The effect of Pb2+ on 3H-DL-Glutamate (3H-DL-Glu) binding in the membrane preparations from the hippocampus of rat brain was investigated with a view to explaining the cognitive and learning deficits produced by the h...The effect of Pb2+ on 3H-DL-Glutamate (3H-DL-Glu) binding in the membrane preparations from the hippocampus of rat brain was investigated with a view to explaining the cognitive and learning deficits produced by the heavy metal. The results indicated that Pb2+ (3. 1-25. 0 μmol.L -1 ) inhibited 3 H-DL-Glu binding in a concentration-dependent manner . Scatchard analysis further revealed that at a concentration of 6. 3 μmol.L-1 Pb2 + interfered with binding mainly through significantly decreasing the density of binding sites. This finding provided an important insight into Pb2+ -induced impairments in learning and memory previously documented in children and in experimental animals chronically exposed to Pb^(2+)展开更多
文摘The effect of Pb2+ on 3H-DL-Glutamate (3H-DL-Glu) binding in the membrane preparations from the hippocampus of rat brain was investigated with a view to explaining the cognitive and learning deficits produced by the heavy metal. The results indicated that Pb2+ (3. 1-25. 0 μmol.L -1 ) inhibited 3 H-DL-Glu binding in a concentration-dependent manner . Scatchard analysis further revealed that at a concentration of 6. 3 μmol.L-1 Pb2 + interfered with binding mainly through significantly decreasing the density of binding sites. This finding provided an important insight into Pb2+ -induced impairments in learning and memory previously documented in children and in experimental animals chronically exposed to Pb^(2+)
