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Thymoquinone Suppresses Cellular Proliferation, Inhibits VEGF Production and Obstructs Tumor Progression and Invasion in the Rat Model of DMH-Induced Colon Carcinogenesis 被引量:2
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作者 Wasfi Asfour Sawsan Almadi Lina Haffar 《Pharmacology & Pharmacy》 2013年第1期7-17,共11页
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertak... A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQ’s chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable negative impact of TQ on vascular endothelial growth factor (VEGF) production in tumor-bearing rats. Furthermore, we provided evidence that TQ-treatment, in both phases, tended to considerably suppress tumor progression and invasion. Taken together, the present study demonstrated that TQ, at an orally daily dose of 10 mg/kg, has a chemopreventive effect in the initiation phase, and has the potential to attenuate tumor burden, suppress progression of pre-neoplastic lesions and to inhibit tumor growth in the post-initiation phase of DMH-induced colon carcinogenesis, We surmise that such effects of TQ may be due to suppression of cellular proliferation and inhibition of VEGF production. The results could provide an effective chemopreventive approach in the primary prevention of colon cancer in humans in the next future, and illuminate a promising horizon to combat progression of benign colonic pre-neoplastic lesions into malignant metastatic tumors and to manage colon cancer. 展开更多
关键词 THYMOQUINONE PCNA-LI VEGF Serum Levels Tumor Progression INVASION Rat dmh-induced colon carcinogenesis INITIATION Post INITIATION Phase Modified Duke’s Classification Chemoprevention
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Prevention and treatment of hypoxia-induced colorectal cancer damage in albino Wister rats
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作者 Ishrat Jahan Manju Pandey +3 位作者 Shalini Pal Bushra Jabi Mohd Yaqub Khan Gaurav Kaithwas 《Life Research》 2024年第1期16-23,共8页
Background:In the early metastasis of colon cancer,cancer cells detach,migrate,and infiltrate surrounding tissues,including lymph vessels and blood vessels.Tumor heterogeneity arises from both tumor cells and distinct... Background:In the early metastasis of colon cancer,cancer cells detach,migrate,and infiltrate surrounding tissues,including lymph vessels and blood vessels.Tumor heterogeneity arises from both tumor cells and distinct microenvironments.Maldistribution of blood vessels,creates hypoxic regions within the tumors,fostering cancer stem cell-like properties due to reduced oxygen and nutrient supply.Under hypoxia,tumor cells shift to a glycolytic pathway,producing more lactic acid that acidifies the microenvironment and leads to unstable heart rate variability(HRV)factors,weight disparity,and a higher incidence of aberrant crypt foci(ACF).These hypoxic-induced parameters promote cancer cell invasion,increase radiation resistance,and facilitate cancer cell migration.Methods:In this study,we induced hypoxia-preneoplastic colon damage in albino Wister rats by administrating 1,2-dimethyl hydrazine(DMH).After successfully creating a hypoxic environment in albino Wister rats,resulting in preneoplastic