiki N. Mjema Doris Rwenyagila Eusebius Maro Fredrick Mbise Gilleard Masenga Patricia S. Swai 《Open Journal of Obstetrics and Gynecology》 2024年第6期923-937,共15页
Background: Postpartum hemorrhage (PPH) is the major contributor to maternal mortality and morbidity worldwide as well as in Tanzania. Studies have shown Pre-eclampsia as a risk indicator for Postpartum hemorrhage and... Background: Postpartum hemorrhage (PPH) is the major contributor to maternal mortality and morbidity worldwide as well as in Tanzania. Studies have shown Pre-eclampsia as a risk indicator for Postpartum hemorrhage and D-dimer tends to rise in women with pre-eclampsia. Few studies that have shown the association between D-dimer and PPH have been controversial and differ according to ethnicity and lifestyle. Hence there is no suitable reference interval for D-dimer in predicting Postpartum hemorrhage among women with pre-eclampsia. Broad Objective: This study aimed to assess the association, sensitivity, and specificity of D-dimer as a laboratory predictor of postpartum hemorrhage among women with pre-eclampsia at KCMC hospital. Methodology: This was a hospital-based analytical cross-sectional study conducted at KCMC Hospital in Northern Tanzania from September 2022 to March 2023. A total of 195 women with pre-eclampsia were included in this study. Plasma D-dimer levels were taken from women with pre-eclampsia pre-delivery. Haematocrit was compared before and after delivery, and a fall of 10% was considered as Postpartum hemorrhage together with clinical assessment of the patient. Participants were divided among those who had severe features and those who did not have severe features and were further categorized into those who had PPH and those who did not have PPH. Logistic regression was used to determine the association between D-dimer and PPH adjusting for other factors. The Receiver Operating Curve (ROC) was used to evaluate the predictive value. Results: Higher median D-dimer levels were seen among women who had PPH compared to those who had no PPH. D-dimer was seen to be associated with PPH, thus for every unit increase of µg/ml of D-dimer among women who had pre-eclampsia without severe features there was a 14% significant increase in the odds of having postpartum hemorrhage and a 45% significant increase of having postpartum hemorrhage among those who had pre-eclampsia with severe features. Furthermore, the cut-off point of a D-dimer level of 0.66 µg/ml significantly predicts postpartum hemorrhage with a sensitivity of 75% and specificity of 55%. For those who had no severe features the cut-off point was 0.53 µg/ml with a sensitivity of 95% and specificity of 53%, and for those who had severe features the cut-off point was 3.58 µg/ml with a sensitivity of 50% and specificity of 96%. Conclusion: D-dimer can be used to predict postpartum hemorrhage among pre-eclampsia, especially among those who have severe features. This shows that D-dimer has specificity in predicting PPH in women with pre-eclampsia and can be applied in clinical services to save women from maternal morbidity and mortality. Blood products such as fresh frozen plasma, platelets, and whole blood together with tranexamic acid should be readily available in women with pre-eclampsia especially those with severe features with a D-dimer level of 3.58 µg/ml and above during delivery as they are at high risk of developing PPH. 展开更多
关键词 d-dimer PREECLAMPSIA Postpartum Hemorrhage Tanzania
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Analysis of the Role of D-Dimer,Interleukin-6,and Interleukin-18 in Differential Diagnosis of Pediatric Refractory Mycoplasma pneumoniae Pneumonia
