Based on the sedimentary characteristics study of Holocene borax\|bearing mirabilite beds of Dong Co(lake) two sections, DZ01 and DZ02, in the center of North\|Tibetan Plateau,combined with dating of 14 C, applied the...Based on the sedimentary characteristics study of Holocene borax\|bearing mirabilite beds of Dong Co(lake) two sections, DZ01 and DZ02, in the center of North\|Tibetan Plateau,combined with dating of 14 C, applied theory and method of comparative salinology, it is determined that the palaeoclimate framework of Dong Co during early\|middle Holocene, and reckoned the range of the temperature variation. Furthermore, after completing regional analogue, discovered that the palaeoclimate environment is fully comparative and consistent with the synchronous lake\|water retreating trace of Zhaduixiong spits in Zabuye Lake basin, with palaeoclimate changes recorded by pollen in adjacent Zabuye Lake, with Holocene plaeoclimate environment indicated by drilling\|hole in Bangong Co,with palaeoclimate significance traced by δ 18 O value in Qinghai Lake and Siling Co and with the palaeoclimate framework during the 5th Level Arid (Salinization) Extension Period of Quaternary arid center of Western China.展开更多
Objective To observe the injury of spatial memory in the rat of continuative illumination and the protection of catgut implantation at Nèiguān （内关 PC6） from the injury. Methods After training for 7 days in M...Objective To observe the injury of spatial memory in the rat of continuative illumination and the protection of catgut implantation at Nèiguān （内关 PC6） from the injury. Methods After training for 7 days in Morris＇s water maze of 4 quadrants, on the 8th day, 48 male Wistar rats of clear grade were randomly divided into a normal group, a model group, a melatonin （MT） group and a catgut implantation group, 12 rats each group. The spatial injury in the rats was induced by continuative and long-term （24 h and 42 days） illumination, and at the same time, they were treated with catgut implantation at Nèiguān （内关 PC6） and intraperitoneal injection of MT; changes of spatial memory ability and ultrastructures of the neurons of the hippocampus were detected by Morris＇s water maze and transmission electron microscope, respectively. Results The searching platform latency （SPL） in the Morris＇s water maze in the model group significantly prolonged as compared with that before modeling （P〈0.05）, and after treatment it was significantly shortened in the MT group and the catgut implantation group as compared with the model group （both P 〈 0.05）, but with no significant differences as compared with that before treatment （both P 〉0.05）. Mitochondria, synapses, axes and vascular endothelium in the hippocampus in the model group were injured in varying degrees, but a less injury was found in the MT group and the catgut implantation group which was similar to that in the normal group. Conclusion Catgut Implantation at Nèiguān （1内关 PC6） can protect from the injury of spatial memory in the rat of continuative illumination.展开更多
BACKGROUND： Han＇s acupoint nerve stimulator （HANS） has been frequently used to relieve pain by promoting the central nerve system＇s release of endogenous opioid peptides through electric stimulation to the body s...BACKGROUND： Han＇s acupoint nerve stimulator （HANS） has been frequently used to relieve pain by promoting the central nerve system＇s release of endogenous opioid peptides through electric stimulation to the body surface. OBJECTIVE： To investigate the pain-relieving effects of HANS, combined with patient-controlled analgesia, following neurosurgery, and to observe adverse reactions and effects. DESIGN, TIME AND SETTING： A randomized control observation was performed at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College （Ganzhou, Jiangxi Province, China） from January 2005 to February 2006. PARTICIPANTS： Forty patients, who were selected for craniotomy and required pain relief following surgery at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College （China）, were included in this study. METHODS： Forty patients underwent neurosurgery and were randomly divided into two groups： patient-controlled analgesia plus HANS （＋HANS, n = 20） and patient-controlled analgesia （-HANS, n = 20）. Both groups were well matched in baseline data. Automatic syringe infusion pump ZZB-150 was the product of Nantong Aipeng Medical Instruments Co., Ltd. （China）. Patient-controlled analgesia consisted of 100 mL 0.02% lappaconitine/0.02% metoclopramide. LH-402 HANS instrument was produced in Beijing （China）, with a serial number of 402183. The HANS instrumentation was used to stimulate the Hegu-Laogong acupoint on one side and Jiaogan, Shenmen penetrating Shen, Waifei, Naogan penetrating Pizhixia ear acupoints on the affected side for one hour, with 2-hour intervals. The disperse-dense wave was alternating, with a 2/100 Hz frequency of electrical stimulation. MAIN OUTCOME MEASURE： The scores of visual analogue scale and incidence of adverse reaction were observed in two groups following surgery. RESULTS： Compared with the HANS group, the visual analogue scale scores were remarkably lower in the ＋HANS group six hours after surgery （P 〈 0.01）, and the incidence rate of adverse reactions, such as nausea and vomiting, was also decreased （P 〈 0.05）.CONCLUSION： The application of HANS to induce body surface stimulation can enhance the effect of pain relief and reduce adverse reactions when used in combination with patient-controlled analgesia following neurosurgery. The effect of combined therapy is superior to patient-controlled analgesia alone.展开更多
