烟草企业财会监督效能DISE模型构建与应用研究

随着信息化和数字化技术的飞速发展,传统的财会监督方式已无法满足现代烟草企业的管理需求,财会监督工作也迎来了新的机遇与挑战。本文基于DISE(DigitalIntelligenceforSupervisionEnhancement)模型,以烟草企业为例,通过分析当前数字化技术对当前烟草企业财会监督带来的机遇与挑战,详细阐述了如何基于DISE模型构建数字化财会监督平台,强化预算管理和推动财会人员转型升级,旨在提升烟草企业财会监督效能,助力企业更好地适应数字化时代的发展趋势,实现财会监督工作的创新与优化。

Serum beta 2-microglobulin as a biomarker in inflammatory bowel disease

AIM: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD).

Pathogenesis of Crohn's disease: Bug or no bug

The possibility of an infectious origin in inflammatory bowel disease(IBD)has been postulated since the first description of Crohn’s disease(CD).Many observations implicate bacteria as a trigger for the development of CD:lesions occur in regions with higher bacterial concentrations;aphthous ulcers occur in Peyer’s patches;inflammation resolves when the fecal stream is diverted and is reactivated following reinfusion ofbowel contents;severity of the disease is correlated with bacterial density in the mucosa;granulomas can contain bacteria;and susceptible mice raised in germfree conditions develop inflammation when bacteria are introduced in the 1990’s,several studies sought to establish a relationship with viral infections and the onset of IBD,finally concluding that no direct link had been demonstrated.In the past fifteen years,evidence relating IBD pathogenesis to Mycobacterium avium paratuberculosis,salmonella,campylobacter,etc.,has been found.The tendency now under discussion to regard microbiota as the primary catalyst has led to the latest studies on microbiota as pathogens,focusing on Escherichia coli,mainly in ileal CD.The present review discusses the literature available on these"bugs".

Role of the diet as a link between oxidative stress and liver diseases

Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities.

Adalimumab-induced interstitial pneumonia in a patient with Crohn's disease

There are several reports of anti-tumor necrosis factor(TNF)-induced lung disease,especially in patients with rheumatologic diseases.Adalimumab is an antiTNF drug used to induce and maintain remission in patients with immune-mediated diseases,such as Crohn’s disease.Although pulmonary disorders could be an extra-intestinal manifestation of inflammatory bowel disease,biologic therapy could also be a cause of lung injury.Only few cases of adalimumab-induced lung toxicity have been reported,and the majority of them were in patients with rheumatologic diseases.Lung injury secondary to anti-TNF therapy should,after ruling out other etiologies,be considered in patients who have a temporal association between the onset of respiratory symptoms and the exposure to these drugs.A compatible pattern in the biopsy and the clinical improvement after discontinuation of the anti-TNF drug would strongly support the diagnosis.

Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease

AIM: To analyze the cellular immune response towards microsatellite-instability(MSI)-induced frameshift-peptides(FSPs) in patients suffering from inflammatory bowel disease(IBD) with and without thiopurine-based immunosuppressive treatment.METHODS: Frequencies of peripheral blood T cell responses of IBD patients(n = 75) against FSPs derived from 14 microsatellite-containing candidate genes were quantified by interferon-γ enzyme-linked immunospot.T cells derived from 20 healthy individuals served as controls.RESULTS: Significant T cell reactivities against MSIinduced FSPs were observed in 59 of 75 IBD patients(78.7%).This was significantly more as we could observe in 20 healthy controls(P = 0.001).Overall,the reactivity was significantly influenced by thiopurine treatment(P = 0.032) and duration of disease(P = 0.002) but not by duration or cumulative amount of thiopurine therapy(P = 0.476).Unexpected,15 of 24(62.5%) IBD patients without prior thiopurine treatment also showed increased FSP-specific immune responses(P = 0.001).CONCLUSION: These findings propose FSPs as potential novel class of inflammation-associated antigens and this in turn may have implications for screening,diagnosis as well as clinical management of patients suffering from IBD and other inflammatory conditions.

