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考虑dq轴耦合及线路分布参数的分布式电站谐波不稳定分析
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作者 龚利武 陈超 +4 位作者 钱国良 张炜 徐方维 陈锴 郑鸿儒 《浙江电力》 2024年第5期43-52,共10页
针对同时考虑dq轴耦合和线路分布参数两种因素下,分布式电站系统超越方程零、极点难以求解问题,建立同时考虑二者的电站阻抗模型,提出基于Padé近似的超越方程矩阵行列式零、极点求解方法,并给出系统传递函数矩阵行列式零、极点计... 针对同时考虑dq轴耦合和线路分布参数两种因素下,分布式电站系统超越方程零、极点难以求解问题,建立同时考虑二者的电站阻抗模型,提出基于Padé近似的超越方程矩阵行列式零、极点求解方法,并给出系统传递函数矩阵行列式零、极点计算的详细步骤。进一步,分析不同场景下两种因素对系统谐波不稳定分析的影响。研究表明,所提方法可准确分析同时考虑两种因素下的分布式电站谐波不稳定问题,忽略二者中任一因素均可能造成稳定性误判,且考虑线路分布参数是求解高频谐波放大点的必要前提。仿真结果验证了所提方法的有效性。 展开更多
关键词 分布式电站 谐波不稳定 分布参数 dq轴耦合 超越方程 Padé近似
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A Review on Sources,Extractions and Analysis Methods of a Sustainable Biomaterial:Tannins 被引量:2
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作者 Antonio Pizzi Marie-Pierre Laborie Zeki Candan 《Journal of Renewable Materials》 EI CAS 2024年第3期397-425,共29页
Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly ... Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products.They are a definite class of sustainable materials of the forestry industry.They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries,such as wood adhesives,metal coating,pharmaceutical/medical applications and several others.This review presents the main sources,either already or potentially commercial of this forestry by-materials,their industrial and laboratory extraction systems,their systems of analysis with their advantages and drawbacks,be these methods so simple to even appear primitive but nonetheless of proven effectiveness,or very modern and instrumental.It constitutes a basic but essential summary of what is necessary to know of these sustainable materials.In doing so,the review highlights some of the main challenges that remain to be addressed to deliver the quality and economics of tannin supply necessary to fulfill the industrial production requirements for some materials-based uses. 展开更多
关键词 TANNINS FLAVONOIDS SOURCES extraction methods analysis methods
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Drilling-based measuring method for the c-φ parameter of rock and its field application 被引量:3
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作者 Bei Jiang Fenglin Ma +5 位作者 Qi Wang Hongke Gao Dahu Zhai Yusong Deng Chuanjie Xu Liangdi Yao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第1期65-76,共12页
The technology of drilling tests makes it possible to obtain the strength parameter of rock accurately in situ. In this paper, a new rock cutting analysis model that considers the influence of the rock crushing zone(R... The technology of drilling tests makes it possible to obtain the strength parameter of rock accurately in situ. In this paper, a new rock cutting analysis model that considers the influence of the rock crushing zone(RCZ) is built. The formula for an ultimate cutting force is established based on the limit equilibrium principle. The relationship between digital drilling parameters(DDP) and the c-φ parameter(DDP-cφ formula, where c refers to the cohesion and φ refers to the internal friction angle) is derived, and the response of drilling parameters and cutting ratio to the strength parameters is analyzed. The drillingbased measuring method for the c-φ parameter of rock is constructed. The laboratory verification test is then completed, and the difference in results between the drilling test and the compression test is less than 6%. On this basis, in-situ rock drilling tests in a traffic tunnel and a coal mine roadway are carried out, and the strength parameters of the surrounding rock are effectively tested. The average difference ratio of the results is less than 11%, which verifies the effectiveness of the proposed method for obtaining the strength parameters based on digital drilling. This study provides methodological support for field testing of rock strength parameters. 展开更多
关键词 Digital drilling Rock crushing zone c-u parameter Measurement method Field application
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A comparison study on structure-function relationship of polysaccharides obtained from sea buckthorn berries using different methods:antioxidant and bile acid-binding capacity 被引量:5
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作者 Qiaoyun Li Zuman Dou +5 位作者 Qingfei Duan Chun Chen Ruihai Liu Yueming Jiang Bao Yang Xiong Fu 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期494-505,共12页