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作者 Yong Peng Aimin Li 《Journal of Clinical and Nursing Research》 2024年第7期118-122,共5页
Objective:To analyze the value of D-dimer(D-D),interleukin-6(IL-6),and IL-18 in the differential diagnosis of children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods:The medical records of 92 children w... Objective:To analyze the value of D-dimer(D-D),interleukin-6(IL-6),and IL-18 in the differential diagnosis of children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods:The medical records of 92 children with Mycoplasma pneumoniae pneumonia(MPP)treated in the hospital were selected for retrospective analysis from January 2023 to January 2024.After comprehensive examinations such as computed tomography examination of the chest,48 children with general Mycoplasma pneumoniae pneumonia(GMPP)were put in the GMPP group and 44 children with RMPP were grouped in the RMPP group.The IL-6,IL-18,and D-D levels were compared between the two groups,and the receiver operating characteristic(ROC)curves were plotted to analyze their value for differential diagnosis of RMPP.Results:The levels of IL-6,IL-18,and D-D in the RMPP group were higher than those in the GMPP group(P<0.05);the ROC curves showed that the specificity of the differential diagnosis of IL-6,IL-18,and D-D was higher,and their diagnostic value was significant.Conclusion:Determination of IL-6,IL-18,and D-D levels in children with MPP can further diagnose the children’s condition,which can help physicians formulate targeted treatment plans,and is of great significance to the improvement of the children’s condition,which is worthy of attention. 展开更多
关键词 Refractory Mycoplasma pneumoniae pneumonia d-dimer INTERLEUKIN-6 INTERLEUKIN-18 Differential diagnosis
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Correlation Analysis Between Changes of D-Dimer Level and Rheumatoid Arthritis Complicated with Interstitial Lung Disease
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作者 Ying Li 《Journal of Clinical and Nursing Research》 2024年第6期393-397,共5页
Objective:To explore the correlation between the change of D-dimer level and rheumatoid arthritis complicated with interstitial lung disease.Methods:From January 2022 to February 2024,20 rheumatoid arthritis patients ... Objective:To explore the correlation between the change of D-dimer level and rheumatoid arthritis complicated with interstitial lung disease.Methods:From January 2022 to February 2024,20 rheumatoid arthritis patients complicated with interstitial lung disease(interstitial lung disease group),20 rheumatoid arthritis patients without interstitial lung disease(without interstitial lung disease group),and 20 healthy people(control group)in Xijing Hospital were selected for this study.The fasting venous blood of the three groups of subjects was collected and their D-dimer,C-reactive protein(CRP),rheumatoid factor(RF),and erythrocyte sedimentation rate(ESR)were detected.Subsequently,the correlation between each index and rheumatoid arthritis complicated with interstitial lung disease was analyzed.Results:The D-dimer level of the interstitial lung disease group was significantly higher than the other two groups(P<0.05).The D-dimer level of the group without interstitial lung disease was significantly higher than the control group(P<0.05).CRP levels in the interstitial lung disease group and the group without interstitial lung disease were significantly higher than those of the control group(P<0.05).The ESR and RF levels of the interstitial lung disease group were significantly higher than the other two groups(P<0.05).The levels of ESR and RF levels of the group without interstitial lung disease were significantly higher than the control group(P<0.05).Conclusion:D-dimer levels of rheumatoid arthritis patients are higher than those of healthy individuals,and those complicated with interstitial lung disease present even higher levels.This finding shows that there is a correlation between D-dimer levels and rheumatoid arthritis with interstitial lung disease,which may facilitate the evaluation and diagnosis of this disease. 展开更多