DISE Learning Model for Teaching Writing to Elementary School Students

DISE learning model refers to the one which is dialogue-based using scientific approach containing edutainment element. DISE is the acronym of dialog, scientific, and edutainment. It is a learning model which is developed for the fifth graders of elementary school particularly for teaching writing of personal recount. This article described DISE learning model from the theoretical basis, meaning, and syntax. DISE was the product of Research and Development design conducted in Banyumas Regency, Central Java Province, Indonesia. DISE learning model can serve as a reference for elementary school teachers for teaching writing.

A Paradise for Gourmets

DUBBED a“paradise on earth”for its picturesque West Lake,Hangzhou in east China’s Zhejiang Province is also known as a business center and culinary hub.Historically,it was the capital of the Southern Song Dynasty(1127-1279),when numerous literati residing there helped create a unique charm of the Hangzhou cuisine featuring the combination of culinary essence from north and south China.

Beijing vs Paradise

Living on a tropical island,with waves lappingup on thesand and the sun shining-sounds like a dream come true,right?Well,for me,it was a 100-percent no.After seven years in China and always wondering what it would be like to live in paradise,I decided to take the plunge and move to another country,destination Thailand.

Roles of interleukin-10 in acute graft-versus-host disease and graft rejection

To study the role of interleukin(IL)-10 in acute-graft-versus-host disease (aGVHD) and graft rejection Methods Serum concentrations of IL-10 in 28 patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) were measured by enzymed-linked immunosorbent assay (ELISA) IL-10 gene expression in peripheral mononuclear cells was measured by reverse-transcriptase polymerase chain reaction (RT-PCR) after transplantation Results Seven patients developed grade Ⅰ GVHD, 7 patients developed grade Ⅱ-Ⅳ GVHD, 4 patients had graft rejection Before transplantation, the concentrations of IL-10 were higher in patients who later did not developed aGVHD After transplantation, IL-10 levels increased in patients without aGVHD, but decreased in patients with aGVHD or graft rejection And IL-10mRNA was more frequent in patients without aGVHD compared to those with aGVHD Conclusions IL-10 plays a negative role in the development of aGVHD and graft rejection

基于现代中医视角深度解析气血

气是人体生命活动的基本物质基础,气聚成形而生万物,血是濡养五脏六腑、四肢百骸的精微物质,气血关系密切,可相互协同发挥作用,又可相互转化。本文从现代中医视角,从常见症状与疾病的病因、临床表现、辨证、经络、腧穴、养生、膳食调养等方面深度解析气血本质,将抽象的中医理念具象化,增强群众的健康意识、改善体质、通过补养气血、疏通经络等,整体预防慢性病的发生与发展。

女性不同年龄段阴道微生态、阴道疾病及人乳头瘤病毒感染状况

目的探讨女性不同年龄段阴道微生态、阴道疾病及人乳头瘤病毒(HPV)感染状况。方法选取2019年5月至2020年4月于包头医学院第二附属医院妇产科门诊行HPV与阴道微生态检测的752例患者。分析检查结果。结果752例中,阴道微生态正常检出率为56.91%;阴道微生态失调检出率为43.09%,其中无明确感染的阴道微生态失调13.03%、混合感染1.86%、细菌性阴道病(BV)中间型7.71%、BV 12.77%、外阴阴道假丝酵母菌病(VVC)5.85%、滴虫性阴道炎(TV)1.86%,未检出需氧菌性阴道炎(AV)。HPV感染率为24.20%。随年龄的增长pH>4.5、白细胞>10个/HPF、乳杆菌减少、无明确感染的阴道微生态失调、HPV感染检出率增高(P<0.05);随年龄的增长阴道微生态正常检出率降低(P<0.05)。不同年龄段的混合感染、BV中间型、BV、VVC、TV的检出率比较,差异无统计学意义(P>0.05)。随年龄的增长HPV31、68型检出率增高,39型检出率降低(P<0.05);其他基因型不随年龄的变化而变化(P>0.05)。结论阴道微生态、阴道疾病及HPV感染在女性不同年龄段的检出率有所差异,临床可根据不同年龄段进行针对性预防、干预。

