Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan...Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.展开更多
1型糖尿病(diabetes mellitus type 1,T1DM)又称为胰岛素依赖型糖尿病,是指胰岛β细胞破坏导致体内胰岛素分泌绝对缺乏而引发的代谢紊乱性疾病。T1DM是危害儿童健康的重大儿科内分泌疾病,儿童T1DM发病率快速增加且低龄化趋势明显,但T1D...1型糖尿病(diabetes mellitus type 1,T1DM)又称为胰岛素依赖型糖尿病,是指胰岛β细胞破坏导致体内胰岛素分泌绝对缺乏而引发的代谢紊乱性疾病。T1DM是危害儿童健康的重大儿科内分泌疾病,儿童T1DM发病率快速增加且低龄化趋势明显,但T1DM的发病机制并未完全阐明。目前主要认为是遗传及环境因素的共同影响,导致胰岛β细胞受到自身免疫系统的攻击而被破坏,从而导致一系列不可逆的影响。与过去相比,由于外源性胰岛素的应用,T1DM患者的预期寿命大幅增加,但仍比健康人短。为减少儿童T1DM发病率并提高预后,对儿童T1DM发病危险因素的研究就显得尤为重要。展开更多
The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adju...The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the treatment.We aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,Hungary.Measures:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were measured.Children having depressive symptoms drew fewer circles with less area.Children not drawing any important relationships possessed more depressive symptoms.Those diagnosed at a younger age displayed smaller distance between the Self-and Illness-circles.The PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.展开更多
基金funded by the National Natural Science Foundation of China (32371341,31872674)the Scientific and Technologic Foundation of Jilin Province (20230202050NC)the Fundamental Research Funds for the Central Universities (CGZH202206)。
文摘Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.
文摘1型糖尿病(diabetes mellitus type 1,T1DM)又称为胰岛素依赖型糖尿病,是指胰岛β细胞破坏导致体内胰岛素分泌绝对缺乏而引发的代谢紊乱性疾病。T1DM是危害儿童健康的重大儿科内分泌疾病,儿童T1DM发病率快速增加且低龄化趋势明显,但T1DM的发病机制并未完全阐明。目前主要认为是遗传及环境因素的共同影响,导致胰岛β细胞受到自身免疫系统的攻击而被破坏,从而导致一系列不可逆的影响。与过去相比,由于外源性胰岛素的应用,T1DM患者的预期寿命大幅增加,但仍比健康人短。为减少儿童T1DM发病率并提高预后,对儿童T1DM发病危险因素的研究就显得尤为重要。
文摘The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the treatment.We aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,Hungary.Measures:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were measured.Children having depressive symptoms drew fewer circles with less area.Children not drawing any important relationships possessed more depressive symptoms.Those diagnosed at a younger age displayed smaller distance between the Self-and Illness-circles.The PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.
