4-Amino-4-deoxy-4′-demethylepipodophyllotoxin has beendirectly synthesized from 4′-demethylepipodophyllotoxin and HN<sub>3</sub>in the presence of BF3·Et<sub>2</sub>O,followed by hydroge...4-Amino-4-deoxy-4′-demethylepipodophyllotoxin has beendirectly synthesized from 4′-demethylepipodophyllotoxin and HN<sub>3</sub>in the presence of BF3·Et<sub>2</sub>O,followed by hydrogenation withpalladium on charcoal as catalyst.展开更多
We really appreciated Lin et al.’s“The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarci...We really appreciated Lin et al.’s“The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma”in HepatoBiliary Surgery and Nutrition(1).A 291-patient population affected by intrahepatic cholangiocarcinoma(ICC)was retrospectively analyzed with the aim of assessing the accuracy of preoperative staging and treatment reallocation by ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)(1).展开更多
Sodium dithionite-initiated addition of R<sub>F</sub>I（1）[R<sub>F</sub>.=1a,Cl（CF<sub>2</sub>）<sub>4</sub>;1b,Cl（CF<sub>2</sub>）<sub>6</sub>...Sodium dithionite-initiated addition of R<sub>F</sub>I（1）[R<sub>F</sub>.=1a,Cl（CF<sub>2</sub>）<sub>4</sub>;1b,Cl（CF<sub>2</sub>）<sub>6</sub>;1c,Cl（CF<sub>2</sub>）<sub>6</sub>;1d,n-C<sub>6</sub>F<sub>13</sub>;1e,n-C<sub>8</sub>F<sub>17</sub>]to the properly protected glucose derivatives 2,9,12 and 15 gavepolyfluoroalkylated glucose derivatives 7,11,14 and 17 respectively in good yields after reduction anddeprotection.These compounds are strongly surface active.展开更多
In addition to 2-deoxycrustecdysone(1),we isolated and identi-fied two new natural moulting hormones-2-deoxy-3-epicrustecdysone(2)and2-deoxycrustecdysone-3-O-β-D-glucopyranoside(3)from the roots of Tino-spora capilli...In addition to 2-deoxycrustecdysone(1),we isolated and identi-fied two new natural moulting hormones-2-deoxy-3-epicrustecdysone(2)and2-deoxycrustecdysone-3-O-β-D-glucopyranoside(3)from the roots of Tino-spora capillipes,it is the first time to get ecdysteroids from this genus.展开更多
Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid(4)and 9-(2’-deoxy-2’-(benzyloxycarbonyl)-methylene-β-D-rihohept-2’-enofuranosyluranate)adenine(11),were synthesized.The form...Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid(4)and 9-(2’-deoxy-2’-(benzyloxycarbonyl)-methylene-β-D-rihohept-2’-enofuranosyluranate)adenine(11),were synthesized.The formation of lactone of 5’-deoxy-adenosineacetic acid(AAA,3)wasinvestigated by using different reagents for lactonization from AAA,but all of the efforts failed,and sone unexpected compounds were obtained.展开更多
Data security is a major cloud computing issue due to different usertransactions in the system. The evolution of cryptography and cryptographic analysis are regarded domains of current research. deoxyribo nucleic aci...Data security is a major cloud computing issue due to different usertransactions in the system. The evolution of cryptography and cryptographic analysis are regarded domains of current research. deoxyribo nucleic acid (DNA) cryptography makes use of DNA as a sensing platform, which is then manipulated usinga variety of molecular methods. Many security mechanisms including knowledgebased authentication, two-factor authentication, adaptive authentication, multifactorauthentication and single password authentication have been deployed. These cryptographic techniques have been developed to ensure confidentiality, but most ofthem are based on complex mathematical calculations and equations. In the proposed approach, a novel and unique Hybrid helix scuttle-deoxy ribo nucleic acids(HHS-DNA) encryption algorithm has been proposed which is inspired by DNAcryptography and Helix scuttle. The proposed HHS-DNA is a type of multifold binary version of DNA (MF-BDNA). The major role of this paper is to present a multifold HHS-DNA algorithm to encrypt the cloud data assuring more security with lesscomplexity. The experimentation is carried out and it reduces the encryption time,cipher text size, and improves throughput. When compared with previous techniques, there is a 45% improvement in throughput, 37% fast in encryption time,54.67% cipher text size. The relevant experimental results and foregoing analysisshow that this method is of good robustness, stability, and security.展开更多
Polysaceharide is a polyhydroxyl maeromolecular compound. Owing to the influence of the intermolecular and intramolecular hydrogenbonds and difficulty in achieving reaction in solution, it is difficult to obtain produ...Polysaceharide is a polyhydroxyl maeromolecular compound. Owing to the influence of the intermolecular and intramolecular hydrogenbonds and difficulty in achieving reaction in solution, it is difficult to obtain products of its complete or selective substitution in the research of polysaccharide modification or structure. The展开更多
The introduction of a 15-methyl group into a prostaglandin E2 （or its methyl ester） molecule blocks the metabolic action of the 15-hydroxyprostaglandin dehydrogenase and results in a considerable increase of the bio...The introduction of a 15-methyl group into a prostaglandin E2 （or its methyl ester） molecule blocks the metabolic action of the 15-hydroxyprostaglandin dehydrogenase and results in a considerable increase of the biological activities as well as prolongs the duration of the action of resulting derivative. Up to date, only one route for展开更多
文摘4-Amino-4-deoxy-4′-demethylepipodophyllotoxin has beendirectly synthesized from 4′-demethylepipodophyllotoxin and HN<sub>3</sub>in the presence of BF3·Et<sub>2</sub>O,followed by hydrogenation withpalladium on charcoal as catalyst.