关键词 d-dimer Rheumatoid arthritis complicated with interstitial lung disease ESR Rheumatoid factor Correlation analysis
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Role of fibrinogen,albumin and fibrinogen to albumin ratio in determining angiographic severity and outcomes in acute coronary syndrome
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作者 Kunaal Makkar Yash Paul Sharma +2 位作者 Akash Batta Juniali Hatwal Prashant Kumar Panda 《World Journal of Cardiology》 2023年第1期13-22,共10页
BACKGROUND Coronavirus disease 2019(COVID-19)pandemic unmasked the huge deficit in healthcare resources worldwide.It highlighted the need for efficient risk stratification in management of cardiovascular emergencies.A... BACKGROUND Coronavirus disease 2019(COVID-19)pandemic unmasked the huge deficit in healthcare resources worldwide.It highlighted the need for efficient risk stratification in management of cardiovascular emergencies.AIM To study the applicability of the old,available and affordable nonconventional biomarkers:albumin and fibrinogen in their ability to predict angiographic severity and clinical outcomes in patients with acute coronary syndrome(ACS).METHODS In this prospective,observational study,166 consecutive patients with ACS were enrolled.Fibrinogen,albumin and their ratio were determined from serum.Patients with underlying chronic liver disease,active malignancy,autoimmune disease,active COVID-19 infection and undergoing thrombolysis were excluded.RESULTS Mean age of the population was 60.5±1.5 years,74.1%being males.ST elevation myocardial infarction(STEMI)was most common presentation of ACS seen in 57%patients.Fibrinogen albumin ratio(FAR)≥19.2,had a sensitivity of 76.9%and specificity of 78.9%[area under the receiver operating characteristic curves(AUROC)=0.8,P=0.001]to predict≤thrombolysis in myocardial infarction(TIMI)1 flow in culprit artery in STEMI patients.Even in non-STEMI patients,FAR≥18.85 predicted the same with 80%sensitivity and 63%specificity(AUROC=0.715,P=0.006).CONCLUSION Novel biomarkers,with their high cost,lack of availability and long turn over time are impractical for real-world use.Identifying≤TIMI 1 flow in the culprit artery has significant impact of management and outcome.Our study has shown that readily available biomarkers like fibrinogen and albumin can help identify these high-risk patients with good accuracy.This allows risk-stratification and individualization of treatment in ACS. 展开更多
关键词 Acute coronary syndrome ALBUMIN fibrinogen fibrinogen to albumin ratio Total occlusion of culprit artery
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凝血功能四项、FDP及D-Dimer检测在产后出血诊断中的应用分析 被引量:4
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作者 路娟 何凤 《贵州医药》 CAS 2023年第1期116-117,共2页
目的分析产后出血诊断中凝血功能四项、D-Dimer、FDP检测的应用。方法将100例于本院分娩产妇依据产后出血发生情况分为发生组和未发生组两组各50例,对所有产妇的TT、PT、APTT、FIB等凝血功能四项水平进行测定并分析,对D-dime、FDP水平... 目的分析产后出血诊断中凝血功能四项、D-Dimer、FDP检测的应用。方法将100例于本院分娩产妇依据产后出血发生情况分为发生组和未发生组两组各50例,对所有产妇的TT、PT、APTT、FIB等凝血功能四项水平进行测定并分析,对D-dime、FDP水平进行测定并分析。结果分娩后,发生组的PT、APTT均长于未发生组(P<0.05),FIB水平低于未发生组(P<0.05)。分娩前后发生组的D-Dimer、FDP水平均高于未发生组(P<0.05)。分娩前后发生组的凝血功能四项、D-Dimer、FDP检测正常率均低于未发生组(P<0.05),异常率均高于未发生组(P<0.05)。结论产后出血诊断中凝血功能四项、D-Dimer、FDP检测的应用价值高。 展开更多
