Art Deco风格是上世纪初流行于全世界的装饰风格,我国几大通商口岸城市也曾深受其影响。文章基于中国知网、万方数据和维普期刊1988—2021年间的309篇相关文献,以文献计量学的方法,通过CiteSpace软件生成可视化图谱,解读其研究热点和发...Art Deco风格是上世纪初流行于全世界的装饰风格,我国几大通商口岸城市也曾深受其影响。文章基于中国知网、万方数据和维普期刊1988—2021年间的309篇相关文献,以文献计量学的方法,通过CiteSpace软件生成可视化图谱,解读其研究热点和发展趋势,梳理概括了各阶段研究的特征,总结现阶段研究存在的不足,并对未来Art Deco风格的研究提出展望。展开更多
Art deco作为人们追求时尚的生活,同时又体现出人们享受自由,不受传统的束缚,它的复兴所引发的思考正好体现在中国的地域文化和民族精神上。Art deco风格作为国际性风格,一直引领潮流的方向,正因为它具有多元文化特征,所以在设计上吸收...Art deco作为人们追求时尚的生活,同时又体现出人们享受自由,不受传统的束缚,它的复兴所引发的思考正好体现在中国的地域文化和民族精神上。Art deco风格作为国际性风格,一直引领潮流的方向,正因为它具有多元文化特征,所以在设计上吸收本土的民族精神和各国风情,同时包含地域性的文化概念,我们要将这种风格应用到室内设计当中,以及探讨中国的元素应用,面对文化思潮的兴起,我们要冷静思考。展开更多
Art Deco 风格的建筑在河南不断呈现,新时代的风格在新时期有哪些特性,及其在建筑设计和环境设计中所起的作用,以及对河南居住建筑的发展及人居环境改善,所起到的积极作用作以探讨。本文首先介绍了 Art Deco 风格特点以及,然后探讨了 Ar...Art Deco 风格的建筑在河南不断呈现,新时代的风格在新时期有哪些特性,及其在建筑设计和环境设计中所起的作用,以及对河南居住建筑的发展及人居环境改善,所起到的积极作用作以探讨。本文首先介绍了 Art Deco 风格特点以及,然后探讨了 Art Deco 风格在河南鹤壁一号城邦建筑设计中的体现和在环境设计的体现。Art Deco风格和河南地域结合起来产生经典的建筑和环境,改变了中原的居住环境,传播了先进的文化,丰富了河南人的精神生活。展开更多
Art Deco是20世纪二三十年代风行于世界的一种装饰艺术设计风格,以大胆的轮廓、几何的形体、阶梯状的造型、新材料的运用为特点。虽然Art Deco是从欧美输入的建筑风格,但传入中国不久便吸收了中国传统建筑元素,在小木作装修、局部装饰...Art Deco是20世纪二三十年代风行于世界的一种装饰艺术设计风格,以大胆的轮廓、几何的形体、阶梯状的造型、新材料的运用为特点。虽然Art Deco是从欧美输入的建筑风格,但传入中国不久便吸收了中国传统建筑元素,在小木作装修、局部装饰、简化元素等方面加以运用,逐渐形成中西合璧的独特风格。展开更多
AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted...AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1.展开更多
The ther m al deco m position mechanism of a m m oniu m thiotungstate of the size of 63 ～75 μmin H2 has been investigated by D T A and X R D methods . The ther m al deco m position activationenergies and the ord...The ther m al deco m position mechanism of a m m oniu m thiotungstate of the size of 63 ～75 μmin H2 has been investigated by D T A and X R D methods . The ther m al deco m position activationenergies and the orders of a m m oniu m thiotu ngstate were calculated by means of Kissinger , Freem an Carroll and Coast Redfern m ethods . It w as also obtained that therm al deco m posi tion is cond ucted according to four reaction equations :( N H4) 2 W S4· H2 O(s) ( N H4) 2 W S4(s) + H2 O(g) W S2(s) + 2 N H3(g) + H2(g) + 2 S(s) + H2 O(g) W S2(s) + 2 N H3(g) + 2 H2 S(g) + H2 O(g) W S2(s) + W(s) + 2 N H3(g) + 2 H2 S(g) + H2 O(g) .展开更多
文摘Art Deco 风格的建筑在河南不断呈现,新时代的风格在新时期有哪些特性,及其在建筑设计和环境设计中所起的作用,以及对河南居住建筑的发展及人居环境改善,所起到的积极作用作以探讨。本文首先介绍了 Art Deco 风格特点以及,然后探讨了 Art Deco 风格在河南鹤壁一号城邦建筑设计中的体现和在环境设计的体现。Art Deco风格和河南地域结合起来产生经典的建筑和环境,改变了中原的居住环境,传播了先进的文化,丰富了河南人的精神生活。
基金Supported by Project of Experimental Animal Research(the Science and Technology Commission of Shanghai),No.13140901803
文摘AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1.
文摘The ther m al deco m position mechanism of a m m oniu m thiotungstate of the size of 63 ～75 μmin H2 has been investigated by D T A and X R D methods . The ther m al deco m position activationenergies and the orders of a m m oniu m thiotu ngstate were calculated by means of Kissinger , Freem an Carroll and Coast Redfern m ethods . It w as also obtained that therm al deco m posi tion is cond ucted according to four reaction equations :( N H4) 2 W S4· H2 O(s) ( N H4) 2 W S4(s) + H2 O(g) W S2(s) + 2 N H3(g) + H2(g) + 2 S(s) + H2 O(g) W S2(s) + 2 N H3(g) + 2 H2 S(g) + H2 O(g) W S2(s) + W(s) + 2 N H3(g) + 2 H2 S(g) + H2 O(g) .