colon damage,we randomly allocated Wistar albino rats into seven groups,each containing 8 animals,and conducted a 6-week study.Group 1-Normal control(administered 1 mM EDTA+saline,2 ml/kg/day,p.o.);group 2-Toxic control(administered DMH,30 mg/kg/week,s.c.);group 3-Standard treatment(DMH,30 mg/kg/week,s.c.for 6 weeks),followed by 5-fluorouracil and Leucovorin(25 mg/kg each on 1^(st),3^(rd),7^(th),and 10^(th) days,i.p.after 6 weeks administration of DMH);group 4-Low dose of P1(DMH,30 mg/kg/week,s.c.+P1,2 mg/kg,i.v.,weekly for 3 weeks);group 5-High dose P1(DMH,30 mg/kg/week,s.c.+P1,4 mg/kg,i.v.,weekly for 3 weeks),group 6-Low dose of P2(DMH,30 mg/kg/week,s.c.,+P2,2 mg/kg,i.v.,weekly for 3 weeks),group 7-High dose of P2(DMH,30 mg/kg/week,s.c.,+P2,4 mg/kg,i.v.weekly for 3 weeks).Results:DMH-treated rats exhibited alterations in HRV factors,weight disparity,elevated gastric pH,increased total acidity,a higher incidence of ACF,and changes in antioxidant markers(TBARs,SOD,catalase,GSH).Brightfield microscopy at 40x magnification revealed the presence of large crypts within aberrant crypt foci in the toxic control group.Conclusion:Treatment groups P1 and P2 containing triazine derivatives initiated proteasomal degradation of Hypoxia Inducible Factor-1α(HIF-1α)by activating Prolyl Hydroxylase(PHDs)pathways.HIF-1αunder a hypoxic environment is responsible for activating a multitude of genes involved in angiogenesis,metastasis,invasiveness,pH changes,metabolic reprogramming,stem cell maintenance,resistance to radiation,and downstream regulation of the immune system.Treatment with P1 and P2 groups helped minimize the ACF count and restored HRV factors,weight disparity,pH levels,total acidity,and oxidative balance.Our findings emphasize the potential role of 1,2,4-triazine derivatives in suppressing hypoxia-induced colon carcinogenesis. 展开更多
关键词 colon cancer 1 2 4-triazine derivatives oxidative stress hypoxia-induced colon carcinogenesis
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Therapeutic implications of colon cancer stem cells 被引量:8
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作者 Eros Fabrizi Simona di Martino +1 位作者 Federica Pelacchi Lucia Ricci-Vitiani 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第31期3871-3877,共7页
Colorectal cancer is the second most common cause of cancer-related death in many industrialized countries and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, the conc... Colorectal cancer is the second most common cause of cancer-related death in many industrialized countries and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, the concept that cancer might arise from a rare population of cells with stem cell-like properties has received support with regard to several solid tumors, including colorectal cancer. According to the cancer stem cell hypothesis, cancer can be considered a disease in which mutations either convert normal stem cells into aberrant counterparts or cause a more differentiated cell to revert toward a stem cell-like behaviour; either way these cells are thought to be responsible for tumor generation and propagation. The statement that only a subset of cells drives tumor formation has major implications for the development of new targeted therapeutic strategies aimed at eradicating the tumor stem cell population. This review will focus on the biology of normal and malignant colonic stem cells, which might contribute to our understanding of the mechanisms responsible for tumor development and resistance to therapy. 展开更多