关键词 产后出血 凝血功能四项 d-dimer FDP
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Recent Advances in Fibrinogen Research in Colorectal Cancer 被引量:1
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作者 Wenjing Jiang Di Wang Junyan Yu 《Journal of Biosciences and Medicines》 2023年第4期28-38,共11页
Colorectal Cancer (CRC) is a common malignant tumour of the gastrointestinal tract in China, with increasing morbidity and mortality rates year by year. Most patients are in the middle and late stage when diagnosed, a... Colorectal Cancer (CRC) is a common malignant tumour of the gastrointestinal tract in China, with increasing morbidity and mortality rates year by year. Most patients are in the middle and late stage when diagnosed, and its high mortality and poor prognosis have seriously threatened the health and life. Fibrinogen (FIB) is mainly used as a coagulation factor in the body to participate in the process of coagulation and haemostasis, and is the main protein in the coagulation process. In recent years, studies at home and abroad have shown that FIB levels correlate with the diagnosis, outcome prediction and prognosis of CRC, and some of the findings are still controversial. This article aims to review the related research and new progress of the relationship between FIB and CRC in recent years. 展开更多
关键词 fibrinogen Colorectal Cancer Coagulation Function
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PCT、IL-6与D-Dimer、TAT联合检测评估患者细菌感染程度和发生血栓风险的研究
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作者 刘丹丹 李敏 +1 位作者 王奎 王亚洲 《中文科技期刊数据库(引文版)医药卫生》 2023年第4期54-58,共5页
探讨PCT、IL-6与D-Dimer、TAT联合检测在评估患者细菌感染程度和发生血栓风险的临床应用价值。方法 收集和选用无血栓背景的肺部细菌感染患者样本55例、脓毒血症患者样本66例、无细菌感染的样本10例,总样本量共131例。采用化学发光法(CL... 探讨PCT、IL-6与D-Dimer、TAT联合检测在评估患者细菌感染程度和发生血栓风险的临床应用价值。方法 收集和选用无血栓背景的肺部细菌感染患者样本55例、脓毒血症患者样本66例、无细菌感染的样本10例,总样本量共131例。采用化学发光法(CLIA)检测患者血浆中PCT、IL-6与D-Dimer、TAT的表达水平,比较4中血浆标志物的表达差异。结果 PCT和IL-6联合检测在细菌感染的诊断价值高于PCT和IL-6单项指标的检测价值。D-Dimer和TAT联合检测在血栓形成风险的诊断价值高于D-Dimer和TAT单项指标的检测价值。结论 细菌感染的严重程度与血栓形成的风险呈正相关;采用PCT、IL-6与 D-Dimer、TAT四项联合检测,能同时评估患者细菌感染程度和发生血栓的风险,避免患者因细菌感染而发生血栓,对机体造成更大的伤害,起到早期预警、早期干预、早期治疗的作用。 展开更多
关键词 炎症 血栓 联合检测 PCT IL-6 d-dimer TAT
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Utility of D-dimer in total joint arthroplasty
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作者 Brenden Cutter Zachary C Lum +1 位作者 Mauro Giordani John P Meehan 《World Journal of Orthopedics》 2023年第3期90-102,共13页
As the number of patients receiving total joint replacements continues to rise,considerable attention has been directed towards the early detection and prevention of postoperative complications.While D-dimer has long ... As the number of patients receiving total joint replacements continues to rise,considerable attention has been directed towards the early detection and prevention of postoperative complications.While D-dimer has long been studied as a diagnostic tool in venous thromboembolism(VTE),this assay has recently received considerable attention in the diagnosis of periprosthetic joint infection(PJI).D-dimer values are substantially elevated in the acute postoperative period after total joint arthroplasty,with levels often exceeding the standard institutional cutoff for VTE(500µg/L).The utility of D-dimer in detecting VTE after total joint replacement is currently limited,and more research to assess its value in the setting of contemporary prophylaxis protocols is warranted.Recent literature supports D-dimer as a good to excellent biomarker for the diagnosis of chronic PJI,especially when