基金supported by Italian Ministry of Health-Ricerca Corrente Annual Program 2023.
文摘We really appreciated Lin et al.’s“The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma”in HepatoBiliary Surgery and Nutrition(1).A 291-patient population affected by intrahepatic cholangiocarcinoma(ICC)was retrospectively analyzed with the aim of assessing the accuracy of preoperative staging and treatment reallocation by ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)(1).
基金This work was partially supported by the National Natural Science Foundation of China.
文摘Sodium dithionite-initiated addition of R<sub>F</sub>I（1）[R<sub>F</sub>.=1a,Cl（CF<sub>2</sub>）<sub>4</sub>;1b,Cl（CF<sub>2</sub>）<sub>6</sub>;1c,Cl（CF<sub>2</sub>）<sub>6</sub>;1d,n-C<sub>6</sub>F<sub>13</sub>;1e,n-C<sub>8</sub>F<sub>17</sub>]to the properly protected glucose derivatives 2,9,12 and 15 gavepolyfluoroalkylated glucose derivatives 7,11,14 and 17 respectively in good yields after reduction anddeprotection.These compounds are strongly surface active.
文摘In addition to 2-deoxycrustecdysone(1),we isolated and identi-fied two new natural moulting hormones-2-deoxy-3-epicrustecdysone(2)and2-deoxycrustecdysone-3-O-β-D-glucopyranoside(3)from the roots of Tino-spora capillipes,it is the first time to get ecdysteroids from this genus.
基金The project was supported by the National Natural Science Foundation of China.
文摘Some nucleoside carhoxylic acid derivatives,such as(±)ethyl ester of griseolic acid(4)and 9-(2’-deoxy-2’-(benzyloxycarbonyl)-methylene-β-D-rihohept-2’-enofuranosyluranate)adenine(11),were synthesized.The formation of lactone of 5’-deoxy-adenosineacetic acid(AAA,3)wasinvestigated by using different reagents for lactonization from AAA,but all of the efforts failed,and sone unexpected compounds were obtained.
文摘Data security is a major cloud computing issue due to different usertransactions in the system. The evolution of cryptography and cryptographic analysis are regarded domains of current research. deoxyribo nucleic acid (DNA) cryptography makes use of DNA as a sensing platform, which is then manipulated usinga variety of molecular methods. Many security mechanisms including knowledgebased authentication, two-factor authentication, adaptive authentication, multifactorauthentication and single password authentication have been deployed. These cryptographic techniques have been developed to ensure confidentiality, but most ofthem are based on complex mathematical calculations and equations. In the proposed approach, a novel and unique Hybrid helix scuttle-deoxy ribo nucleic acids(HHS-DNA) encryption algorithm has been proposed which is inspired by DNAcryptography and Helix scuttle. The proposed HHS-DNA is a type of multifold binary version of DNA (MF-BDNA). The major role of this paper is to present a multifold HHS-DNA algorithm to encrypt the cloud data assuring more security with lesscomplexity. The experimentation is carried out and it reduces the encryption time,cipher text size, and improves throughput. When compared with previous techniques, there is a 45% improvement in throughput, 37% fast in encryption time,54.67% cipher text size. The relevant experimental results and foregoing analysisshow that this method is of good robustness, stability, and security.
文摘Polysaceharide is a polyhydroxyl maeromolecular compound. Owing to the influence of the intermolecular and intramolecular hydrogenbonds and difficulty in achieving reaction in solution, it is difficult to obtain products of its complete or selective substitution in the research of polysaccharide modification or structure. The
文摘The introduction of a 15-methyl group into a prostaglandin E2 （or its methyl ester） molecule blocks the metabolic action of the 15-hydroxyprostaglandin dehydrogenase and results in a considerable increase of the biological activities as well as prolongs the duration of the action of resulting derivative. Up to date, only one route for