关键词 colon cancer initiating cells colon carcinogenesis Target therapy
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Azoxymethane-induced rat aberrant crypt foci:Relevance in studying chemoprevention of colon cancer 被引量:5
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作者 Jayadev Raju 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第43期6632-6635,共4页
结肠癌的致病包含顺序并且多走与定义癌症前期的中间人开始到一个癌的状态的上皮细胞的前进。异常地窟 foci (ACF ) 在试验动物和人在冒号致癌作用期间代表最早可看作是相同的中间的癌前期损害。ACF 被冒号特定的致癌物容易在啮齿类动... 结肠癌的致病包含顺序并且多走与定义癌症前期的中间人开始到一个癌的状态的上皮细胞的前进。异常地窟 foci (ACF ) 在试验动物和人在冒号致癌作用期间代表最早可看作是相同的中间的癌前期损害。ACF 被冒号特定的致癌物容易在啮齿类动物导致并且能被用来进一步了解冒号致癌作用的过程。为超过二十年,自从它的第一发现, azoxymethane (AOM ) 导致了啮齿类动物 ACF 在屏蔽各种各样的反致癌物和致癌物用作代理人简历标记。几饮食的成分和 phytochemicals 用 ACF 系统为他们的结肠癌 chemopreventive 功效被测试了。在以理解他们的分子的组成定义并且精制 ACF 有实质的努力,并且这个领域里的广泛的研究当前在进行中。在 chemoprevention 研究,导致 AOM 的老鼠 ACF 作为简历标记很成功,并且提供了数据的几标准化分析。有几研究,报导了然而,那个 ACF 数据不相关到实际冒号肿瘤结果并且在那里因此有作为简历标记是关于他们的角色的歧义。这微型评论的范围是在结肠癌 chemoprevention 研究作为简历标记提供导致 AOM 的老鼠 ACF 的珍贵卓见和限制。动力学的角色和 ACF 的生物异质在在 chemoprevention 研究作为简历标记理解他们是关键的。 展开更多
关键词 异常隐窝 致癌作用 结肠癌 症状
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结肠癌与直肠癌癌变相关基因及蛋白表达的差异分析 被引量:1
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作者 赵莉 韩涛涛 +2 位作者 李可敏 王静 李骥 《北京医学》 CAS 2023年第4期284-288,共5页
目的 探讨结肠癌及直肠癌癌变相关基因及蛋白表达的差异。方法 选取1999—2008年北京协和医院结肠癌和直肠癌住院患者石蜡组织标本各30例,比较两组患者的一般资料、癌变相关蛋白的阳性率、肿瘤组织错配修复系统蛋白表达的阳性率和肿瘤K-... 目的 探讨结肠癌及直肠癌癌变相关基因及蛋白表达的差异。方法 选取1999—2008年北京协和医院结肠癌和直肠癌住院患者石蜡组织标本各30例,比较两组患者的一般资料、癌变相关蛋白的阳性率、肿瘤组织错配修复系统蛋白表达的阳性率和肿瘤K-ras基因突变频率。结果 60例患者中,男34例,女26例;平均年龄(61.9±15.4)岁。两组在肿瘤易感基因结肠腺瘤性息肉病(adenomatous polyposis coli,APC)蛋白的阳性率(60.0%比53.3%)、Wnt1蛋白的阳性率(50.0%比66.7%)、β连环蛋白(β-catenin)的阳性率(93.3%比90.0%)、p53蛋白的阳性率(76.7%比86.7%)、结肠癌组织K-ras突变频率(53.3%比36.6%)的比较,差异均无统计学意义(P> 0.05)。结肠癌组Mut L同源基因1(mut L homolog1,MLH1)蛋白的阳性率(76.7%比100.0%)、减数分裂后分裂蛋白2(post meiotic segregation 2,PMS2)蛋白的阳性率(76.7%比100.0%)、MLH1和PMS2蛋白同时阳性率(76.7%比100.0%)均低于直肠癌组,差异均有统计学意义(P <0.01)。结论 肿瘤驱动基因APC、Wnt1、β-catenin及p53在结肠癌及直肠癌癌变过程中均发挥重要作用,K-ras在结肠癌中存在高频突变,错配修复系统相关蛋白MLH1及PMS2在结肠癌中存在高频表达缺失,提示结肠癌及直肠癌癌变机制可能存在差异。 展开更多
关键词 结肠癌 直肠癌 癌变相关基因 蛋白表达
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SH2-B在结肠癌组织中表达及临床意义 被引量:9
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作者 李建国 华建江 +3 位作者 黄大毛 曾亮 段朝军 唐发清 《中国现代医学杂志》 CAS CSCD 北大核心 2010年第13期2004-2007,共4页
目的探讨SH2-B在结肠癌癌变过程中的演变规律,分析SH2-B表达与结肠癌临床分期的关系,分析SH2-B表达与结肠癌转移的关系。方法免疫组织化学方法检测69例结肠癌组织、27例结肠腺瘤组织、29例结肠息肉组织中SH2-B蛋白的表达。69例结肠癌患... 目的探讨SH2-B在结肠癌癌变过程中的演变规律,分析SH2-B表达与结肠癌临床分期的关系,分析SH2-B表达与结肠癌转移的关系。方法免疫组织化学方法检测69例结肠癌组织、27例结肠腺瘤组织、29例结肠息肉组织中SH2-B蛋白的表达。69例结肠癌患者Ⅰ期11例、Ⅱ期22例、Ⅲ期19例、Ⅳ期17例,其中无转移34例,淋巴节转移35例。结果免疫组织化学检测结果显示,SH2-B蛋白在结肠息肉组织、结肠腺瘤组织、结肠癌组织中的表达呈浆-核型,以胞浆为主。结肠息肉患者SH2-B阳性率为31%(9/29),结肠腺瘤患者SH2-B阳性率为52%(14/27),结肠癌患者SH2-B阳性率为93%(27/29)。结肠癌组织中SH2-B的阳性细胞率(0.64±0.26)明显高于结肠腺瘤组织(0.26±0.27)和结肠息肉组织(0.12±0.21)(P<0.001),结肠腺瘤组织中阳性细胞表达率明显高于结肠息肉组织(P<0.05)。结肠癌Ⅰ、Ⅱ、Ⅲ和Ⅳ期强阳性率分别为18.2%(2/11)、45.4%(10/22)、57.9%(11/19)和82.3%(14/17)。转移组和非转移组强阳性率为45.7%(16/35)和23.5%(8/34),转移组SH2-B强阳性率显著高于无转移组(P<0.05)。结论 SH2-B过表达可能参与了结肠癌癌变过程,可能是结肠癌变的早期事件。SH2-B表达与结肠临床分期有关。SH2-B可能参与了结肠癌转移,SH2-B高表达与结肠癌转移呈正相关。 展开更多
