To improve robustness of mechanical properties of semi-solid cast A356 alloy using taguchi design method

Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase variations.The present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid casting.The focus was primarily on the robustness of mechanical properties based on Taguchi design method.By analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 h.In a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory robustness.The hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.

Seismic effectiveness evaluation and optimized design of tie up method for securing museum collections

To quantify the seismic effectiveness of the most commonly used fishing line tie up method for securing museum collections and optimize fixed strategies for exhibitions,shaking table tests of the seismic systems used for typical museum collection replicas have been carried out.The influence of body shape and fixed measure parameters on the seismic responses of replicas and the interaction behavior between replicas and fixed measures have been explored.Based on the results,seismic effectiveness evaluation indexes of the tie up method are proposed.Reasonable suggestions for fixed strategies are given,which provide a basis for the exhibition of delicate museum collections considering the principle of minimizing seismic responses and intervention.The analysis results show that a larger ratio of height of mass center to bottom diameter led to more intense rocking responses.Increasing the initial pretension of fishing lines was conducive to reducing the seismic responses and stress variation of the lines.Through comprehensive consideration of the interaction forces and effective securement,it is recommended to apply 20%of breaking stress as the initial pretension.For specific museum collections that cannot be effectively protected by the independent tie up method,an optimized strategy of a combination of fishing lines and fasteners is recommended.

A Hybrid Level Set Optimization Design Method of Functionally Graded Cellular Structures Considering Connectivity

With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown significantly.However,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular structures.The HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure interfaces.Initially,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both sides.Subsequently,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent microstructures.The method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology optimization.In essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures.

Support design method for deep soft-rock tunnels in non-hydrostatic high in-situ stress field

Due to the long-term plate tectonic movements in southwestern China,the in-situ stress field in deep formations is complex.When passing through deep soft-rock mass under non-hydrostatic high in-situ stress field,tunnels will suffer serious asymmetric deformation.There is no available support design method for tunnels under such a situation in existing studies to clarify the support time and support stiffness.This study first analyzed the mechanical behavior of tunnels in non-hydrostatic in-situ stress field and derived the theoretical equations of the ground squeezing curve(GSC)and ground loosening curve(GLC).Then,based on the convergence confinement theory,the support design method of deep soft-rock tunnels under non-hydrostatic high in-situ stress field was established considering both squeezing and loosening pressures.In addition,this method can provide the clear support time and support stiffness of the second layer of initial support.The proposed design method was applied to the Wanhe tunnel of the China-Laos railway in China.Monitoring data indicated that the optimal support scheme had a good effect on controlling the tunnel deformation in non-hydrostatic high in-situ stress field.Field applications showed that the secondary lining could be constructed properly.

Research on the design method for uniform wear of shield cutters in sand-pebble strata

During shield tunneling in highly abrasive formations such as sand–pebble strata,nonuniform wear of shield cutters is inevitable due to the different cutting distances.Frequent downtimes and cutter replacements have become major obstacles to long-distance shield driving in sand–pebble strata.Based on the cutter wear characteristics in sand–pebble strata in Beijing,a design methodology for the cutterhead and cutters was established in this study to achieve uniform wear of all cutters by the principle of frictional wear.The applicability of the design method was verified through three-dimensional simulations using the engineering discrete element method.The results show that uniform wear of all cutters on the cutterhead could be achieved by installing different numbers of cutters on each trajectory radius and designing a curved spoke with a certain arch height according to the shield diameter.Under the uniform wear scheme,the cutter wear coefficient is greatly reduced,and the largest shield driving distance is increased by approximately 47%over the engineering scheme.The research results indicate that the problem of nonuniform cutter wear in shield excavation could be overcome,thereby providing guiding significance for theoretical innovation and construction of long-distance shield excavation in highly abrasive strata.

A Mixed-Variable Experimental Design Method

Mixed-variable problems are inevitable in engineering. However, few researches pay attention to discrete variables. This paper proposed a mixed-variable experimental design method (ODCD): first, the design variables were divided into discrete variables and continuous variables;then, the DVD method was employed for handling discrete variables, the LHD method was applied for continuous variables, and finally, a Columnwise-Pairwise Algorithm was used for the overall optimization of the design matrix. Experimental results demonstrated that the ODCD method outperforms in terms of the sample space coverage performance.

