BACKGROUND Tyrosine kinase inhibitors(TKI)have been the standard first-line therapy for advanced non-small cell lung cancer(NSCLC)of epidermal growth factor receptor(EGFR)sensitive mutations.Uncommon EGFR mutations ar...BACKGROUND Tyrosine kinase inhibitors(TKI)have been the standard first-line therapy for advanced non-small cell lung cancer(NSCLC)of epidermal growth factor receptor(EGFR)sensitive mutations.Uncommon EGFR mutations are increasingly reported with the development of next-generation sequencing.However,their sensitivity to TKIs is variable with limited clinical evidence.CASE SUMMARY Here,we report a patient with the rare delE709_T710insD mutation,who showed the favorable efficacy of dacomitinib and achieved a partial response with a progression-free survival of 7.0 mo.CONCLUSION To our knowledge,this is the first report displaying the clinical efficacy of dacomitinib for patients with delE709_T710insD,which may help to provide alternatives in non-classical variant NSCLC patients.Further studies are warranted to make the optimal choice of EGFR-TKI for rare mutations.展开更多
At the invitation of CAFIU,an 8-member delegation of the Kazankai Foundation of Japan headed by Executive Director Hoshi Hiroto visited China from June 29 to July 3,2015.In Beijing,CAFIU Vice-President Ai Ping met wit...At the invitation of CAFIU,an 8-member delegation of the Kazankai Foundation of Japan headed by Executive Director Hoshi Hiroto visited China from June 29 to July 3,2015.In Beijing,CAFIU Vice-President Ai Ping met with thedelegation.Ai Ping stressed that China-Japan people-to-people exchanges should play a positive role in improving the bilateral relations展开更多
At the invitation of the China-Malaysia Friendship Association, a 96-member Chi- nese youth dance delegation organized by the CPAFFC and the Chinese Dancers Association, went to Pinang, a famous
基于场景的需求捕获方法存在需求偏差和缺失、可追溯性和一致性不足等问题。本文基于模型的系统工程(MBSE,model-based system engineering)在体系结构框架下建立可视化视点模型,形成“运行场景—功能需求”过程的映射关系,提出基于运...基于场景的需求捕获方法存在需求偏差和缺失、可追溯性和一致性不足等问题。本文基于模型的系统工程(MBSE,model-based system engineering)在体系结构框架下建立可视化视点模型,形成“运行场景—功能需求”过程的映射关系,提出基于运行场景的结构化民机系统功能需求捕获方法。以平视显示器(HUD,head-up display)系统为例,构建多维度、多层次场景和多视图体系结构模型,实现系统功能需求开发的“正向设计”,验证了该方法的可操作性和有效性。该方法对提升民机系统需求分析能力及系统开发思路具有重要参考意义。展开更多
文摘BACKGROUND Tyrosine kinase inhibitors(TKI)have been the standard first-line therapy for advanced non-small cell lung cancer(NSCLC)of epidermal growth factor receptor(EGFR)sensitive mutations.Uncommon EGFR mutations are increasingly reported with the development of next-generation sequencing.However,their sensitivity to TKIs is variable with limited clinical evidence.CASE SUMMARY Here,we report a patient with the rare delE709_T710insD mutation,who showed the favorable efficacy of dacomitinib and achieved a partial response with a progression-free survival of 7.0 mo.CONCLUSION To our knowledge,this is the first report displaying the clinical efficacy of dacomitinib for patients with delE709_T710insD,which may help to provide alternatives in non-classical variant NSCLC patients.Further studies are warranted to make the optimal choice of EGFR-TKI for rare mutations.
文摘At the invitation of CAFIU,an 8-member delegation of the Kazankai Foundation of Japan headed by Executive Director Hoshi Hiroto visited China from June 29 to July 3,2015.In Beijing,CAFIU Vice-President Ai Ping met with thedelegation.Ai Ping stressed that China-Japan people-to-people exchanges should play a positive role in improving the bilateral relations
文摘At the invitation of the China-Malaysia Friendship Association, a 96-member Chi- nese youth dance delegation organized by the CPAFFC and the Chinese Dancers Association, went to Pinang, a famous
文摘基于场景的需求捕获方法存在需求偏差和缺失、可追溯性和一致性不足等问题。本文基于模型的系统工程(MBSE,model-based system engineering)在体系结构框架下建立可视化视点模型,形成“运行场景—功能需求”过程的映射关系,提出基于运行场景的结构化民机系统功能需求捕获方法。以平视显示器(HUD,head-up display)系统为例,构建多维度、多层次场景和多视图体系结构模型,实现系统功能需求开发的“正向设计”,验证了该方法的可操作性和有效性。该方法对提升民机系统需求分析能力及系统开发思路具有重要参考意义。