关键词 结肠癌 SH2-B 免疫组织化学 临床分期 转移
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RUNX3、β-catenin、C-myc在结直肠腺瘤癌变中的作用 被引量:10
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作者 吴林林 李岩 +2 位作者 刘辉 胡艳萍 刘凤阁 《疑难病杂志》 CAS 2018年第2期176-179,F0003,共5页
目的检测人类runt相关转录因子基因(RUNX3)、β-连珠蛋白(β-catenin)、原癌基因(C-myc)在结直肠腺瘤癌变中的表达,探讨其在结直肠癌变中的作用。方法回顾性分析2014年1月—2016年1月首都医科大学附属北京潞河医院结直肠腺瘤癌变病例57... 目的检测人类runt相关转录因子基因(RUNX3)、β-连珠蛋白(β-catenin)、原癌基因(C-myc)在结直肠腺瘤癌变中的表达,探讨其在结直肠癌变中的作用。方法回顾性分析2014年1月—2016年1月首都医科大学附属北京潞河医院结直肠腺瘤癌变病例57例(结直肠瘤癌变组),另外选择结直肠腺瘤33例(结直肠腺瘤组),正常结直肠黏膜20例(正常组织组)。应用免疫组织化学的方法分别检测RUNX3、β-catenin、C-myc在结直肠腺瘤癌变组、结直肠腺瘤组及正常组织组中的表达情况。结果 RUNX3在结直肠腺瘤癌变组的阳性表达率显著低于结直肠腺瘤组及正常组织组(χ~2=29.788,P=0.000);β-catenin、C-myc在结直肠腺瘤癌变组阳性表达率显著高于腺瘤组及正常组(χ~2=24.338、52.711,P均=0.000)。在结直肠腺瘤癌变组中,RUNX3与β-catenin呈负相关(r=-0.475,P=0.000);β-catenin与C-myc呈正相关(r=0.362,P=0.006);RUNX3与C-myc无相关性(r=-0.200,P=0.136)。结论 RUNX3在结直肠腺瘤癌变组表达下调,从而影响β-catenin、C-myc表达上调,RUNX3、β-catenin、C-myc在结直肠腺瘤癌变中具有重要作用。 展开更多
关键词 腺瘤癌变 结直肠 人类runt相关转录因子基因 β-连珠蛋白 原癌基因
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硫氧还蛋白及硫氧还蛋白相互作用蛋白在结肠息肉癌变中的表达及意义 被引量:5
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作者 杨婕琳 翟明慧 +1 位作者 张凡 赵东强 《西部医学》 2021年第9期1359-1363,1368,共6页
目的探讨硫氧还蛋白(thioredoxin,Trx)与硫氧还蛋白相互作用蛋白(thioredoxin-interacting protein,TXNIP)在结肠息肉、结肠腺瘤及结肠癌中的表达,分析Trx、TXNIP在结肠息肉癌变中的作用。方法收集河北北方学院附属第一医院2019年1月~2... 目的探讨硫氧还蛋白(thioredoxin,Trx)与硫氧还蛋白相互作用蛋白(thioredoxin-interacting protein,TXNIP)在结肠息肉、结肠腺瘤及结肠癌中的表达,分析Trx、TXNIP在结肠息肉癌变中的作用。方法收集河北北方学院附属第一医院2019年1月~2019年10月就诊的结肠息肉(结肠息肉组)20例、结肠腺瘤(结肠腺瘤组)40例、结肠癌(结肠癌组)20例以及正常结肠(正常结肠组)20例,通过ELISA法检测血清Trx、TXNIP的含量,采用胰岛素还原法检测血清Trx活性,苏木精-伊红染色(HE)法观察各组织的形态学,应用免疫组织化学法检测组织中Trx、TXNIP的表达,实时荧光定量PCR检测组织中Trx mRNA与TXNIP mRNA的表达水平。结果与正常结肠组比较,结肠腺瘤组与结肠癌组患者血清中Trx含量和活性明显升高,结肠息肉组、结肠腺瘤组患者与结肠癌组患者血清中TXNIP含量较正常结肠组明显下降,差异均有统计学意义(P<0.05);在结肠腺瘤组和结肠癌组组织中Trx阳性表达率明显高于正常结肠组,而TXNIP阳性表达率明显低于正常结肠组,差异均有统计学意义(P<0.05);与正常结肠组比较,结肠息肉组、结肠腺瘤组及结肠癌组组织中Trx mRNA的表达水平均明显上调,TXNIP mRNA的表达水平均明显下调,差异具有统计学意义(P<0.05)。结论Trx在结肠息肉癌变中高表达,而TXNIP表达降低,表明两者都参与结肠癌前病变与癌组织的发生及发展,两者均在结肠息肉癌变过程中起着重要的作用。 展开更多
关键词 癌变 结肠息肉 结肠腺瘤 结肠癌 硫氧还蛋白 硫氧还蛋白相互作用蛋白
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Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights 被引量:9
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作者 Hisham Hussan Steven K Clinton +1 位作者 Kristen Roberts Michael T Bailey 《World Journal of Gastroenterology》 SCIE CAS 2017年第48期8626-8650,共25页
AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles pu... AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above criteria.RESULTS Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with an F. nucleatum protein,fibroblast activation protein 2(FAP2). The clinical significance of detection or enrichment of Fusobacterium in colorectal neoplasia is ambiguous,but data suggest a procarcinogenic effect of F. nucleatum,likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. This is hypothesized to be mediated by certain F. nucleatum strains carrying invasive properties and virulence factors such as Fad A and FAP.CONCLUSION Evidence suggests a potential active role of Fusobacterium,specifically F. nucleatum,in CRC. Future prospective and experimental human studies would fill an important gap in this literature. 展开更多