Exploring Digital Visualization Methods in Urban Public Building Space Design

Digital technology has driven the innovation of architectural design methods and tools,applying digital techniques to allow greater possibilities for more innovative and scientific design of public building spaces.This article first analyzes the characteristics of digital visualization and its advantages in the design of urban public building spaces,including aspects such as visualizing three-dimensional expression,rational analysis of building space,Virtual Reality Experience,and integration of design and construction processes.Subsequently,by introducing digital design methods such as parametric design,algorithmic generation,nonlinear design,and artificial intelligence-assisted design,it explores the methods and implementation approaches of digital visualization in the design of public building spaces.The aim is to offer insights and references for the deeper integration of digital technology into architectural design practices.

Selection of Water Transmission Method and Analysis of Pipe Network Zoning in Municipal Water Supply and Drainage Design

With the acceleration of urbanization,the demand for water supply and drainage pipe networks has increased significantly.In the planning of urban construction,it is necessary to optimize the design of the water supply and drainage system pipe network to effectively save energy while providing residents with more accessible water resources.Therefore,the municipal water supply and drainage system and the water transmission methods should be designed according to the geographical conditions of the city.In this paper,we mainly analyze the design of municipal water supply and drainage systems and the selection of water transmission methods.Besides,the optimization of the water supply and drainage network zoning process and pipe network maintenance is also discussed,so as to provide a reference for municipal water supply and drainage work.

App Designer辅助教学方法探索与实践——以软件无线电课程为例

软件无线电作为通信学科的必修课程,具有承上启下的重要作用。因课程原理抽象、理论公式复杂,学员在学习过程存在理解掌握难、实践应用难等问题。通过对当前软件无线电教学过程中存在的不足与困难进行分析,提出利用MATLAB App Designer辅助课程教学,从教学准备、课堂互动、自主实验、反馈提升四个方面开展课程教学改革。实践表明,该方法对于提升学员的工程思维、系统思维具有显著效果,同时可以增强学员理论联系实际的能力。

Design methods for antimicrobial peptides with improved performance

The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating bacterial infections more difficult.In this regard,developing new antimicrobial agents to combat antibiotic-resistant strains has become a top priority.Antimicrobial peptides(AMPs),a ubiquitous class of naturally occurring compounds with broadspectrum antipathogenic activity,hold significant promise as an effective solution to the current antimicrobial resistance(AMR)crisis.Several AMPs have been identified and evaluated for their therapeutic application,with many already in the drug development pipeline.Their distinct properties,such as high target specificity,potency,and ability to bypass microbial resistance mechanisms,make AMPs a promising alternative to traditional antibiotics.Nonetheless,several challenges,such as high toxicity,lability to proteolytic degradation,low stability,poor pharmacokinetics,and high production costs,continue to hamper their clinical applicability.Therefore,recent research has focused on optimizing the properties of AMPs to improve their performance.By understanding the physicochemical properties of AMPs that correspond to their activity,such as amphipathicity,hydrophobicity,structural conformation,amino acid distribution,and composition,researchers can design AMPs with desired and improved performance.In this review,we highlight some of the key strategies used to optimize the performance of AMPs,including rational design and de novo synthesis.We also discuss the growing role of predictive computational tools,utilizing artificial intelligence and machine learning,in the design and synthesis of highly efficacious lead drug candidates.

Optimization of mechanical properties using D-optimal factorial design of experiment: Electromagnetic stir casting process of A357-SiC nanocomposite