using serum sample technique.Providers should exercise caution when interpreting D-dimer levels in patients with inflammatory and hypercoagulability disorders,as the diagnostic value is decreased.The updated 2018 Musculoskeletal Infection Society criteria,which includes D-dimer levels>860µg/L as a minor criterion,may be the most accurate for diagnosing chronic PJI to date.Larger prospective trials with transparent lab testing protocols are needed to establish best assay practices and optimal cutoff values for D-dimer in the diagnosis of PJI.This review summarizes the most current literature on the value of D-dimer in total joint arthroplasty and elucidates areas for future progress. 展开更多
关键词 d-dimer DIAGNOSIS Periprosthetic joint infection Venous thromboembolism Deep vein thrombosis ARTHROPLASTY
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Effect of electroacupuncture at "Bǎihuì"(百会GV 20) and "Shuǐgōu"(水沟GV 26) acupoints on the contents of plasma D-dimer and fibrinogen in rats with acute cerebral infarction 被引量:2
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作者 王述菊 孙国杰 +2 位作者 吴绪平 黄伟 丁昀 《World Journal of Acupuncture-Moxibustion》 2009年第3期49-53,共5页
Objective To investigate the mechanisms of electroacupuncture (EA) at "Baihui" (百会 GV 20) and "Shuigou" (水沟 GV 26) for treating cerebral infarction. Methods Forty healthy SD rats were randomly divided in... Objective To investigate the mechanisms of electroacupuncture (EA) at "Baihui" (百会 GV 20) and "Shuigou" (水沟 GV 26) for treating cerebral infarction. Methods Forty healthy SD rats were randomly divided into model group (n = 10), EA group (n = 10), normal group (n = 10), and sham operation group (n = 10). The model of acute cerebral infarction was established by blocking the middle cerebral artery with an intraluminal thread. EA was applied at "Baihui" (百会 GV 20) and "Shuigou" (水沟GV 26) in the rats of EA group after the models were developed. The contents of D-dimer (D-D) and fibrinogen (Fib) were measured in each group. Results The contents of D-D and Fib increased signifi- cantly in model group as compared with normal and sham operation groups, respectively (P〈0.01), and they decreased significantly in EA group as compared with model group (P〈0.01). Conclusion EA can ob-viously decrease the contents of D-D and Fib, improve abnormal fibrinolysis, lower blood viscosity and ameliorate cerebral blood circulation in the rats with acute cerebral infarction. 展开更多
关键词 Cerebral Infarction ELECTROACUPUNCTURE d-dimer fibrinogen
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Influence of Heparin on Fibrinogen Assay by Clauss Method
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作者 Yanan Meng Yan Wang +2 位作者 Yankui Shi Yueyang Chen Chengbi Tong 《Journal of Clinical and Nursing Research》 2023年第3期54-59,共6页
Objective:To investigate the effect of heparin on fibrinogen detection by Clauss method.Methods:A normal plasma pool(NPP)of 20 healthy people was prepared with 3.2%sodium citrate anticoagulant.For experimental group 1... Objective:To investigate the effect of heparin on fibrinogen detection by Clauss method.Methods:A normal plasma pool(NPP)of 20 healthy people was prepared with 3.2%sodium citrate anticoagulant.For experimental group 1,samples containing different concentrations of heparin were prepared.For experimental group 2,samples of experimental group 1 were diluted twice.For experimental group 3,samples of experimental group 1 were diluted 4 times.For the control group,samples of normal saline with the same volume as heparin in experimental group 1 were prepared.The fibrinogen contents of experimental group 1,experimental