Acupuncture at certain acupoints （specific sites for needle insertion） can induce the activation of specific regions of the brain. This activated brain region influences the target organ or tissue in order to treat ...Acupuncture at certain acupoints （specific sites for needle insertion） can induce the activation of specific regions of the brain. This activated brain region influences the target organ or tissue in order to treat the disease. Acupoint specificity is the basis of acupuncture therapy.展开更多
Background:Obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the ef...Background:Obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the efficacy of acupoint catgut embedding(ACE)in abdominal obesity(AO),it is necessary to elucidate the mechanism of ACE for AO.The intestinal flora is closely associated with obesity,and the study of its intestinal flora may provide evidence to clarify the mechanism of obesity treatment by ACE.Methods:75 participants will be recruited in this study,including 60 eligible female patients diagnosed with AO and 15 healthy female participants.60 female AO patients will be randomized to ACE group,sham ACE group,and waiting list(WL)group in a ratio of 1:1:1.Patients in two ACE groups will receive one ACE treatment per week for 12 consecutive weeks,and in the WL group will not receive any treatment;only their data will be extracted.The primary outcome is the mean change in body mass index.Secondary effects include waist circumference,body weight,the visual analog score of appetite,and the Gastrointestinal Symptom Rating Scale.High-throughput 16S ribosomal ribonucleic acid gene sequencing will be used to detect intestinal flora in each group before and after the intervention.Conclusion:The results of this trial are expected to identify the critical intestinal flora causing AO and the target intestinal flora of AO regulated by ACE,providing further theoretical support for ACE in the clinical treatment of obesity.展开更多
Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tole...Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS （2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks）. Cancer pain, quality of life （QOL）, anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale （SAS）/ self-rating depression scale （SDS）, respectively; the therapeutic frequency of breakthrough pain （BP） and daily opioid dose were also recorded. Results： Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient＇s ＂worst＂ and ＂least＂ pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions： To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients＇ QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.展开更多
文摘Based on the sedimentary characteristics study of Holocene borax\|bearing mirabilite beds of Dong Co(lake) two sections, DZ01 and DZ02, in the center of North\|Tibetan Plateau,combined with dating of 14 C, applied theory and method of comparative salinology, it is determined that the palaeoclimate framework of Dong Co during early\|middle Holocene, and reckoned the range of the temperature variation. Furthermore, after completing regional analogue, discovered that the palaeoclimate environment is fully comparative and consistent with the synchronous lake\|water retreating trace of Zhaduixiong spits in Zabuye Lake basin, with palaeoclimate changes recorded by pollen in adjacent Zabuye Lake, with Holocene plaeoclimate environment indicated by drilling\|hole in Bangong Co,with palaeoclimate significance traced by δ 18 O value in Qinghai Lake and Siling Co and with the palaeoclimate framework during the 5th Level Arid (Salinization) Extension Period of Quaternary arid center of Western China.
文摘Objective To observe the injury of spatial memory in the rat of continuative illumination and the protection of catgut implantation at Nèiguān （内关 PC6） from the injury. Methods After training for 7 days in Morris＇s water maze of 4 quadrants, on the 8th day, 48 male Wistar rats of clear grade were randomly divided into a normal group, a model group, a melatonin （MT） group and a catgut implantation group, 12 rats each group. The spatial injury in the rats was induced by continuative and long-term （24 h and 42 days） illumination, and at the same time, they were treated with catgut implantation at Nèiguān （内关 PC6） and intraperitoneal injection of MT; changes of spatial memory ability and ultrastructures of the neurons of the hippocampus were detected by Morris＇s water maze and transmission electron microscope, respectively. Results The searching platform latency （SPL） in the Morris＇s water maze in the model group significantly prolonged as compared with that before modeling （P〈0.05）, and after treatment it was significantly shortened in the MT group and the catgut implantation group as compared with the model group （both P 〈 0.05）, but with no significant differences as compared with that before treatment （both P 〉0.05）. Mitochondria, synapses, axes and vascular endothelium in the hippocampus in the model group were injured in varying degrees, but a less injury was found in the MT group and the catgut implantation group which was similar to that in the normal group. Conclusion Catgut Implantation at Nèiguān （1内关 PC6） can protect from the injury of spatial memory in the rat of continuative illumination.