峡部裂性与退变性腰椎滑脱患者腰椎退变程度的影像学比较研究

目的:比较峡部裂性与退变性腰椎滑脱患者的腰椎退变程度。方法:回顾性分析2015年1月至2022年3月在南通市中医院收治的170例腰椎滑脱患者的病例资料,其中峡部裂性滑脱85例(峡部裂组)、退变性滑脱85例(退变组)。在腰椎侧位X线片上采用Meyerding分级标准评估腰椎滑脱程度;在腰椎MRI上采用Pfirrmann分级标准评估椎间盘退变程度,采用Modic改变分级标准评估终板退变程度,采用Weishaupt分级标准评估关节突关节退变程度。比较2组患者的腰椎滑脱Meyerding分级、椎间盘Pfirrmann分级、终板Modic改变分级及关节突关节Weishaupt分级。结果:①腰椎滑脱Meyerding分级。峡部裂组腰椎滑脱MeyerdingⅠ度32例、Ⅱ度48例、Ⅲ度5例,退变组腰椎滑脱MeyerdingⅠ度59例、Ⅱ度26例;峡部裂组腰椎滑脱程度较退变组更严重(Z=-4.323,P=0.000)。②椎间盘Pfirrmann分级。峡部裂组椎间盘Pfirrmann Ⅲ级43例、Ⅳ级34例、Ⅴ级8例,退变组椎间盘Pfirrmann Ⅲ级33例、Ⅳ级47例、Ⅴ级5例;2组患者椎间盘退变程度比较,差异无统计学意义(Z=-1.121,P=0.262)。③终板Modic改变分级。峡部裂组终板Modic0级18例、Ⅰ级7例、Ⅱ级46例、Ⅲ级14例,退变组终板Modic0级27例、Ⅰ级6例、Ⅱ级47例、Ⅲ级5例;峡部裂组终板退变程度较退变组更严重(Z=-2.051,P=0.040)。④关节突关节Weishaupt分级。峡部裂组关节突关节Weishaupt 0级2例、Ⅰ级27例、Ⅱ级33例、Ⅲ级23例,退变组关节突关节WeishauptⅠ级25例、Ⅱ级30例、Ⅲ级30例;2组患者关节突关节退变程度比较,差异无统计学意义(Z=-1.140,P=0.254)。结论:峡部裂性腰椎滑脱患者与退变性腰椎滑脱患者的椎间盘与关节突关节退变程度相似,但前者的腰椎滑脱和终板退变程度较后者更严重。

岩土工程专题数据库的规划与建设

文章介绍了天津城市建设学院图书馆馆藏特色以及人员和技术、设备的优势,论述了该馆在利用方正DISE数字图书馆建设与管理平台,探讨建设岩土工程专题数据库的过程及成果,并指出了在建库中应注意的问题。