关键词 colon MICROBIOTA FUSOBACTERIUM Systematic review FUSOBACTERIUM nucleatum COLORECTAL cancer COLORECTAL POLYPS carcinogenesis
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二甲肼和葡聚糖硫酸钠建立溃疡性结肠炎相关性大肠癌小鼠模型 被引量:1
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作者 王冬飞 沈晓伶 王建国 《胃肠病学和肝病学杂志》 CAS 2006年第5期511-515,共5页
目的建立溃疡性结肠炎相关性大肠癌的动物模型,并检测该模型诱发的不典型增生及癌变组织中β-catenin和p53的表达情况。方法单次小剂量腹腔注射二甲肼(20mg/kg)联合三循环3%葡聚糖硫酸钠自由饮用建立小鼠溃疡性结肠炎相关性大肠癌模型,H... 目的建立溃疡性结肠炎相关性大肠癌的动物模型,并检测该模型诱发的不典型增生及癌变组织中β-catenin和p53的表达情况。方法单次小剂量腹腔注射二甲肼(20mg/kg)联合三循环3%葡聚糖硫酸钠自由饮用建立小鼠溃疡性结肠炎相关性大肠癌模型,HE染色观察结肠、盲肠黏膜不典型增生及癌变的发生,免疫组组织化学法观察不典型增生及癌变组织中β-catenin和p53的表达情况。结果低剂量二甲肼腹腔注射联合葡聚糖硫酸钠三个循环11只小鼠10周内共诱发4处原位癌,36处不典型增生,肿瘤主要位于远端结肠,单独二甲肼或葡聚糖硫酸钠处理无肿瘤发生。原位癌和不典型增生组织中β-catenin在细胞核,细胞浆和细胞膜中均有表达。高度不典型增生(73.3%:2+)比低度不典型增生(30.0%:2+)表达强。p53在原位癌和大肠典型增生组织中均无表达。结论单剂量二甲肼利葡聚糖硫酸钠合川在短期内能诱导实验小鼠结肠肿瘤发生。此模型对溃疡性结肠炎相关的人肠癌的研究可能有应用价值。 展开更多
关键词 二甲肼 葡聚糖硫酸钠 溃疡性结肠炎相关性人肠癌 Β-CATENIN P53
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Epigenetic field defects in progression to cancer 被引量:4
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作者 Carol Bernstein Valentine Nfonsam +1 位作者 Anil Ramarao Prasad Harris Bernstein 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2013年第3期43-49,共7页
A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent research indicates that cells within a fi... A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent research indicates that cells within a field defect characteristically have an increased frequency of epigenetic alterations and these may be fundamentally important as underlying factors in progression to cancer. However, understanding of epigenetic field defects is at an early stage, and the work of Katsurano et al published this year, is a key contribution to this field. One question examined by Katsurano et al was how early could the formation of an epigenetic field defect be de-tected in a mouse colitis model of tumorigenesis. They highlighted a number of measurable epigenetic altera-tions, detected very early in normal appearing tissue undergoing histologically invisible tumorigenesis. They also documented the increasing presence of the epigenetic alterations at successive times during progression to cancer. In this commentary, we offer a perspective on the changes they observed within a broader sequence of epigenetic events that occur in progressionto cancer. In particular, we highlight the likely central role of epigenetic deficiencies in DNA repair gene expression that arise during progression to cancer. 展开更多
关键词 FIELD defect Epigenetics TUMORIGENESIS carcinogenesis DNA damage DNA repair colon CANCER Mouse Human
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Potential beneficial effects of butyrate in intestinal and extraintestinal diseases 被引量:56
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作者 Roberto Berni Canani Margherita Di Costanzo +3 位作者 Ludovica Leone Monica Pedata Rosaria Meli Antonio Calignano 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第12期1519-1528,共10页