Electromagnetic stir casting process of A357-Si C nanocomposite was discussed using the D-optimal design of experiment(DODOE) method. As the main objective, nine random experiments obtained by DX-7 software were performed. By this method, A357-Si C nanocomposites with 0.5, 1.0 and 1.5 wt.% Si C were fabricated at three different frequencies(10, 35 and 60 Hz) in the experimental stage. The microstructural evolution was characterized by scanning electron and optical microscopes, and the mechanical properties were investigated using hardness and roomtemperature uniaxial tensile tests. The results showed that the homogeneous distribution of Si C nanoparticles leads to the microstructure evolution from dendritic to non-dendritic form and a reduction of size by 73.9%. Additionally, based on DODOE, F-values of 44.80 and 179.64 were achieved for yield stress(YS) and ultimate tensile strength(UTS), respectively, implying that the model is significant and the variables(Si C fraction and stirring frequency) were appropriately selected. The optimum values of the Si C fraction and stirring frequency were found to be 1.5 wt.% and 60 Hz, respectively. In this case, YS and UTS for A357-Si C nanocomposites were obtained to be 120 and 188 MPa(57.7% and 57.9 % increase compared with those of the as-cast sample), respectively.

Bamboo Fiber Modified Asphalt Mixture Proportion Design and Road Performances Based on Response Surface Method

In order to comprehensively utilize the remaining bamboo residue of bamboo products,this paper presents a research on recycling the bamboo fibers from bamboo residue for improving the performance of the asphalt mixtures.First of all,the basic performance parameters of sinocalamus affinis fiber,phyllostachys pubescens fiber,green bamboo fiber were tested and analyzed,and the optimal content and length were put forward.Then,the mix ratio design of the bamboo fiber modified asphalt mixture was further designed through the response surface method,and was verified the rationality of the mix ratio.Finally,the mixture specimens were made according to the experimental design mix ratio,and the high temperature,low temperature performance and moisture susceptibility of the bamboo fiber modified mixtures asphalt were tested.The results showed that the high temperature performance,low temperature performance and moisture susceptibility of bamboo fiber modified asphalt mixtures were improved compared with the performance of SBS modified asphalt mixture.When the length of bamboo fiber is 7.25 mm and the content of 0.22%,the road performance of the asphalt mixture was optimal.Consequentially,the decomposition of bamboo residue into bamboo fiber and its application in asphalt pavement can improve the reuse of bamboo waste,with remarkable environmental benefits and great promotion value.

An Uncertainty Analysis and Reliability-Based Multidisciplinary Design Optimization Method Using Fourth-Moment Saddlepoint Approximation

In uncertainty analysis and reliability-based multidisciplinary design and optimization(RBMDO)of engineering structures,the saddlepoint approximation(SA)method can be utilized to enhance the accuracy and efficiency of reliability evaluation.However,the random variables involved in SA should be easy to handle.Additionally,the corresponding saddlepoint equation should not be complicated.Both of them limit the application of SA for engineering problems.The moment method can construct an approximate cumulative distribution function of the performance function based on the first few statistical moments.However,the traditional moment matching method is not very accurate generally.In order to take advantage of the SA method and the moment matching method to enhance the efficiency of design and optimization,a fourth-moment saddlepoint approximation(FMSA)method is introduced into RBMDO.In FMSA,the approximate cumulative generating functions are constructed based on the first four moments of the limit state function.The probability density function and cumulative distribution function are estimated based on this approximate cumulative generating function.Furthermore,the FMSA method is introduced and combined into RBMDO within the framework of sequence optimization and reliability assessment,which is based on the performance measure approach strategy.Two engineering examples are introduced to verify the effectiveness of proposed method.

Optimization of Proportion and Formulation Process of Jinweng Granule by D-Optimal Mixture Design

[Objectives] To study the optimal proportion and formulation process of Jinweng granule,the physicochemical properties of the optimal preparing process was observed. [Methods] Adopting the D-optimal mixture design method,selecting the mixing ratio of starch,dextrin,fumei powder and lactose as tested factors,and selecting the most significant factor between hygroscopicity,formability,solubility as the evaluation index,the optimal proportion of filler was examined by system experiments. Granularity,solubility,the angle of repose,and critical relative humidity( CRH) were used to evaluate the optimal proportion and formulation process of Jinweng granule. [Results]The optimal prescription of Jinweng granule is extract∶ starch∶ dextrin∶ lactose∶ fumei powder( 1∶ 0. 5∶ 0. 05∶ 0. 3∶ 0. 15),and the binder was consisted of 1% sodium carboxymethylcellulose( CMC) slurry and 3% starch syrup. The CRH of the optimum formulation process of granule is 72%,and the fluidity,solubility and granularity were qualified. [Conclusions] The process model established by D-optimum mixture design has good predictability,and the granule prepared by the optimal proportion has good repeatability,and the granule proportion and formulation process is stable and reliable.