In this study,the structural characters,antioxidant activities and bile acid-binding ability of sea buckthorn polysaccharides(HRPs)obtained by the commonly used hot water(HRP-W),pressurized hot water(HRP-H),ultrasonic... In this study,the structural characters,antioxidant activities and bile acid-binding ability of sea buckthorn polysaccharides(HRPs)obtained by the commonly used hot water(HRP-W),pressurized hot water(HRP-H),ultrasonic(HRP-U),acid(HRP-C)and alkali(HRP-A)assisted extraction methods were investigated.The results demonstrated that extraction methods had significant effects on extraction yield,monosaccharide composition,molecular weight,particle size,triple-helical structure,and surface morphology of HRPs except for the major linkage bands.Thermogravimetric analysis showed that HRP-U with filamentous reticular microstructure exhibited better thermal stability.The HRP-A with the lowest molecular weight and highest arabinose content possessed the best antioxidant activities.Moreover,the rheological analysis indicated that HRPs with higher galacturonic acid content and molecular weight showed higher viscosity and stronger crosslinking network(HRP-C,HRP-W and HRP-U),which exhibited stronger bile acid binding capacity.The present findings provide scientific evidence in the preparation technology of sea buckthorn polysaccharides with good antioxidant and bile acid binding capacity which are related to the structure affected by the extraction methods. 展开更多
关键词 Sea buckthorn Extraction method STRUCTURE Rheological properties Antioxidant activity Bile acid binding capacity
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DQ变换和MUSIC算法在ITER磁体电源信号间谐波检测中的应用
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作者 张文晋 马渊明 +1 位作者 陈兴 王亚洲 《合肥工业大学学报(自然科学版)》 CAS 北大核心 2024年第7期912-916,共5页
随着国际热核聚变实验堆(International Thermonuclear Experimental Reactor,ITER)计划的逐步开展,保证ITER磁体电源系统的稳定运行显得尤为重要。文章采用将DQ变换和多信号分类(multiple signal classification,MUSIC)算法相结合的方... 随着国际热核聚变实验堆(International Thermonuclear Experimental Reactor,ITER)计划的逐步开展,保证ITER磁体电源系统的稳定运行显得尤为重要。文章采用将DQ变换和多信号分类(multiple signal classification,MUSIC)算法相结合的方法进行间谐波频率检测,信号的幅度和相位由最小二乘法来估计。DQ变换可以消除大幅度ITER基波分量,MUSIC算法可以通过矩阵特征分解检测出短数据条件下的谐波和间谐波,适用短时平稳的间谐波检测,两者相结合可以有效检测出大幅度基波附近存在小幅度间谐波。仿真实验表明,计算经DQ变换后检测出的ITER信号谐波频率时,取中间信号计算真实频谱较为正确,两侧信号则有较大的误差。 展开更多
关键词 国际热核聚变实验堆(ITER)磁体电源系统 间谐波 dq变换 最小二乘法 多信号分类(MUSIC)算法
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Volumetric lattice Boltzmann method for pore-scale mass diffusionadvection process in geopolymer porous structures 被引量:1
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作者 Xiaoyu Zhang Zirui Mao +6 位作者 Floyd W.Hilty Yulan Li Agnes Grandjean Robert Montgomery Hans-Conrad zur Loye Huidan Yu Shenyang Hu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2126-2136,共11页
Porous materials present significant advantages for absorbing radioactive isotopes in nuclear waste streams.To improve absorption efficiency in nuclear waste treatment,a thorough understanding of the diffusion-advecti... Porous materials present significant advantages for absorbing radioactive isotopes in nuclear waste streams.To improve absorption efficiency in nuclear waste treatment,a thorough understanding of the diffusion-advection process within porous structures is essential for material design.In this study,we present advancements in the volumetric lattice Boltzmann method(VLBM)for modeling and simulating pore-scale diffusion-advection of radioactive isotopes within geopolymer porous structures.These structures are created using the phase field method(PFM)to precisely control pore architectures.In our VLBM approach,we introduce a concentration field of an isotope seamlessly coupled with the velocity field and solve it by the time evolution of its particle population function.To address the computational intensity inherent in the coupled lattice Boltzmann equations for velocity and concentration fields,we implement graphics processing unit(GPU)parallelization.Validation of the developed model involves examining the flow and diffusion fields in porous structures.Remarkably,good agreement is observed for both the velocity field from VLBM and multiphysics object-oriented simulation environment(MOOSE),and the concentration field from VLBM and the finite difference method(FDM).Furthermore,we investigate the effects of