Objective：To explore the expression of DNA polymerase iota in transitional cell carcinoma ceils and tissues; Methods： RT-PCR was applied to detect the expression of polymerase iota in BIU87 and T24 ceils, then the e...Objective：To explore the expression of DNA polymerase iota in transitional cell carcinoma ceils and tissues; Methods： RT-PCR was applied to detect the expression of polymerase iota in BIU87 and T24 ceils, then the expression of polymerase iota was also detected in the same way in transitional cell car- cinoma which was derived from clinical bladder carcinoma and renal pelvic carcinoma. Results ： The expres- sion of Poh was low in bladder normal membrana mucosa but significantly elevated in transitional cell car- cinoma ceils. Compared with the expression of polymerase iota in bladder normal mucous membranes, the expression of polymerase iota was significantly increased in transitional cell carcinoma tissue （P〈0. 01 ） and associated with the grade of transitional cell carcinoma. Conclusion： The significantly increased ex- pression of polymerase iota may be associated with the generation and development of transitional cell carcinoma, even with its high heterogenicity.展开更多
基金the Scientific Research Foundation for Medi-cal Science and Public Health of PLA(06H026)
文摘Objective：To explore the expression of DNA polymerase iota in transitional cell carcinoma ceils and tissues; Methods： RT-PCR was applied to detect the expression of polymerase iota in BIU87 and T24 ceils, then the expression of polymerase iota was also detected in the same way in transitional cell car- cinoma which was derived from clinical bladder carcinoma and renal pelvic carcinoma. Results ： The expres- sion of Poh was low in bladder normal membrana mucosa but significantly elevated in transitional cell car- cinoma ceils. Compared with the expression of polymerase iota in bladder normal mucous membranes, the expression of polymerase iota was significantly increased in transitional cell carcinoma tissue （P〈0. 01 ） and associated with the grade of transitional cell carcinoma. Conclusion： The significantly increased ex- pression of polymerase iota may be associated with the generation and development of transitional cell carcinoma, even with its high heterogenicity.