Optimum Design of Stair-Climbing Robots Using Taguchi Method

Environmental issues like pollution are major threats to human health.Many systems are developed to reduce pollution.In this paper,an optimal mobile robot design to reduce pollution in Green supply chain management system.Green supply chain management involves as similating environmentally and eco-nomically feasible solutions into the supply chain life-cycle.Smartness,advanced technologies,and advanced networks are becoming pillars of a sustainable supply chain management system.At the same time,there is much change happening in the logistics industry.They are moving towards a new logistics model.In the new model,robotic logistics has a vital role.The reasons for this change are the rapid growth of the e-commerce business and the shortage of workers.The advantages of using robotic logistics are reduction in human errors,faster delivery speed,better customer satisfaction,more safety for workers,and high workforce adaptability.A robot with rocker-bogie suspension is a six-wheeled mobile platform that has a distinctive potential to keep all wheels on the ground continuously.It has been designed to traverse rough and uneven terrain by distributing the load over its wheels equally.However,there is a limitation to achieving high-speed mobility against vertical barriers.In this research,an optimal design of product delivery wheeled robots for a sustainable supply chain system is proposed to ensure higher adaptability and maximum stability during climbing staircases.The design parameters of the proposed robot are optimized using Taguchi Method.The aim is to get a smooth trajectory of the robot’s center-of-mass.The proposed approach realizes a robot with much-improved stability which can climb over heights more than the size of the wheel(i.e.,3 times the radius of wheels).The results reveal that the modified rocker-bogie system not only increases the stair-climbing capability but also thwarts instability due to overturning of a wheel of the robot.

Design of N-11-Azaartemisinins Potentially Active against Plasmodium falciparum by Combined Molecular Electrostatic Potential, Ligand-Receptor Interaction and Models Built with Supervised Machine Learning Methods

N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning methods (PCA, HCA, KNN, SIMCA, and SDA). The optimization of molecular structures was performed using the B3LYP/6-31G* approach. MEP maps and ligand-receptor interactions were used to investigate key structural features required for biological activities and likely interactions between N-11-azaartemisinins and heme, respectively. The supervised machine learning methods allowed the separation of the investigated compounds into two classes: cha and cla, with the properties εLUMO+1 (one level above lowest unoccupied molecular orbital energy), d(C6-C5) (distance between C6 and C5 atoms in ligands), and TSA (total surface area) responsible for the classification. The insights extracted from the investigation developed and the chemical intuition enabled the design of sixteen new N-11-azaartemisinins (prediction set), moreover, models built with supervised machine learning methods were applied to this prediction set. The result of this application showed twelve new promising N-11-azaartemisinins for synthesis and biological evaluation.

Current situation and development trend of design methods for subgrade structure of high speed railways

Purpose–This method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approach–This paper summarizes the structural types and design methods of subgrade bed for high speed railways in China,Japan,France,Germany,the United States and other countries based on the study and analysis of existing literature and combined with the research results and practices of high speed railway subgrade engineering at home and abroad.Findings–It is found that in foreign countries,the layered reinforced structure is generally adopted for the subgrade bed of high speed railways,and the unified double-layer or multi-layer structure is adopted for the surface layer of subgrade bed,while the simple structure is adopted in China;in foreign countries,different inspection parameters are adopted to evaluate the compaction state of fillers according to their respective understanding and practice,while in China,compaction coefficient,subsoil coefficient and dynamic deformation modulus are adopted for such evaluation;in foreign countries,the subgrade top deformation control method,the subgrade bottom deformation control method,the subsurface fill strength control method are mainly adopted in subgrade bed structure design of high speed railways,while in China,dynamic deformation control of subgrade surface and dynamic strain control of subgrade bed bottom layer is adopted in the design.However,the cumulative deformation of subgrade caused by train cyclic vibration load is not considered in the existing design methods.Originality/value–This paper introduces a new subgrade structure design method based on whole-process dynamics analysis that meets subgrade functional requirements and is established on the basis of the existing research at home and abroad on prediction methods for cumulative deformation of subgrade soil.