background flow,species diffusivity,and porosity on the diffusion-advection behavior by varying the background flow velocity,diffusion coefficient,and pore volume fraction,respectively.Notably,all three parameters exert an influence on the diffusion-advection process.Increased background flow and diffusivity markedly accelerate the process due to increased advection intensity and enhanced diffusion capability,respectively.Conversely,increasing the porosity has a less significant effect,causing a slight slowdown of the diffusion-advection process due to the expanded pore volume.This comprehensive parametric study provides valuable insights into the kinetics of isotope uptake in porous structures,facilitating the development of porous materials for nuclear waste treatment applications. 展开更多
关键词 Volumetric lattice Boltzmann method(VLBM) Phase field method(PFM) Pore-scale diffusion-advection Nuclear waste treatment Porous media flow Graphics processing unit(GPU) parallelization
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Material point method simulation of hydro-mechanical behaviour in twophase porous geomaterials: A state-of-the-art review 被引量:1
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作者 Xiangcou Zheng Shuying Wang +1 位作者 Feng Yang Junsheng Yang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2341-2350,共10页
The material point method(MPM)has been gaining increasing popularity as an appropriate approach to the solution of coupled hydro-mechanical problems involving large deformation.In this paper,we survey the current stat... The material point method(MPM)has been gaining increasing popularity as an appropriate approach to the solution of coupled hydro-mechanical problems involving large deformation.In this paper,we survey the current state-of-the-art in the MPM simulation of hydro-mechanical behaviour in two-phase porous geomaterials.The review covers the recent advances and developments in the MPM and their extensions to capture the coupled hydro-mechanical problems involving large deformations.The focus of this review is aiming at providing a clear picture of what has or has not been developed or implemented for simulating two-phase coupled large deformation problems,which will provide some direct reference for both practitioners and researchers. 展开更多
关键词 Coupled problems Hydro-mechanical behaviour Large deformation Material Point method(MPM)
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Sparse Modal Decomposition Method Addressing Underdetermined Vortex-Induced Vibration Reconstruction Problem for Marine Risers 被引量:1
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作者 DU Zun-feng ZHU Hai-ming YU Jian-xing 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期285-296,共12页
When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fa... When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fatigue monitoring of real risers.The problem is conventionally solved using the modal decomposition method,based on the principle that the response can be approximated by a weighted sum of limited vibration modes.However,the method is not valid when the problem is underdetermined,i.e.,the number of unknown mode weights is more than the number of known measurements.This study proposed a sparse modal decomposition method based on the compressed sensing theory and the Compressive Sampling Matching Pursuit(Co Sa MP)algorithm,exploiting the sparsity of VIV in the modal space.In the validation study based on high-order VIV experiment data,the proposed method successfully reconstructed the response using only seven acceleration measurements when the conventional methods failed.A primary advantage of the proposed method is that it offers a completely data-driven approach for the underdetermined VIV reconstruction problem,which is more favorable than existing model-dependent solutions for many practical applications such as riser structural health monitoring. 展开更多
关键词 motion reconstruction vortex-induced vibration(VIV) marine riser modal decomposition method compressed sensing
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不平衡电网下双dq坐标变换的M3C微分平坦控制策略
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作者 程启明 杜婷伟 赖宇生 《电机与控制学报》 EI CSCD 北大核心 2024年第1期49-60,共12页