文摘BACKGROUND： Han＇s acupoint nerve stimulator （HANS） has been frequently used to relieve pain by promoting the central nerve system＇s release of endogenous opioid peptides through electric stimulation to the body surface. OBJECTIVE： To investigate the pain-relieving effects of HANS, combined with patient-controlled analgesia, following neurosurgery, and to observe adverse reactions and effects. DESIGN, TIME AND SETTING： A randomized control observation was performed at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College （Ganzhou, Jiangxi Province, China） from January 2005 to February 2006. PARTICIPANTS： Forty patients, who were selected for craniotomy and required pain relief following surgery at the Department of Neurology in the First Affiliated Hospital of Gannan Medical College （China）, were included in this study. METHODS： Forty patients underwent neurosurgery and were randomly divided into two groups： patient-controlled analgesia plus HANS （＋HANS, n = 20） and patient-controlled analgesia （-HANS, n = 20）. Both groups were well matched in baseline data. Automatic syringe infusion pump ZZB-150 was the product of Nantong Aipeng Medical Instruments Co., Ltd. （China）. Patient-controlled analgesia consisted of 100 mL 0.02% lappaconitine/0.02% metoclopramide. LH-402 HANS instrument was produced in Beijing （China）, with a serial number of 402183. The HANS instrumentation was used to stimulate the Hegu-Laogong acupoint on one side and Jiaogan, Shenmen penetrating Shen, Waifei, Naogan penetrating Pizhixia ear acupoints on the affected side for one hour, with 2-hour intervals. The disperse-dense wave was alternating, with a 2/100 Hz frequency of electrical stimulation. MAIN OUTCOME MEASURE： The scores of visual analogue scale and incidence of adverse reaction were observed in two groups following surgery. RESULTS： Compared with the HANS group, the visual analogue scale scores were remarkably lower in the ＋HANS group six hours after surgery （P 〈 0.01）, and the incidence rate of adverse reactions, such as nausea and vomiting, was also decreased （P 〈 0.05）.CONCLUSION： The application of HANS to induce body surface stimulation can enhance the effect of pain relief and reduce adverse reactions when used in combination with patient-controlled analgesia following neurosurgery. The effect of combined therapy is superior to patient-controlled analgesia alone.
文摘Acupuncture at certain acupoints （specific sites for needle insertion） can induce the activation of specific regions of the brain. This activated brain region influences the target organ or tissue in order to treat the disease. Acupoint specificity is the basis of acupuncture therapy.
基金supported by The Youth Special of Yunnan Province Ten-thousand Plan(YNWR-QNBJ-2019-257)the Human Resources and Social Security Department of Yunnan Province and Yunnan Provincial Science Plan Project-Joint of Traditional Chinese Medicine(2017FF117-011,2019FF002-021,202101AZ070001-096)the Science&Technology Department of Yunnan Province.
文摘Background:Obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the efficacy of acupoint catgut embedding(ACE)in abdominal obesity(AO),it is necessary to elucidate the mechanism of ACE for AO.The intestinal flora is closely associated with obesity,and the study of its intestinal flora may provide evidence to clarify the mechanism of obesity treatment by ACE.Methods:75 participants will be recruited in this study,including 60 eligible female patients diagnosed with AO and 15 healthy female participants.60 female AO patients will be randomized to ACE group,sham ACE group,and waiting list(WL)group in a ratio of 1:1:1.Patients in two ACE groups will receive one ACE treatment per week for 12 consecutive weeks,and in the WL group will not receive any treatment;only their data will be extracted.The primary outcome is the mean change in body mass index.Secondary effects include waist circumference,body weight,the visual analog score of appetite,and the Gastrointestinal Symptom Rating Scale.High-throughput 16S ribosomal ribonucleic acid gene sequencing will be used to detect intestinal flora in each group before and after the intervention.Conclusion:The results of this trial are expected to identify the critical intestinal flora causing AO and the target intestinal flora of AO regulated by ACE,providing further theoretical support for ACE in the clinical treatment of obesity.
文摘Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS （2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks）. Cancer pain, quality of life （QOL）, anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale （SAS）/ self-rating depression scale （SDS）, respectively; the therapeutic frequency of breakthrough pain （BP） and daily opioid dose were also recorded. Results： Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient＇s ＂worst＂ and ＂least＂ pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions： To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients＇ QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression.