The multiple beneficial effects on human health of the short-chain fatty acid butyrate,synthesized from nonabsorbed carbohydrate by colonic microbiota,are well documented.At the intestinal level,butyrate plays a regul... The multiple beneficial effects on human health of the short-chain fatty acid butyrate,synthesized from nonabsorbed carbohydrate by colonic microbiota,are well documented.At the intestinal level,butyrate plays a regulatory role on the transepithelial fluid transport,ameliorates mucosal inflammation and oxidative status,reinforces the epithelial defense barrier,and modulates visceral sensitivity and intestinal motility.In addition,a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer.At the extraintestinal level,butyrate exerts potentially useful effects on many conditions,including hemoglobinopathies,genetic metabolic diseases,hypercholesterolemia,insulin resistance,and ischemic stroke.The mechanisms of action of butyrate are different;many of these are related to its potent regulatory effects on gene expression.These data suggest a wide spectrum of positive effects exerted by butyrate,with a high potential for a therapeutic use in human medicine. 展开更多
关键词 短链的丰满的酸 饮食的纤维 冒号 离子运输 发炎 carcinogenesis 肠的障碍 氧化应力 内脏的感觉
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CD26: A prognostic marker of other systemic malignancies besides colo-rectal carcinomas
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作者 Shailendra Kapoor 《World Journal of Clinical Oncology》 CAS 2012年第8期126-127,共2页
I read with great interest the recent article by Cordero et al in a recent issue of your esteemed journal.Interestingly,the past few years have seen the emergence of CD26 as an important diagnostic and prognostic mark... I read with great interest the recent article by Cordero et al in a recent issue of your esteemed journal.Interestingly,the past few years have seen the emergence of CD26 as an important diagnostic and prognostic marker for a number of systemic malignancies besides colo-rectal carcinomas.For instance,serum CD26 levels are an important emerging marker of B-cell chronic lymphocytic leukemia(B-CLL).In fact,Molica et al have recently reported shorter time to first treatment in B-CLL which exhibit higher serum CD26 levels and simultaneously demonstrate absence of mutation in Ig V(H).Similarly,CD26 serves as a marker of poor prognosis in T cell lymphomas.Simultaneously,a poor response to 2’-deoxycoformycin is seen T cell lymphomas expressing CD26.Similarly,breast carcinomas exhibit decreased CD26 mean fluorescence intensity and a decreased percentage of CD26 positive lymphocytes in comparison to benign breast tumors and healthy individuals. 展开更多
关键词 CD26 CANCER carcinogenesis colon CANCER Marker
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Colorectal cancer,one entity or three 被引量:10
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作者 Feng-ying LI Mao-de LAI 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2009年第3期219-229,共11页
Understanding of the mechanism of colorectal carcinogenesis has been gaining momentum for some years on account of its high incidence and impact on the lives of individuals affected. Different genetic abnormalities ha... Understanding of the mechanism of colorectal carcinogenesis has been gaining momentum for some years on account of its high incidence and impact on the lives of individuals affected. Different genetic abnormalities have been found in colorectal cancers from different sites. For