针对目前模块化多电平矩阵变换器(M3C)研究中常用的双αβ坐标变换解耦不彻底、传统PID控制方法效果差、不平衡工况研究少等问题,在分析拓扑结构和数学模型的基础上,采用双dq坐标变换对电气量进行解耦,建立了M3C的输入输出侧数学模型,... 针对目前模块化多电平矩阵变换器(M3C)研究中常用的双αβ坐标变换解耦不彻底、传统PID控制方法效果差、不平衡工况研究少等问题,在分析拓扑结构和数学模型的基础上,采用双dq坐标变换对电气量进行解耦,建立了M3C的输入输出侧数学模型,分别对电压、电流进行正负序分离,并结合微分平坦理论,推导了输入侧、输出侧的微分平坦控制(DFC),最后模拟了两种不平衡工况下的运行情况。仿真结果表明,与线性PID控制相比,非线性的微分平坦控制提高了内环电流的跟踪速度和精度,更适用于非线性的M3C系统。在电网平衡或电网出现不对称故障时,微分平坦控制下M3C系统的动态稳定性与快速性更好,电能质量更高,电流谐波含量最多可以降低1.42%,能够更有效地抑制负序电流。 展开更多
关键词 海上风力发电 模块化多电平矩阵变换器 不平衡电网 dq坐标变换 微分平坦控制 PID控制
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Numerical manifold method for thermo-mechanical coupling simulation of fractured rock mass 被引量:1
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作者 Jiawei Liang Defu Tong +3 位作者 Fei Tan Xiongwei Yi Junpeng Zou Jiahe Lv 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期1977-1992,共16页
As a calculation method based on the Galerkin variation,the numerical manifold method(NMM)adopts a double covering system,which can easily deal with discontinuous deformation problems and has a high calculation accura... As a calculation method based on the Galerkin variation,the numerical manifold method(NMM)adopts a double covering system,which can easily deal with discontinuous deformation problems and has a high calculation accuracy.Aiming at the thermo-mechanical(TM)coupling problem of fractured rock masses,this study uses the NMM to simulate the processes of crack initiation and propagation in a rock mass under the influence of temperature field,deduces related system equations,and proposes a penalty function method to deal with boundary conditions.Numerical examples are employed to confirm the effectiveness and high accuracy of this method.By the thermal stress analysis of a thick-walled cylinder(TWC),the simulation of cracking in the TWC under heating and cooling conditions,and the simulation of thermal cracking of the SwedishÄspöPillar Stability Experiment(APSE)rock column,the thermal stress,and TM coupling are obtained.The numerical simulation results are in good agreement with the test data and other numerical results,thus verifying the effectiveness of the NMM in dealing with thermal stress and crack propagation problems of fractured rock masses. 展开更多
关键词 Heat conduction Fractured rock mass Crack propagation Galerkin variation Numerical manifold method(NMM)
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A stable implicit nodal integration-based particle finite element method(N-PFEM)for modelling saturated soil dynamics 被引量:1
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作者 Liang Wang Xue Zhang +1 位作者 Jingjing Meng Qinghua Lei 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2172-2183,共12页
In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated soils.Our approach incorporates the nodal integration technique into a gene... In this study,we present a novel nodal integration-based particle finite element method(N-PFEM)designed for the dynamic analysis of saturated soils.Our approach incorporates the nodal integration technique into a generalised Hellinger-Reissner(HR)variational principle,creating an implicit PFEM formulation.To mitigate the volumetric locking issue in low-order elements,we employ a node-based strain smoothing technique.By discretising field variables at the centre of smoothing cells,we achieve nodal integration over cells,eliminating the need for sophisticated mapping operations after re-meshing in the PFEM.We express the discretised governing equations as a min-max optimisation problem,which is further reformulated as a standard second-order cone programming(SOCP)problem.Stresses,pore water pressure,and displacements are simultaneously determined using the advanced primal-dual interior point method.Consequently,our numerical model offers improved accuracy for stresses and pore water pressure compared to the displacement-based PFEM formulation.Numerical experiments demonstrate that the N-PFEM efficiently captures both transient and long-term hydro-mechanical behaviour of saturated soils with high accuracy,obviating the need for stabilisation or regularisation techniques commonly employed in other nodal integration-based PFEM approaches.This work holds significant implications for the development of robust and accurate numerical tools for studying saturated soil dynamics. 展开更多
关键词 Particle finite element method Nodal integration Dynamic saturated media Second-order cone programming(SOCP)
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An inverse analysis of fluid flow through granular media using differentiable lattice Boltzmann method 被引量:1
