OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hy...OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hyperuricemia.METHODS: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, Yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using immunofluorescence.RESULTS: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly improved.When the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the Yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the groups.CONCLUSION: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.展开更多
全球气候变化对全球生态环境的影响越来越引起人们的关注。荒漠植被作为荒漠生态系统的一个重要组分,对全球气候变化的响应较为敏感。本文以准噶尔盆地南缘的典型荒漠植被梭梭(Haloxylon ammodendron)作为研究对象,采用OTC(Open top cha...全球气候变化对全球生态环境的影响越来越引起人们的关注。荒漠植被作为荒漠生态系统的一个重要组分,对全球气候变化的响应较为敏感。本文以准噶尔盆地南缘的典型荒漠植被梭梭(Haloxylon ammodendron)作为研究对象,采用OTC(Open top chamber)开顶箱方式模拟温室效应。通过研究增温处理对梭梭同化枝气体交换参数(PAR,Tleaf,Pn,Gs)、丙二醛(MDA)含量、抗氧化酶(SOD,POD,CAT)活性和渗透调节物质(Pro,SS,Pr)含量的影响,为荒漠植被在全球进一步变暖下产生的反映提供科学的预判和依据。结果表明:增温组梭梭的PAR,Pn及Gs均低于对照组;而Tleaf,MDA含量、抗氧化酶(SOD,POD,CAT)活性及渗透调节物质(Pro,SS,Pr)含量均高于对照组,说明增温生境下梭梭受胁迫程度加强。与此同时,也更进一步预示着未来全球气候变化格局下,梭梭将面临的一个更为严峻的生存挑战。展开更多
基金Supported by Central Universities Fundamental Research Funds Project(Graduate Programs)from the Beijing University of Chinese Medicine:Experiment Research on the Effects of Acupuncturing Shu,Yuan,and Mu Acupoints in a Rat Model of Gout and Hyperuricemia(No.2015-JYB-XS127)
文摘OBJECTIVE: To investigate the effects of needling the Shu, Yuan, and Mu acupoints on serum uric acid(SUA), xanthine oxidase(XOD), and alkaline phosphatase(ALP) levels and the kidney index in a rat model of gout and hyperuricemia.METHODS: Fifty rats were randomly divided into five groups: blank, model, Shu-acupoint, Yuan-acupoint, and Mu-acupoint groups. A rat model of hyperuricemia was developed by intragastric administration of adenine and ethambutol. This experiment last for 90 d in total. Treatment groups underwent 3 courses of acupuncture. Each course involved a total of 10 interventions(one intervention every second day) with each intervention lasting15 min. There was a break for 10 d between courses. SUA and ALP were analyzed using an automatic biochemical analyzer and XOD was analyzed using immunofluorescence.RESULTS: Compared with the blank group, SUA and XOD levels in the model group were significantly higher and the renal index significantly improved. Compared with the model group, SUA and XOD levels in the three treatment groups decreased and the renal index significantly improved.When the three treatment groups were compared,the Mu-acupoint group showed the greatest decreases in SUA and XOD levels, followed by the Yuan-acupoint group. There was no significant difference in kidney index among the three treatment groups. There was no significant difference in ALP levels among the groups.CONCLUSION: The three treatments showed significantly reduced SUA and XOD levels compared with the control groups, possibly suggesting reduced renal damage.
文摘全球气候变化对全球生态环境的影响越来越引起人们的关注。荒漠植被作为荒漠生态系统的一个重要组分,对全球气候变化的响应较为敏感。本文以准噶尔盆地南缘的典型荒漠植被梭梭(Haloxylon ammodendron)作为研究对象,采用OTC(Open top chamber)开顶箱方式模拟温室效应。通过研究增温处理对梭梭同化枝气体交换参数(PAR,Tleaf,Pn,Gs)、丙二醛(MDA)含量、抗氧化酶(SOD,POD,CAT)活性和渗透调节物质(Pro,SS,Pr)含量的影响,为荒漠植被在全球进一步变暖下产生的反映提供科学的预判和依据。结果表明:增温组梭梭的PAR,Pn及Gs均低于对照组;而Tleaf,MDA含量、抗氧化酶(SOD,POD,CAT)活性及渗透调节物质(Pro,SS,Pr)含量均高于对照组,说明增温生境下梭梭受胁迫程度加强。与此同时,也更进一步预示着未来全球气候变化格局下,梭梭将面临的一个更为严峻的生存挑战。