example,proximal colon cancer is usually related to the nucleotide instability pathway,as microsatellite instability(MSI). However,distal colon cancer is usually associated with specific chromosomal instability(CIN). The development of cancer at the rectum,though similar to that at the colon,displays its own unique features. These differences might be partially attributed to different embryological development and physiological circumstances. Environmental factors such as diet and alcohol intake also differ in their role in the development of tumors in the three segments,proximal colon,distal colon,and rectum. "Proximal shift" of colon cancer has been known for some time,and survival rates of colorectal cancer are higher when rectal cancers are excluded,both of which emphasize the three different segments of colorectal cancer and their different properties. Meanwhile,colonic and rectal cancers are distinctive therapeutic entities. The concept of three entities of colorectal cancer may be important in designing clinical trails or therapeutic strategies. However,the dispute about the inconsistency of data concerning the site-specific mechanism of colorectal carcinoma does exist,and more evidence about molecular events of carcinogenesis and targeted therapy needs to be collected to definitely confirm the conception. 展开更多
关键词 大肠癌 实体 微卫星不稳定性 染色体不稳定性 结肠癌 直肠癌 异常发现 胚胎发育
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450例结肠息肉临床特点及癌变相关因素分析 被引量:3
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作者 周超 付翠平 《慢性病学杂志》 2019年第12期1803-1806,共4页
目的总结结肠息肉患者的临床及病理组织学特点,探讨相关癌变因素。方法回顾性分析450例结肠息肉患者的临床资料,根据病理特点分为非腺瘤性息肉组(142例)及腺瘤性息肉组(308例),腺瘤性息肉组根据患者上皮内瘤变程度分为低级别瘤变组(237... 目的总结结肠息肉患者的临床及病理组织学特点,探讨相关癌变因素。方法回顾性分析450例结肠息肉患者的临床资料,根据病理特点分为非腺瘤性息肉组(142例)及腺瘤性息肉组(308例),腺瘤性息肉组根据患者上皮内瘤变程度分为低级别瘤变组(237例)及高级别瘤变组(71例),对各组间年龄、性别及息肉数目、直径、分布位置、山田分型、表面黏膜情况、分叶、临床表现进行统计分析。结果结肠息肉患者中腺瘤发生率为68.44%,腺瘤性息肉中高级别瘤变组与低级别瘤变组在消化道出血症状差异有统计学意义(P<0.05),腺瘤性息肉和非腺瘤性息肉组在性别、分布部位差异无统计学意义(P>0.05);在年龄、息肉数目、息肉直径、山田分型、表面黏膜形态、分叶情况方面差异有统计学意义(P<0.05),高级别瘤变组与低级别瘤变组在息肉直径、山田分型、表面黏膜形态、分叶情况方面差异有统计学意义(P<0.05)。结论结肠息肉的临床特点中高级别瘤变患者更容易出现消化道出血,息肉直径大于1 cm、山田Ⅲ型及Ⅳ型、表面糜烂或溃疡、分叶者高级别上皮内瘤变发生率增高。 展开更多
关键词 结肠息肉 临床特点 癌变 相关因素
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Digestive Tract
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《China Medical Abstracts(Internal Medicine)》 2011年第1期41-46,共6页
2011080 Annexin A2 expression in human esophagealsquamous cell carcinoma and its correlation withinvasion and metastasis. FENG Junguo (冯军国), etal. Med Res Center, 1st Affil Hosp, Xinjiang Med Univ,Urumqi 830054 . C... 2011080 Annexin A2 expression in human esophagealsquamous cell carcinoma and its correlation withinvasion and metastasis. FENG Junguo (冯军国), etal. Med Res Center, 1st Affil Hosp, Xinjiang Med Univ,Urumqi 830054 . Chin J Dig 2010; 30 (11):798-802. 展开更多
关键词 COLORECTAL metastasis adenomatous colon ESOPHAGEAL MUCOSA carcinogenesis invasion 冯军 PERSONALITY
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Digestive Tract
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《China Medical Abstracts(Internal Medicine)》 2010年第1期40-44,共5页
关键词 colorectal HNPCC esophageal STOMACH carcinogenesis colon PRECANCEROUS mutation MUCOSA infiltrating
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