Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical v...Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical value.In order to fix this problem,we investigate the micromechanics of dsDNA based on the worm-like chain model and flexible hinge model by using Monte Carlo algorithm.The simulation results not only address Hari Shroff’s experiment difficulty reasonably,but also provide strong support for flexible hinge mechanism put forward recently by Yan and Marko[Phys.Rev.Lett.93(2004)].展开更多
基金This research was supported by the Young Investigator Award received by Yan in 2006 and the Foundation for the Visiting PhD Candidate of the Chinese Academy of Science received by Liu in 2006Liu is also supported by the Innovation Foundation for Graduate Students of Guizhou University(2007022).
文摘Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical value.In order to fix this problem,we investigate the micromechanics of dsDNA based on the worm-like chain model and flexible hinge model by using Monte Carlo algorithm.The simulation results not only address Hari Shroff’s experiment difficulty reasonably,but also provide strong support for flexible hinge mechanism put forward recently by Yan and Marko[Phys.Rev.Lett.93(2004)].