改良TESSYS技术对腰椎间盘突出症患者腰部活动度及脊柱稳定性的影响

目的探讨改良经椎间孔脊柱内镜系统(TESSYS)技术对腰椎间盘突出症(LDH)患者腰部活动度及脊柱稳定性的影响。方法回顾性分析2019年2月至2022年2月疼痛科收治的110例LDH患者的临床资料,根据不同术式将患者分为对照组和研究组,各55例。对照组给予椎间盘镜技术治疗,研究组给予改良TESSYS技术治疗。比较两组患者的手术指标以及手术前、后的腰部活动度、脊柱稳定性及腰椎功能。结果研究组的切口长度小于对照组,手术时间、卧床时间及住院时间短于对照组,术中出血量少于对照组(P<0.05)。术后1个月,研究组的腰椎曲度、腰屈曲范围、腰背肌后伸活动度及腰背屈肌/伸肌比值(F/E)均显著优于对照组(P<0.05)。术后1个月,研究组的腰椎前凸角、腰骨倾斜角、矢状面平衡及颌眉角均显著优于对照组,差异具有统计学意义(P<0.05)。术后3个月,研究组的Roland-Morris功能障碍调查表(RMQ)、视觉模拟疼痛评分量表(VAS)评分低于对照组,日本骨科协会(JOA)评分高于对照组,腰椎关节活动度(ROM)大于对照组,差异具有统计学意义(P<0.05)。结论相较于椎间盘镜技术,改良TESSYS技术在LDH患者的治疗中更具优势,其创伤小,术中出血少,有利于改善腰部活动度,恢复脊柱稳定性,从而更好地改善腰椎功能,值得临床应用推广。

FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

AIM: To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and the underlying mechanism.

数据密集型科学与工程：需求和挑战

科学研究在经历了实验科学、理论科学、计算科学阶段后,进入了数据密集型科学阶段,与之相伴的是大数据时代的到来.大数据泛指规模达到几百TB,甚至PB级的数据①,其典型的特征是分布、异构、低质量等.尽管传统数据库管理技术(特别是商业关系型数据库)在过去40年间取得了巨大成功,但是这些技术和系统无法有效管理支持数据密集型科学与工程(Data-Intensive Science and Engineering,DISE)的大数据.文中探讨数据密集型科学与工程的具体需求和现实挑战.它涵盖的内容表现在4个层面,包括数据存储与组织、计算方法、数据分析以及用户接口技术等.同时,数据质量、数据安全、数据监护等内容也需要在各层面得到重视.文中尝试梳理了数据密集型科学与工程的整体架构,回顾了相关领域的新近发展,分析了面临的挑战,探讨了未来的研究方向.

胸腰段椎间盘突出症的手术治疗及入路选择

目的:探讨胸腰段椎间盘突出症手术治疗的入路选择。方法:对我院1992￣2000年间接受手术治疗并获得随访的38例胸腰段椎间盘突出症患者的临床资料进行回顾性分析。男27例,女11例;年龄20￣65岁,病程3个月￣11年。侧前方入路行椎间盘切除术30例,15例同时行内固定;侧后方肋骨横突切除入路行椎间盘切除术5例;后方椎板切除入路行椎间盘切除术3例。结果:侧前方入路组术野直视、显露清晰、便于操作,无神经系统并发症发生,术中发生胸膜破裂2例,腹膜破裂1例,硬脊膜破裂2例;术后发生胸腔积液2例,气胸1例,肺炎1例,脑脊液漏1例。经相应处理后获得治愈。侧后方肋骨横突切除入路难以直视硬膜和脊髓的腹侧,显露欠佳,未发生神经系统并发症;术中发生胸膜破裂2例,经修补术后未出现肺部并发症。后方椎板切除入路组手术方法相对简单,但术中难以避免对脊髓造成的牵拉损伤,2例术后发生下肢神经症状加重,至术后2周出院时1例恢复至术前水平,另1例加重的症状无明显缓解。术后平均随访5.8年(4￣12年),疗效参照Macnab法和Otani法评定,优17例(44.7%),良15例(39.5%),可5例(13.1%),差1例(2.7%)。结论:经侧前方入路行胸腰段椎间盘切除术术野直视、清晰,相对安全且有效,是胸腰段椎间盘突出症外科治疗的首选术式;经侧后方肋骨横突切除入路只适合于极外侧型或外侧型胸腰段椎间盘突出症;经后方椎板切除入路应视为胸腰段椎间盘突出症手术的禁忌。

