目的 应用DICE方案治疗30例难治性非何杰金淋巴瘤,观察其近期疗效。方法 地塞米松10mg,ivd_1;异环磷酰胺(IFO)1.5～2.0g/m^2,ivgt^(tt)d_(1-5),Mesna400mg,ivat0、4、8h after IFO;DDP20mg/m^2,ivg^(tt)d_(1-5);V_(ρ)-16100mg/m^2ivg^(...目的 应用DICE方案治疗30例难治性非何杰金淋巴瘤,观察其近期疗效。方法 地塞米松10mg,ivd_1;异环磷酰胺(IFO)1.5～2.0g/m^2,ivgt^(tt)d_(1-5),Mesna400mg,ivat0、4、8h after IFO;DDP20mg/m^2,ivg^(tt)d_(1-5);V_(ρ)-16100mg/m^2ivg^(tt)d_(1-4)。21天为1周期,共2个周期以上。结果 全组总有效率为76.7％,其中,完全缓解率占26.7％(8/30),部分缓解率为50％(15/30)。主要毒副反应为血液毒性及消化道反应,其次表现为乏力、脱发,少数表现为一过性尿路刺激症状,无致死性毒副反应发生。展开更多
Objective: To compare efficacies and safeties of DICE and CHOP regimens in treating intermediate and high grade non-Hodgkin's lymphoma (NHL), and indicate the standard treatment for it. Methods: A total of 74 pati...Objective: To compare efficacies and safeties of DICE and CHOP regimens in treating intermediate and high grade non-Hodgkin's lymphoma (NHL), and indicate the standard treatment for it. Methods: A total of 74 patients with moder- ately or highly malignant NHL, verified by pathology or histology, were randomized into the trial group (37 patients treated with DICE regimen) and the control group (37 patients treated with CHOP regimen). Survival rate was analyzed by Kaplan-Meier method. Chi-square test was performed between groups. Results: The complete response rate, partial response rate, and response rate were significantly higher in DICE group than in CHOP group (40.5% vs. 29.7%, 37.8% vs. 27.0%, and 78.3% vs. 56.7%, respectively, P < 0.05). The 1-, 3-, and 5-year survival rates were significantly higher in DICE group than in CHOP group (89.2% vs. 81.2%, 76.0% vs. 52.6%%, and 46.7% vs. 36.4%, respectively, P < 0.05). The major side effects, appeared with no differences (P > 0.05) in incidences between the two groups, were leukopenia, thrombocytopenia, and nausea. There were only three episodes of clinical cystitis or gross haematuria in DICE regimen. Conclusion: The results showed higher efficacy of DICE regimen over CHOP regimen. DICE regimen may prolong the survival time of patients with moderately and highly malignant NHL.展开更多
文摘Objective: To compare efficacies and safeties of DICE and CHOP regimens in treating intermediate and high grade non-Hodgkin's lymphoma (NHL), and indicate the standard treatment for it. Methods: A total of 74 patients with moder- ately or highly malignant NHL, verified by pathology or histology, were randomized into the trial group (37 patients treated with DICE regimen) and the control group (37 patients treated with CHOP regimen). Survival rate was analyzed by Kaplan-Meier method. Chi-square test was performed between groups. Results: The complete response rate, partial response rate, and response rate were significantly higher in DICE group than in CHOP group (40.5% vs. 29.7%, 37.8% vs. 27.0%, and 78.3% vs. 56.7%, respectively, P < 0.05). The 1-, 3-, and 5-year survival rates were significantly higher in DICE group than in CHOP group (89.2% vs. 81.2%, 76.0% vs. 52.6%%, and 46.7% vs. 36.4%, respectively, P < 0.05). The major side effects, appeared with no differences (P > 0.05) in incidences between the two groups, were leukopenia, thrombocytopenia, and nausea. There were only three episodes of clinical cystitis or gross haematuria in DICE regimen. Conclusion: The results showed higher efficacy of DICE regimen over CHOP regimen. DICE regimen may prolong the survival time of patients with moderately and highly malignant NHL.