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作者 Qiuyu Wang Krishna Kumar 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第6期2077-2090,共14页
This study presents a method for the inverse analysis of fluid flow problems.The focus is put on accurately determining boundary conditions and characterizing the physical properties of granular media,such as permeabi... This study presents a method for the inverse analysis of fluid flow problems.The focus is put on accurately determining boundary conditions and characterizing the physical properties of granular media,such as permeability,and fluid components,like viscosity.The primary aim is to deduce either constant pressure head or pressure profiles,given the known velocity field at a steady-state flow through a conduit containing obstacles,including walls,spheres,and grains.The lattice Boltzmann method(LBM)combined with automatic differentiation(AD)(AD-LBM)is employed,with the help of the GPU-capable Taichi programming language.A lightweight tape is used to generate gradients for the entire LBM simulation,enabling end-to-end backpropagation.Our AD-LBM approach accurately estimates the boundary conditions for complex flow paths in porous media,leading to observed steady-state velocity fields and deriving macro-scale permeability and fluid viscosity.The method demonstrates significant advantages in terms of prediction accuracy and computational efficiency,making it a powerful tool for solving inverse fluid flow problems in various applications. 展开更多
关键词 Inverse problem Fluid flow Granular media Automatic differentiation(AD) Lattice Boltzmann method(LBM)
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Robustness Study and Superior Method Development and Validation for Analytical Assay Method of Atropine Sulfate in Pharmaceutical Ophthalmic Solution
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作者 Md. Nazmus Sakib Chowdhury Sreekanta Nath Dalal +4 位作者 Md. Ariful Islam Md. Anwar Hossain Pranab Kumar Das Shakawat Hossain Parajit Das 《American Journal of Analytical Chemistry》 CAS 2024年第5期151-164,共14页
Background: The robustness is a measurement of an analytical chemical method and its ability to contain unaffected by little with deliberate variation of analytical chemical method parameters. The analytical chemical ... Background: The robustness is a measurement of an analytical chemical method and its ability to contain unaffected by little with deliberate variation of analytical chemical method parameters. The analytical chemical method variation parameters are based on pH variability of buffer solution of mobile phase, organic ratio composition changes, stationary phase (column) manufacture, brand name and lot number variation;flow rate variation and temperature variation of chromatographic system. The analytical chemical method for assay of Atropine Sulfate conducted for robustness evaluation. The typical variation considered for mobile phase organic ratio change, change of pH, change of temperature, change of flow rate, change of column etc. Purpose: The aim of this study is to develop a cost effective, short run time and robust analytical chemical method for the assay quantification of Atropine in Pharmaceutical Ophthalmic Solution. This will help to make analytical decisions quickly for research and development scientists as well as will help with quality control product release for patient consumption. This analytical method will help to meet the market demand through quick quality control test of Atropine Ophthalmic Solution and it is very easy for maintaining (GDP) good documentation practices within the shortest period of time. Method: HPLC method has been selected for developing superior method to Compendial method. Both the compendial HPLC method and developed HPLC method was run into the same HPLC system to prove the superiority of developed method. Sensitivity, precision, reproducibility, accuracy parameters were considered for superiority of method. Mobile phase ratio change, pH of buffer solution, change of stationary phase temperature, change of flow rate and change of column were taken into consideration for robustness study of the developed method. Results: The limit of quantitation (LOQ) of developed method was much low than the compendial method. The % RSD for the six sample assay of developed method was 0.4% where the % RSD of the compendial method was 1.2%. The reproducibility between two analysts was 100.4% for developed method on the contrary the compendial method was 98.4%. 展开更多