西藏驱龙铜矿西部斑岩与成矿关系的厘定：对矿床未来勘探方向的重要启示

对正在勘查中的西藏驱龙斑岩铜矿床,任何关于基础矿床地质认识上的改变,都可能会引发勘查方向上的重大变动。驱龙铜矿的勘探工作是围绕矿区内出露的几套斑岩体进行的。然而,野外调查发现,矿区西部斑岩体(指原Ⅱ、Ⅲ及Ⅳ号斑岩)却表现出与东部斑岩体(原Ⅰ号斑岩)截然不同的蚀变、矿化及岩石学特征:西部斑岩蚀变以石英-绢云母化为主,局部可见青磐岩化;矿化主要为黄铁矿化,黄铜矿很少;通常产于斑岩铜矿外围的黄铁矿D脉发育。这些特征均表明,西部斑岩整体处于斑岩矿化系统的绢英岩化带,局部甚至处于青磐岩化蚀变带内,并非像东部斑岩(出现以斑岩体为中心、呈同心环状分带的蚀变及矿化系统)一样。西部斑岩还发生了明显的韧性变形,经历了比东部斑岩更为复杂的地质演化过程,其形成时间明显早于东部斑岩。因此,推断西部斑岩对成矿的贡献不大。为证实野外观察的正确性,作者对西部斑岩开展了详细的岩石学、岩石地球化学及年代学研究,结果显示,西部斑岩为高钾钙碱性系列,具有明显的Eu负异常,富集大离子亲石元素,亏损高场强元素,但不亏损Ta,其锆石U-PbSHRIMP年龄为(182.3±1.5)Ma,为早侏罗世的产物,明显不同于形成于中新世的东部斑岩。因此,驱龙铜矿床未来的勘探工程布置方案更加清晰,应紧紧围绕东部斑岩所形成的矿化系统进行。由于西部斑岩出露面积较大,与叶巴组火山岩一样,仅为围岩,并没有形成自己的蚀变与矿化系统,建议不要对该斑岩布置太多的勘查工程。在矿床勘探过程中,详细的野外观察,辅以适当的科学分析手段,往往能够避免投入过多无谓的勘查工程,减少浪费。

糖尿病与非糖尿病患者外周动脉病变血管造影对比研究

目的 比较糖尿病和非糖尿病患者外周动脉病变的分布及其严重程度。 方法 2型糖尿病 (T2DM)患者 (DM组 ) 4 3例 ,非糖尿病动脉硬化症患者 (NDM组 ) 39例。将造影动脉所见分为腹主、髂总、髂内、髂外、股深、股浅、、胫前、胫后和腓动脉共 10段 ,用分段积分法进行动脉管腔狭窄程度比较。 结果 腹主、腹部内脏、股深及胫前动脉病变发生率在NDM组分别为 33/ 34(97% )、11/ 30 (37% )、11/ 6 9(16 % )和 2 5 / 4 2 (6 0 % ) ,在T2DM组分别为 2 6 / 36 (72 % )、1/ 36 (3% )、2 4 / 78(31% )和 6 1/ 75 (81% ) ;NDM组腹主动脉积分为 0 2 6± 0 6 7、髂总动脉积分为 0 5 5± 1 0 6、髂内动脉积分为 1 0 8± 1 2 9;T2DM组相应的动脉积分分别为 0、0 15± 0 5 8和 0 5 7± 1 0 5 ;这些差异均有显著意义。T2DM组股深、、胫前、胫后、腓动脉积分分别为 0 6 0± 0 6 1、1 15± 0 82、1 92± 1 39、1 72± 1 85和 1 99± 1 0 5 ,均明显高于NDM组的 0 17± 0 4 8、0 75± 1 2 2、0 81± 0 94、1 0 7±1 0 0和 0 98± 1 0 0。 结论 NDM组较T2DM组血管病变更常累及腹主动脉及腹部内脏动脉 ,T2DM组较NDM组更常累及股深动脉和胫前动脉 。