The Ultimate Anti-Seismic Design Method

The design mechanisms and methods of the invention are intended to minimize problems related to the safety of structures in the event of natural phenomena such as earthquakes, tornadoes, and strong winds. It is achieved by controlling the deformations of the structure. Damage and deformation are closely related concepts since the control of deformations also controls the damage. The design method of applying artificial compression to the ends of all longitudinal reinforced concrete walls and, at the same time, connecting the ends of the walls to the ground using ground anchors placed at the depths of the boreholes, transfers the inertial stresses of the structure in the ground, which reacts as an external force in the structure’s response to seismic displacements. The wall with the artificial compression acquires dynamic, larger active cross-section and high axial and torsional stiffness, preventing all failures caused by inelastic deformation. By connecting the ends of all walls to the ground, we control the eigenfrequency of the structure and the ground during each seismic loading cycle, preventing inelastic displacements. At the same time, we ensure the strong bearing capacity of the foundation soil and the structure. By designing the walls correctly and placing them in proper locations, we prevent the torsional flexural buckling that occurs in asymmetrical floor plans, and metal and tall structures. Compression of the wall sections at the ends and their anchoring to the ground mitigates the transfer of deformations to the connection nodes, strengthens the wall section in terms of base shear force and shear stress of the sections, and increases the strength of the cross-sections to the tensile at the ends of the walls by introducing counteractive forces. The use of tendons within the ducts prevents longitudinal shear in the overlay concrete, while anchoring the walls to the foundation not only dissipates inertial forces to the ground but also prevents rotation of the walls, thus maintaining the structural integrity of the beams. The prestressing at the bilateral ends of the walls restores the structure to its original position even inelastic displacements by closing the opening of the developing cracks.

Accelerating Factor Xa inhibitor discovery with a de novo drug design pipeline

Small-molecule drugs are essential for maintaining human health. The objective of this study is to identify a molecule that can inhibit the Factor Xa protein and be easily procured. An optimization-based de novo drug design framework, Drug CAMD, that integrates a deep learning model with a mixed-integer nonlinear programming model is used for designing drug candidates. Within this framework, a virtual chemical library is specifically tailored to inhibit Factor Xa. To further filter and narrow down the lead compounds from the designed compounds, comprehensive approaches involving molecular docking,binding pose metadynamics(BPMD), binding free energy calculations, and enzyme activity inhibition analysis are utilized. To maximize efficiency in terms of time and resources, molecules for in vitro activity testing are initially selected from commercially available portions of customized virtual chemical libraries. In vitro studies assessing inhibitor activities have confirmed that the compound EN300-331859shows potential Factor Xa inhibition, with an IC_(50)value of 34.57 μmol·L^(-1). Through in silico molecular docking and BPMD, the most plausible binding pose for the EN300-331859-Factor Xa complex are identified. The estimated binding free energy values correlate well with the results obtained from biological assays. Consequently, EN300-331859 is identified as a novel and effective sub-micromolar inhibitor of Factor Xa.

An Efficient Reliability-Based Optimization Method Utilizing High-Dimensional Model Representation and Weight-Point Estimation Method

The objective of reliability-based design optimization(RBDO)is to minimize the optimization objective while satisfying the corresponding reliability requirements.However,the nested loop characteristic reduces the efficiency of RBDO algorithm,which hinders their application to high-dimensional engineering problems.To address these issues,this paper proposes an efficient decoupled RBDO method combining high dimensional model representation(HDMR)and the weight-point estimation method(WPEM).First,we decouple the RBDO model using HDMR and WPEM.Second,Lagrange interpolation is used to approximate a univariate function.Finally,based on the results of the first two steps,the original nested loop reliability optimization model is completely transformed into a deterministic design optimization model that can be solved by a series of mature constrained optimization methods without any additional calculations.Two numerical examples of a planar 10-bar structure and an aviation hydraulic piping system with 28 design variables are analyzed to illustrate the performance and practicability of the proposed method.