group 2,experimental group 3,and control group were detected by Clauss method and prothrombin time(PT)-derived method,and the fibrinogen detection results of different groups were analyzed.Results:The trend of fibrinogen detected by Clauss method and PT-derived method in experimental group 1 was different;there was significant difference between the results of experimental group 1 and the control group(P<0.05);there was no significant difference between the results of experimental group 2 and the control group(P>0.05);there was no significant difference between the results of experimental group 3 and the control group(P>0.05);there was no significant difference between the results of experimental group 2 and experimental group 3(P>0.05);the relative deviation between experimental group 1 and the control group was higher in high-concentration heparin sample.Conclusion:Heparin affects fibrinogen detection by Clauss method,and the effect can be reduced by sample dilution. 展开更多
关键词 HEPARIN Clauss method PT-derived method fibrinogen
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D-Dimer对原发膜性肾病患者预后评价的研究
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作者 沈婕 《中文科技期刊数据库(引文版)医药卫生》 2023年第9期33-35,共3页
探讨D-Dimer对原发膜性肾病患者预后评价。方法 收集2022年3月~2023年3月于我院肾内科住院接受肾活检的明确原发性膜性肾病患者50例作为研究对象,观察其年龄(Age)、性别(Sex)、D-二聚体(D-Dimer)、24小时尿蛋白定量(24hUTP)、尿白蛋白/... 探讨D-Dimer对原发膜性肾病患者预后评价。方法 收集2022年3月~2023年3月于我院肾内科住院接受肾活检的明确原发性膜性肾病患者50例作为研究对象,观察其年龄(Age)、性别(Sex)、D-二聚体(D-Dimer)、24小时尿蛋白定量(24hUTP)、尿白蛋白/肌酐比值(ACR)、尿红细胞数(RBC)、纤维蛋白原降解产物(FDP)等数据,并选择正常体检者50例作为对照组,收集上述数据进行对比。经免疫治疗后对观察组患者进行预后随访(包括磷脂酶A2受体抗体(PLA2RAb)、D-Dimer、24hUTP、ACR、RBC、FDP等),进行统计分析。结果 与观察组比较,对照组D-Dimer、24hUTP、ACR、RBC、FDP水平较低,差异有统计学意义(P<0.05)。与治疗后比较,治疗前观察组血清PLA2RAb表达、D-Dimer、24hUTP、ACR、RBC、FDP水平较高,差异有统计学意义(P<0.05)。结论 D-Dimer水平检测有助于原发膜性肾病的诊断,具有检测成本低、方便快速等更好的应用价值。 展开更多
关键词 d-dimer 原发膜性肾病 预后
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凝血指标D-Dimer联合Khorana评分模型预测肿瘤患者化疗后静脉血栓风险的价值 被引量:3
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作者 陈丽霞 李博 韩永清 《现代肿瘤医学》 CAS 北大核心 2023年第9期1712-1715,共4页
目的:探讨凝血指标联合Khorana评分模型预测肿瘤患者化疗后静脉血栓风险的价值。方法:选取2019年01月至2022年09月某三级甲等医院收治确诊恶性肿瘤并接受化学治疗的患者100例,包括60例静脉血栓栓塞(venous thromboembolism, VTE)患者为... 目的:探讨凝血指标联合Khorana评分模型预测肿瘤患者化疗后静脉血栓风险的价值。方法:选取2019年01月至2022年09月某三级甲等医院收治确诊恶性肿瘤并接受化学治疗的患者100例,包括60例静脉血栓栓塞(venous thromboembolism, VTE)患者为试验组,40例无VTE的患者为对照组;采用彩色多普勒超声检查或肺动脉造影检查确诊VTE,比较两组患者一般资料及凝血指标[D-二聚体(D-Dimer)、纤维蛋白原(fibrinogen, Fib)],通过绘制受试者工作特征曲线(receiver operating characteristic curve, ROC)评价凝血指标联合Khorana评分对肿瘤患者静脉血栓风险预测的灵敏度及特异度。结果:两组患者D-Dimer及Fib水平具有统计学差异(P<0.05),试验组D-Dimer及Fib水平均明显高于对照组;D-Dimer对静脉血栓风险的预测价值高于Fib, D-Dimer最佳截断值为2.28 mg/L;将D-Dimer纳入Khorana模型中的评估项,赋分1~3分,其中赋予2分后,新评估模型静脉血栓风险的预测的特异度及灵敏度与Khorana模型相比均有较大的提升,AUC为0.901,约登指数为0.658,灵敏度为0.733,特异度为0.925。结论:凝血指标D-Dimer对于提高Khorana评分模型对肿瘤患者化疗后血栓发生风险的预测有着重要价值。 展开更多
关键词 恶性肿瘤 化疗 静脉血栓 Khorana 纤维蛋白原 D-二聚体
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D-dimer与纤维蛋白原比值在静脉血栓栓塞诊断中的应用价值 被引量:8
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作者 鲁炳怀 朱凤霞 +1 位作者 史丽娜 杨静 《中国实验诊断学》 2012年第7期1189-1191,共3页
目的探讨D-dimer、纤维蛋白原(Fg)、D-dimer与Fg比值(D/F)以及C反应蛋白(CRP)在静脉血栓栓塞(VTE)中的临床诊断价值。方法对民航总医院就诊的221例急诊与住院疑似VTE患者D-dimer、Fg及CRP进行检测,并计算D/F,采用胸部CT、病理诊断等对... 目的探讨D-dimer、纤维蛋白原(Fg)、D-dimer与Fg比值(D/F)以及C反应蛋白(CRP)在静脉血栓栓塞(VTE)中的临床诊断价值。方法对民航总医院就诊的221例急诊与住院疑似VTE患者D-dimer、Fg及CRP进行检测,并计算D/F,采用胸部CT、病理诊断等对疑似患者明确诊断。结果 VTE人群的Fg水平低于非VTE人群(t=6.421,P<0.01),而D-dimer、D/F、CRP均显著增高;在VTE诊断灵敏度达到100%时,D/F特异度与阳性预测值(PPV)(73.2%,56.4%)优于使用单独使用D-dimer(47.0%,39.6%);ROC曲线分析表明上述指标在VTE诊断中的准确性顺序为D/F>D-dimer>CRP。结论采用D/F可提高VTE临床诊断的特异性,可作为一项有益的指标应用于VTE辅助诊断。 展开更多
关键词 静脉血栓栓塞 d-dimer 纤维蛋白原
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