THE ancient town of Huangyao located in Zhaoping County,Hezhou City,south China’s Guangxi Zhuang Autonomous Region,is renown for its time-honored Douchi processing techniques.Douchi is a kind of popular Chinese food ...THE ancient town of Huangyao located in Zhaoping County,Hezhou City,south China’s Guangxi Zhuang Autonomous Region,is renown for its time-honored Douchi processing techniques.Douchi is a kind of popular Chinese food made from fermented and salted black beans,which is commonly used as a condiment or seasoning for a variety of dishes.The history of Huangyao’s Douchi processing techniques can be traced back to the late Yuan Dynasty(1271-1368)and the early Ming Dynasty(1368-1644).According to a historical record of the Qing Dynasty(1644-1911),“Huangyao is famous for its Douchi and has no rivals.”展开更多
Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agric...Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agricultural science and technology,problems of rural drinking water safety,problems of rural roads and transportation,low levels of health care,weak rural public culture,short supply of farmers' education.Secondly,the system and level of urban public goods provision can't meet migrant workers' demand,for example,less migrant workers are employed by the governments' direction;migrant workers are isolated by urban housing project and these workers have difficulty in receiving city social security.One reason of new generation migrant workers facing the double marginalization of rural and urban crisis is that urban and rural public goods supply are different in particular the inadequate supply of public goods in rural areas.Three countermeasures are put forward in order to relieve new generation migrant workers' double marginalization of urban and rural,which include increasing financial input in rural areas in order to achieve equalization of urban and rural public goods,perfecting the preferential agricultural policy to increase rural public goods supply,making urban public goods supply as a guide to promote the new generation migrant workers into the city.展开更多
Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corres...Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.展开更多
文摘THE ancient town of Huangyao located in Zhaoping County,Hezhou City,south China’s Guangxi Zhuang Autonomous Region,is renown for its time-honored Douchi processing techniques.Douchi is a kind of popular Chinese food made from fermented and salted black beans,which is commonly used as a condiment or seasoning for a variety of dishes.The history of Huangyao’s Douchi processing techniques can be traced back to the late Yuan Dynasty(1271-1368)and the early Ming Dynasty(1368-1644).According to a historical record of the Qing Dynasty(1644-1911),“Huangyao is famous for its Douchi and has no rivals.”
基金Supported by Research Projects of Guangxi Provincial Education Department(200911LX465)
文摘Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agricultural science and technology,problems of rural drinking water safety,problems of rural roads and transportation,low levels of health care,weak rural public culture,short supply of farmers' education.Secondly,the system and level of urban public goods provision can't meet migrant workers' demand,for example,less migrant workers are employed by the governments' direction;migrant workers are isolated by urban housing project and these workers have difficulty in receiving city social security.One reason of new generation migrant workers facing the double marginalization of rural and urban crisis is that urban and rural public goods supply are different in particular the inadequate supply of public goods in rural areas.Three countermeasures are put forward in order to relieve new generation migrant workers' double marginalization of urban and rural,which include increasing financial input in rural areas in order to achieve equalization of urban and rural public goods,perfecting the preferential agricultural policy to increase rural public goods supply,making urban public goods supply as a guide to promote the new generation migrant workers into the city.
基金supported by the National Natural Science Foundation of China(No.81973825)the Natural Science Research Foundation of Anhui Province Universities(No.KJ2020A0436)。
文摘Objective:To explore and verify the mechanism of Gan Dou Ling in improving liver fibrosis in Wilson disease(WD)by network pharmacology and copper loaded mice experiments.Methods:The main chemical components and corresponding gene targets of each drug in Gan Dou Ling were obtained by using TCMSP database.The database of gene mutation and disease related gene was searched through the GeneCards database,DrugBank database,PharmGKB database and the DisGeNET database.After the intersection of drug and disease target genes.The STRING website was used to analyze the protein-protein interaction degree of target genes,and import the data to Cytoscape software 38.2 to analyze protein interaction network.The GO databases and KEGG databases were obtained in R language for enrichment analysis.On this basis,Masson staining were used to observe the degree of liver fibrosis in copper loaded mouse model,and the results of network pharmacological analysis were verified by Western Blot(WB).Results:A total of 108 drug disease intersection genes were analyzed by network pharmacology.Through PPI network analysis,JUN was found to be the key genes.The enrichment analysis of KEGG pathway showed that MAPK signal pathway was the important potential target pathways.Animal experiments showed that Gan Dou Ling could reduce liver fibrosis and inhibit the phosphorylation of P38,JNK and C-JUN in copper loaded mice.Conclusion:Gan Dou Ling may achieve the effect of treating WD liver fibrosis by inhibiting P38/JNK signaling pathway.