关键词 ROBUSTNESS method Validation HPLC Compendial method method Development GDP LOQ
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Cascading multi-segment rupture process of the 2023 Turkish earthquake doublet on a complex fault system revealed by teleseismic P wave back projection method 被引量:1
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作者 Bonan Cao Zengxi Ge 《Earthquake Science》 2024年第2期158-173,共16页
In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back proj... In this study,the vertical components of broadband teleseismic P wave data recorded by China Earthquake Network are used to image the rupture processes of the February 6th,2023 Turkish earthquake doublet via back projection analysis.Data in two frequency bands(0.5-2 Hz and 1-3 Hz)are used in the imaging processes.The results show that the rupture of the first event extends about 200 km to the northeast and about 150 km to the southwest,lasting~90 s in total.The southwestern rupture is triggered by the northeastern rupture,demonstrating a sequential bidirectional unilateral rupture pattern.The rupture of the second event extends approximately 80 km in both northeast and west directions,lasting~35 s in total and demonstrates a typical bilateral rupture feature.The cascading ruptures on both sides also reflect the occurrence of selective rupture behaviors on bifurcated faults.In addition,we observe super-shear ruptures on certain fault sections with relatively straight fault structures and sparse aftershocks. 展开更多
关键词 2023 Turkish earthquake doublet back projection method cascading segmented rupture process coseismic triggering super-shear ruptures
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Hybrid Strategy of Partitioned and Monolithic Methods for Solving Strongly Coupled Analysis of Inverse and Direct Piezoelectric and Circuit Coupling
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作者 Daisuke Ishihara Syunnosuke Nozaki +1 位作者 Tomoya Niho Naoto Takayama 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第8期1371-1386,共16页
The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy harvesters.Existing strongly coupled analysis methods based on direct n... The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy harvesters.Existing strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic formulations.Each formulation has its advantages and disadvantages,and the choice depends on the characteristics of each coupled problem.This study proposes a new option:a coupled analysis strategy that combines the best features of the existing formulations,namely,the hybrid partitioned-monolithic method.The analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric and circuit interaction are strongly coupled using a partitioned iterative hierarchical algorithm.In a typical benchmark problem of a piezoelectric energy harvester,this research compares the results from the proposed method to those from the conventional strongly coupled partitioned iterative method,discussing the accuracy,stability,and computational cost.The proposed hybrid concept is effective for coupled multi-physics problems,including various coupling conditions. 展开更多
关键词 Structure-piezoelectric-circuit interaction energy harvesting partitioned method monolithic method hybrid method
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Gas Chromatographic Method for Identification and Quantification of Commonly Used Residual Solvents in Pharmaceuticals Products
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作者 Sreekanta Nath Dalal Pranab Kumar Das 《American Journal of Analytical Chemistry》 CAS 2024年第8期241-252,共12页
Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three dif... Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three different types of impurities are generally available in the pharmaceutical’s product specification: organic impurities, inorganic impurities, and residual solvents. Residual solvents are organic volatile chemicals used or generated during the manufacturing of drug substances or drug products. Purpose: The aim of this study is to develop a cost-effective gas chromatographic method for the identification and quantification of some commonly used solvents—methanol, acetone, isopropyl alcohol (IPA), methylene chloride, ethyl acetate, tetrahydrofuran (THF), benzene, toluene, and pyridine—in pharmaceutical product manufacturing. This method will be able to identify and quantify the multiple solvents within a single gas chromatographic procedure. Method: A gas chromatography (GC) equipped with a headspace sampler and a flame ionization detector, and a column DB 624, 30-meter-long × 0.32-millimeter internal diameter, 1,8 μm-thick, Brand-Agilent was used to develop this method. The initial GC oven temperature was 40°C and held for 5 minutes. It was then increase to 80˚C at a rate of 2˚C per minute, followed by a further increase to 225˚C at a rate of 30˚C per minute, with a final hold at 225˚C for 10 minutes. Nitrogen was used as a carrier gas at a flow rate of 1.20 mL per minute. Dimethyl sulfoxide (DMSO) was selected as sample solvent. Results: The developed method is precise and specific. The percent RSD for the areas of six replicate injections of this gas chromatographic method was within 10.0 and the recovery result found within 80.0% to 120.0%. 展开更多
关键词 method Development Gas Chromatography Compendial method GDP SPECIFICITY RECOVERY
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A High-Accuracy Curve Boundary Recognition Method Based on the Lattice Boltzmann Method and Immersed Moving Boundary Method
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作者 Jie-Di Weng Yong-Zheng Jiang +2 位作者 Long-Chao Chen Xu Zhang Guan-Yong Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第9期2533-2557,共25页
Applying numerical simulation technology to investigate fluid-solid interaction involving complex curved bound-aries is vital in aircraft design,ocean,and construction engineering.However,current methods such as Latti... Applying numerical simulation technology to investigate fluid-solid interaction involving complex curved bound-aries is vital in aircraft design,ocean,and construction engineering.However,current methods such as Lattice Boltzmann(LBM)and the immersion boundary method based on solid ratio(IMB)have limitations in identifying custom curved boundaries.Meanwhile,IBM based on velocity correction(IBM-VC)suffers from inaccuracies and numerical instability.Therefore,this study introduces a high-accuracy curve boundary recognition method(IMB-CB),which identifies boundary nodes by moving the search box,and corrects the weighting function in LBM by calculating the solid ratio of the boundary nodes,achieving accurate recognition of custom curve boundaries.In addition,curve boundary image and dot methods are utilized to verify IMB-CB.The findings revealed that IMB-CB can accurately identify the boundary,showing an error of less than 1.8%with 500 lattices.Also,the flow in the custom curve boundary and aerodynamic characteristics of the NACA0012 airfoil are calculated and compared to IBM-VC.Results showed that IMB-CB yields lower lift and drag coefficient errors than IBM-VC,with a 1.45%drag coefficient error.In addition,the characteristic curve of IMB-CB is very stable,whereas that of IBM-VC is not.For the moving boundary problem,LBM-IMB-CB with discrete element method(DEM)is capable of accurately simulating the physical phenomena of multi-moving particle flow in complex curved pipelines.This research proposes a new curve boundary recognition method,which can significantly promote the stability and accuracy of fluid-solid interaction simulations and thus has huge applications in engineering. 展开更多
关键词 Fluid-solid interaction curve boundary recognition method Lattice Boltzmann method immersed moving boundary method
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Stability Analysis and Performance Evaluation of Additive Mixed-Precision Runge-Kutta Methods
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作者 Ben Burnett Sigal Gottlieb Zachary J.Grant 《Communications on Applied Mathematics and Computation》 EI 2024年第1期705-738,共34页
Additive Runge-Kutta methods designed for preserving highly accurate solutions in mixed-precision computation were previously proposed and analyzed.These specially designed methods use reduced precision for the implic... Additive Runge-Kutta methods designed for preserving highly accurate solutions in mixed-precision computation were previously proposed and analyzed.These specially designed methods use reduced precision for the implicit computations and full precision for the explicit computations.In this work,we analyze the stability properties of these methods and their sensitivity to the low-precision rounding errors,and demonstrate their performance in terms of accuracy and efficiency.We develop codes in FORTRAN and Julia to solve nonlinear systems of ODEs and PDEs using the mixed-precision additive Runge-Kutta(MP-ARK)methods.The convergence,accuracy,and runtime of these methods are explored.We show that for a given level of accuracy,suitably chosen MP-ARK methods may provide significant reductions in runtime. 展开更多
关键词 Mixed precision Runge-Kutta methods Additive methods ACCURACY
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High-Order Decoupled and Bound Preserving Local Discontinuous Galerkin Methods for a Class of Chemotaxis Models
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作者 Wei Zheng Yan Xu 《Communications on Applied Mathematics and Computation》 EI 2024年第1期372-398,共27页
In this paper,we explore bound preserving and high-order accurate local discontinuous Galerkin(LDG)schemes to solve a class of chemotaxis models,including the classical Keller-Segel(KS)model and two other density-depe... In this paper,we explore bound preserving and high-order accurate local discontinuous Galerkin(LDG)schemes to solve a class of chemotaxis models,including the classical Keller-Segel(KS)model and two other density-dependent problems.We use the convex splitting method,the variant energy quadratization method,and the scalar auxiliary variable method coupled with the LDG method to construct first-order temporal accurate schemes based on the gradient flow structure of the models.These semi-implicit schemes are decoupled,energy stable,and can be extended to high accuracy schemes using the semi-implicit spectral deferred correction method.Many bound preserving DG discretizations are only worked on explicit time integration methods and are difficult to get high-order accuracy.To overcome these difficulties,we use the Lagrange multipliers to enforce the implicit or semi-implicit LDG schemes to satisfy the bound constraints at each time step.This bound preserving limiter results in the Karush-Kuhn-Tucker condition,which can be solved by an efficient active set semi-smooth Newton method.Various numerical experiments illustrate the high-order accuracy and the effect of bound preserving. 展开更多
关键词 Chemotaxis models Local discontinuous Galerkin(LDG)scheme Convex splitting method Variant energy quadratization method Scalar auxiliary variable method Spectral deferred correction method
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Optimization of Random Feature Method in the High-Precision Regime
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作者 Jingrun Chen Weinan E Yifei Sun 《Communications on Applied Mathematics and Computation》 EI 2024年第2期1490-1517,共28页
Machine learning has been widely used for solving partial differential equations(PDEs)in recent years,among which the random feature method(RFM)exhibits spectral accuracy and can compete with traditional solvers in te... Machine learning has been widely used for solving partial differential equations(PDEs)in recent years,among which the random feature method(RFM)exhibits spectral accuracy and can compete with traditional solvers in terms of both accuracy and efficiency.Potentially,the optimization problem in the RFM is more difficult to solve than those that arise in traditional methods.Unlike the broader machine-learning research,which frequently targets tasks within the low-precision regime,our study focuses on the high-precision regime crucial for solving PDEs.In this work,we study this problem from the following aspects:(i)we analyze the coeffcient matrix that arises in the RFM by studying the distribution of singular values;(ii)we investigate whether the continuous training causes the overfitting issue;(ii)we test direct and iterative methods as well as randomized methods for solving the optimization problem.Based on these results,we find that direct methods are superior to other methods if memory is not an issue,while iterative methods typically have low accuracy and can be improved by preconditioning to some extent. 展开更多
关键词 Random feature method(RFM) Partial differential equation(PDE) Least-squares problem Direct method Iterative method
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